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Critical Reviews in Clinical Laboratory Sciences Volume 30, 1993 - Issue 3
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Research Article

Pepsinogens in Health and Disease

M. Plebani Department of Laboratory Medicine, University Hospital, Padova, Italy; Center for Biomedical Research, Castelfranco, Veneto, (TV), Italy
&
Or. Sander Szabo Harvard Medical School, Brighamand Women's Hospital, 75 Francis Street, Boston, MA, 02115
Pages 273-328 | Published online: 27 Sep 2008

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S. Hokkanen, T. U. Kosunen, S. Sarna, A. Miettinen, A. Salomaa, A. Aromaa, P. Knekt & H. I. Rautelin. (2005) Normal serum pepsinogen I levels in adults: A population‐based study with special reference to Helicobacter pylori infection and parietal cell antibodies. Scandinavian Journal of Clinical and Laboratory Investigation 65:4, pages 291-300.
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ME Matz & WG Guilford. (2003) Laboratory procedures for the diagnosis of gastrointestinal tract diseases of dogs and cats. New Zealand Veterinary Journal 51:6, pages 292-301.
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N. N. Abdelshaheed & D. M. Goldberg. (1997) Biochemical Tests in Diseases of the Intestinal Tract: Their Contributions to Diagnosis, Management, and Understanding the Pathophysiology of Specific Disease States. Critical Reviews in Clinical Laboratory Sciences 34:2, pages 141-223.
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Articles from other publishers (34)

