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Gynecological Endocrinology Volume 32, 2016 - Issue 6
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Preimplantation Genetic Screening

Should pre-implantation genetic screening be implemented to routine clinical practice?

Raoul OrvietoInfertility and IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center (Tel Hashomer), Ramat Gan, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelCorrespondence[email protected]
,
Yulia ShulyInfertility and IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center (Tel Hashomer), Ramat Gan, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
,
Masha BrengauzInfertility and IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center (Tel Hashomer), Ramat Gan, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
&
Baruch FeldmanInfertility and IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center (Tel Hashomer), Ramat Gan, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Pages 506-508 | Received 16 Dec 2015, Accepted 13 Jan 2016, Published online: 12 Feb 2016

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Elena M. Fedorova, Svetlana A. Shlykova, Ksenia V. Shunkina, Olga G. Zaitceva, Elena N. Lapina, Taras V. Yanchuk & Alla S. Kalugina. (2017) Outcomes of IVF cycles coupled with PGS by aCGH of embryos from donor and autologous oocytes, transferred after vitrification to women of advanced maternal age. Gynecological Endocrinology 33:9, pages 737-740.
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Guoxia Yang, Yan Xu, Yanhong Zeng, Jing Guo, Jiafu Pan, Canquan Zhou & Yanwen Xu. (2022) Comparison of chromosomal status in reserved multiple displacement amplification products of embryos that resulted in miscarriages or live births: a blinded, nonselection case–control study. BMC Medical Genomics 15:1.
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Norbert Gleicher, David H Barad, Pasquale Patrizio & Raoul Orvieto. (2022) We have reached a dead end for preimplantation genetic testing for aneuploidy. Human Reproduction 37:12, pages 2730-2734.
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Effrosyni Chavli, Myrthe van den Born, Cindy Eleveld, Marjan Boter, Ronald van Marion, Lies Hoefsloot, Joop Laven, Esther Baart & Diane Van Opstal. (2022) Chromosomal mosaicism in human blastocysts: a cytogenetic comparison of trophectoderm and inner cell mass after next-generation sequencing. Reproductive BioMedicine Online 45:5, pages 867-877.
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Sargunadevi Sivanantham, Mahalakshmi Saravanan, Nidhi Sharma, Jayashree Shrinivasan & Ramesh Raja. (2022) Morphology of inner cell mass: a better predictive biomarker of blastocyst viability. PeerJ 10, pages e13935.
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Abraham Zavala-Garcia & Juan M. Moreno-Garcia. (2022) Diagnóstico genético pre-implantacional no invasivo como método de detección de aneuploidías embrionarias: una revisión sistemática. Medicina Reproductiva y Embriología Clínica 9:1, pages 100108.
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Baoli Yin, Huijuan Zhang, Juanke Xie, Yubao Wei, Cuilian Zhang & Li Meng. (2021) Validation of preimplantation genetic tests for aneuploidy (PGT-A) with DNA from spent culture media (SCM): concordance assessment and implication. Reproductive Biology and Endocrinology 19:1.
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Igor N. Lebedev & Daria I. Zhigalina. (2021) From contemplation to classification of chromosomal mosaicism in human preimplantation embryos. Journal of Assisted Reproduction and Genetics 38:11, pages 2833-2848.
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Raoul Orvieto, Adva Aizer & Norbert Gleicher. (2021) Is there still a rationale for non-invasive PGT-A by analysis of cell-free DNA released by human embryos into culture medium?. Human Reproduction 36:5, pages 1186-1190.
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Diego Marin, Jia Xu & Nathan R. Treff. (2020) Preimplantation genetic testing for aneuploidy: A review of published blastocyst reanalysis concordance data. Prenatal Diagnosis 41:5, pages 545-553.
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Raoul Orvieto, Chen Shimon, Shlomit Rienstein, Anat Jonish-Grossman, Hagit Shani & Adva Aizer. (2020) Do human embryos have the ability of self-correction?. Reproductive Biology and Endocrinology 18:1.
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N. Gleicher, D. F. Albertini, D. H. Barad, H. Homer, D. Modi, M. Murtinger, P. Patrizio, R. Orvieto, S. Takahashi, A. Weghofer, S. Ziebe & N. Noyes. (2020) The 2019 PGDIS position statement on transfer of mosaic embryos within a context of new information on PGT-A. Reproductive Biology and Endocrinology 18:1.
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Raoul Orvieto. (2020) The reproducibility of trophectoderm biopsies – The chaos behind preimplantation genetic testing for aneuploidy. European Journal of Obstetrics & Gynecology and Reproductive Biology 254, pages 57-58.
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Chun-I Lee, En-Hui Cheng, Maw-Sheng Lee, Pin-Yao Lin, Yi-Chun Chen, Chien-Hong Chen, Lii-Shung Huang, Chun-Chia Huang & Tsung-Hsien Lee. (2020) Healthy live births from transfer of low-mosaicism embryos after preimplantation genetic testing for aneuploidy. Journal of Assisted Reproduction and Genetics 37:9, pages 2305-2313.
