Toxicological aspects of cyclamate and cyclohexylamine

References

• Audrieth L. F., Sveda M., U.S. Patent No. 2,275,125, 1942, March 3
   Google Scholar
• Audrieth L. F., Sveda M. Preparation and properties of some N-substituted sulfamic acids. J. Org. Chem. 1944; 9: 89
   Google Scholar
• Beck K. M. Properties of the synthetic sweetening agent, cyclamate. Food Technol. 1957; 11: 156
   Web of Science ®Google Scholar
• Beck K. M. Nonnutritive sweeteners: saccharin and cyclamate. CRC Handbook of Food Additives 2nd ed., T. E. Furia. CRC Press, Boca Raton, Fla 1980; Vol. II: 125
   Google Scholar
• Abbott Laboratories. 1950, New Drug Application No. 7258 for Sucaryl Sodium, Jan. 17
   Google Scholar
• Federal Register. 1959; 24, 9368, November 20
   Google Scholar
• Vincent H. C., Lynch M. J., Pohley F. M., Helgren F. J., Kirchmeyer F. J. A taste panel study of cyclamate-saccharin mixture and of its components. J. Am. Pharm. Assoc. 1955; 44: 442
   Google Scholar
• Kojima S., Ichibagase H. Studies on synthetic sweetening agents. VIII. Cyclohexylamine, a metabolite of sodium cyclamate. Chem. Pharm. Bull. 1966; 14: 971
   PubMed Web of Science ®Google Scholar
• Price J. M., Biava C. G., Oser B. L., Vogin E. E., Steinfeld J., Ley H. L. Bladder tumors in rats fed cyclohexylamine or high doses of a mixture of cyclamate and saccharin. Science 1970; 167: 1131
   PubMed Web of Science ®Google Scholar
• Federal Register October 21, 1969; 34: 17063
   Google Scholar
• Federal Register August 27, 1970; 35: 13644
   Google Scholar
• Abbott Laboratories, Cyclamic acid and its salts. Food Additive Petition November 15, 1973; 4A2975
   Google Scholar
• Fed. Reg. February 8, 1974; 39: 4935
   Google Scholar
• Abbott Laboratories. Supplement to Food Additive Petition October 25, 1974; 4A2975
   Google Scholar
• Abbott Laboratories. Supplement to Food Additive Petition November 17, 1975; 4A2975
   Google Scholar
• Report of the Temporary Committee for the Review of Data on Carcinogenicity of Cyclamate. DHEW Publication No. (NIH)77–1437, Department of Health, Education, and Welfare February, 1976
   Google Scholar
• Federal Register October 4, 1976; 41: 43754
   Google Scholar
• Federal Register March 4, 1977; 42: 12515
   Google Scholar
• Food and Drug Administration. Hearing on cyclamate, Docket No. 76F-0392
   Google Scholar
• Davidson D. Initial decision, August 4, 1978, and Initial decision on further hearing February 4, 1980
   Google Scholar
• Food and Drug Administration. Cyclamate (cyclamic acid, calcium cyclamate, and sodium cyclamate), Commissioner's decision, Fed. Reg. September 16, 1980; 45: 61474
   Google Scholar
• American Statistical Association. Letter to the Commissioner of the Food and Drug Administration April 7, 1981
   Google Scholar
• Task Force of Past Presidents of the Society of Toxicology, Animal data in hazard evaluation: paths and pitfalls. Fundam. Appl. Toxicol. 1982; 2: 101
   PubMedGoogle Scholar
• The Calorie Control Council and Abbott Laboratories. Food Additive Petition for Cyclamate September 22, 1982; 2A3672
   Google Scholar
• Cancer Assessment Committee (CAC). Center for Food Safety and Applied Nutrition, Food and Drug Administration, Scientific review of the long-term carcinogen bioassays performed on the artificial sweetener, cyclamate April, 1984
   Google Scholar
• National Academy of Sciences, National Research Council, Committee on the Evaluation of Cyclamate for Carcinogenicity. Evaluation of Cyclamate for Carcinogenicity. National Academy Press, Washington, DC 1985
   Google Scholar
• World Health Organization. 21st Report of the Joint FAO/WHO Expert Committee on Food Additives, Evaluation of Certain Food Additives. Tech. Rep. Ser. April 18–27, 1977; 617, 1978
   Google Scholar
• International Agency for Research on Cancer. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Some Non-nutritive Sweetening Agents. IARC, Lyon 1980; Vol. 22: 33
   Google Scholar
• Lu F. C. International activities in the field of food additives with particular reference to carcinogenicity. Ecotoxicol. Environ. Safety 1979; 3: 301
   PubMed Web of Science ®Google Scholar
• Richards R. K., Taylor J. D., O'Brien J. L., Duescher H. O. Studies on cyclamate sodium (sucaryl sodium), a new non-caloric sweetening agent. J. Am. Pharm. Assoc. Sci. Ed. 1951; 40: 1
   Google Scholar
• National Academy of Sciences – National Research Council Ad Hoc Committee on Non-Nutritive Sweeteners. Food Protection Committee, Non-nutritive sweeteners, an interim report to the U.S. Food and Drug Administration. Department of Health, Education, and Welfare. 1968
   Google Scholar
• Taylor J. D., Richards R. K., Wiegand R. G., Weinberg M. S. Toxicological studies with sodium cyclamate and saccharin. Food Cosmet. Toxicol. 1968; 6: 313
   PubMedGoogle Scholar
• Althoff J., Cardesa A., Pour P., Shubik P. A. A chronic study of artificial sweeteners in Syrian golden hamsters. Cancer Lett. 1975; 1: 21
   PubMed Web of Science ®Google Scholar
• Oser B. L., Carson S., Cox G. E., Vogin E. E., Sternberg S. S. Chronic toxicity study of cyclamate:saccharin (10:1) in rats. Toxicology 1975; 4: 315
   PubMed Web of Science ®Google Scholar
• Oser B. L. Chronic feeding studies with cyclamate:saccharin in rats. Food and Drug Research Laboratories. November, 1970, unpublished report
   Google Scholar
• Schoenig G., Fancher O. E. Acute intragastric toxicity study on sodium cyclamate-sodium saccharin (10:1) blend. Industrial Biotest Laboratories. April 17, 1968, unpublished report
   Google Scholar
• Miyata T., Kase Y., Kamikawa Y., Kataoka M., Kikuchi K., Touchi T. Pharmacological characteristics of cyclohexylamine, one of the metabolites of cyclamate. Life Sci. 1969; 8: 843
   PubMed Web of Science ®Google Scholar
• Lee I. P., Dixon R. L. Factors affecting cyclohexylamine lethality in mice. Toxicol. Appl. Pharmacol. 1969; 14: 654
   Web of Science ®Google Scholar
• Lee I. P., Dixon R. L. Various factors affecting the lethality of cyclohexylamine. Toxicol. Appl. Pharmacol. 1972; 22: 465
   PubMed Web of Science ®Google Scholar
• Pliss G. B. The carcinogenic activity of dicyclohexylamine and its nitrite salt. Prob. Oncol. 1958; 4: 22
   Google Scholar
• Smyth H. F., Jr., Carpenter C. P., Weil C. S., Pozzani U. C., Striegel J. A., Nycum J. S. Range finding toxicity data: list VII. J. Am. Ind. Hyg. Assoc. 1969; 30: 470
   PubMedGoogle Scholar
• Tanaka S., Nakaura S., Kawashima K., Nagao S., Kuwamura T., Omori Y. Studies on the teratogenicity of food additives. 2. Effects of cyclohexylamine and cyclohexylamine sulfate on the fetal development in rats. J. Food Hyg. Soc. 1973; 14: 542
   Google Scholar
• Mallette F. S., von Haam E. Studies on the toxicity and skin effects of compounds used in the rubber and plastic industries. A.M.A. Arch. Ind. Hyg. Occup. Med. 1952; 5: 311
   PubMedGoogle Scholar
• Lomonova G. V. Toxicity of cyclohexylamine and dicyclohexylamine. Fed. Proc. Trans. Suppl. 1965; 24: T96
   PubMedGoogle Scholar
• Bar F., Griepentrog F. Two-year feeding study of sodium cyclamate in rats. Deut. Apotheker 1973; 26: 66
   Google Scholar
• Brantom P. G., Gaunt I. F., Grasso P. Long-term toxicity of sodium cyclamate in mice. Food Cosmet. Toxicol. 1973; 11: 735
   PubMedGoogle Scholar
• Fancher O. E., Palazzolo R. J., Blockus L., Weinberg M. S., Calandra J. C. Chronic studies with sodium saccharin and sodium cyclamate in dogs. Toxicol. Appl. Pharmacol. 1968; 12: 291
   Web of Science ®Google Scholar
• Calandra J. C. Two-year reproduction study with sodium saccharin and sodium cyclamate in beagle dogs. Industrial Bio-Test Laboratories. 1968, unpublished report
   Google Scholar
• Coulston F., McChesney E. W., Golberg L. Long-term administration of artificial sweeteners to the rhesus monkey (M. mulatta). Food Cosmet. Toxicol. 1975; 13: 297
   PubMedGoogle Scholar
• Coulston F., McChesney E. W., Benitz K -F. Eight-year study of cyclamate in Rhesus monkeys. Toxicol. Appl. Pharmacol. 1977; 41: 164
   Web of Science ®Google Scholar
• Dalderup L. M., Visser W. Influence of extra sucrose, fats, protein and of cyclamate in the daily food on the life-span of rats. Experientia 1971; 15: 519
   Google Scholar
• Dalderup L. M., Keller G. H. M., Schouten F. J. M., Visser W. The effect of sodium cyclamate on growth, food efficiency and reproduction in the rat and the body composition of the offspring. Voeding 1971; 32: 144
   Google Scholar
• Ferrando M. R., Huchet B. Study of possible activity of sodium cyclamate on the rat in the course of three generations. Bull. Acad. Nat. Med. 1968; 153: 36
   Google Scholar
• Fitzhugh O. G., Nelson A. A., Frawley J. P. A comparison of the chronic toxicities of synthetic sweetening agents. J. Am. Pharm. Assoc. Sci. Ed. 1951; 40: 583
   Google Scholar
• Friedman L., Richardson H. L., Richardson M. E., Lethco E. J., Wallace W. C., Sauro F. M. Toxic response of rats to cyclamates in chow and semi-synthetic diets. J. Natl. Cancer Inst. 1972; 49: 751
   PubMed Web of Science ®Google Scholar
