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Simon G. Patching. (2011) NMR structures of polytopic integral membrane proteins. Molecular Membrane Biology 28:6, pages 370-397.
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Lukas Helfinger & Christopher G. Tate. 2023.
Zoe Köck, Utz Ermel, Janosch Martin, Nina Morgner, Achilleas S. Frangakis, Volker Dötsch, Daniel Hilger & Frank Bernhard. (2022) Biochemical Characterization of Cell-free Synthesized Human β1 Adrenergic Receptor Cotranslationally Inserted into Nanodiscs. Journal of Molecular Biology 434:16, pages 167687.
Crossref
Crossref
Clare.R. Harwood, David A. Sykes, Bradley L. Hoare, Franziska M. Heydenreich, Romez Uddin, David R. Poyner, Stephen J. Briddon & D.B. Veprintsev. (2021) Functional solubilization of the β2-adrenoceptor using diisobutylene maleic acid. iScience 24:12, pages 103362.
Crossref
Crossref
Sanychen Muk, Soumadwip Ghosh, Srisairam Achuthan, Xiaomin Chen, XiaoJie Yao, Manbir Sandhu, Matthew C. Griffor, Kimberly F. Fennell, Ye Che, Veerabahu Shanmugasundaram, Xiayang Qiu, Christopher G. Tate & Nagarajan Vaidehi. (2019) Machine Learning for Prioritization of Thermostabilizing Mutations for G-Protein Coupled Receptors. Biophysical Journal 117:11, pages 2228-2239.
Crossref
Crossref
Petr Popov, Igor Kozlovskii & Vsevolod Katritch. (2019) Computational design for thermostabilization of GPCRs. Current Opinion in Structural Biology 55, pages 25-33.
Crossref
Crossref
Ji-Hye Yun, Xuanxuan Li, Jae-Hyun Park, Yang Wang, Mio Ohki, Zeyu Jin, Wonbin Lee, Sam-Yong Park, Hao Hu, Chufeng Li, Nadia Zatsepin, Mark S. Hunter, Raymond G. Sierra, Jake Koralek, Chun Hong Yoon, Hyun-Soo Cho, Uwe Weierstall, Leihan Tang, Haiguang Liu & Weontae Lee. (2019) Non-cryogenic structure of a chloride pump provides crucial clues to temperature-dependent channel transport efficiency. Journal of Biological Chemistry 294:3, pages 794-804.
Crossref
Crossref
Soumadwip Ghosh, Tobias Bierig, Sangbae Lee, Suvamay Jana, Adelheid Löhle, Gisela Schnapp, Christofer S. Tautermann & Nagarajan Vaidehi. (2018) Engineering Salt Bridge Networks between Transmembrane Helices Confers Thermostability in G-Protein-Coupled Receptors. Journal of Chemical Theory and Computation 14:12, pages 6574-6585.
Crossref
Crossref
James Birch, Danny Axford, James Foadi, Arne Meyer, Annette Eckhardt, Yvonne Thielmann & Isabel Moraes. (2018) The fine art of integral membrane protein crystallisation. Methods 147, pages 150-162.
Crossref
Crossref
Petr Popov, Yao Peng, Ling Shen, Raymond C Stevens, Vadim Cherezov, Zhi-Jie Liu & Vsevolod Katritch. (2018) Computational design of thermostabilizing point mutations for G protein-coupled receptors. eLife 7.
Crossref
Crossref
Sébastien Igonet, Claire Raingeval, Erika Cecon, Maja Pučić-Baković, Gordan Lauc, Olivier Cala, Maciej Baranowski, Javier Perez, Ralf Jockers, Isabelle Krimm & Anass Jawhari. (2018) Enabling STD-NMR fragment screening using stabilized native GPCR: A case study of adenosine receptor. Scientific Reports 8:1.
Crossref
Crossref
Rony Nehm?Byron Carpenter, Ankita Singhal, Annette Strege, Patricia C. Edwards, Courtney F. White, Haijuan Du, Reinhard Grisshammer & Christopher G. Tate. (2017) Mini-G proteins: Novel tools for studying GPCRs in their active conformation. PLOS ONE 12:4, pages e0175642.
Crossref
Crossref
Katrien Claes, Kristof Vandewalle, Bram Laukens, Toon Laeremans, Olivier Vosters, Ingrid Langer, Marc Parmentier, Jan Steyaert & Nico Callewaert. (2016)
Modular Integrated Secretory System Engineering in
Pichia pastoris
To Enhance G-Protein Coupled Receptor Expression
. ACS Synthetic Biology 5:10, pages 1070-1075.
