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Original Articles

Phase-transition W/O Microemulsions for Ocular Delivery: Evaluation of Antibacterial Activity in the Treatment of Bacterial Keratitis

, MPharm & , MPharm, PhD
Pages 463-474 | Received 04 Sep 2015, Accepted 04 Jan 2016, Published online: 04 Mar 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Parasuraman Mohan, Vinod D. Rangari & Karthikeyan Kesavan. (2022) Cationic Chitosan/Pectin Polyelectrolyte Nanocapsules of Moxifloxacin as Novel Topical Management System for Bacterial Keratitis. Current Eye Research 47:11, pages 1498-1507.
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Kangmin Lee, Gahye Lee, Soomin Lee & Choul Yong Park. (2022) Advances in ophthalmic drug delivery technology for postoperative management after cataract surgery. Expert Opinion on Drug Delivery 19:8, pages 945-964.
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Wenxiang Lin, Libei Zhao, Qian Tan & Ding Lin. (2021) Treatment of Severe Acute Bacterial Keratitis in Rabbits Using Continuous Topical Ocular Instillation with Norvancomycin. Drug Design, Development and Therapy 15, pages 617-628.
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Panoraia I. Siafaka, Emre Şefik Çağlar, Hande Sipahi, Mohammad Charehsaz, Ahmet Aydın & Neslihan Üstündağ Okur. (2021) Ocular microemulsion of brinzolamide: Formulation, physicochemical characterization, and in vitro irritation studies based on EpiOcular™ eye irritation assay. Pharmaceutical Development and Technology 26:7, pages 765-778.
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Prashant Garg, Venkata Vamsi Krishna Venuganti, Aravind Roy & Girdhari Roy. (2019) Novel drug delivery methods for the treatment of keratitis: moving away from surgical intervention. Expert Opinion on Drug Delivery 16:12, pages 1381-1391.
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Rahul Tiwari, Vibhuti Dubey & Karthikeyan Kesavan. (2019) Ocular Self-Microemulsifying Drug Delivery System of Prednisolone Improves Therapeutic Effectiveness in the Treatment of Experimental Uveitis. Ocular Immunology and Inflammation 27:2, pages 303-311.
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Rahul Tiwari, Vikas Pandey, Saket Asati, Vandana Soni & Dharmendra Jain. (2018) Therapeutic challenges in ocular delivery of lipid based emulsion. Egyptian Journal of Basic and Applied Sciences 5:2, pages 121-129.
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Articles from other publishers (23)