• Furuya T., Kawamata K., Kaneko T., Uchida O., Horiuchi S., Ikeda Y. Long-term toxicity study of sodium cyclamate and sodium saccharin in rats. Jpn. J. Pharmacol. 1975; 25(Suppl. 1)55P
   PubMedGoogle Scholar
• Ikeda Y., Horiuchi S., Furuya T., Kawamata K., Kaneko T., Uchida O. Long-term toxicity study of sodium cyclamate and saccharin sodium in rats. National Institute of Hygienic Sciences, TokyoJapan 1973, unpublished report
   Google Scholar
• Gottinger E., Hagmüller K., Hellauer H., Vinazzer H. The effect of cyclamate, a sweetening agent, on liver parenchyma, corresponding enzymes and blood clotting factors. Wein. Klin. Wschr. 1968; 80: 328
   PubMedGoogle Scholar
• Hagmüller K., Hellauer H., Winkler R., Zangger J. New histological findings and further experimental data on the question of cyclamate tolerance in the guinea pig. Wein. Klin. Wschr. 1969; 81: 927
   PubMedGoogle Scholar
• Homburger F. Studies on saccharin and cyclamate. Bio-Research Consultants, Inc. 1973, unpublished report
   Google Scholar
• Kroes R., Peters P. W. J., Berkvens J. M., Verschuuren H. G., deVries T., Van Esch G. J. Long-term toxicity and reproduction study (including a teratogenicity study) with cyclamate, saccharin and cyclohexylamine. Toxicology 1977; 8: 285
   PubMed Web of Science ®Google Scholar
• Lake N., Harrill I. Blood constituents and hepatic lipids in rats fed sucrose or starch with or without cyclamate. Metabolism 1972; 21: 533
   PubMed Web of Science ®Google Scholar
• Löser E. Subchronic toxicological study on cyclamate sodium in dogs. Arzneim-Forsch./ Drug Res. 1977; 27: 128
   PubMed Web of Science ®Google Scholar
• Löser E., Lorke D. Effect of cyclamate sodium on growing rats. Arzneim-Forsch./Drug Res. 1972; 22: 1174
   PubMedGoogle Scholar
• Nees P. O., Derse P. H. Feeding and reproduction of rats fed calcium cyclamate. Nature (London) 1965; 208: 81
   PubMed Web of Science ®Google Scholar
• Nees P. O., Derse P. H. Effect of feeding calcium cyclamate to rats. Nature (London) 1967; 213: 1191
   Web of Science ®Google Scholar
• Oser B. L., Carson S., Vogin E. E. Growth and reproduction studies with cyclamate – saccharin (10:1) in rats. Toxicol. Appl. Pharmacol. 1968; 12: 290
   Web of Science ®Google Scholar
• Roe F. J. C., Levy L. S., Carter R. L. Feeding studies on sodium cyclamate, saccharin, and sucrose for carcinogenic and tumor-promoting activity. Food Cosmet. Toxicol. 1970; 8: 135
   PubMedGoogle Scholar
• Schmähl D. Absence of carcinogenic activity of cyclamate, cyclohexylamine and saccharin in rats. Arzneim-Forsch./Drug Res. 1973; 23: 1466
   PubMed Web of Science ®Google Scholar
• Schmähl D., Habs M. Investigations on the carcinogenicity of the artificial sweeteners sodium cyclamate and sodium saccharin in rats in a two-generation experiment. Arzneim-Forsch./Drug Res. 1984; 34: 604
   PubMed Web of Science ®Google Scholar
• Sieber S. M., Adamson R. H. Long-term studies on the potential carcinogenicity of artificial sweeteners in non-human primates. Health and Sugar Substitutes, B. Guggenheim. S. Karger, Basel 1979; 266
   Google Scholar
• Taylor J. M. Sodium saccharin: combined chronic feeding and a three-generation reproduction study in rats. Food and Drug Administration. May 15, 1973, unpublished report
   Google Scholar
• Taylor J. M., Weinberger M. A., Friedman L. Chronic toxicity and carcinogenicity to the urinary bladder of sodium saccharin in the in utero exposed rat. Toxicol. Appl. Pharmacol. 1980; 54: 57
   PubMed Web of Science ®Google Scholar
• Weinberg M. S., Horrington E. M. Nutritional studies with calcium cyclamate in rats. Toxicol. Appl. Pharmacol. 1968; 12: 290
   Web of Science ®Google Scholar
• Stein A. A., Serrone D. M., Coulston F. Ultrastructural and biochemical studies of sodium cyclamate. Toxicol. Appl. Pharmacol. 1967; 10: 381
   Web of Science ®Google Scholar
• Richter W. R., Stein R. J., Rdzok E. J., Moize S. M. An investigation of the effects of massive doses of cyclamate Na on the ultrastructure of monkey liver. Proc. 25th meet. Electron Microsc. Soc. Am. 1967; 154
   Google Scholar
• Berryman G. H., Hazel G. R., Taylor J. D., Sanders P., Weinberg M. A case for safety of cyclamate and cyclamate-saccharin combinations. Am. J. Clin. Nutr. 1968; 21: 673
   PubMed Web of Science ®Google Scholar
• Radding R. S. Chronic use of cyclamate by human volunteers. Abbott Laboratories. 1967, unpublished report
   Google Scholar
• Zöllner N., Schnelle K. Clinical study of the toxicity of prolonged administration of cyclamate in patients with liver and kidney disease. Arzneim-Forsch./Drug Res. 1967; 17: 1568
   PubMedGoogle Scholar
• Zöllner N., Schnelle K. Further clinical investigations on the toxicity of long-term administration of cyclamate in patients with liver and kidney disease. Arzneim-Forsch./Drug Res. 1969; 19: 913
   PubMedGoogle Scholar
• Zöllner N., Pieper M. Concluding report of a 3-year clinical study on cyclamate. Arzneim-Forsch./ Drug Res. 1971; 21: 431
   PubMedGoogle Scholar
• Wills J. H., Jameson E., Stoewsand G., Coulston F. A three-month study of daily intake of sodium cyclamate by man. Toxicol. Appl. Pharmacol. 1968; 12: 292
   Web of Science ®Google Scholar
• Wills J. H., Serrone D. M., Coulston F. A 7-month study of ingestion of sodium cyclamate by human volunteers. Reg. Toxicol. Pharmacol. 1981; 1: 163
   Google Scholar
• Schoenberger J. A., Rix D. M., Sakamoto A., Taylor J. D., Kark R. M. Metabolic effects, toxicity, and excretion of calciumN-cyclohexylsulfamate (Sucaryl) in man. Am. J. Med. Sci. 1953; 225: 551
   PubMed Web of Science ®Google Scholar
• Beringer A. Is the use of sweeteners dangerous for diabetic patients?. Wein. Med. Wschr. 1973; 123: 41
   PubMedGoogle Scholar
• Arnold D. L., Moodie C. A., Grice H. C., Charbonneau S. M., Stavric B., Collins B. T., McGuire P. F., Zawidzka Z. Z., Munro I. C. Long-term toxicity of ortho-toluenesulfonamide and sodium saccharin in the rat. Toxicol. Appl. Pharmacol. 1980; 52: 113
   PubMed Web of Science ®Google Scholar
• Van der Hem G. K., Freeland J. P., Kallmeyer J. C., Kark R. N. Longitudinal studies of renal function in aged patients. Abbott Laboratories. 1967, unpublished report
   Google Scholar
• Hwang K. Mechanism of the laxative effect of sodium sulfate, sodium cyclamate and calcium cyclamate. Arch. Int. Pharmacodyn. Ther. 1966; 163: 302
   Google Scholar
• Pritchard A. B., Warner R. G. Some effects of diet on cyclamate toxicity. Fed. Proc. 1977; 36: 1117
   Google Scholar
• Ershoff B. H. Comparative effects of a purified diet and stock ration on sodium cyclamate toxicity in rats. Proc. Soc. Exp. Biol. Med. 1972; 141: 857
   PubMed Web of Science ®Google Scholar
• Ershoff B. H., Marshall W. E. Protective effects of dietary fiber in rats fed toxic doses of sodium cyclamate and polyoxyethylene sorbitan monostearate (Tween 60). J. Food Sci. 1975; 40: 357
   Web of Science ®Google Scholar
• Ershoff B. H. Protective effects of cholestyramine in rats fed a low-fiber containing toxic doses of sodium cyclamate or amaranth. Proc. Soc. Exp. Biol. Med. 1976; 152: 253
   PubMed Web of Science ®Google Scholar
• Ershoff B. H. Effects of dietary carbohydrate on sodium cyclamate toxicity in rats fed a purified, low-fiber diet. Proc. Soc. Exp. Biol. Med. 1977; 154: 65
   PubMed Web of Science ®Google Scholar
• Batterman R. C. Tolerance of cyclamate by patients with functional gastrointestinal disease. Abbott Laboratories. 1966, unpublished report
   Google Scholar
• Olson W. H. A tolerance study ofN-cyclohexylsulfamate on the gastrointestinal tract. Abbott Laboratories. 1955, unpublished report
   Google Scholar
• Calandra J. C., Berndt C. W. Sucaryl and water passage through the gastrointestinal tract. Abbott Laboratories. 1965, unpublished report
   Google Scholar
• Freese H., Jenike T. S., Ruben-Koenig H. Calcium cyclamate studies in children. Abbott Laboratories. 1955, unpublished report
   Google Scholar
• Bernier J. J., Bognel J. C., Bognel C. Effects of long-term administration of cyclamate calcium on the intestinal mucosa of rats. Bull. Acad. Nat. Med. 1968; 152: 7
   PubMedGoogle Scholar
• Bajusz E. Myocardial lesions a reassessment of the toxicology of calcium cyclamate. Nature (London) 1969; 223: 406
   PubMed Web of Science ®Google Scholar
• Bajusz E. Myocardial lesions induced by calcium cyclamate in Syrian hamsters. Toxicol. Appl. Pharmacol. 1970; 16: 282
   Google Scholar
• Nadkarni B. B., Heggtveit H. A. Cardiotoxic effects of calcium cyclamate in the hamster. Am. J. Pathol. 1971; 62: 88A
   Web of Science ®Google Scholar
• Weiss L. R., Orzel R. A., Krop S. Acute toxicity and electrocardiographic changes after calcium and sodium cyclamate in hamsters. Pharmacologist 1971; 13: 240
   Google Scholar
• Egli H. Physiological effects of cyclamates on blood coagulation. Wiss. Veröff. Deut. Ges. Ernährung 1971; 20: 119
   Google Scholar
• Holcenberg J. S., Bidgood M., Dixon R. L. Studies of the possible therapeutic interaction between cyclamate and warfarin. Curr. Ther. Res. 1969; 11: 577
   PubMed Web of Science ®Google Scholar
• Wills J. H. Protein bound iodine and sodium cyclamate. Am. J. Clin. Nurt. 1969; 12: 1548