Crossref
Crossref
Francesca Magnani, Maria J Serrano-Vega, Yoko Shibata, Saba Abdul-Hussein, Guillaume Lebon, Jennifer Miller-Gallacher, Ankita Singhal, Annette Strege, Jennifer A Thomas & Christopher G Tate. (2016) A mutagenesis and screening strategy to generate optimally thermostabilized membrane proteins for structural studies. Nature Protocols 11:8, pages 1554-1571.
Crossref
Crossref
Ralf-Bernhardt Rues, Volker Dötsch & Frank Bernhard. (2016) Co-translational formation and pharmacological characterization of beta1-adrenergic receptor/nanodisc complexes with different lipid environments. Biochimica et Biophysica Acta (BBA) - Biomembranes 1858:6, pages 1306-1316.
Crossref
Crossref
Nagarajan Vaidehi, Reinhard Grisshammer & Christopher G. Tate. (2016) How Can Mutations Thermostabilize G-Protein-Coupled Receptors?. Trends in Pharmacological Sciences 37:1, pages 37-46.
Crossref
Crossref
David B. Sauer, Nathan K. Karpowich, Jin Mei Song & Da-Neng Wang. (2015) Rapid Bioinformatic Identification of Thermostabilizing Mutations. Biophysical Journal 109:7, pages 1420-1428.
Crossref
Crossref
C. L. Piscitelli, J. Kean, C. de Graaf & X. Deupi. (2015) A Molecular Pharmacologist's Guide to G Protein-Coupled Receptor Crystallography. Molecular Pharmacology 88:3, pages 536-551.
Crossref
Crossref
Dalibor MilićDmitry B. Veprintsev. (2015) Large-scale production and protein engineering of G protein-coupled receptors for structural studies. Frontiers in Pharmacology 6.
Crossref
Crossref
Jeffrey Zuber, Shairy Azmy Danial, Sara M. Connelly, Fred Naider & Mark E. Dumont. (2015)
Identification of Destabilizing and Stabilizing Mutations of Ste2p, a G Protein-Coupled Receptor in
Saccharomyces cerevisiae
. Biochemistry 54:9, pages 1787-1806.
Crossref
Crossref
Supriyo Bhattacharya, Sangbae Lee, Reinhard Grisshammer, Christopher G. Tate & Nagarajan Vaidehi. (2014) Rapid Computational Prediction of Thermostabilizing Mutations for G Protein-Coupled Receptors. Journal of Chemical Theory and Computation 10:11, pages 5149-5160.
Crossref
Crossref
Anita Emmerstorfer, Tamara Wriessnegger, Melanie Hirz & Harald Pichler. (2014) Overexpression of membrane proteins from higher eukaryotes in yeasts. Applied Microbiology and Biotechnology 98:18, pages 7671-7698.
Crossref
Crossref
John W. Cuozzo & Holly H. Soutter. (2014) Overview of Recent Progress in Protein-Expression Technologies for Small-Molecule Screening. SLAS Discovery 19:7, pages 1000-1013.
Crossref
Crossref
Isabel Moraes, Gwyndaf Evans, Juan Sanchez-Weatherby, Simon Newstead & Patrick D. Shaw Stewart. (2014) Membrane protein structure determination — The next generation. Biochimica et Biophysica Acta (BBA) - Biomembranes 1838:1, pages 78-87.
Crossref
Crossref
Nagarajan Vaidehi, Supriyo Bhattacharya & Adrien B. Larsen. 2014. G Protein-Coupled Receptors - Modeling and Simulation. G Protein-Coupled Receptors - Modeling and Simulation
37
54
.
Nicolas Bertheleme, Shweta Singh, Simon J Dowell, Julia Hubbard & Bernadette Byrne. (2013)
Loss of constitutive activity is correlated with increased thermostability of the human adenosine A
2A
receptor
. British Journal of Pharmacology 169:5, pages 988-998.
Crossref
Crossref
Saba Abdul-Hussein, Juni Andr?ll & Christopher G. Tate. (2013) Thermostabilisation of the Serotonin Transporter in a Cocaine-Bound Conformation. Journal of Molecular Biology 425:12, pages 2198-2207.
Crossref
Crossref
Yoko Shibata, Jelena Gvozdenovic-Jeremic, James Love, Brian Kloss, Jim F. White, Reinhard Grisshammer & Christopher G. Tate. (2013) Optimising the combination of thermostabilising mutations in the neurotensin receptor for structure determination. Biochimica et Biophysica Acta (BBA) - Biomembranes 1828:4, pages 1293-1301.