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Rostislav Navratil, Jakub Horak, Miroslav Hornak, David Kubicek, Maria Balcova, Gabriela Tauwinklova, Pavel Travnik & Katerina Vesela. (2020) Concordance of various chromosomal errors among different parts of the embryo and the value of re-biopsy in embryos with segmental aneuploidies. Molecular Human Reproduction 26:4, pages 269-276.
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Mina Popovic, Lien Dhaenens, Annekatrien Boel, Björn Menten & Björn Heindryckx. (2020) Chromosomal mosaicism in human blastocysts: the ultimate diagnostic dilemma. Human Reproduction Update 26:3, pages 313-334.
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Xinyuan Li, Yan Hao, Nagwa Elshewy, Xiaoqian Zhu, Zhiguo Zhang & Ping Zhou. (2019) The mechanisms and clinical application of mosaicism in preimplantation embryos. Journal of Assisted Reproduction and Genetics 37:3, pages 497-508.
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Michal Kirshenbaum & Raoul Orvieto. (2019) Should We Offer In Vitro Fertilization to Couples with Unexplained Recurrent Pregnancy Loss?. Journal of Clinical Medicine 8:11, pages 2001.
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Norbert Gleicher & David H. Barad. (2019) Not even noninvasive cell-free DNA can rescue preimplantation genetic testing. Proceedings of the National Academy of Sciences 116:44, pages 21976-21977.
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B Lawrenz, I El Khatib, A Liñán, A Bayram, A Arnanz, R Chopra, N De Munck & H M Fatemi. (2019) The clinicians´ dilemma with mosaicism—an insight from inner cell mass biopsies. Human Reproduction 34:6, pages 998-1010.
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Alessandra Alteri, Laura Corti, Ana M. Sanchez, Elisa Rabellotti, Enrico Papaleo & Paola Viganò. (2019) Assessment of pre-implantation genetic testing for embryo aneuploidies: A SWOT analysis. Clinical Genetics 95:4, pages 479-487.
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Hayden Anthony Homer. (2019) Preimplantation genetic testing for aneuploidy (PGT‐A): The biology, the technology and the clinical outcomes. Australian and New Zealand Journal of Obstetrics and Gynaecology 59:2, pages 317-324.
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Min Kyoung Kim, Jae Kyun Park, Yunmi Jeon, Seung-Ah Choe, Hee Jun Lee, Jayeon Kim, Eun Mi Chang, Ji Won Kim, Sang Woo Lyu, Jin Young Kim, In Pyung Kwak, Woo Sik Lee & Tae Ki Yoon. (2019) Correlation between Morphologic Grading and Euploidy Rates of Blastocysts, and Clinical Outcomes in In Vitro Fertilization Preimplantation Genetic Screening. Journal of Korean Medical Science 34:4.
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Pasquale Patrizio & Sherman Silber. 2018. Reproductive Medicine for Clinical Practice. Reproductive Medicine for Clinical Practice 77 82 .
Norbert Gleicher & Raoul Orvieto. (2017) Is the hypothesis of preimplantation genetic screening (PGS) still supportable? A review. Journal of Ovarian Research 10:1.
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Norbert Gleicher, Jacob Metzger, Gist Croft, Vitaly A. Kushnir, David F. Albertini & David H Barad. (2017) A single trophectoderm biopsy at blastocyst stage is mathematically unable to determine embryo ploidy accurately enough for clinical use. Reproductive Biology and Endocrinology 15:1.
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Norbert Gleicher, Andrea Vidali, Jeffrey Braverman, Vitaly A. Kushnir, David H. Barad, Cynthia Hudson, Yang-Guan Wu, Qi Wang & Lin Zhang. (2017) Response to comment on: Gleicher N et al., 2016. Reprod biol endocrinol Sep 5;14(1):54. Reproductive Biology and Endocrinology 15:1.
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Raoul Orvieto. (2017) Re-analysis of aneuploidy blastocysts with an inner cell mass and different regional trophectoderm cells. Journal of Assisted Reproduction and Genetics 34:6, pages 827-827.
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Sanaz Ghazal & Pasquale Patrizio. (2016) Embryo wastage rates remain high in assisted reproductive technology (ART): a look at the trends from 2004–2013 in the USA. Journal of Assisted Reproduction and Genetics 34:2, pages 159-166.
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Pasquale Patrizio & Sherman Silber. (2016) Improving IVF: is there a limit to our ability to manipulate human biology?. Journal of Assisted Reproduction and Genetics 34:1, pages 7-9.
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Norbert Gleicher, Andrea Vidali, Jeffrey Braverman, Vitaly A. Kushnir, David H. Barad, Cynthia Hudson, Yang-Guan Wu, Qi Wang, Lin Zhang & David F. Albertini. (2016) Accuracy of preimplantation genetic screening (PGS) is compromised by degree of mosaicism of human embryos. Reproductive Biology and Endocrinology 14:1.
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Yu Su, Jian-Jun Li, Cassie Wang, Ghassan Haddad & Wei-Hua Wang. (2016) Aneuploidy analysis in day 7 human blastocysts produced by in vitro fertilization. Reproductive Biology and Endocrinology 14:1.
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Min Liu, Yu Su & Wei-Hua Wang. (2016) Assessment of clinical application of preimplantation genetic screening on cryopreserved human blastocysts. Reproductive Biology and Endocrinology 14:1.
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Navid Esfandiari, Megan E. Bunnell & Robert F. Casper. (2016) Human embryo mosaicism: did we drop the ball on chromosomal testing?. Journal of Assisted Reproduction and Genetics 33:11, pages 1439-1444.
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