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Original Article

Ligand-Induced Homo-and Hetero-Dimerization of Platelet-Derived Growth Factor α- and β-Receptors in Intact Cells

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Pages 1-14 | Received 09 Aug 1991, Accepted 22 Aug 1991, Published online: 11 Jul 2009

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Bengt Westermark & Carl-Henrik Heldin. (1993) Platelet-Derived Growth Factor Structure, function and implications in normal and malignant cell growth. Acta Oncologica 32:2, pages 101-105.
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Federica Toffalini, Carina Hellberg & Jean-Baptiste Demoulin. (2010) Critical Role of the Platelet-derived Growth Factor Receptor (PDGFR) β Transmembrane Domain in the TEL-PDGFRβ Cytosolic Oncoprotein. Journal of Biological Chemistry 285:16, pages 12268-12278.
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M. Autiero, A. Luttun, M. Tjwa & P. Carmeliet. (2003) Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders. Journal of Thrombosis and Haemostasis 1:7, pages 1356-1370.
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Pascal N. Bernatchez, Shay Soker & Martin G. Sirois. (1999) Vascular Endothelial Growth Factor Effect on Endothelial Cell Proliferation, Migration, and Platelet-activating Factor Synthesis Is Flk-1-dependent. Journal of Biological Chemistry 274:43, pages 31047-31054.
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Carol Bell, Eric Lynam, Darla J. Landfair, Nebojsa Janjic & Marc E. Wiles. (1999) Oligonucleotide NX1838 inhibits VEGF165-mediated cellular responses in vitro. In Vitro Cellular & Developmental Biology - Animal 35:9, pages 533-542.
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Levon M. KhachigianFernando S. SantiagoLouise A. RaftyOnza L.-W. ChanGabrielle J. DelbridgeAlex BobikTucker CollinsAlfred C. Johnson. (1999) GC Factor 2 Represses Platelet-Derived Growth Factor A-Chain Gene Transcription and Is Itself Induced by Arterial Injury. Circulation Research 84:11, pages 1258-1267.
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Char-Chang Lai, Carl Henningson & Daniel DiMaio. (1998) Bovine papillomavirus E5 protein induces oligomerization and trans-phosphorylation of the platelet-derived growth factor β receptor. Proceedings of the National Academy of Sciences 95:26, pages 15241-15246.
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Jay D. Potts, Sylvia Kornacker & David C. Beebe. (1998) Activation of the Jak–STAT-Signaling Pathway in Embryonic Lens Cells. Developmental Biology 204:1, pages 277-292.
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Christine Kupprion, Kouros Motamed & E. Helene Sage. (1998) SPARC (BM-40, Osteonectin) Inhibits the Mitogenic Effect of Vascular Endothelial Growth Factor on Microvascular Endothelial Cells. Journal of Biological Chemistry 273:45, pages 29635-29640.
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Nathalie A. Lokker, James P. O'Hare, Arpy Barsoumian, James E. Tomlinson, Vanitha Ramakrishnan, Larry J. Fretto & Neill A. Giese. (1997) Functional Importance of Platelet-derived Growth Factor (PDGF) Receptor Extracellular Immunoglobulin-like Domains. Journal of Biological Chemistry 272:52, pages 33037-33044.
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R. J. Green, M. L. Usui, C. E. Hart, W. F. Ammons & A. S. Narayanan. (2006) Immunolocalization of platelet‐derived growth factor A and B chains and PDGF‐α and β receptors in human gingival wounds. Journal of Periodontal Research 32:2, pages 209-214.
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Levent M. Aky??rek, Leendert C. Paul, Keiko Funa, Erik Larsson & Bengt C. Fellstr??m. (1996) SMOOTH MUSCLE CELL MIGRATION INTO INTIMA AND ADVENTITIA DURING DEVELOPMENT OF TRANSPLANT VASCULOPATHY1. Transplantation 62:10, pages 1526-1529.
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Bruce A. Keyt, Hung V. Nguyen, Lea T. Berleau, Carlos M. Duarte, Jeanie Park, Helen Chen & Napoleone Ferrara. (1996) Identification of Vascular Endothelial Growth Factor Determinants for Binding KDR and FLT-1 Receptors. Journal of Biological Chemistry 271:10, pages 5638-5646.
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Daruka Mahadevan, Jin-Chen Yu, Jose W. Saldanha, Narmada Thanki, Peter McPhie, Aykut Uren, William J. LaRochelle & Mohammad A. Heidaran. (1995) Structural Role of Extracellular Domain 1 of α-Platelet-derived Growth Factor (PDGF) Receptor for PDGF-AA and PDGF-BB Binding. Journal of Biological Chemistry 270:46, pages 27595-27600.
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Georg Breier, Matthias Clauss & Werner Risau. (2005) Coordinate expression of vascular endothelial growth factor receptor‐1 (fit‐1) and its ligand suggests a paracrine regulation of murine vascular development. Developmental Dynamics 204:3, pages 228-239.
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M.L. Akyürek, A. Wanders, M. Aurivillius, E. Larsson, K. Funa & B.C. Fellström. (1995) Effects of angiopeptin on transplant arteriosclerosis in the rat. Transplant International 8:2, pages 103-110.
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M. L. Aky�rek, A. Wanders, M. Aurivillius, E. Larsson, K. Funa & B. C. Fellstr�m. (1995) Effects of angiopeptin on transplant arteriosclerosis in the rat. Transplant International 8:2, pages 103-110.
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Eva Rupp, Agneta Siegbahn, Lars Rönnstrand, Christer Wernstedt, Lena Claesson‐Welsh & Carl‐Henrik Heldin. (2005) A Unique Autophosphorylation Site in the Platelet‐Derived Growth Factor α Receptor from a Heterodimeric Receptor Complex. European Journal of Biochemistry 225:1, pages 29-41.
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J Waltenberger, L Claesson-Welsh, A Siegbahn, M Shibuya & C H Heldin. (1994) Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.. Journal of Biological Chemistry 269:43, pages 26988-26995.
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W.C. Kenney, M. Haniu, A.C. Herman, T. Arakawa, V.J. Costigan, J. Lary, D.A. Yphantis & A.R. Thomason. (1994) Formation of mitogenically active PDGF-B dimer does not require interchain disulfide bonds.. Journal of Biological Chemistry 269:16, pages 12351-12359.
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Flemming S. Vassbotn, Arne Östman, Nina Langeland, Holm Holmsen, Bengt Westermark, Carl‐Henrik Heldin & Monica Nistér. (2005) Activated platelet‐derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line. Journal of Cellular Physiology 158:2, pages 381-389.
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Lena Claesson-Welsh. (1994) Signal transduction by the PDGF receptors. Progress in Growth Factor Research 5:1, pages 37-54.
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Alexander Sorkin, Anders Eriksson, Carl‐Henrik Heldin, Bengt Westermark & Lena Claesson‐Welsh. (2005) Pool of ligand‐bound platelet‐derived growth factor β‐receptors remain activated and tyrosine phosphorylated after internalization. Journal of Cellular Physiology 156:2, pages 373-382.
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F.S. Vassbotn, A Ostman, A Siegbahn, H Holmsen & C.H. Heldin. (1992) Neomycin is a platelet-derived growth factor (PDGF) antagonist that allows discrimination of PDGF alpha- and beta-receptor signals in cells expressing both receptor types.. Journal of Biological Chemistry 267:22, pages 15635-15641.
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U Engström, A Engström, A Ernlund, B Westermark & C.H. Heldin. (1992) Identification of a peptide antagonist for platelet-derived growth factor.. Journal of Biological Chemistry 267:23, pages 16581-16587.
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