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Biocatalysis and Biotransformation Volume 28, 2010 - Issue 4
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ORIGINAL ARTICLE

High-yielding cascade enzymatic synthesis of 5-methyluridine using a novel combination of nucleoside phosphorylases

Daniel F. Visser CSIR Biosciences, Private Bag X2, Modderfontein, 1645, South AfricaCorrespondence[email protected]
,
Konanani J. Rashamuse CSIR Biosciences, Private Bag X2, Modderfontein, 1645, South Africa
,
Fritha Hennessy CSIR Biosciences, Private Bag X2, Modderfontein, 1645, South Africa
,
Gregory E.R. Gordon CSIR Biosciences, Private Bag X2, Modderfontein, 1645, South Africa
,
Petrus J. Van Zyl CSIR Biosciences, Private Bag X2, Modderfontein, 1645, South Africa
,
Kgama Mathiba CSIR Biosciences, Private Bag X2, Modderfontein, 1645, South Africa
,
Moira L. Bode CSIR Biosciences, Private Bag X2, Modderfontein, 1645, South Africa
&
Dean Brady CSIR Biosciences, Private Bag X2, Modderfontein, 1645, South Africa
 show all
Pages 245-253 | Received 25 Jan 2010, Accepted 11 May 2010, Published online: 01 Jul 2010

Citations (10)

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Read on this site (1)

Sebastian C. Cosgrove & Gavin J. Miller. (2022) Advances in biocatalytic and chemoenzymatic synthesis of nucleoside analogues. Expert Opinion on Drug Discovery 17:4, pages 355-364.
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Articles from other publishers (9)

Sjoerd Slagman & Wolf-Dieter Fessner. (2021) Biocatalytic routes to anti-viral agents and their synthetic intermediates. Chemical Society Reviews 50:3, pages 1968-2009.
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Yiyuan Wang, Yingxiu Cao, Yuanxiu Li, Jiayu Jin, Jinliang Li & Hao Song. (2017) Asymmetric biosynthesis of intermediates of anti-HIV drugs. Tetrahedron: Asymmetry 28:6, pages 745-757.
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Jesús Fernández-Lucas. (2015) Multienzymatic synthesis of nucleic acid derivatives: a general perspective. Applied Microbiology and Biotechnology 99:11, pages 4615-4627.
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Shaozhou Zhu, Dawei Song, Cuiyu Gong, Pingwah Tang, Xingzhou Li, Jianjun Wang & Guojun Zheng. (2012) Biosynthesis of nucleoside analogues via thermostable nucleoside phosphorylase. Applied Microbiology and Biotechnology 97:15, pages 6769-6778.
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Juan Xiong, Wenquan Zhang, Jingtan Su, Junlong Shangguan, Yin Lin, Yang Yang, Rongqing Zhang, Liping Xie & Hongzhong Wang. (2011) Improved synthesis of 2?-deoxyadenosine and 5-methyluridine by Escherichia coli using an auto-induction system. World Journal of Microbiology and Biotechnology 28:2, pages 721-727.
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Daniel F. Visser, Fritha Hennessy, Justice Rashamuse, Brett Pletschke & Dean Brady. (2011) Stabilization of Escherichia coli uridine phosphorylase by evolution and immobilization. Journal of Molecular Catalysis B: Enzymatic 68:3-4, pages 279-285.
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Igor A. Mikhailopulo & Anatoly I. Miroshnikov. (2011) Biologically important nucleosides: modern trends in biotechnology and application. Mendeleev Communications 21:2, pages 57-68.
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Gregory E. R. Gordon, Moira L. Bode, Daniel F. Visser, M. Jerry Lepuru, Jacob G. Zeevaart, Nasheen Ragubeer, Molala Ratsaka, David R. Walwyn & Dean Brady. (2010) An Integrated Chemo-enzymatic Route for Preparation of β-Thymidine, a Key Intermediate in the Preparation of Antiretrovirals. Organic Process Research & Development 15:1, pages 258-265.
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Gregory E.R. Gordon, Daniel F. Visser, Dean Brady, Nelly Raseroka & Moira L. Bode. (2011) Defining a process operating window for the synthesis of 5-methyluridine by transglycosylation of guanosine and thymine. Journal of Biotechnology 151:1, pages 108-113.
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