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Review Article

Current status and perspectives on protein-based pneumococcal vaccines

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Pages 190-200 | Received 28 Mar 2013, Accepted 07 Jun 2013, Published online: 29 Jul 2013

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Jingwen Wu, Kaifeng Wu, Wenchun Xu, Taixian Yuan, Xiaofang Wang, Jinghui Zhang, Yajun Min, Yibing Yin & Xuemei Zhang. (2018) Engineering detoxified pneumococcal pneumolysin derivative ΔA146PLY for self-biomineralization of calcium phosphate: Assessment of their protective efficacy in murine infection models. Biomaterials 155, pages 152-164.
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Keith P. Klugman, Ron Dagan, Richard Malley & Cynthia G. Whitney. 2018. Plotkin's Vaccines. Plotkin's Vaccines 773 815.e18 .
Cibelly Goulart, Dunia Rodriguez, Alex I. Kanno, Thiago Rojas Converso, Ying-Jie Lu, Richard Malley & Luciana C. C. Leite. (2017) A Combination of Recombinant Mycobacterium bovis BCG Strains Expressing Pneumococcal Proteins Induces Cellular and Humoral Immune Responses and Protects against Pneumococcal Colonization and Sepsis. Clinical and Vaccine Immunology 24:10.
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T.R. Converso, C. Goulart, D. Rodriguez, M. Darrieux & L.C.C. Leite. (2017) Rational selection of broadly cross-reactive family 2 PspA molecules for inclusion in chimeric pneumococcal vaccines. Microbial Pathogenesis 109, pages 233-238.
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Ana Paula Corrêa Argondizzo, Cláudio Marcos Rocha-de-Souza, Marta de Almeida Santiago, Ricardo Galler, Joice Neves Reis & Marco Alberto Medeiros. (2017) Pneumococcal Predictive Proteins Selected by Microbial Genomic Approach Are Serotype Cross-Reactive and Bind to Host Extracellular Matrix Proteins. Applied Biochemistry and Biotechnology 182:4, pages 1518-1539.
Crossref
Jingcai Lu, Hongjia Hou, Dandan Wang, Kees Leenhouts, Maarten L.van Roosmalen, Tianxu Sun, Tiejun Gu, Yueshuang Song, Chunlai Jiang, Wei Kong & Yongge Wu. (2017) Systemic and mucosal immune responses elicited by intranasal immunization with a pneumococcal bacterium-like particle-based vaccine displaying pneumolysin mutant Plym2. Immunology Letters 187, pages 41-46.
Crossref
Q. Xu, J.R. Casey, A. Almudevar & M.E. Pichichero. (2017) Correlation of higher antibody levels to pneumococcal proteins with protection from pneumococcal acute otitis media but not protection from nasopharyngeal colonization in young children. Clinical Microbiology and Infection 23:7, pages 487.e1-487.e6.
Crossref
Majela González-Miro, Laura Rodríguez-Noda, Mildrey Fariñas-Medina, Dagmar García-Rivera, Vicente Vérez-Bencomo & Bernd H.A. Rehm. (2017) Self-assembled particulate PsaA as vaccine against Streptococcus pneumoniae infection. Heliyon 3:4, pages e00291.
Crossref
Cibelly Goulart, Dunia Rodriguez, Alex I. Kanno, Ying-Jie Lu, Richard Malley & Luciana C.C. Leite. (2017) Recombinant BCG expressing a PspA-PdT fusion protein protects mice against pneumococcal lethal challenge in a prime-boost strategy. Vaccine 35:13, pages 1683-1691.
Crossref
Greiciely O. Andre, Thiago R. Converso, Walter R. Politano, Lucio F. C. Ferraz, Marcelo L. Ribeiro, Luciana C. C. Leite & Michelle Darrieux. (2017) Role of Streptococcus pneumoniae Proteins in Evasion of Complement-Mediated Immunity. Frontiers in Microbiology 8.