   Google Scholar
• Usami M., Seino Y., Takai J., Nakahara H., Seino S., Ikeda M., Imura H. Effect of cyclamate sodium, saccharin sodium and stevioside on arginine-induced insulin and glucagon secretion in the isolated perfused rat pancreas. Horm. Metab. Res. 1980; 12: 705
   PubMed Web of Science ®Google Scholar
• Lockwood R. R., Dixon R. L. Effect of cyclamate on the hypoglycaemic response of tolbutamide and chlorpropamide in rats. Food Cosmet. Toxicol. 1969; 7: 565
   PubMedGoogle Scholar
• Berryman G. H., Blockus L. E., Sanders P. G. Observations on fasting blood glucose, blood pressure, and pulse rate in ambulatory subjects ingesting a single dose of two grams cyclamate. Abbott Laboratories. 1965
   Google Scholar
• Stern S., Sanders P., Weinberg M. Chronic administration of high levels of sodium cyclamate and sodium saccharin to diabetics. Diabetes 1968; 17(Suppl. 1)346
   Google Scholar
• Stern S. B. Cyclamate study in diabetic patients. Abbott Laboratories. 1967, unpublished report
   Google Scholar
• Pröls H., Wittmann P., Haslbeck M., Mehnert H. Study of the effects of high doses of sodium cyclamate on the blood sugar of diabetics. 1974, unpublished report
   Google Scholar
• Grossman M. I. Toxicity study of cyclohexylsulfamate. Abbott Laboratories. 1950, unpublished report
   Google Scholar
• Vavrikova J., Mareckova O. Cyclamates: new non-caloric sweeteners. Cesk. Gastroent. Viz. 1968; 22: 486
   PubMedGoogle Scholar
• Thompson G. R., Sanders P. G. Testicular effects produced by cyclamate and cyclohexylamine – a review. Fed. Proc. 1976; 35: 727
   Google Scholar
• Lamming G. E. Nutrition and the endocrine system. Nutr. Abstr. Rev. 1966; 36: 1
   Google Scholar
• Leathem J. H. Nutrition. The Testes, A. D. Johnson, W. R. Gomes, N. L. Vandemark. Academic Press, New York 1970; Vol. 3: 169
   Google Scholar
• James R. W., Heywood R. Age-related variations in the testes of Sprague-Dawley rats. Toxicol. Lett. 1979; 4: 257
   Web of Science ®Google Scholar
• Goodman D. G., Ward J. M., Squire R. A., Paxton M. B., Reichardt W. D., Chu K. C., Linhart M. S. Neoplastic and non-neoplastic lesions in aging Osborne-Mendel rats. Toxicol. Appl. Pharmacol. 1980; 55: 433
   PubMed Web of Science ®Google Scholar
• Russfield A. B. Pathology of the endocrine glands, ovary and testis of rats and mice. Pathology of Laboratory Rats and Mice, E. Cotchin, F. J. C. Roe. Blackwell Scientific, Oxford 1967; 467
   Google Scholar
• Sieber S., personal communication
   Google Scholar
• Plank J., Keplinger M. L., Fancher O. E. Two-year chronic oral toxicity of cyclohexylamine sulfate-albino rats. Industrial Bio-Test Laboratories. 1969, unpublished report
   Google Scholar
• Industrial Bio-Test Laboratories. Chronic oral toxicity study with cyclohexylamine sulfate in beagle dogs. April 21, 1981, unpublished report
   Google Scholar
• Collings A. J., Kirkby W. W. The toxicity of cyclohexylamine hydrochloride in the rat, 90-day feeding study. Unilever Research Laboratory. 1974, unpublished report
   Google Scholar
• Gaunt I. F., Sharratt M., Grasso P., Lansdown A. B. G., Gangolli S. D. Short-term toxicity of cyclohexylamine hydrochloride in the rat. Food Cosmet. Toxicol. 1974; 12: 609
   PubMedGoogle Scholar
• Gaunt I. F., Hardy J., Grasso P., Gangolli S. D., Butterworth K. R. Long-term toxicity of cyclohexylamine hydrochloride in the rat. Food Cosmet. Toxicol. 1976; 14: 255
   PubMedGoogle Scholar
• Oser B. L., Carson S., Cox G. E., Vogin E. E., Sternberg S. S. Long-term and multigeneration toxicity studies with cyclohexylamine hydrochloride. Toxicology 1976; 6: 47
   PubMed Web of Science ®Google Scholar
• Oser B. L., Carson S., Vogin E. E. Toxicological, reproductive, and mutagenic studies with cyclohexylamine in rats. Food and Drug Research Laboratories. May 31, 1972, unpublished report
   Google Scholar
• Hardy J., Gaunt I. F., Hooson J., Hendy R. J., Butterworth K. R. Long-term toxicity of cyclohexylamine hydrochloride in mice. Food Cosmet. Toxicol. 1976; 14: 269
   PubMedGoogle Scholar
• Barger G., Dale H. H. Chemical structure and sympathomimetic action of amines. J. Physiol. 1910; 41: 19
   PubMedGoogle Scholar
• Classen H. G., Marquardt P., Spath M. Sympathomimetic effects of cyclohexylamine. Arzneim-Forsch./Drug Res. 1968; 18: 590
   PubMedGoogle Scholar
• Classen H. G. The effect of cyclohexylamine on blood circulation and nictitating membrane of the cat after oral administration, extirpation of the adrenal glands, and pretreatment with cocaine and reserpine. Arzneim-Forsch./Drug Res. 1968; 18: 1191
   PubMedGoogle Scholar
• Classen H. G., Marquardt P. On the pharmacology of cyclohexylamine, a substance found in the urine of persons using cyclamates. N.-S. Arch. Pharmakol. Exp. Pathol. 1969; 263: 263
   PubMedGoogle Scholar
• Classen H. G., Marquardt P. Pharmacology of cyclohexylamine, a product found in the human urine after ingestion of cyclamate. Klin. Wschr. 1969; 47: 223
   PubMedGoogle Scholar
• Classen H. G., Marquardt P., Schoffel E., Schumacher K. A. Circulatory reactions and change of blood flow in cats following administration of cyclohexylamine. Arzneim-Forsch./Drug Res. 1971; 21: 489
   PubMedGoogle Scholar
• Classen H. G., Marquardt P. Origin, pharmacology and toxicology of cyclohexylamine, the raw material for the synthesis of cyclamate. Ernährungs-Umschau 1972; 19: 13
   Google Scholar
• Marquardt P., Classen H. G. Circulatory effects of cyclohexylamine and its effect on the action of catecholamines. Wiss. Veröff. Deut. Ges. Ernährung 1971; 20: 128
   Google Scholar
• Rosenblum I. Responses to cyclohexylamine in animals. Toxicol. Appl. Pharmacol. 1968; 12: 289
   Web of Science ®Google Scholar
• Rosenblum I., Rosenblum G. Cardiovascular responses to cyclohexylamine. Toxicol. Appl. Pharmacol. 1968; 12: 260
   PubMed Web of Science ®Google Scholar
• Yamamura H. I., Dixon R. L. The sympathomimetic action of cyclohexylamine, a metabolite of cyclamate. Toxicol. Appl. Pharmacol. 1968; 12: 289
   Web of Science ®Google Scholar
• Yamamura H. I., Lee I. P., Dixon R. L. Study of sympathomimetic action of cyclohexylamine, a possible metabolite of cyclamate. J. Pharm. Sci. 1968; 57: 1132
   PubMed Web of Science ®Google Scholar
• Wechsler A. S., Epstein S. E., Glick G. Cyclohexylamine, a newly recognized class of catecholamine-releasing agents. Fed. Proc. 1968; 27: 601
   Google Scholar
• Wechsler A. S., Epstein S. E., Glick G. Mechanism of the sympathomimetic action of cyclohexylamine and hexylamine, release of catecholamines from nerve endings. J. Pharmacol. Exp. Ther. 1969; 170: 62
   PubMed Web of Science ®Google Scholar
• Classen H. G. The influence of guanethidine and cyclazenin on the sympathomimetic effects of cyclohexylamine. Arzneim-Forsch./Drug Res. 1969; 19: 929
   PubMedGoogle Scholar
• Classen H. G., Spaczynski K. Effect of cyclohexylamine on isolated aorta strips of guinea pigs. Arzneim-Forsch./Drug Res. 1969; 19: 928
   PubMedGoogle Scholar
• Eichelbaum M., Hengstmann J., Dengler H. J. The inhibition by cyclohexylamine of the uptake and storage of norepinephrine in the rat heart. N.-S. Arch. Pharmakol. 1970; 267: 353
   PubMedGoogle Scholar
• Hengstmann J., Eichelbaum M., Dengler H. J. Pharmacokinetic properties and cardiovascular actions of cyclohexylamine in human beings. N.-S. Arch. Pharmakol. 1971; 270: R60
   Google Scholar
• Eichelbaum M., Hengstmann J. H., Rost H. D., Brecht T., Dengler H. J. Pharmacokinetics, cardiovascular and metabolic actions of cyclohexylamine in man. Arch. Toxikol. 1974; 31: 243
   PubMedGoogle Scholar
• Glick G. Failure of chronic cyclamate ingestion alone and in the presence of monoamine oxidase inhibition and SKF-525A to alter heart rate and arterial pressure in dogs. 1973, unpublished report
   Google Scholar
• Litchfield M. H., Swan A. A. B. Cyclohexylamine production and physiological measurements in subjects ingesting sodium cyclamate. Toxicol. Appl. Pharmacol. 1971; 18: 535
   PubMed Web of Science ®Google Scholar
• Collings A. J. Effect of dietary level and the role of intestinal flora on the conversion of cyclamate to cyclohexylamine. Unilever Research Laboratory. 1969, unpublished report
   Google Scholar
• Sonders R. C., Wiegand R. G. Preliminary report on the metabolism of cyclamate and cyclohexylamine. Abbott Laboratories. 1967, unpublished report
   Google Scholar
• Classen H. G., Gardell C., Kovacs K., Solymoss B., Varga S. Electrocardiographic and histologic changes in the adrenergic cardiopathy aggravated by cyclohexylamine. Arzneim-Forsch./Drug Res. 1970; 20: 27
   PubMedGoogle Scholar
• Classen H. G., Marquardt P., Solymoss B., Varga S. The influence of cyclohexylamine on experimental cardiac necrosis and blood flow. N.-S. Arch. Pharmakol. 1970; 266: 310
   PubMedGoogle Scholar
• Classen H. G., Solymoss B., Varga S. Aggravation of adrenergic cardiopathy by cyclohexylamine. Arzneim-Forsch./Drug Res. 1969; 19: 1805
   PubMedGoogle Scholar
• Classen H. G., Solymoss B., Varga S. Influence of cyclohexylamine on the adrenergic cardiopathy. Can. J. Physiol. Pharmacol. 1970; 48: 226
   PubMed Web of Science ®Google Scholar