Crossref
Crossref
Hae Joo Kang, Chiara Lee & David Drew. (2013) Breaking the barriers in membrane protein crystallography. The International Journal of Biochemistry & Cell Biology 45:3, pages 636-644.
Crossref
Crossref
Tony WarneChristopher G. Tate. (2013) The importance of interactions with helix 5 in determining the efficacy of β-adrenoceptor ligands. Biochemical Society Transactions 41:1, pages 159-165.
Crossref
Crossref
Florian Brueckner, Chayne L. Piscitelli, Ching-Ju Tsai, Jörg Standfuss, Xavier Deupi & Gebhard F.X. Schertler. 2013. G Protein Coupled Receptors - Structure. G Protein Coupled Receptors - Structure
117
151
.
Christopher G. Tate. (2012) A crystal clear solution for determining G-protein-coupled receptor structures. Trends in Biochemical Sciences 37:9, pages 343-352.
Crossref
Crossref
Tony Warne, Patricia C. Edwards, Andrew G.W. Leslie & Christopher G. Tate. (2012) Crystal Structures of a Stabilized β1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol. Structure 20:5, pages 841-849.
Crossref
Crossref
C?dric Fiez-Vandal, Lukas Leder, Felix Freuler, David Sykes, Steven J. Charlton, Sandra Siehler, Ulrich Schopfer & Myriam Duckely. (2012) HDL-like discs for assaying membrane proteins in drug discovery. Biophysical Chemistry 165-166, pages 56-61.
Crossref
Crossref
N.D. DiBartolo & P.J. Booth. 2012. Comprehensive Biophysics. Comprehensive Biophysics
290
316
.
Romina Mancusso, Nathan K. Karpowich, Bryan K. Czyzewski & Da-Neng Wang. (2011) Simple screening method for improving membrane protein thermostability. Methods 55:4, pages 324-329.
Crossref
Crossref
Jennifer L. Miller & Christopher G. Tate. (2011) Engineering an Ultra-Thermostable β1-Adrenoceptor. Journal of Molecular Biology 413:3, pages 628-638.
Crossref
Crossref
Jillian G. Baker, Richard G. W. Proudman & Christopher G. Tate. (2011) The pharmacological effects of the thermostabilising (m23) mutations and intra and extracellular (β36) deletions essential for crystallisation of the turkey β-adrenoceptor. Naunyn-Schmiedeberg's Archives of Pharmacology 384:1, pages 71-91.
Crossref
Crossref
Guillaume Lebon, Kirstie Bennett, Ali Jazayeri & Christopher G. Tate. (2011) Thermostabilisation of an Agonist-Bound Conformation of the Human Adenosine A2A Receptor. Journal of Molecular Biology 409:3, pages 298-310.
Crossref
Crossref
Roslyn M Bill, Peter J F Henderson, So Iwata, Edmund R S Kunji, Hartmut Michel, Richard Neutze, Simon Newstead, Bert Poolman, Christopher G Tate & Horst Vogel. (2011) Overcoming barriers to membrane protein structure determination. Nature Biotechnology 29:4, pages 335-340.
Crossref
Crossref
Rebecca L. Rich, James Errey, Fiona Marshall & David G. Myszka. (2011) Biacore analysis with stabilized G-protein-coupled receptors. Analytical Biochemistry 409:2, pages 267-272.
Crossref
Crossref
Tony Warne, Rouslan Moukhametzianov, Jillian G. Baker, Rony Nehmé, Patricia C. Edwards, Andrew G. W. Leslie, Gebhard F. X. Schertler & Christopher G. Tate. (2011) The structural basis for agonist and partial agonist action on a β1-adrenergic receptor. Nature 469:7329, pages 241-244.
Crossref
Crossref
Nathan Robertson, Ali Jazayeri, James Errey, Asma Baig, Edward Hurrell, Andrei Zhukov, Christopher J. Langmead, Malcolm Weir & Fiona H. Marshall. (2011) The properties of thermostabilised G protein-coupled receptors (StaRs) and their use in drug discovery. Neuropharmacology 60:1, pages 36-44.
Crossref
Crossref
Gouthaman S. Balaraman, Supriyo Bhattacharya & Nagarajan Vaidehi. (2010) Structural Insights into Conformational Stability of Wild-Type and Mutant β1-Adrenergic Receptor. Biophysical Journal 99:2, pages 568-577.
Crossref
Crossref
Zygmunt S. Derewenda. (2010) Application of protein engineering to enhance crystallizability and improve crystal properties. Acta Crystallographica Section D Biological Crystallography 66:5, pages 604-615.
Crossref
Crossref