Crossref
T.R. Converso, C. Goulart, D. Rodriguez, M. Darrieux & L.C.C. Leite. (2017) Systemic immunization with rPotD reduces Streptococcus pneumoniae nasopharyngeal colonization in mice. Vaccine 35:1, pages 149-155.
Crossref
Fiona McGill, Robert S Heyderman, Stavros Panagiotou, Allan R Tunkel & Tom Solomon. (2016) Acute bacterial meningitis in adults. The Lancet 388:10063, pages 3036-3047.
Crossref
Sylvia Kohler, Franziska Voß, Alejandro Gómez Mejia, Jeremy S. Brown & Sven Hammerschmidt. (2016) Pneumococcal lipoproteins involved in bacterial fitness, virulence, and immune evasion. FEBS Letters 590:21, pages 3820-3839.
Crossref
I. B. Semenova & N. A. Mikhailova. (2016) SEROTYPE-INDEPENDENT VACCINES AGAINST PNEUMOCOCCAL INFECTION. Journal of microbiology, epidemiology and immunobiology 93:4, pages 76-85.
Crossref
Larry S. McDaniel & Edwin Swiatlo. (2016) Should Pneumococcal Vaccines Eliminate Nasopharyngeal Colonization?. mBio 7:3.
Crossref
Qingfu Xu, Janet R. Casey, Emily Newman & Michael E. Pichichero. (2016) Otitis-prone Children Have Immunologic Deficiencies in Naturally Acquired Nasopharyngeal Mucosal Antibody Response after Streptococcus pneumoniae Colonization. Pediatric Infectious Disease Journal 35:1, pages 54-60.
Crossref
K. Moffitt, A. Howard, S. Martin, E. Cheung, M. Herd, A. Basset & R. Malley. (2015) T H 17-Mediated Protection against Pneumococcal Carriage by a Whole-Cell Vaccine Is Dependent on Toll-Like Receptor 2 and Surface Lipoproteins . Clinical and Vaccine Immunology 22:8, pages 909-916.
Crossref
Irene Jiménez-Munguía, Willem J.B. van Wamel, Alfonso Olaya-Abril, Emilio García-Cabrera, Manuel J. Rodríguez-Ortega & Ignacio Obando. (2015) Proteomics-driven design of a multiplex bead-based platform to assess natural IgG antibodies to pneumococcal protein antigens in children. Journal of Proteomics 126, pages 228-233.
Crossref
Neha Kothari, Sudeep Kothari, Young Joo Choi, Ayan Dey, David E. Briles, Dong Kwon Rhee & Rodney Carbis. (2015) A bivalent conjugate vaccine containing PspA families 1 and 2 has the potential to protect against a wide range of Streptococcus pneumoniae strains and Salmonella Typhi. Vaccine 33:6, pages 783-788.
Crossref
Mario Ramirez. 2015. Molecular Medical Microbiology. Molecular Medical Microbiology 1529 1546 .
Ravinder Kaur, Naveen Surendran, Martina Ochs & Michael E. Pichichero. (2014) Human Antibodies to PhtD, PcpA, and Ply Reduce Adherence to Human Lung Epithelial Cells and Murine Nasopharyngeal Colonization by Streptococcus pneumoniae. Infection and Immunity 82:12, pages 5069-5075.
Crossref
C. Forstner & M.W. Pletz. (2014) PneumokokkenimpfungPneumococcal vaccination. Der Pneumologe 11:6, pages 506-515.
Crossref
Kaifeng Wu, Run Yao, Hong Wang, Dan Pang, Yusi Liu, Hongmei Xu, Shuai Zhang, Xuemei Zhang & Yibing Yin. (2014) Mucosal and systemic immunization with a novel attenuated pneumococcal vaccine candidate confer serotype independent protection against Streptococcus pneumoniae in mice. Vaccine 32:33, pages 4179-4188.
Crossref
Kristin Moffitt, Mojca Skoberne, Angela Howard, L. Cristina Gavrilescu, Todd Gierahn, Scott Munzer, Bharat Dixit, Paul Giannasca, Jessica Baker Flechtner & Richard Malley. (2014) Toll-Like Receptor 2-Dependent Protection against Pneumococcal Carriage by Immunization with Lipidated Pneumococcal Proteins. Infection and Immunity 82:5, pages 2079-2086.
Crossref

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