• Rosenblum I., Rosenblum G. Autonomic stimulating and direct actions of cyclohexylamine in isolated tissues. Toxicol. Appl. Pharmacol. 1968; 13: 339
   PubMed Web of Science ®Google Scholar
• Kidman C. D., Mottram D. R., Hickman J. A. Potentiation of the response of rat vas deferens to noradrenaline by dicyclohexylamine and related amines. Arch. Int. Pharmacodyn. 1979; 238: 180
   PubMedGoogle Scholar
• Feldman J. M., Lebovitz H. E. The nature of the interaction of amines with the pancreatic beta cell to influence insulin secretion. J. Pharmacol. Exp. Ther. 1971; 179: 56
   PubMed Web of Science ®Google Scholar
• Polacek I., Breuer H. Hypoglycemic activity of amine derivatives. Arzneim-Forsch./Drug Res. 1978; 28(I)791
   PubMedGoogle Scholar
• Gondry E. Diabetogenic action of cyclohexylamine. Ann. Endocrinol. 1971; 32: 711
   PubMed Web of Science ®Google Scholar
• Gondry E. Research on the toxicity of cyclohexylamine, cyclohexanone and cyclohexanol, metabolites of cyclamate. Eur. J. Toxicol. 1972; 5: 227
   PubMedGoogle Scholar
• Mason P. L., Thompson G. R. Testicular effects of cyclohexylamine hydrochloride in the rat. Toxicology 1977; 8: 143
   PubMed Web of Science ®Google Scholar
• Brune H., Mohr U., Deutsch-Wenzel R. P. Establishment of the no-effect dosage of cyclohexylamine hydrochloride in male Sprague-Dawley rats with respect to growth and testicular atrophy. 1978, unpublished report
   Google Scholar
• Crampton R. F. British Industrial Biological Research Association, correspondence to H. Blumental. Food and Drug Administration. December 19, 1975
   Google Scholar
• Gray T. J. B., Beamand J. A. Effect of some phthalate esters and other testicular toxins on primary cultures of testicular cells. Food Chem. Toxicol. 1984; 22: 123
   PubMed Web of Science ®Google Scholar
• James R. W., Heywood R., Crook D. Testicular responses of rats and dogs to cyclohexylamine overdosage. Food Cosmet. Toxicol. 1981; 19: 291
   PubMedGoogle Scholar
• Tanaka R. LD50 of saccharin or cyclamate for mice embryos on the 7th day of pregnancy (fetal median lethal dose: FLD50). J. Iwate Med. Assoc. 1964; 16: 330
   Google Scholar
• Tanaka R. Toxicity of synthetic sweetening agents to the mouse embryo. Jpn. J. Pub. Health 1964; 11: 909
   Google Scholar
• Lorke D. On the toxicity of cyclamate for mouse embryos. Arzneim-Forsch./Drug Res. 1969; 19: 923
   PubMedGoogle Scholar
• Verrett M. J. Teratogenic effects of cyclamate and related compounds in the chicken embryo. Food and Drug Administration. 1969
   Google Scholar
• Ghiani P., Muratori R. A. Teratogenic effects of cyclamates in chick embryos. Ric. Sci. 1968; 38: 1260
   PubMedGoogle Scholar
• Wolf A., Jelinek J., Faltysova J. Teratogenicity of cyclamate. Ernährungsforschung 1971; 16: 537
   Google Scholar
• Lorke D. Studies of possible embryotoxic and teratogenic effects of cyclamate and saccharin in mice. Arzneim-Forsch./Drug Res. 1969; 19: 920
   PubMedGoogle Scholar
• Fritz H., Hess R. Prenatal development in the rat following administration of cyclamate, saccharin, and sucrose. Experientia 1968; 24: 1140
   PubMedGoogle Scholar
• Klotzsche C. On the question of teratogenic and embryotoxic effects of cyclamate, saccharin, and sucrose. Arzneim-Forsch./Drug Res. 1969; 19: 925
   PubMedGoogle Scholar
• Vogin E. E., Oser B. L. Effects of a cyclamate-saccharin mixture on reproduction and organogenesis in rats and rabbits. Fed. Proc. 1969; 28: 743
   Google Scholar
• Tuchmann-Duplessis H., Mercier-Parot L. Influence of sodium cyclamate on the fertility and pre-and post-natal development of the rat. Therapie 1970; 25: 915
   PubMedGoogle Scholar
• Kaziwara K., Mizutani M. Teratological studies of cyclamate and cyclohexylamine in mice and rats and preliminary cytogenetic study in mice of cyclohexylamine. Takeda Chemical Industries, Ltd. 1970, unpublished report
   Google Scholar
• Lederer J., Collin J. P., Pottier-Arnould A. M., Gondry E. Cytogenic and teratogenic effects of cyclamate and its metabolites. Therapeutique 1971; 47: 357
   PubMedGoogle Scholar
• Luckhaus G., Machemer L. Histological examination of perinatal eye development in the rat after ingestion of sodium cyclamate and sodium saccharin during pregnancy. Food Cosmet. Toxicol. 1978; 16: 7
   PubMedGoogle Scholar
• Derse P. Toxicology of the cyclamate. Wiss. Veröff. Deut. Ges. Ernährung 1971; 20: 110
   Google Scholar
• Wilson J. G. Abnormalities of intrauterine development in nonhuman primates. Acta Endocrinol. 1972; 71(Suppl. 166)261
   Google Scholar
• Flint O. P., Orton T. C., Ferguson R. A. Differentiation of rat embryo cells in culture: response following acute maternal exposure to teratogens and non-teratogens. J. Appl. Toxicol. 1984; 4: 109
   PubMed Web of Science ®Google Scholar
• Mauer R. E. Testing for teratogenic effects of compounds on tubal stage rabbit embryos. Abbott Laboratories. 1967, unpublished reports, 1968
   Google Scholar
• Zeman F. J. Effect of maternal calcium cyclamate intake on cellular development in the young rat. Am. J. Clin. Nutr. 1970; 23: 782
   PubMed Web of Science ®Google Scholar
• Lederer J., Pottier-Arnould A. M. Toxicity of cyclamate sodium and of saccharin for the offspring of pregnant mice. Le Diabete 1969; 17: 103
   PubMedGoogle Scholar
• Kennedy G. L., Sanders P. G., Weinberg M. S., Arnold D. W., Keplinger M. L. Reproduction studies in rats and rabbits with cyclohexylamine sulfate. Toxicol. Appl. Pharmacol. 1969; 14: 656
   Web of Science ®Google Scholar
• Khera K. S., Stoltz D. R., Gunner S. W., Lyon D. A., Grice H. C. Reproduction study in rats orally treated with cyclohexylamine sulfate. Toxicol. Appl. Pharmacol. 1971; 18: 263
   PubMed Web of Science ®Google Scholar
• Khera K. S., Stoltz D. R. Effects of cyclohexylamine on rat fertility. Experientia 1970; 26: 761
   PubMedGoogle Scholar
• Green S., Palmer K. A., Legator M. S. Effects of cyclohexylamine on the fertility of male rats. Food Cosmet. Toxicol. 1972; 10: 29
   Google Scholar
• Becker B. A., Gibson J. E. Teratogenicity of cyclohexylamine in mammals. Toxicol. Appl. Pharmacol. 1970; 17: 551
   PubMed Web of Science ®Google Scholar
• Takano K., Masaaki S. Cyclohexylamine, a chromosome aberration inducing substance: no teratogenicity in mice. Congenital Anomalies 1971; 11: 51, in Biol. Abst., 54, 24703
   Google Scholar
• Lorke D., Machemer L. The effect of cyclohexylamine on the embryo following oral administration to mice and rats. Toxicol. Lett. 1983; 17: 137
   PubMed Web of Science ®Google Scholar
• Kitchin K. T., Ebron M. T. Studies of saccharin and cyclohexylamine in a coupled microsomal activating/embryo culture system. Food Chem. Toxicol. 1983; 21: 537
   PubMed Web of Science ®Google Scholar
• Clayson D. B. Bladder carcinogenesis in rats and mice: possibility of artifacts. J. Natl. Cancer Inst. 1974; 52: 1685
   PubMed Web of Science ®Google Scholar
• Clayson D. B. Endpoints in bladder cancer. Health and Sugar Substitutes, B. Guggenheim. S. Kager, Basel 1979; 54
   Google Scholar
• Issenberg P., Clayson D. B. The significance of urolithiasis in bladder tumor formation in rodents with particular reference to sulfonamides. Implications for carcinogenicity testing of saccharin at high dietary levels. Rep. Temporary Comm. Rev. of Data on Carcinogenicity of Cyclamate. Department of Health, Education, and Welfare. 1976; 77–1437, DHEW Publication No. (NIH)
   Google Scholar
• Cheng L. Urinary tract calculi in man and laboratory animals: incidence, composition and etiology. J. Environ. Pathol. Toxicol. 1980; 4: 317
   PubMed Web of Science ®Google Scholar
• Chapman W. H. Infection with Trichosomoides crassicauda as a factor in the induction of bladder tumors in rats fed 2-acetylaminofluorene. Invest. Urol. 1969; 7: 154
   PubMedGoogle Scholar
• Bryan G. T., Ertürk E. Production of mouse urinary bladder carcinomas by sodium cyclamate. Science 1970; 167: 996
   PubMed Web of Science ®Google Scholar
• Cook C. E. A. Cyclamates: a review of the current position. Curr. Med. Res. Opin. 1975; 3: 218
   PubMedGoogle Scholar
• Coon J. M. Evaluation of cyclamate and saccharin. Int. Congr. Pharmacol. 1975; 6: 117
   Google Scholar
• Thompson G. R., Becker B. A., Levin S. Assessment of the carcinogenicity of non-nutritive sweeteners II: cyclamates and cyclohexylamine. Proc. West. Pharmacol. Soc. 1975; 18: 311
   PubMedGoogle Scholar
• Bungard G. Absence of carcinogenicity concerning saccharin and sodium saccharin, cyclamates, their possible metabolite, cyclohexylamine, as well as mixtures of 10 parts sodium cyclamate and one part sodium saccharin. Part II. Mixture of 10 parts sodium cyclamate and one part sodium saccharin. Deut. Apotheker 1974; 26: 20
   Google Scholar
• Bungard G. Absence of carcinogenicity concerning saccharin and sodium saccharin, cyclamates, their possible metabolite, cyclohexylamine, as well as mixtures of 10 parts sodium cyclamate and one part sodium saccharin. Part III. Cyclamates. Deut. Apotheker 1974; 26: 66
   Google Scholar
