299
Views
56
CrossRef citations to date
0
Altmetric
Research Article

Toxicological aspects of cyclamate and cyclohexylamine

, , &
Pages 213-306 | Published online: 26 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Mustafa M. Kadhim, Taleeb Zedan Taban, Sallal A.H. Abdullaha, Ahmed Salah Al-Shati, Ahmed Mahdi Rheima & Safa K. Hachim. (2023) A computational investigation on the cyclohexylamine recognition using the pure and Cu-doped BN nanotube. Molecular Simulation 49:4, pages 386-392.
Read now
Quan Zhou, Zhongtian Peng & Xialing Huang. (2022) Establishment of a Stable Acute Drug-Induced Liver Injury Mouse Model by Sodium Cyclamate. Journal of Inflammation Research 15, pages 1599-1615.
Read now
Alicja Mortensen. (2006) Sweeteners permitted in the European Union: safety aspects. Scandinavian Journal of Food and Nutrition 50:3, pages 104-116.
Read now
Farid E. Ahmed & David B. Thomas. (1992) Assessment of the Carcinogenicity of the Nonnutritive Sweetener Cyclamate. Critical Reviews in Toxicology 22:2, pages 81-118.
Read now
E. Poulsen. (1991) Safety evaluation of substances consumed as technical ingredients (food additives). Food Additives & Contaminants 8:2, pages 125-133.
Read now
Gunnar Damgård Nielsen. (1991) Mechanisms of Activation of the Sensory Irritant Receptor by Airborne Chemicals. Critical Reviews in Toxicology 21:3, pages 183-208.
Read now
A. G. Renwick. (1990) Acceptable daily intake and the regulation of intense sweeteners. Food Additives & Contaminants 7:4, pages 463-475.
Read now

Articles from other publishers (49)

Suresh Nagaral, Kamran Habib Awan, Sudha Patil, Hosam Ali Baeshen, Joshua Finch, Shankargouda Patil, Rua Adnan Saeed Jalal, Dhalia Hassan Albar, Sandesh Jagdish Bansal & Christopher Alexander Bernard. (2023) Intake of Artificial Sweeteners by Children: Boon or Bane?. The Journal of Contemporary Dental Practice 24:2, pages 137-145.
Crossref
Sofia Pavanello, Angelo Moretto, Carlo La Vecchia & Gianfranco Alicandro. (2023) Non-sugar sweeteners and cancer: Toxicological and epidemiological evidence. Regulatory Toxicology and Pharmacology 139, pages 105369.
Crossref
Marcos Mateo-Fernández, Miguel Josué González-Jiménez, Mercedes Del Río Celestino, Rafel Font, Ángeles Alonso-Moraga & Tania Merinas-Amo. (2022) Toxicological and Nutraceutical Screening Assays of Some Artificial Sweeteners. Processes 10:2, pages 410.
Crossref
Ram Snehi DwivediRam Snehi Dwivedi. 2022. Alternative Sweet and Supersweet Principles. Alternative Sweet and Supersweet Principles 29 74 .
Ashley Roberts, Andrew G. Renwick, Diane Stannard, David Myers, George Pugh & Sachin Bhusari. (2021) The potential developmental neurotoxicity of calcium cyclamate in CD rats. Food and Chemical Toxicology 153, pages 112236.
Crossref
Yanhui Deng, Ping Shuai, Haixin Wang, Shanshan Zhang, Jie Li, Mingyan Du, Peirong Huang, Chao Qu & Lulin Huang. (2021) Untargeted metabolomics for uncovering plasma biological markers of wet age-related macular degeneration. Aging 13:10, pages 13968-14000.
Crossref
Kanagamani Krishnasamy. 2020. Weight Management. Weight Management.
Joseph A. Rothwell, Francisco Madrid-Gambin, Mar Garcia-Aloy, Cristina Andres-Lacueva, Caomhan Logue, Alison M. Gallagher, Carina Mack, Sabine E. Kulling, Qian Gao, Giulia Praticò, Lars O. Dragsted & Augustin Scalbert. (2018) Biomarkers of intake for coffee, tea, and sweetened beverages. Genes & Nutrition 13:1.
Crossref
Sasisekhar Bennuru, Sara Lustigman, David Abraham & Thomas B. Nutman. (2017) Metabolite profiling of infection-associated metabolic markers of onchocerciasis. Molecular and Biochemical Parasitology 215, pages 58-69.