Jie Chen, Ling Gui, Boyu Chen, Yuang Sun, Yongcan Zhao, Fuping Lu & Ming Li. (2023) Improving Expression of Pepsinogen A from Homo sapiens in Aspergillus niger by Using a Multi-Copy Gene Knock-in Strategy. Fermentation 9:6, pages 538.
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Shin‐ichi Fujiwara, Mutsuko Konno, Satoshi Watanabe, Nariaki Toita & Michiko Takahashi. (2022) Serum pepsinogen cut‐off values in Helicobacter pylori ‐infected children . Pediatrics International 64:1.
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Daniela Ennulat, Karen M. Lynch, Carie L. Kimbrough, Rosanna C. Mirabile & Sabine Rehm. (2016) Evaluation of Pepsinogen I as a Biomarker of Drug-induced Gastric Mucosal Injury in Cynomolgus Monkeys. Toxicologic Pathology 45:2, pages 296-301.
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Elizabeth M. Duncan, Brian J. Dale & John V. Lloyd. (2014) Investigation of a link between raised levels of pepsinogen in blood as a mediator of in-vitro clot lysis in acid and a cause of abnormal factor XIII screening tests. Blood Coagulation & Fibrinolysis 25:4, pages 340-348.
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K. Toyoda, N. Furusyo, T. Ihara, H. Ikezaki, Y. Urita & J. Hayashi. (2012) Serum pepsinogen and Helicobacter pylori infection—a Japanese population study. European Journal of Clinical Microbiology & Infectious Diseases 31:9, pages 2117-2124.
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Michaela Rajčanová, Marie Tichá & Zdenka Kučerová. (2012) Application of heptapeptides containing D ‐amino acid residues immobilized to magnetic particles and S epharose for the study of binding properties of gastric aspartic proteases . Journal of Separation Science 35:15, pages 1899-1905.
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Michaela Filuszová, Zdenka Kučerová & Marie Tichá. (2009) Peptide inhibitor modified magnetic particles for pepsin separation. Journal of Separation Science 32:12, pages 2017-2021.
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Graziella Guariso, Daniela Basso, Carla-Federica Bortoluzzi, Alessandra Meneghel, Stefania Schiavon, Paola Fogar, Maria Farina, Filippo Navaglia, Eliana Greco, Claudia Mescoli, Carlo-Federico Zambon & Mario Plebani. (2009) GastroPanel: Evaluation of the usefulness in the diagnosis of gastro-duodenal mucosal alterations in children. Clinica Chimica Acta 402:1-2, pages 54-60.
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Jana Frýdlová, Zdenka Kučerová & Marie Tichá. (2008) Interaction of pepsin with aromatic amino acids and their derivatives immobilized to Sepharose. Journal of Chromatography B 863:1, pages 135-140.
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Mario Plebani & Daniela Basso. (2007) Non-invasive assessment of chronic liver and gastric diseases. Clinica Chimica Acta 381:1, pages 39-49.
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Biao Huang, Xiangrui Zhang, Lan Zhu, Haiyan Liu, Yehua Jiang & Jian Jin. (2006) Eu-Chelate Construct Ultrasensitive Time-Resolved Fluoroimmunoassay-Assay of Pepsinogen I. Journal of Rare Earths 24:3, pages 381-384.
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M. SUGIMOTO, T. FURUTA, N. SHIRAI, A. NAKAMURA, M. KAJIMURA, H. SUGIMURA, A. HISHIDA & T. ISHIZAKI. (2005) Poor metabolizer genotype status of CYP2C19 is a risk factor for developing gastric cancer in Japanese patients with Helicobacter pylori infection. Alimentary Pharmacology and Therapeutics 22:10, pages 1033-1040.
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Ursula Tress, Jörg M. Steiner, Craig G. Ruaux, Jan S. Suchodolski & David A. Williams. (2004) Purification and partial characterization of feline pepsinogen. American Journal of Veterinary Research 65:9, pages 1195-1199.
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Jana Frýdlová, Zdenka Kučerová & Marie Tichá. (2004) Affinity chromatography of porcine pepsin and pepsinogen using immobilized ligands derived from the specific substrate for this enzyme. Journal of Chromatography B 800:1-2, pages 109-114.
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Abelardo Aguilera, M.Auxiliadora Bajo, Mauricio Espinoza, Antonio Olveira, Ana M Paiva, Rosa Codoceo, Pilar Garcıéa, Sonia Sánchez, Olga Celadilla, Maria Jose Castro & Rafael Selgas. (2003) Gastrointestinal and pancreatic function in peritoneal dialysis patients: their relationship with malnutrition and peritoneal membrane abnormalities. American Journal of Kidney Diseases 42:4, pages 787-796.
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Jan S. Suchodolski, Jörg M. Steiner, Craig G. Ruaux & David A. Williams. (2003) Serum concentrations of pepsinogen A in healthy dogs after food deprivation and after feeding. American Journal of Veterinary Research 64:9, pages 1146-1150.
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Zdenka Kučerová & Marie Tichá. (2003) Preparation of affinity carriers for the study of binding properties of aspartic proteinases. Journal of Separation Science 26:8, pages 669-673.
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N Broutet, M Plebani, C Sakarovitch, P Sipponen & F Mégraud. (2003) Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics. British Journal of Cancer 88:8, pages 1239-1247.
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Jan S. Suchodolski, Jörg M. Steiner, Craig G. Ruaux, Andrea Boari & David A. Williams. (2002) Purification and partial characterization of canine pepsinogen A and B. American Journal of Veterinary Research 63:11, pages 1585-1590.
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Takahisa Furuta, Emad M. El–Omar, Fang Xiao, Naohito Shirai, Misako Takashima & Haruhiko Sugimurra. (2002) Interleukin 1β polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan. Gastroenterology 123:1, pages 92-105.
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J. Riordan. 2002. Encyclopedia of Molecular Biology. Encyclopedia of Molecular Biology.
Reynold Homan & Mahendra Kumar Jain. 2001. Intestinal Lipid Metabolism. Intestinal Lipid Metabolism 81 104 .
I. GRITTI, G. BANFI & G.S. ROI. (2000) PEPSINOGENS: PHYSIOLOGY, PHARMACOLOGY PATHOPHYSIOLOGY AND EXERCISE. Pharmacological Research 41:3, pages 265-281.
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Mario Plebani, Graziella Guariso, Paola Fogar, Daniela Basso, Nicoletta Gallo, Carlo Federico Zambon, Renata Mozrzymas, Marilena Celadin & Franco Zacchello. (2001) Effect of cag A Status on the Sensitivity of Enzyme Immunoassay in Diagnosing Helicobacter pylori –Infected Children . Helicobacter 4:4, pages 226-232.
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F Navaglia, D Basso, M G Piva, L Brigato, A Stefani, N Dal Bò, F Di Mario, M Rugge & M Plebani. (1998) Helicobacter pylori Cytotoxic Genotype Is Associated With Peptic Ulcer and Influences Serology. American Journal of Gastroenterology 93:2, pages 227-230.
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Mario PlebaniDaniela BassoFilippo NavagliaFrancesco DiMario. (2008) Helicobacter pylori Genotypes Inf luence Serum Pepsinogen C Levels . Helicobacter 2:4, pages 172-175.
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Hans-Karl Heim, Markus Piller, Jörn Schwede, Petra Kilian, Susanne Netz-Piepenbrink & Karl-Friedrich Sewing. (1997) Pepsinogen synthesis during long-term culture of porcine chief cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1359:1, pages 35-47.
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Eleftherios P Diamandis, Sheila Nadkarni, Banani Bhaumik, Aly Abdelrahman, Dimitrios N Melegos, Gudrun Borchert, Margot H Black, Marta Alonso, Ana Salas, Juan R de los Toyos, Andres Sampedro & Carlos López-Otín. (1997) Immunofluorometric assay of pepsinogen C and preliminary clinical applications. Clinical Chemistry 43:8, pages 1365-1371.
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RONALD J. SCHLEMPER, SJOERD DJ WERF, JAN P. VANDENBROUCKE, IZÄK BIEMOND & CORNELIS BHW LAMERS. (1996) Risk factors of peptic ulcer disease: Different impact of Helicobacter pylori in Dutch and Japanese populations?. Journal of Gastroenterology and Hepatology 11:9, pages 825-831.
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Mario Plebani, Daniela Basso, Marina Scrigner, Andrea Toma, Francesco Di Mario, Nadia Dal Bò & I. Michael Samloff. (1996) Serum pepsinogen C: A useful marker of Helicobacter pylori eradication?. Journal of Clinical Laboratory Analysis 10:1, pages 1-5.
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M. Plebani, D. Basso, G. Busatto, L. Brigato, M. Battistel & M. Rugge. (1995) Gastrin stimulates gastric mast cells in rabbits. Research in Experimental Medicine 195:1, pages 365-371.
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Paola Dotto, Fabio Vianello, Mario Plebani, Marina Ferrana, Nadia Dal Bó, Tiziana Del Bianco, Simonetta Salandin, Daniela Basso, Gioacchino Leandro, Giuseppe Battaglia & Francesco Di Mario. (1995) Serum pepsinogens as markers of Helicobacter pylori eradication. Current Therapeutic Research 56:8, pages 777-786.
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A. J. GAW, L. V. WILLIAMS, C. F. SPRAGGS & C. C. JORDAN. (2007) Role of pepsin in the development of indomethacin‐induced antral ulceration in the rat. Alimentary Pharmacology & Therapeutics 9:2, pages 167-172.
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Mario Plebani, Fabio Vianello & Francesco Di Mario. (1994) Laboratory medicine in ulcer disease. Clinical Biochemistry 27:3, pages 141-150.
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