• Bungard G. Absence of carcinogenicity concerning saccharin and sodium saccharin, cyclamates, their possible metabolite, cyclohexylamine, as well as mixtures of 10 parts sodium cyclamate and one part sodium saccharin. Part IV. Cyclohexylamine. Deut. Apotheker 1974; 26: 117
   Google Scholar
• Schmähl D., Kruger F. W. Lack of syncarcinogenic action of cyclamate in the induction of bladder cancer by butyl-butanolnitrosamine in rats. Arzneim-Forsch./Drug Res. 1972; 22: 999
   PubMed Web of Science ®Google Scholar
• Schmähl D., Habs M. Absence of carcinogenic response to cyclamate and saccharin in Sprague-Dawley rats after transplacental application. Arzneim-Forsch./Drug Res. 1980; 30: 1905
   PubMed Web of Science ®Google Scholar
• Hicks R. M., Wakefield J. St. J., Chowaniec J. Evaluation of a new model to detect bladder carcinogens or co-carcinogens; results obtained with saccharin, cyclamate and cyclophosphamide. Chem.-Biol. Interactions 1975; 11: 225
   PubMed Web of Science ®Google Scholar
• Hicks R. M., Chowaniec J. The importance of synergy between weak carcinogens in the induction of bladder cancer in experimental animals and humans. Cancer Res. 1977; 37: 2943
   PubMed Web of Science ®Google Scholar
• Rudali G., Coezy E., Muranyi-Kovacs I. Investigations on the carcinogenic activity of sodium cyclamate in mice. C. R. Acad. Sci. Paris 1969; 269: 1910
   Google Scholar
• Havender W. R. The science and politics of cyclamate. Public Interest, Spring. 1983; 17
   Google Scholar
• Jull J. W. The induction of tumours of the bladder epithelium in mice by the direct application of a carcinogen. Br. J. Cancer 1951; 5: 328
   PubMed Web of Science ®Google Scholar
• Jull J. W. Carcinogenesis by chemicals implanted into the bladder: an evaluation. Gann Monograph on Cancer Res. 1975; 17: 383
   Google Scholar
• Jull J. W. The effect of time on the incidence of carcinomas obtained by the implantation of paraffin wax pellets into mouse bladder. Cancer Lett. 1979; 6: 21
   PubMed Web of Science ®Google Scholar
• Strömbeck J. P. Azotoluene bladder tumors in rats. J. Pathol. Bacteriol. 1946; 58: 275
   PubMedGoogle Scholar
• Dunning W. F., Curtis M. R., Segaloff A. Strain differences in response to diethylstilbestrol and the induction of mammary gland and bladder cancer in the rat. Cancer Res. 1947; 7: 511
   Web of Science ®Google Scholar
• Fitzhugh O. G., Nelson A. A. Comparison of the chronic toxicity of triethylene glycol with that of diethylene glycol. J. Ind. Hyg. Toxicol. 1946; 28: 40
   PubMedGoogle Scholar
• Weil C. S., Carpenter C. P., Smyth H. F., Jr. Urinary bladder response to diethylene glycol. Calculi and tumors following repeated feeding and implants. Arch. Environ. Health 1965; 11: 569
   PubMed Web of Science ®Google Scholar
• Weil C. S., Carpenter C. P., Smyth H. F., Jr. Urinary bladder calculus and tumor response following either repeated feeding of diethylene glycol or calcium oxalate stone implantation. Ind. Med. Surg. 1967; 36: 55
   PubMedGoogle Scholar
• Fitzhugh O. G., Bourke A. R., Nelson A. A., Frawley J. P. Chronic oral toxicities of four stearic acid emulsifiers. Toxicol. Appl. Pharmacol. 1959; 1: 315
   PubMed Web of Science ®Google Scholar
• Hueper W. C., Payne W. W. Polyoxyethylene-(8)-stearate. Arch. Environ. Health 1963; 6: 484
   PubMed Web of Science ®Google Scholar
• Clayson D. B., Pringle J. A., Bonser G. M. 4-Ethyl-sulphonylnaphthalene-1-sulfonamide: a new chemical for the study of bladder cancer in the mouse. Biochem. Pharmacol. 1967; 16: 619
   PubMed Web of Science ®Google Scholar
• Flaks A., Hamilton J. M., Clayson D. B. Effect of ammonium chloride on incidence of bladder tumors induced by 4-ethyl-sulfonylnaphthalene-1-sulfonamide. J. Natl. Cancer Inst. 1973; 51: 2007
   PubMed Web of Science ®Google Scholar
• Melnick R. L., Boorman G. A., Haseman J. K., Montali R. J., Huff J. Urolithiasis and bladder carcinogenicity of melamine in rodents. Toxicol. Appl. Pharmacol. 1984; 72: 292
   PubMed Web of Science ®Google Scholar
• Ministry of Agriculture, Fisheries and Food, Food Additives and Contaminants Committee. Report on the review of sweeteners in food. 1982, FAC/REP/34
   Google Scholar
• Muranyi-Kovacs I., Rudall G. Comparative study of carcinogenic activity of hydroxyurea and urethane in XVII/G mice. Eur. J. Clin. Biol. Res. 1972; 17: 93
   PubMedGoogle Scholar
• Muranyi-Kovacs I., Rudali G., Imbert J. Bioassay of 2,4,5-trichlorophenoxyacetic acid for carcinogenicity in mice. Br. J. Cancer 1976; 33: 626
   PubMed Web of Science ®Google Scholar
• Ershoff B. H., Bajwa G. S. Inhibitory effect of sodium cyclamate and sodium saccharin on tumor induction by 2-acetylaminoflurene in rats. Proc. Soc. Exp. Biol. Med. 1974; 145: 1293
   PubMed Web of Science ®Google Scholar
• Rudali G., Muranyi-Kovacs I., Coezy E., Aussepe L. The carcinogenicity of sodium cyclamate in combination with other oncogenic agents. Proc. Am. Assoc. Cancer Res. 1973; 14: 93
   Google Scholar
• Aeschbacher H. U., Bexter A., Würzner H. P., Luginbühl H. Effect of simultaneous administration of saccharin or cyclamate and a nitrosamide (MNU) on bladder epithelium and the dominant lethal test. Toxicol. Lett. 1979; 3: 273
   Web of Science ®Google Scholar
• Chowaniec J., Wakefield J. St. J., Hicks R. M. Syncarcinogenesis withN-methyl-N-nitrosourea (MNU) and cyclamate in rat urinary bladder. Br. J. Cancer 1974; 30: 180
   PubMed Web of Science ®Google Scholar
• Hicks R. M., Chowaniec J., Wakefield J. St. J. Experimental induction of bladder tumors by a two-stage system. Carcinogenesis, T. J. Slaga, A. Sivak, R. K. Boutwell. Raven Press, New York 1978; Vol. 2: 475
   Google Scholar
• Hicks R. M. Promotion in bladder cancer. Carcinogenesis, E. Hecker. Raven Press, New York 1982; Vol. 7: 139
   Google Scholar
• Hicks R. M. Multistage carcinogenesis in the urinary bladder. Br. Med. Bull. 1980; 36: 39
   PubMed Web of Science ®Google Scholar
• Green U., Rippel W. Bladder calculi in rats treated with nitrosomethylurea and fed artificial sweeteners. Exp. Pathol. 1979; 17: 561
   Google Scholar
• Mohr U., Green U., Althoff J., Schneider P. Syncarcinogenic action of saccharin and sodium cyclamate in the induction of bladder tumours in MNU-pretreated rats. Health and Sugar Substitutes, B. Guggenheim. S. Karger, Basel 1979; 64
   Google Scholar
• Green U., Schneider P., Deutsch-Wenzel R., Brune H., Althoff J. Syncarcinogenic action of saccharin or sodium cyclamate in the induction of bladder tumors in MNU pretreated rats. Food Cosmet. Toxicol. 1980; 18: 575
   PubMedGoogle Scholar
• Soudah B., Green U., Schneider P., Althoff J. Neoplastic lesions in the urinary tract of Wistar rats after treatment withN-methyl-N-nitrosourea (MNU) and artificial sweeteners. Exp. Pathol. 1981; 20: 197
   PubMedGoogle Scholar
• Severs N. J., Barnes S. H., Wright R., Hicks R. M. Induction of bladder cancer in rats by fractionated intravesicular doses ofN-methyl-N-nitrosourea. Br. J. Cancer 1982; 45: 337
   PubMed Web of Science ®Google Scholar
• Hooson J., Hicks R. M., Grasso P., Chowaniec J. Orthotoluene sulfonamide and saccharin in the promotion of bladder cancer in the rat. Br. J. Cancer 1980; 42: 129
   PubMed Web of Science ®Google Scholar
• Kadlubar F. F. NCTR studies on saccharin. Proc. European Toxicology Forum. The Toxicology Forum. October 18–22, 1983; 245, 1983
   Google Scholar
• Cohen S. M., Greenfield R. E., Ellwein L. B. Multistage carcinogenesis in the urinary bladder. Environ. Health Perspect. 1983; 49: 209
   PubMed Web of Science ®Google Scholar
• Ito N., Fukushima S., Shirai T., Nakanishi K. Effects of promoters onN-butyl-N-(4-hy-droxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat. Environ. Health Perspect. 1983; 50: 61
   PubMed Web of Science ®Google Scholar
• Fukushima H., Hirose M., Okuda M., Nakanowatari J., Hatano A., Ito N. Effect of partial cystectomy on the induction of preneoplastic lesions in rat bladder initiated withN-butyl-N-(4-hydroxybutyl)nitrosamine followed by bladder carcinogens and promoters. Urol. Res. 1982; 10: 115
   PubMedGoogle Scholar
• Ishii D. N. Inhibition of iodinated nerve growth factor binding by the suspected tumor promoters saccharin and cyclamate. J. Natl. Cancer Inst. 1982; 68: 299
   PubMedGoogle Scholar
• Ishii D. N. Effect of the suspected tumor promoters saccharin, cyclamate and phenol on nerve growth factor binding and response in cultured embryonic chick ganglia. Cancer Res. 1982; 42: 429
   PubMed Web of Science ®Google Scholar
• Lee L. S. Saccharin and cyclamate inhibit binding of epidermal growth factor. Proc. Natl. Acad. Sci., U.S.A. 1981; 78: 1042
   PubMed Web of Science ®Google Scholar
• Lee L. S. Inhibition of epidermal growth factor binding by phorbol esters, saccharin and cyclamate and its implications in the mechanism of tumor promotion. Carcinogenesis, E. Hecker. Raven Press, , NY 1982; Vol. 7: 471
   Google Scholar
• Lee L. S. Inhibition of MSA (multiplication stimulating activity) binding and insulin binding by saccharin and cyclamate. Proc. Am. Assoc. Cancer Res. 1981; 22: 131
   Google Scholar
• Shoyab M., Todaro G. Specific high affinity cell membrane receptors for biologically active phorbol and ingenol esters. Nature (London) 1980; 288: 451