Crossref
Nitzan Koppel, Vayu Maini Rekdal & Emily P. Balskus. (2017) Chemical transformation of xenobiotics by the human gut microbiota. Science 356:6344.
Crossref
Caomhan Logue, Le Roy C. Dowey, J. J. Strain, Hans Verhagen, Stephen McClean & Alison M. Gallagher. (2017) Application of Liquid Chromatography–Tandem Mass Spectrometry To Determine Urinary Concentrations of Five Commonly Used Low-Calorie Sweeteners: A Novel Biomarker Approach for Assessing Recent Intakes?. Journal of Agricultural and Food Chemistry 65:22, pages 4516-4525.
Crossref
Jianjun Li, Yun Liu, Qianping Liu, Junfeng Hui & Yangzi Liu. (2017) On-cartridge derivatisation using matrix solid phase dispersion for the determination of cyclamate in foods. Analytica Chimica Acta 972, pages 46-53.
Crossref
C. Logue, L. C. Dowey, J. J. Strain, H. Verhagen & A. M. Gallagher. (2016) The potential application of a biomarker approach for the investigation of low-calorie sweetener exposure. Proceedings of the Nutrition Society 75:2, pages 216-225.
Crossref
Tao Zhang, Zhiwei Gan, Chuanzi Gao, Ling Ma, Yanxi Li, Xiao Li & Hongwen Sun. (2016) Occurrence of artificial sweeteners in human liver and paired blood and urine samples from adults in Tianjin, China and their implications for human exposure. Environmental Science: Processes & Impacts 18:9, pages 1169-1176.
Crossref
Gert-Wolfhard von Rymon Lipinski. 2000. Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry 1 25 .
Sanchari Chattopadhyay, Utpal Raychaudhuri & Runu Chakraborty. (2011) Artificial sweeteners – a review. Journal of Food Science and Technology 51:4, pages 611-621.
Crossref
Grant E. Dubois. 2012. Sweeteners and Sugar Alternatives in Food Technology. Sweeteners and Sugar Alternatives in Food Technology 137 166 .
Theodoros Varzakas, Athanasios Labropoulos & Stylianos AnestisAlicja Mortensen & John Larsen. 2012. Sweeteners. Sweeteners 419 436 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 74 100 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 25 .
Marianna A. Patrauchan, J. Jacob Parnell, Michael P. McLeod, Christine Florizone, James M. Tiedje & Lindsay D. Eltis. (2011) Genomic analysis of the phenylacetyl-CoA pathway in Burkholderia xenovorans LB400. Archives of Microbiology 193:9, pages 641-650.
Crossref
Ashley Roberts & Andrew G. Renwick. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Yi Shen, Da-Zhong Yan, Xiang-Qun Chi, Yan-Yan Yang, David J. Leak & Ning-Yi Zhou. (2008) Degradation of cyclohexylamine by a new isolate of Pseudomonas plecoglossicida. World Journal of Microbiology and Biotechnology 24:8, pages 1623-1625.
Crossref
Shozo TAKAYAMA, Unnur P. THORGEIRSSON & Richard H. ADAMSON. (2008) Chemical carcinogenesis studies in nonhuman primates. Proceedings of the Japan Academy, Series B 84:6, pages 176-188.
Crossref
Júlio César M Santos Jr.. (2007) Câncer ano-reto-cólico: aspectos atuais II - câncer colorretal - fatores de riscos e prevenção. Revista Brasileira de Coloproctologia 27:4, pages 459-473.
Crossref
Grant E. DuBois. 2006. Sweeteners and Sugar Alternatives in Food Technology. Sweeteners and Sugar Alternatives in Food Technology 103 129 .
Manfred Kroger, Kathleen Meister & Ruth Kava. (2006) Low‐calorie Sweeteners and Other Sugar Substitutes: A Review of the Safety Issues. Comprehensive Reviews in Food Science and Food Safety 5:2, pages 35-47.
Crossref
S.E. Kemp. 2006. Optimising Sweet Taste in Foods. Optimising Sweet Taste in Foods 175 251 .
M.R. Weihrauch & V. Diehl. (2004) Artificial sweeteners—do they bear a carcinogenic risk?. Annals of Oncology 15:10, pages 1460-1465.
Crossref
José Germano Ferraz de Arruda, Alex Tadeu Martins & Reinaldo Azoubel. (2003) Ciclamato de sódio e rim fetal. Revista Brasileira de Saúde Materno Infantil 3:2, pages 147-150.