Khushwant S. Yadav, Govind Soni, Deepak Choudhary, Arushee Khanduri, Ayush Bhandari & Garima Joshi. (2023) Microemulsions for enhancing drug delivery of hydrophilic drugs: Exploring various routes of administration. Medicine in Drug Discovery 20, pages 100162.
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Vildan Yozgatlı, Neslihan Üstündağ Okur, Mehmet Evren Okur, Hande Sipahi, Mohammad Charehsaz, Ahmet Aydın & Timuçin Uğurlu. (2023) Managing allergic conjunctivitis via ophthalmic microemulsions: Formulation, characterization, in vitro irritation studies based on EpiOcular ™ eye irritation assay and in vivo studies in rabbit eye . Journal of Surfactants and Detergents 26:6, pages 853-866.
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Sachin Nashik Sanap, Amol Chhatrapati Bisen, Sristi Agrawal, Ashwini Kedar & Rabi Sankar Bhatta. (2023) Ophthalmic nano-bioconjugates: critical challenges and technological advances. Therapeutic Delivery.
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Wenting Cai, Tianyi Shen, Dong Wang, Tingting Li, Jing Yu, Chen Peng & Ben Zhong Tang. (2023) Efficient antibacterial AIEgens induced ROS for selective photodynamic treatment of bacterial keratitis. Frontiers in Chemistry 10.
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Jasjeet Kaur Narang, Kiranjeet Kaur, Gurpreet Kaur, Anmol Dogra & Deepti Pandita. 2023. Nanotechnology in Ophthalmology. Nanotechnology in Ophthalmology 151 179 .
Yue Sun, Wei Zhang, Menghui Wang, Huijie Liu, Qun Li, Jiazhe Luo, Mengzhen Zhao, Shichen Liu & Xiaolei Wang. (2022) Terbium-doped zinc oxide constructed dual-light-responsive nitric oxide-releasing platform for bacterial keratitis treatment. Nano Research 16:1, pages 849-857.
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Yang Ye, Jian He, Hanle Wang, Wenbo Li, Qingya Wang, Chenqi Luo, Xiajing Tang, Xiaoyuan Chen, Xiuming Jin, Ke Yao & Min Zhou. (2022) Cell Wall Destruction and Internal Cascade Synergistic Antifungal Strategy for Fungal Keratitis. ACS Nano 16:11, pages 18729-18745.
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Manisha Choudhari, Kritika Nayak, Noriaki Nagai, Yosuke Nakazawa, Dignesh Khunt & Manju Misra. (2022) Role of mucoadhesive agent in ocular delivery of ganciclovir microemulsion: cytotoxicity evaluation in vitro and ex vivo. International Ophthalmology 43:4, pages 1153-1167.
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Heybet Kerem PolatNihat Kurt, Eren AytekinSibel Bozdağ PehlivanSema Çalış. (2022) Novel Drug Delivery Systems to Improve the Treatment of Keratitis. Journal of Ocular Pharmacology and Therapeutics.
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Hatem A.F.M. Hassan, Amir I. Ali, Esraa M. ElDesawy & Ahmed H. ElShafeey. (2022) Pharmacokinetic and Pharmacodynamic Evaluation of Gemifloxacin Chitosan Nanoparticles As an Antibacterial Ocular Dosage Form. Journal of Pharmaceutical Sciences 111:5, pages 1497-1508.
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Rohan Bir Singh, Sujata Das, James Chodosh, Namrata Sharma, Michael E. Zegans, Regis P. Kowalski & Vishal Jhanji. (2022) Paradox of complex diversity: Challenges in the diagnosis and management of bacterial keratitis. Progress in Retinal and Eye Research 88, pages 101028.
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Chen Peng, Wenjie Sun, Chengcheng Zhou, Sujing Qiang, Meijuan Jiang, Jacky W.Y. Lam, Zheng Zhao, Ryan T.K. Kwok, Wenting Cai & Ben Zhong Tang. (2021) Vision redemption: Self-reporting AIEgens for combined treatment of bacterial keratitis. Biomaterials 279, pages 121227.
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Rui Wang, Duoduo Lu, Hui Wang, Haoyu Zou, Ting Bai, Chulei Feng & Quankui Lin. (2021) “Kill-release” antibacterial polysaccharides multilayer coating based therapeutic contact lens for effective bacterial keratitis treatment. RSC Advances 11:42, pages 26160-26167.
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Jose Navarro-Partida, Carlos Rodrigo Castro-Castaneda, Francisco J. Santa Cruz-Pavlovich, Luis Abraham Aceves-Franco, Tomer Ori Guy & Arturo Santos. (2021) Lipid-Based Nanocarriers as Topical Drug Delivery Systems for Intraocular Diseases. Pharmaceutics 13:5, pages 678.
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Nattakanwadee Khumpirapang, Srikanjana Klayraung, Singkome Tima & Siriporn Okonogi. (2021) Development of Microemulsion Containing Alpinia galanga Oil and Its Major Compounds: Enhancement of Antimicrobial Activities. Pharmaceutics 13:2, pages 265.
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Shiva Taghe, Shahla Mirzaeei, Raid G. Alany & Ali Nokhodchi. (2020) Polymeric Inserts Containing Eudragit® L100 Nanoparticle for Improved Ocular Delivery of Azithromycin. Biomedicines 8:11, pages 466.
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Kaichao Song, Meixing Yan, Mengshuang Li, Yiwan Geng & Xianggen Wu. (2020) Preparation and in vitro–in vivo evaluation of novel ocular nanomicelle formulation of thymol based on glycyrrhizin. Colloids and Surfaces B: Biointerfaces 194, pages 111157.
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Neslihan Üstündağ OkurEmre Şefik ÇağlarPanoraia I. Siafaka. (2020) Novel Ocular Drug Delivery Systems: An Update on Microemulsions. Journal of Ocular Pharmacology and Therapeutics 36:6, pages 342-354.
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Reshal Suri, Sarwar Beg & Kanchan Kohli. (2020) Target strategies for drug delivery bypassing ocular barriers. Journal of Drug Delivery Science and Technology 55, pages 101389.
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Kanika Thakur, Gajanand Sharma, Bhupindar Singh & Om Prakash Katare. (2019) Topical Drug Delivery of Anti-infectives Employing Lipid-Based Nanocarriers: Dermatokinetics as an Important Tool. Current Pharmaceutical Design 24:43, pages 5108-5128.
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Rinda Bachu, Pallabitha Chowdhury, Zahraa Al-Saedi, Pradeep Karla & Sai Boddu. (2018) Ocular Drug Delivery Barriers—Role of Nanocarriers in the Treatment of Anterior Segment Ocular Diseases. Pharmaceutics 10:1, pages 28.
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Marion Dubald, Sandrine Bourgeois, Véronique Andrieu & Hatem Fessi. (2018) Ophthalmic Drug Delivery Systems for Antibiotherapy—A Review. Pharmaceutics 10:1, pages 10.
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Nivedita Gautam & Karthikeyan Kesavan. (2017) Development of microemulsions for ocular delivery. Therapeutic Delivery 8:5, pages 313-330.
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