   PubMed Web of Science ®Google Scholar
• Spinelli W., Ishii D. N. Tumor promoter receptors regulating neurite formation in cultured human neuroblastoma cells. Cancer Res. 1983; 43: 4119
   PubMed Web of Science ®Google Scholar
• Daya-Grosjean L., Sarasin A., Monier R. Effect of tumor promoters on soft-agar growth of Swiss3T3 cells infected with SV40 tsA mutants. Carcinogenesis 1982; 3: 833
   PubMed Web of Science ®Google Scholar
• Boyland E. Surface active agents as tumor promoters. Environ. Health Perspect. 1983; 50: 347
   PubMed Web of Science ®Google Scholar
• Boyland E., Mohiuddin J. Surface activity of some tumor promoters. I.R.C.S. Med. Sci. 1981; 9: 753
   Google Scholar
• Freedman H. J., Parker N. B., Marinello A. J., Gurtoo H. L., Minowada J. Induction, inhibition, and biological properties of aryl hydrocarbon hydroxylase in a stable human B-lymphocyte cell line, RPMI-1788. Cancer Res. 1979; 39: 4612
   PubMed Web of Science ®Google Scholar
• Grasso P., Gangolli S. D., Golberg L., Hooson J. Physicochemical and other factors determining local sarcoma production by food additives. Food Cosmet. Toxicol. 1971; 9: 463
   PubMedGoogle Scholar
• Hoover R. N., Strasser P. H. Artificial sweeteners and human bladder cancer. Lancet 1980; 1: 837
   PubMed Web of Science ®Google Scholar
• Kessler I. I., Clark J. P. Saccharin, cyclamate, and human bladder cancer: no evidence of an association. JAMA 1978; 240: 349
   PubMed Web of Science ®Google Scholar
• Morrison A. S., Buring J. E. Artificial sweeteners and cancer of the lower urinary tract. N. Engl. J. Med. 1980; 302: 537
   PubMed Web of Science ®Google Scholar
• Wynder E. L., Stellman S. D. Artificial sweetener use and bladder cancer: a case-control study. Science 1980; 207: 1214
   PubMed Web of Science ®Google Scholar
• Simon D., Yen S., Cole P. Coffee drinking and cancer of the lower urinary tract. J. Natl. Cancer Inst. 1975; 54: 587
   PubMedGoogle Scholar
• Barkin M., Comisarow R. H., Taranger L. A., Canada A. Three cases of human bladder cancer following high-dose cyclamate ingestion. J. Urol. 1977; 118: 258
   PubMed Web of Science ®Google Scholar
• Armstrong B., Doll R. Bladder cancer mortality in England and Wales in relation to cigarette smoking and saccharin consumption. Br. J. Prev. Soc. Med. 1974; 28: 233
   PubMedGoogle Scholar
• Burbank F., Fraumeni J. F., Jr. Synthetic sweetener consumption and bladder cancer trends in the U.S. Nature (London) 1970; 227: 296
   PubMed Web of Science ®Google Scholar
• Armstrong B., Doll R. Bladder cancer mortality in diabetics in relation to saccharin consumption and smoking habits. Br. J. Prev. Soc. Med. 1975; 29: 73
   PubMedGoogle Scholar
• Armstrong B., Lea A. J., Adelstein A. M., Donovan J. W., White G. C., Ruttle S. Cancer mortality and saccharin consumption in diabetics. Br. J. Prev. Soc. Med. 1976; 30: 151
   PubMedGoogle Scholar
• Kessler I. I. Cancer mortality among diabetics. J. Natl. Cancer Inst. 1970; 44: 673
   PubMedGoogle Scholar
• Kessler I. I. Cancer and diabetes mellitus a review of the literature. J. Chron. Dis. 1971; 23: 579
   PubMedGoogle Scholar
• Fagerberg S. E., Jonsson A. Diabetes mellitus-cyclamate-cancer of the urinary bladder. Nord. Med. 1971; 86: 1284
   Google Scholar
• Cartwright R. A., Adib R., Glashan R., Gray B. K. The epidemiology of bladder cancer in West Yorkshire: a preliminary report on non-occupational aetiologies. Carcinogenesis 1981; 2: 343
   PubMed Web of Science ®Google Scholar
• Connolly J. G., Rider W. D., Rosenbaum L., Chapman J. A. Relation between the use of artificial sweeteners and bladder cancer. Can. Med. Assoc. J. 1978; 119: 408
   PubMed Web of Science ®Google Scholar
• Hoover R., Hartge P. Non-nutritive sweeteners and bladder cancer. Am. J. Publ. Health 1982; 72: 382
   PubMed Web of Science ®Google Scholar
• Howe G. R., Burch J. D., Miller A. B., Morrison B., Gordon P., Weldon L., Chambers L. W., Fodor G., Winsor G. M. Artificial sweeteners and human bladder cancer. Lancet 1977; 2: 578
   PubMed Web of Science ®Google Scholar
• Howe G. R., Burch J. D., Miller A. B., Cook G. M., Esteve J., Morrison B., Gordon P., Chambers L. W., Fodor G., Winsor G. M. Tobacco use, occupation, coffee, various nutrients, and bladder cancer. J. Natl. Cancer Inst. 1980; 64: 701
   PubMedGoogle Scholar
• Kessler I. I. Non-nutritive sweeteners and human bladder cancer. Health and Sugar Substitutes, B. Guggenheim. S. Karger, Basel 1979; 85
   Google Scholar
• Kessler I. I. Non-nutritive sweeteners and human bladder cancer: preliminary findings. J. Urol. 1976; 115: 143
   PubMed Web of Science ®Google Scholar
• Miller A. B., Howe G. R. Artificial sweeteners and bladder cancer. Lancet 1977; 2: 1221
   PubMed Web of Science ®Google Scholar
• Miller C. T., Neutel C. I., Nair R. C., Marrett L. D., Last J. M., Collins W. E. Relative importance of risk factors in bladder carcinogenesis. J. Chron. Dis. 1978; 31: 51
   PubMedGoogle Scholar
• Morgan R. W., Jain M. G. Bladder cancer: smoking, beverages and artificial sweeteners. Can. Med. Assoc. J. 1974; 111: 1067
   PubMed Web of Science ®Google Scholar
• Morrison A. S. Use of artificial sweeteners by cancer patients. J. Natl. Cancer Inst. 1979; 62: 1397
   PubMedGoogle Scholar
• Morrison A. S., Verhoek W. G., Leck I., Aoki K., Ohno Y., Obata K. Artificial sweeteners and bladder cancer in Manchester, U.K., and Nagoya, Japan. Br. J. Cancer 1982; 45: 332
   PubMed Web of Science ®Google Scholar
• Silverman D. T., Hoover R. N., Swanson G. M. Artificial sweeteners and lower urinary tract cancer: hospital vs. population controls. Am. J. Epidemiol. 1983; 117: 326
   PubMed Web of Science ®Google Scholar
• Walker A. M., Dreyer N. A., Friedlander E., Loughlin J., Rothman K. J., Kohn H. I. An independent analysis of the National Cancer Institute study on non-nutritive sweeteners and bladder cancer. Am. J. Pub. Health 1982; 72: 376
   PubMed Web of Science ®Google Scholar
• Wynder E. L., Goldsmith R. The epidemiology of bladder cancer, a second look. Cancer 1977; 40: 1246
   PubMed Web of Science ®Google Scholar
• Howe G. R., Burch J. D. Artificial sweeteners in relation to the epidemiology of bladder cancer. Nutr. Cancer 1982; 2: 213
   Google Scholar
• Arnold D. L., Krewski D., Munro I. C. Saccharin: a toxicological and historical perspective. Toxicology 1983; 27: 179
   PubMed Web of Science ®Google Scholar
• Jensen O. M. (1983) Artificial sweeteners and bladder cancer: epidemiological evidence. Proc. European Toxicology Forum. October 18–22, 1983, 348, The Toxicology Forum
   Google Scholar
• Morgan R. W. (1983) Epidemiology. Proc. European Toxicology Forum. October 18–22, 1983, 352, The Toxicology Forum
   Google Scholar
• McCann J. Letter to S. Lehrer. Abbott Laboratories. 1976
   Google Scholar
• Anderson D., Styles J. A. Appendix II, The bacterial mutation test. Br. J. Cancer 1978; 37: 924
   PubMed Web of Science ®Google Scholar
• Herbold B. A., Lorke D. On the mutagenicity of artificial sweeteners and their main impurities examined in the Salmonella/microsome test. Mutat. Res. 1980; 74: 155
   Google Scholar
• Herbold B. A., Lorke D. On the mutagenicity of artificial sweeteners and their main impurities. Mutat. Res. 1980; 74: 209
   Google Scholar
• Herbold B. A. Studies to evaluate artificial sweeteners, especially Remsen-Fahlberg saccharin, and their possible impurities, for potential mutagenicity by the Salmonella/mammalian liver microsome test. Mutat. Res. 1981; 90: 365
   PubMedGoogle Scholar
• Bruce W. R., Heddle J. A. The mutagenic activity of 61 agents as determined by the micronucleus,Salmonella, and sperm abnormality assays. Can. J. Genet. Cytol. 1979; 21: 319
   PubMedGoogle Scholar
• Heddle J. A., Bruce W. R. Comparison of tests for mutagenicity or carcinogenicity using assays for sperm abnormalities, formation of micronuclei and mutations in Salmonella. Cold Spring Harbor Conf. Cell Proliferation 1977; 4C: 1549
   Google Scholar
• McGlinchey G., Coakley C., Gestautus-Tansey V., Gault J., Spillane W. In vivo and in vitro studies with sulfamate sweeteners. J. Pharm. Sci. 1982; 71: 661
   PubMed Web of Science ®Google Scholar
• Legator M. S. Mutagenic studies with cyclamate and cyclohexylamine. Food and Drug Administration. 1969, unpublished report
   Google Scholar
• Cattanach B. M. The mutagenicity of cyclamates and their metabolites. Mutat. Res. 1976; 39: 1
   PubMed Web of Science ®Google Scholar
• Buselmaier W., Rohrborn G., Propping P. Mutagenitats-Untersuchungen mit Pestiziden im Host-mediated assay und mit dem Dominanten Letaltest an der Maus. Biol. Zbl. 1972; 91: 311
   Google Scholar
• Fluck E. R., Poirier L. A., Ruelius H. W. Evaluation of a DNA polymerase-deficient mutant ofE. coli for the rapid detection of carcinogens. Chem.-Biol. Interactions 1976; 15: 219
   PubMed Web of Science ®Google Scholar
• Rosenkranz H. S., Leifer Z. Determining the DNA-modifying activity of chemicals using DNA-polymerase deficient. Escherichia coli, Chem. Muta: Prin. Methods Detect. 1980; 6: 109
   Google Scholar
