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Critical Reviews in Toxicology Volume 44, 2014 - Issue 4
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Review Article

An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B1, tamoxifen and vinyl chloride

Lynn H. PottengerThe Dow Chemical Company Midland, MIUSA
,
Larry S. AndrewsThe Dow Chemical Company Midland, MIUSA;Rohm and Haas Company Spring House, PAUSA
,
Ammie N. BachmanExxonMobil Biomedical Sciences Annandale, NJUSA
,
Peter J. BoogaardShell Health, Shell International bv The HagueThe Netherlands
,
Jean CadetDSM/INAC/SCIB UMR-E 3 CEA/UJF & FRE CNRS 3200/“Lésions des Acides Nucléiques” CEA/Grenoble, Grenoble Cedex 9France
,
Michelle R. EmbryILSI Health and Environmental Sciences Institute Washington, DCUSACorrespondence[email protected]
,
Peter B. FarmerDepartment of Cancer Studies and Molecular Medicine, Biocentre, University of Leicester LeicesterUK
,
Matthew W. HimmelsteinDuPont Haskell Global Centers for Health and Environmental Sciences Newark DEUSA
,
Annie M. JarabekNational Center for Environmental Assessment, U.S. Environmental Protection Agency Washington, DCUSA
,
Elizabeth A. MartinDrug Safety and Metabolism, AstraZeneca Alderley Park, Macclesfield, CheshireUK
,
Robert J. MauthePfizer Worldwide Research and Development Groton, CTUSA
,
Rudranath PersaudL'Oreal USA Clark, NJUSA
,
R. Julian PrestonNational Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park NCUSA
,
Rita SchoenyOffice of Water, U.S. Environmental Protection Agency Washington, DCUSA
,
Julie SkareConsultant Mason, OHUSA
,
James A. SwenbergDepartment of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill Chapel Hill, NCUSA
,
Gary M. WilliamsDepartment of Pathology, New York Medical College Valhalla, NYUSA
,
Errol ZeigerErrol Zeiger Consulting Chapel Hill, NCUSA
,
Fagen ZhangThe Dow Chemical Company Midland, MIUSA
&
James H. KimILSI Health and Environmental Sciences Institute Washington, DCUSA
 show all
Pages 348-391 | Received 05 Jun 2013, Accepted 06 Dec 2013, Published online: 04 Feb 2014

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Adeline Clergé, Jérémie Le Goff, Claire Lopez, Jérôme Ledauphin & Raphaël Delépée. (2019) Oxy-PAHs: occurrence in the environment and potential genotoxic/mutagenic risk assessment for human health. Critical Reviews in Toxicology 49:4, pages 302-328.
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Martha M. Moore, Rita S. Schoeny, Richard A. Becker, Kimberly White & Lynn H. Pottenger. (2018) Development of an adverse outcome pathway for chemically induced hepatocellular carcinoma: case study of AFB1, a human carcinogen with a mutagenic mode of action. Critical Reviews in Toxicology 48:4, pages 312-337.
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Articles from other publishers (22)

