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Journal of Dermatological Treatment Volume 27, 2016 - Issue 3
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Atopic Dermatitis

Safety, tolerability and pharmacokinetics of a novel phosphodiesterase inhibitor, E6005 ointment, in healthy volunteers and in patients with atopic dermatitis

Fuminori OhbaEisai Product Creation Systems, Eisai Co., Ltd., Tokyo, JapanCorrespondence[email protected]
,
Maiko NomotoEisai Product Creation Systems, Eisai Co., Ltd., Tokyo, Japan
,
Seiichiro HojoEisai Product Creation Systems, Eisai Co., Ltd., Tokyo, Japan
&
Hideto AkamaEisai Product Creation Systems, Eisai Co., Ltd., Tokyo, Japan
Pages 241-246 | Received 11 Jun 2015, Accepted 05 Sep 2015, Published online: 18 Nov 2015

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Zhihao Liu, Mingjian Liu, Zhenqing Cao, Pengsen Qiu & Gaopeng Song. (2022) Phosphodiesterase‑4 inhibitors: a review of current developments (2013–2021). Expert Opinion on Therapeutic Patents 32:3, pages 261-278.
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Aisleen Diaz & Emma Guttman-Yassky. (2019) Topical agents for the treatment of atopic dermatitis. Expert Review of Clinical Immunology 15:4, pages 369-382.
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Maddalena Napolitano, Claudio Marasca, Gabriella Fabbrocini & Cataldo Patruno. (2018) Adult atopic dermatitis: new and emerging therapies. Expert Review of Clinical Pharmacology 11:9, pages 867-878.
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Masutaka Furue, Takafumi Kadono, Gaku Tsuji & Takeshi Nakahara. (2017) Topical E6005/RVT-501, a novel phosphodiesterase 4 inhibitor, for the treatment of atopic dermatitis. Expert Opinion on Investigational Drugs 26:12, pages 1403-1408.
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Alice C. Cheape & Dedee F. Murrell. (2017) 2% Crisaborole topical ointment for the treatment of mild-to-moderate atopic dermatitis. Expert Review of Clinical Immunology 13:5, pages 415-423.
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Markus Joerger, Stephen P. Finn, Sinead Cuffe, Annette T. Byrne & Steven G. Gray. (2016) The IL-17-Th1/Th17 pathway: an attractive target for lung cancer therapy?. Expert Opinion on Therapeutic Targets 20:11, pages 1339-1356.
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Fuminori Ohba, Shunji Matsuki, Shuhei Imayama, Kyoko Matsuguma, Seiichiro Hojo, Maiko Nomoto & Hideto Akama. (2016) Efficacy of a novel phosphodiesterase inhibitor, E6005, in patients with atopic dermatitis: An investigator-blinded, vehicle-controlled study. Journal of Dermatological Treatment 27:5, pages 467-472.
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Articles from other publishers (8)

Nikolaos Sideris, Eleni Paschou, Katerina Bakirtzi, Dimitra Kiritsi, Ilias Papadimitriou, Aikaterini Tsentemeidou, Elena Sotiriou & Efstratios Vakirlis. (2022) New and Upcoming Topical Treatments for Atopic Dermatitis: A Review of the Literature. Journal of Clinical Medicine 11:17, pages 4974.
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Ana Martín-Santiago, Susana Puig, Daniel Arumi & Francisco Jose Rebollo Laserna. (2022) Safety Profile and Tolerability of Topical Phosphodiesterase 4 Inhibitors for the Treatment of Atopic Dermatitis: A Systematic Review and Meta-Analysis. Current Therapeutic Research 96, pages 100679.
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Silvio Aprile, Marta Serafini & Tracey Pirali. (2019) Soft drugs for dermatological applications: recent trends. Drug Discovery Today 24:12, pages 2234-2246.
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Henry L. Nguyen, Katelyn R. Anderson & Megha M. Tollefson. (2019) New and Emerging Therapies for Pediatric Atopic Dermatitis. Pediatric Drugs 21:4, pages 239-260.
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Emma Guttman‐Yassky, Jon M. Hanifin, Mark Boguniewicz, Andreas Wollenberg, Robert Bissonnette, Vivek Purohit, Iain Kilty, Anna M. Tallman & Michael A. Zielinski. (2018) The role of phosphodiesterase 4 in the pathophysiology of atopic dermatitis and the perspective for its inhibition. Experimental Dermatology.
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Heng Li, Jianping Zuo & Wei Tang. (2018) Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases. Frontiers in Pharmacology 9.
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Rema Zebda & Amy S. Paller. (2018) Phosphodiesterase 4 inhibitors. Journal of the American Academy of Dermatology 78:3, pages S43-S52.
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Diane Wang & Lisa A. Beck. (2016) Immunologic Targets in Atopic Dermatitis and Emerging Therapies: An Update. American Journal of Clinical Dermatology 17:5, pages 425-443.
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