• Mayer V. W., Gabridge M. G., Oswald E. J. Rapid plate test for evaluating phage induction capacity. Appl. Microbiol. 1969; 18: 697
   PubMedGoogle Scholar
• Chu E. H. Y., Bailiff E. G. Mutagenicity test of the metabolic derivatives of cyclamates in mammalian cell cultures. E.M.S. Newsletter 1970; 3: 39
   Google Scholar
• Vogel E., Chandler J. L. R. Mutagenicity testing of cyclamate and some pesticides in Drosophila melanogaster. Experientia 1974; 30: 621
   PubMedGoogle Scholar
• Stith R. B., Bannister N. L., Jemison E. W. Reaction ofDrosophila melanogaster to food substances containing sodium cyclamate, calcium cyclamate and sodium saccharin. Virginia J. Sci. 1970; 21: 116
   Google Scholar
• Majumdar S. K., Freedman C. Mutation test of calcium cyclamate in Drosophila melanogaster. Dros. Inform. Ser. 1971; 46: 114
   Google Scholar
• Rotter D., Mittler S. Failure of monosodium glutamate and calcium cyclamate to induce chromosomal aberrations in Drosophila. Mutat. Res. 1973; 21: 12
   Google Scholar
• Moon M. A., Gerdes R. A., Hupp E. W. Biological activity of saccharins and cyclamates in Drosophila melanogaster. Texas J. Sci. 1972; 23: 574
   Web of Science ®Google Scholar
• Wu C. K., Smith P. The effect of calcium cyclamate on the development ofDrosophila and its induced genetic damage in spermatocytes of Drosophila melanogaster. Genetics 1979; 91: S140
   Web of Science ®Google Scholar
• Sram R., Ondrel M. Mutagenic activity of some drugs and pesticides. Dros. Inform. Ser. 1968; 43: 164
   Google Scholar
• Felix R., de la Rosa M. E. Cytogenetic studies with sodium cyclamate inD. melanogaster females. Dros. Inform. Serv. 1971; 47: 102
   Google Scholar
• Chinnici J. P. The effects of some artificial sweeteners on crossing over and fecundity in Drosophila melanogaster. Sci. Biol. J. 1975; 1: 77
   Google Scholar
• Knaap A. G. A. C., Kramers P. G. N., Sobels F. H. Lack of mutagenicity of the cyclamate metabolites in Drosophila. Mutat. Res. 1973; 21: 341
   Google Scholar
• Browning L. S. Failure to detect mutagenicity by injection of cyclohexylamine andN′-hydroxycycloh-exylamine into Drosophila. E.M.S. Newsletter 1972; 6: 18
   Google Scholar
• Felix R., de la Rosa M. E. Cytogenetic studies with cyclohexylamine inD. melanogaster females. Dros. Inform. Serv. 1971; 47: 114
   Google Scholar
• Sax K., Sax H. J. Possible mutagenic hazards of some food additives, beverages and insecticides. Jpn. J. Genet. 1968; 43: 89
   Google Scholar
• Stone D., Lamson E., Chang Y. S., Pickering K. W. Cytogenetic effects of cyclamates on human cells in vitro. Science 1969; 164: 568
   PubMed Web of Science ®Google Scholar
• Stoltz D. R., Khera K. S., Bendall R., Gunner S. W. Cytogenetic studies with cyclamate and related compounds. Science 1970; 167: 1501
   PubMed Web of Science ®Google Scholar
• Collin J. P. Cytogenic effect of cyclamate, cyclohexanone, and cyclohexanol. Le Diabete 1971; 19: 215
   PubMedGoogle Scholar
• Ebenezer L. N., Sadasivan G. In vitro effect of cyclamates on human chromosomes. Quart. J. Surg. Sci. 1970; 6: 116
   Google Scholar
• Shamberger R. J., Baughman F. B., Kalchert S. L., Willis C. E., Hoffman G. C. Carcinogen-induced chromosomal breakage decreased by antioxidants. Proc. Natl. Acad. Sci. U.S.A. 1973; 70: 1461
   PubMed Web of Science ®Google Scholar
• Perez-Requejo J. L. In vitro effect of cyclamate sodium on human chromosomes. Sangre 1972; 17: 386
   PubMedGoogle Scholar
• Tokumitsu T. Cytogenetic effects of sodium cyclamate on human leucocytes in vitro. Proc. Jpn. Acad. 1971; 47: 635
   Google Scholar
• Rivers B. A., Jemison E. W. Morphological changes in human lymphocytes after calcium cyclamate exposure. Virginia J. Sci. 1977; 28: 66
   Google Scholar
• Jemison E. W., Brown K., Rivers B., Knight R. Cytogenetic effects of cyclamates. Adv. Exp. Med. Biol. 1984; 172: 91
   PubMed Web of Science ®Google Scholar
• Meisner L. F., Inhorn S. L. Chemically induced chromosome changes in human cells in vitro. Acta Cytol. 1972; 16: 41
   PubMed Web of Science ®Google Scholar
• Green S., Palmer K. A., Legator M. S. In vitro cytogenetic investigation of calcium cyclamate, cyclohexylamine and triflupromazine. Food Cosmet. Toxicol. 1970; 8: 617
   PubMedGoogle Scholar
• Kristofferson U. The effect of cyclamate and saccharin on the chromosomes of a Chinese hamster cell line. Heriditas 1972; 70: 271
   PubMed Web of Science ®Google Scholar
• Dixon C. H. In vitro effects of sodium and calcium cyclamates, cyclohexylamine and sucrose on growth rate and chromosomes of Chinese hamster fibroblasts. Diss. Abs. Int. 1973; 33: 5933B
   Google Scholar
• Schoeller L. Effects of cyclohexylamine on chromosomes. Wiss. Veröff. Deut. Ges. Ernährung 1971; 20: 125
   Google Scholar
• Brewen J. G., Pearson F. G., Jones K. P., Luippold H. F. Cytogenetic effects of cyclohexylamine andN-OH-cyclohexylamine on human leukocytes and Chinese hamster bone marrow. Nature (London) New Biol. 1971; 230: 15
   PubMedGoogle Scholar
• Carr J. V., Hybner J., Wragg J. B. Effect of calcium cyclamate and cyclohexylamine on the synthesis of pyrimidine nucleotides, DNA, and RNA in cultured human lung cells. J. Cell Biol. 1970; 47: 30a
   Web of Science ®Google Scholar
• Koizumi A., Tachibana Y., Dobashi Y., Tsuda K., Okino T., Katsunuma H. Cytokinetic study on toxic action of sodium cyclamate and cyclohexylamine. Ind. Health Jpn. 1971; 9: 188
   Google Scholar
• Majumdar S. K., Schlosser S. A. Morphological and histological studies of the effects of sodium cyclamate on Haworthia callus in vitro. Can. J. Bot. 1972; 50: 1013
   Google Scholar
• Holmlund L. G., Tarnvik A. Cytotoxic investigation of cyclohexylamine and decylamine – two corrosion inhibitors. Odontol. Revy 1963; 14: 335
   Google Scholar
• Wolf A., Hrivnak D., Malkus Z. Contribution to the safety of cyclamates. Nahrung 1971; 15: 363
   PubMedGoogle Scholar
• Sonders R. C. Metabolism of¹⁴C-sodium cyclamate in man. Abbott Laboratories. 1967, unpublished report
   Google Scholar
• Legator M. S., Palmer K. A., Green S., Peterson K. W. Cytogenetic studies in rats of cyclohexylamine, a metabolite of cyclamate. Science 1969; 165: 1139
   PubMed Web of Science ®Google Scholar
• Dick C. E., Schniepp M. L., Sonders R. C., Wiegand R. G. Cyclamate and cyclohexylamine: lack of effect on the chromosomes of man and rats in vivo. Mutat. Res. 1974; 26: 199
   PubMedGoogle Scholar
• Bailey D. E., Morgareidge K., Cox G. E., Vogin E. E., Oser B. L. Chronic toxicity, teratology and mutagenicity studies with cyclohexylamine in rats. Toxicol. Appl. Pharmacol. 1972; 22: 330
   Web of Science ®Google Scholar
• Brewen J. G. Host-mediated cytogenetic assay. Mutat. Res 1975; 31: 5
   PubMedGoogle Scholar
• Van Went-de Vries G. F., Freudenthal J., Hogendoom A. M., Kragten M. C. T., Gramberg L. G. In vivo chromosome-damaging effect of cyclohexylamine in the Chinese hamster. Food Cosmet. Toxicol. 1975; 13: 415
   PubMedGoogle Scholar
• Van Went-de Vries G. F., Kragten M. C. T., Van den Bosch R. A. Lack of effect of blood sampling-induced haematopoiesis on in vivo chromosome damage by cyclohexylamine in Chinese hamsters. Food Cosmet. Toxicol. 1975; 13: 419
   PubMedGoogle Scholar
• Mostardi R. A., Keller R., Koo R. Cytogenetic studies of cyclohexylamine, a metabolite of cyclamate. Ohio J. Sci. 1972; 72: 313
   Google Scholar
• Turner J. H., Hutchinson D. L. Cyclohexylamine mutagenicity: an in vivo evaluation utilizing fetal lambs. Mutat. Res. 1974; 26: 407
   PubMedGoogle Scholar
• Majumdar S. K., Solomon M. Chromosome changes in Mongolian gerbil following calcium cyclamate administration. Nucleus 1971; 14: 168
   Web of Science ®Google Scholar
• Majumdar S. K., Solomon M. Cytogenetic studies of calcium cyclamate inMeriones unguiculatus (gerbil) in vivo. Can. J. Genet. Cytol. 1971; 13: 189
   PubMedGoogle Scholar
• Lisker R., Cobo A. Noxious effects of various drugs and medicaments on the genetic material, 3. The case of sodium cyclamate. Gac. Med. Mex. 1971; 101: 298
   PubMedGoogle Scholar
• Bauchinger M., Schmid E., Pieper M., Zollner N. Cytogenetic effects of cyclamate on human peripheral lymphocytes in vivo. Deut. Med. Wschr. 1970; 95: 2220
   PubMed Web of Science ®Google Scholar
• Machemer L., Lorke D. Method for testing mutagenic effect of chemicals on spermatogonia of the Chinese hamster. Arzneim-Forsch./Drug Res. 1975; 25: 1889
   PubMed Web of Science ®Google Scholar
• Leonard A., Linden G. On the mutagenicity of cyclamates in mammals. C. R. Soc. Biol. 1972; 166: 468
   PubMedGoogle Scholar
• Leonard A. Heritable chromosome aberrations in mammals after exposure to chemicals. Rad. Environ. Biophys. 1976; 13: 1
   PubMed Web of Science ®Google Scholar
• Wyrobek A. J., Bruce W. R. Chemical induction of sperm abnormalities in mice. Proc. Natl. Acad. Sci., U.S.A. 1975; 72: 4425
   PubMed Web of Science ®Google Scholar
• Topham J. C. Do induced sperm-head abnormalities in mice specifically identify mammalian mutagens rather than carcinogens?. Mutal. Res. 1980; 74: 379
   PubMed Web of Science ®Google Scholar