Slim Smaoui, Teresa D’Amore, Maria Tarapoulouzi, Sofia Agriopoulou & Theodoros Varzakas. (2023) Aflatoxins Contamination in Feed Commodities: From Occurrence and Toxicity to Recent Advances in Analytical Methods and Detoxification. Microorganisms 11:10, pages 2614.
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Poguang Wang, Elisabeth Roider, Michael E. Coulter, Christopher A. Walsh, Caitlin S. Kramer, Penny J. Beuning & Roger W. Giese. (2021) DNA Adductomics by mass tag prelabeling. Rapid Communications in Mass Spectrometry 35:13.
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Yanying Li, Ping Huang, Fangyuan Gao, Xiyun Xiao & Lingling Li. (2020) Selenium ameliorates aflatoxin B1‐induced uterine injury in female mice and necrosis of human endometrial microvascular endothelial cells. Journal of Applied Toxicology 41:5, pages 799-810.
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. (2020) Outcome of a public consultation on the draft risk assessment of aflatoxins in food. EFSA Supporting Publications 17:3.
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Dieter Schrenk, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Jesús del Mazo, Bettina Grasl‐Kraupp, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Jean‐Charles Leblanc, Carlo Stefano Nebbia, Elsa Nielsen, Evangelia Ntzani, Annette Petersen, Salomon Sand, Tanja Schwerdtle, Christiane Vleminckx, Doris Marko, Isabelle P Oswald, Aldert Piersma, Michael Routledge, Josef Schlatter, Katleen Baert, Petra Gergelova & Heather Wallace. (2020) Risk assessment of aflatoxins in food. EFSA Journal 18:3.
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Byeong Hwa Yun, Jingshu Guo, Medjda Bellamri & Robert J. Turesky. (2018) DNA adducts: Formation, biological effects, and new biospecimens for mass spectrometric measurements in humans. Mass Spectrometry Reviews 39:1-2, pages 55-82.
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Joanna Klapacz & B. Bhaskar Gollapudi. (2019) Considerations for the Use of Mutation as a Regulatory Endpoint in Risk Assessment. Environmental and Molecular Mutagenesis 61:1, pages 84-93.
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Annie M. Jarabek & David E. Hines. (2019) Mechanistic integration of exposure and effects: advances to apply systems toxicology in support of regulatory decision-making. Current Opinion in Toxicology 16, pages 83-92.
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Martha M. Moore, Lynn H. Pottenger & Tamara House‐Knight. (2019) Critical review of styrene genotoxicity focused on the mutagenicity/clastogenicity literature and using current organization of economic cooperation and development guidance. Environmental and Molecular Mutagenesis 60:7, pages 624-663.
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L. H. Pottenger, G. Boysen, K. Brown, J. Cadet, R. P. Fuchs, G. E. Johnson & J. A. Swenberg. (2018) Understanding the importance of low‐molecular weight (ethylene oxide‐ and propylene oxide‐induced) DNA adducts and mutations in risk assessment: Insights from 15 years of research and collaborative discussions. Environmental and Molecular Mutagenesis 60:2, pages 100-121.
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Dana Brown Haine. (2018) The Exposome: Making Chemical Exposures Relevant to Biology Instruction. The American Biology Teacher 80:8, pages 600-607.
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Doo Seok Kang, Jun Hyuek Yang, Hyun Soo Kim, Bon Kon Koo, Cheol Min Lee, Yeon-Soon Ahn, Jong-Hyeon Jung & Young Rok Seo. (2018) Application of the Adverse Outcome Pathway Framework to Risk Assessment for Predicting Carcinogenicity of Chemicals. Journal of Cancer Prevention 23:3, pages 126-133.
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Helle Katrine Knutsen, Jan Alexander, Lars Barregård, Margherita Bignami, Beat Brüschweiler, Sandra Ceccatelli, Bruce Cottrill, Michael Dinovi, Lutz Edler, Bettina Grasl‐Kraupp, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Carlo Stefano Nebbia, Isabelle P Oswald, Martin Rose, Alain‐Claude Roudot, Tanja Schwerdtle, Christiane Vleminckx, Günter Vollmer, Heather Wallace, Peter Fürst, Katleen Baert, José Cortiñas Abrahantes, Bruno Dujardin, Krizia Ferrini & Annette Petersen. (2018) Effect on public health of a possible increase of the maximum level for ‘aflatoxin total’ from 4 to 10 μg/kg in peanuts and processed products thereof, intended for direct human consumption or use as an ingredient in foodstuffs. EFSA Journal 16:2.
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T Kobets & GM. Williams. 2018. Comprehensive Toxicology. Comprehensive Toxicology 409 442 .
Holger B. Deising, Iris Gase & Yasuyuki Kubo. (2017) The unpredictable risk imposed by microbial secondary metabolites: how safe is biological control of plant diseases?. Journal of Plant Diseases and Protection 124:5, pages 413-419.
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Kerry L. Dearfield, B. Bhaskar Gollapudi, Jeffrey C. Bemis, R. Daniel Benz, George R. Douglas, Rosalie K. Elespuru, George E. Johnson, David J. Kirkland, Matthew J. LeBaron, Albert P. Li, Francesco Marchetti, Lynn H. Pottenger, Emiel Rorije, Jennifer Y. Tanir, Veronique Thybaud, Jan van Benthem, Carole L. Yauk, Errol Zeiger & Mirjam Luijten. (2017) Next generation testing strategy for assessment of genomic damage: A conceptual framework and considerations. Environmental and Molecular Mutagenesis 58:5, pages 264-283.
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Paul A. White, George R. Douglas, David H. Phillips & Volker M. Arlt. (2017) Quantitative relationships between lacZ mutant frequency and DNA adduct frequency in Muta™Mouse tissues and cultured cells exposed to 3-nitrobenzanthrone . Mutagenesis, pages gew067.
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Thomas B. Starr & James A. Swenberg. (2016) The bottom-up approach to bounding potential low-dose cancer risks from formaldehyde: An update. Regulatory Toxicology and Pharmacology 77, pages 167-174.
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Daniele Avancini, Georgina E. Menzies, Claire Morgan, John Wills, George E. Johnson, Paul A. White & Paul D. Lewis. (2016) MutAIT: an online genetic toxicology data portal and analysis tools. Mutagenesis 31:3, pages 323-328.
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JingJing Zhang, Zengmei Li, Shancang Zhao & Yi Lu. (2016) Size-dependent modulation of graphene oxide–aptamer interactions for an amplified fluorescence-based detection of aflatoxin B 1 with a tunable dynamic range . The Analyst 141:13, pages 4029-4034.
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Joanna Klapacz, Lynn H. Pottenger, Bevin P. Engelward, Christopher D. Heinen, George E. Johnson, Rebecca A. Clewell, Paul L. Carmichael, Yeyejide Adeleye & Melvin E. Andersen. (2016) Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents. Mutation Research/Reviews in Mutation Research 767, pages 77-91.
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Masahiko Kushida, Tomoya Yamada & Yasuyoshi Okuno. 2016. Thresholds of Genotoxic Carcinogens. Thresholds of Genotoxic Carcinogens 193 203 .

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