Crossref
Gert‐Wolfhard von Rymon Lipinski. 2003. Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry.
M.-L. Hu & H.-H. Tsai. (1998) Reaction of Cyclohexylamine with Hypochlorite and Enhancement of Oxidation of Plasma Sulfhydryl Groupsby Hypochlorite In Vitro. Food and Chemical Toxicology 36:9-10, pages 755-759.
Crossref
Isidre Casals, Maria Reixach, Judith Amat, Margarita Fuentes & Lluís Serra-Majem. (1996) Quantification of cyclamate and cyclohexylamine in urine samples using high-performance liquid chromatography with trinitrobenzenesulfonic acid pre-column derivatization. Journal of Chromatography A 750:1-2, pages 397-402.
Crossref
Kirk T. Kitchin, Janice L. Brown & Arun P. Kulkarni. (2005) Complementarity of genotoxic and nongenotoxic predictors of rodent carcinogenicity. Teratogenesis, Carcinogenesis, and Mutagenesis 14:2, pages 83-100.
Crossref
S.S. Schiffman & C.A. Gatlin. (1993) Sweeteners: State of knowledge review. Neuroscience & Biobehavioral Reviews 17:3, pages 313-345.
Crossref
. (1993) Position of the American dietetic association: Use of nutritive and nonnutritive sweeteners. Journal of the American Dietetic Association 93:7, pages 816-821.
Crossref
N.E. Buss, A.G. Renwick, K.M. Donaldson & C.F. George. (1992) The metabolism of cyclamate to cyclohexylamine and its cardiovascular consequences in human volunteers. Toxicology and Applied Pharmacology 115:2, pages 199-210.
Crossref
F. Richard Christ, Shelley Y. Buchen, David A. Fencil, Patricia M. Knight, Kerry D. Solomon & David J. Apple. (2004) A comparative evaluation of the biostability of a poly (ether urethane) in the intraocular, intramuscular, and subcutaneous environments. Journal of Biomedical Materials Research 26:5, pages 607-629.
Crossref
Kirk T. Kitchin, Janice L. Brown & Arun P. Kulkarni. (1992) Predictive assay for rodent carcinogenicity using in vivo biochemical parameters: operational characteristics and complementarity. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 266:2, pages 253-272.
Crossref
Marie E. Coates & R. Walker. (2007) Interrelationships between the Gastrointestinal Microflora and Non-Nutrient Components of the Diet. Nutrition Research Reviews 5:1, pages 85-96.
Crossref
J. A. Barrowman. 1992. Modern Concepts in Gastroenterology Volume 3. Modern Concepts in Gastroenterology Volume 3 107 128 .
MARILYN C. HENDERSON. 1990. Nitrogen and Phosphorus Solvents. Nitrogen and Phosphorus Solvents 24 37 .
Kirk T. Kitchin, Janice L. Brown & William Lijinsky. (1989) Biochemical studies of six nitrogen-containing heterocycles in rat tissues. Biochemical Pharmacology 38:16, pages 2733-2738.
Crossref
A. Roberts & A.G. Renwick. (1989) The pharmacokinetics and tissue concentrations of cyclohexylamine in rats and mice. Toxicology and Applied Pharmacology 98:2, pages 230-242.
Crossref
A. Roberts, A.G. Renwick, G. Ford, D.M. Creasy & I. Gaunt. (1989) The metabolism and testicular toxicity of cyclohexylamine in rats and mice during chronic dietary administration. Toxicology and Applied Pharmacology 98:2, pages 216-229.
Crossref
Kirk T. Kitchin & Janice L. Brown. (2005) Biochemical studies of promoters of carcinogenesis in rat liver. Teratogenesis, Carcinogenesis, and Mutagenesis 9:5, pages 273-285.
Crossref
A. Roberts & A.G. Renwick. (2016) The Fate of Cyclohexylamine in Rat and Mouse in Relation to Testicular Toxicity. Human Toxicology 7:2, pages 229-229.
Crossref
H. Ernst, S. Rittinghausen, B. Bellmann, Z.-X. Xie & U. Mohr. (1988) Myocardial effects of calcium cyclamate in the BIO FID Alexander Syrian golden hamster. Experimental pathology 34:1, pages 23-27.
Crossref
A.G. RENWICK. 1988. Role of the Gut Flora in Toxicity and Cancer. Role of the Gut Flora in Toxicity and Cancer 175 206 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.