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International Journal of Food Sciences and Nutrition Volume 64, 2013 - Issue 6
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Research Article

The effects of synbiotic supplementation on some cardio-metabolic risk factors in overweight and obese children: a randomized triple-masked controlled trial

Morteza SafaviDepartment of Clinical Nutrition, School of Nutrition and Food Science;Food Security Research Center
,
Sanam FarajianDepartment of Clinical Nutrition, School of Nutrition and Food Science;Food Security Research Center
,
Roya KelishadiPediatrics Department, Faculty of Medicine and Child Growth and Development Research CenterCorrespondence[email protected]
,
Maryam MirlohiDepartment of Clinical Nutrition, School of Nutrition and Food Science;Food Security Research Center;Food Science and Technology Department, School of Nutrition and Food Science, Isfahan University of Medical Sciences IsfahanIran
&
Mahin HashemipourPediatrics Department, Faculty of Medicine and Child Growth and Development Research Center
Pages 687-693 | Received 10 Jul 2012, Accepted 05 Feb 2013, Published online: 12 Mar 2013

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Dong Han, Justyna Zulewska, Ke Xiong & Zhennai Yang. (2022) Synergy between oligosaccharides and probiotics: From metabolic properties to beneficial effects. Critical Reviews in Food Science and Nutrition 0:0, pages 1-23.
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Crossref
John SlatteryDerrick F. MacfabeRichard E. Frye. (2016) The Significance of the Enteric Microbiome on the Development of Childhood Disease: A Review of Prebiotic and Probiotic Therapies in Disorders of Childhood. Clinical Medicine Insights: Pediatrics 10, pages CMPed.S38338.
Crossref
S. Woloszynek, S. Pastor, J.C. Mell, N. Nandi, B. Sokhansanj & G.L. Rosen. 2016. 67 124 .
Maya Raman, Padma Ambalam & Mukesh DobleMaya Raman, Padma Ambalam & Mukesh Doble. 2016. Probiotics and Bioactive Carbohydrates in Colon Cancer Management. Probiotics and Bioactive Carbohydrates in Colon Cancer Management 83 96 .
N. Ipar, S. Durmus Aydogdu, G. Kilic Yildirim, M. Inal, I. Gies, Y. Vandenplas & E.C. Dinleyici. (2015) Effects of synbiotic on anthropometry, lipid profile and oxidative stress in obese children. Beneficial Microbes 6:6, pages 775-781.
Crossref
Luis A. Moreno, Silvia Bel-Serrat, Alba Santaliestra-Pasías & Gloria Bueno. (2015) Dairy products, yogurt consumption, and cardiometabolic risk in children and adolescents. Nutrition Reviews 73:suppl 1, pages 8-14.
Crossref
Jean-Michel Lecerf. (2015) Influence des pré- et probiotiques sur le poids. Pratiques en nutrition 11:43, pages 25-29.
Crossref
Giovanni Tarantino & Carmine Finelli. (2015) Systematic review on intervention with prebiotics/probiotics in patients with obesity-related nonalcoholic fatty liver disease. Future Microbiology 10:5, pages 889-902.
Crossref
Petya Koleva, Sarah Bridgman & Anita Kozyrskyj. (2015) The Infant Gut Microbiome: Evidence for Obesity Risk and Dietary Intervention. Nutrients 7:4, pages 2237-2260.
Crossref
Luis Vitetta, Talia Palacios, Sean Hall & Samantha Coulson. 2015. Novel Natural Products: Therapeutic Effects in Pain, Arthritis and Gastro-intestinal Diseases. Novel Natural Products: Therapeutic Effects in Pain, Arthritis and Gastro-intestinal Diseases 1 33 .
Marina Sanchez, Shirin Panahi & Angelo Tremblay. (2014) Childhood Obesity: A Role for Gut Microbiota?. International Journal of Environmental Research and Public Health 12:1, pages 162-175.
Crossref
Luis Vitetta, Rachel Manuel, Joyce Zhou, Anthony Linnane, Sean Hall & Samantha Coulson. (2014) The Overarching Influence of the Gut Microbiome on End-Organ Function: The Role of Live Probiotic Cultures. Pharmaceuticals 7:9, pages 954-989.
Crossref
André Marette & Eliane Picard-Deland. (2014) Yogurt consumption and impact on health: focus on children and cardiometabolic risk. The American Journal of Clinical Nutrition 99:5, pages 1243S-1247S.
Crossref
Roya Kelishadi, Sanam Farajian, Morteza Safavi, Maryam Mirlohi & Mahin Hashemipour. (2014) A randomized triple-masked controlled trial on the effects of synbiotics on inflammation markers in overweight children. Jornal de Pediatria (Versão em Português) 90:2, pages 161-168.
Crossref
Roya Kelishadi, Sanam Farajian, Morteza Safavi, Maryam Mirlohi & Mahin Hashemipour. (2014) A randomized triple-masked controlled trial on the effects of synbiotics on inflammation markers in overweight children. Jornal de Pediatria 90:2, pages 161-168.
Crossref
Pietro Vajro, Marco Poeta, Luca Pierri, Cristina Pizza, Roberta D’Aniello, Maria Sangermano, Grazia Massa & Giulia Paolella. 2014. Nutrition in the Prevention and Treatment of Abdominal Obesity. Nutrition in the Prevention and Treatment of Abdominal Obesity 363 380 .

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