• Yoshida S., Masubuchi M., Hiraga K. Induced chromosome aberrations by artificial sweeteners in CHO-K1 cells. Mutat. Res. 1978; 54: 262
   Google Scholar
• Food T. M., Schniepp M. L., Biava C. G. Supplementary study on positive control compounds in rat cytogenetics and mouse dominant lethal test. Abbott Laboratories. 1971, unpublished report
   Google Scholar
• Machemer L., Lorke D. Evaluation of the mutagenic potential of cyclohexylamine on spermatogonia of the Chinese hamster. Mutat. Res. 1976; 40: 243
   PubMedGoogle Scholar
• Cattanach B. M., Pollard C. E. Mutagenicity tests with cyclohexylamine in the mouse. Mutat. Res. 1971; 12: 472
   PubMedGoogle Scholar
• Lorke D. Investigations of cyclamate for mutagenic effects by use of the dominant lethal assay in mouse. Humangenetik 1973; 18: 165
   PubMedGoogle Scholar
• Lorke D., Machemer L. Influence of several weeks' treatment of male and female mice with saccharin, cyclamate or cyclohexylamine sulfate on fertility and dominant lethal effects. Humangenetik 1975; 26: 199
   PubMedGoogle Scholar
• Machemer L., Lorke D. Experiences with the dominant lethal test in female mice: effects of alkylating agents and artificial sweeteners on pre-ovulatory oocyte stages. Mutat. Res. 1975; 29: 209
   PubMedGoogle Scholar
• Epstein S. S., Arnold E., Andrea J., Bass W., Bishop Y. Detection of chemical mutagens by the dominant lethal assay in the mouse. Toxicol. Appl. Pharmacol. 1972; 23: 288
   PubMed Web of Science ®Google Scholar
• Peterson K. W., Brandchaft D., Turner M., Figge F. H. J. Dominant lethal study in mice using cyclohexylamine andN-hydroxycyclohexylamine. Anat. Rec. 1970; 166: 362
   Google Scholar
• Peterson K. W., Legator M. S., Figge F. H. J. Dominant-lethal effects of cyclohexylamine in C57B1/Fe mice. Mutat. Res. 1972; 14: 126
   PubMedGoogle Scholar
• Lorke D., Machemer L. Investigation of cyclohexylamine sulfate for dominant lethal effects in the mouse. Toxicology 1974; 2: 231
   PubMed Web of Science ®Google Scholar
• Styles J. A. Imperial Chemical Industries, Ltd. 1977, unpublished report
   Google Scholar
• Styles J. A. Appendix III., Mammalian cell transformation in vitro. Br. J. Cancer 1978; 37: 931
   PubMed Web of Science ®Google Scholar
• Purchase I. F. H., Longstaff E., Ashby J., Styles J. A., Anderson D., Lefevre P. A., Westwood F. R. An evaluation of 6 short-term tests for detecting organic chemical carcinogens. Br. J. Cancer 1978; 37: 873
   PubMed Web of Science ®Google Scholar
• Longstaff E. The sebaceous gland test. Br. J. Cancer 1978; 37: 944
   PubMed Web of Science ®Google Scholar
• Lefevre P. A. The degranulation test. Br. J. Cancer 1978; 37: 937
   PubMed Web of Science ®Google Scholar
• Westwood F. R. The tetrazolium-reduction test. Br. J. Cancer 1978; 37: 949
   PubMed Web of Science ®Google Scholar
• Longstaff E. The implant test. Br. J. Cancer 1978; 37: 954
   PubMed Web of Science ®Google Scholar
• Wolff S. Sister chromatid exchanges as a test for mutagenic carcinogens. Ann. N.Y. Acad. Sci. 1983; 407: 142
   PubMed Web of Science ®Google Scholar
• Renner H. W. Possible mutagenic activity of saccharin. Experientia 1979; 35: 1364
   PubMedGoogle Scholar
• Fahrig R. Effects in the mammalian spot test: cyclamate versus saccharin. Mutat. Res. 1982; 103: 43
   PubMedGoogle Scholar
• Jenssen D., Ramel C. The micronucleus test as part of a short-term mutagenicity test program for the prediction of carcinogenicity evaluated by 143 agents tested. Mutat. Res. 1980; 75: 191
   PubMed Web of Science ®Google Scholar
• Cooper P. Resolving the cyclamate question. Food Cosmet. Toxicol. 1977; 15: 69
   Google Scholar
• Kennedy B., O'Quinn S., Perrett W. J., Tilley J. C., Henington V. M. Phototoxic and photoallergic skin reactions resulting from modern drug therapy. J. La. State Med. Soc. 1961; 113: 365
   PubMedGoogle Scholar
• Boros E. An experience with artificial sweeteners. JAMA 1965; 194: 571
   PubMed Web of Science ®Google Scholar
• Kobori T., Araki H. Photoallergy in dermatology. J. Asthma Res. 1966; 3: 213
   PubMedGoogle Scholar
• Lamberg S. I. A new photosensitizer, the artificial sweetener cyclamate. JAMA 1967; 201: 747
   PubMed Web of Science ®Google Scholar
• Feingold B. F. Recognition of food additives as a cause of symptoms of allergy. Ann. Allergy 1968; 26: 309
   PubMedGoogle Scholar
• Fujita M., Aoki T. Urticaria induced by cyclamate. Arch. Dermatol. 1981; 117: 246
   PubMedGoogle Scholar
• Yong J. M., Sanderson K. V. Photosensitive dermatitis and renal tubular acidosis after ingestion of calcium cyclamate. Lancet 1969; 2: 1273
   PubMed Web of Science ®Google Scholar
• Mavligit G. Calcium cyclamate and renal tubular acidosis. Lancet 1970; 1: 144
   PubMed Web of Science ®Google Scholar
• Hillman D. A., Fraser F. C. Artificial sweeteners and fetal malformations: a rumored relationship. Pediatrics 1969; 44: 299
   PubMed Web of Science ®Google Scholar
• Stone D., Matalka E., Pulaski B. Do artificial sweeteners ingested in pregnancy affect the offspring. Nature (London) 1971; 231: 53
   PubMed Web of Science ®Google Scholar
• Sonders R. C. Metabolism of cyclamate, in Report of the Temporary Committee for the Review of Data on Carcinogenicity of Cyclamate. Department of Health, Education, and Welfare. 1976; 77–1437, DHEW Publication No. (NIH)
   Google Scholar
• Renwick A. G. The metabolism, distribution and elimination of non-nutritive sweeteners. Health and Sugar Substitutes, B. Guggenheim. S. Karger, Basel 1979; 41
   Google Scholar
• Renwick A. G. The fate of non-nutritive sweeteners in the body. Developments in Sweeteners, T. H. Greenby, K. J. Parker, M. G. Lindley. Applied Science, London 1983; Vol. 2: 179
   Google Scholar
• Renwick A. G., Williams R. T. The fate of cyclamate in man and other species. Biochem. J. 1972; 129: 869
   PubMed Web of Science ®Google Scholar
• Smith R. L. The role of the gut flora in the conversion of inactive compounds to active metabolites. Symposium on Mechanisms of Toxicity, W. Aldridge. St. Martins Press, New York 1971; 229
   Google Scholar
• Taylor J. D., Richards R. K., Davin J. C. Excretion and distribution of radioactive35S-cyclamate sodium (sucaryl sodium) in animals. Proc. Soc. Exp. Biol. Med. 1951; 78: 530
   PubMed Web of Science ®Google Scholar
• Wallace W. C., Letheo E. J., Brouwer E. A. The metabolism of cyclamates in rats. J. Pharmacol. Exp. Ther. 1970; 175: 325
   PubMed Web of Science ®Google Scholar
• Williams R. T. The metabolism of certain drugs and food chemicals in man. Ann. N.Y. Acad. Sci. 1971; 179: 141
   PubMed Web of Science ®Google Scholar
• Miller J. P., Crawford L. E. M., Sonders R. C., Cardinal E. V. Distribution and excretion of14C-cyclamate sodium in animals. Biochem. Biophys. Res. Commun. 1966; 25: 153
   PubMed Web of Science ®Google Scholar
• Parekh C., Goldberg E. K., Goldberg L. Fate of sodium cyclamate-C in the Rhesus monkey. Toxicol. Appl. Pharmacol. 1970; 17: 282
   Web of Science ®Google Scholar
• Kojima S., Ichibagase H., Iguchi S. Studies on synthetic sweetening agents. VI. Absorption and excretion of sodium cyclamate (1). Chem. Pharm. Bull. 1966; 14: 959
   PubMedGoogle Scholar
• Sonders R. C. Children cyclamate and cyclohexylamine excretion study. Abbott Laboratories. 1968, unpublished report
   Google Scholar
• Sonders R. C., Netwal J. C., Wiegand R. G. Site of conversion of cyclamate to cyclohexylamine. Pharmacologist 1969; 11: 241, and unpublished report, Abbott Laboratories, 1969
   Google Scholar
• Sonders R. C., Wiegand R. G. Absorption and excretion of cyclamate in animals and man. Toxicol. Appl. Pharmacol. 1968; 12: 291, and unpublished report, Abbott Laboratories, 1968
   Web of Science ®Google Scholar
• Sonders R. C., Wiegand R. G., Netwal J. C. Blood levels and excretion of sodium cyclamate in man. Abbott Laboratories. 1967, unpublished report
   Google Scholar
• Postorino M. J., Estep C. B. Distribution of sodium cyclamate at equilibrium in the rat. Abbott Laboratories. 1967, unpublished report
   Google Scholar
• Kojima S., Ichibagase H. Studies on synthetic sweetening agents. XII. The binding of sodium cyclamate with bovine serum albumin. Chem. Pharm. Bull. 1968; 16: 1619
   PubMed Web of Science ®Google Scholar
• Pitkin R. M., Reynolds W. A., Filer L. J. Cyclamate and cyclohexylamine: transfer across the hemochorial placenta. Proc. Soc. Exp. Biol. Med. 1969; 132: 993
   PubMed Web of Science ®Google Scholar
• Pitkin R. M., Reynolds W. A., Filer L. J. Placental transmission and fetal distribution of cyclamate in early human pregnancy. Am. J. Obst. Gynecol. 1970; 108: 1043
   PubMed Web of Science ®Google Scholar
• Pitkin R. M. Some comparative aspects of fetoplacental physiology in human and rhesus monkey, with special reference to cyclamate. Symposium on Physiological Biochemistry of the Fetus, A. Hodari. Charles C Thomas, Springfield, Ill 1972; Vol. 14: 188
   Google Scholar
• Schechter P. J., Roth L. J. Whole-body autoradiography of14C-sodium cyclamate in pregnant and fetal rats. Toxicol. Appl. Pharmacol. 1971; 20: 130
   PubMed Web of Science ®Google Scholar
• Hood S. L., Somani S. M., Zink V. R., Bogner R. L. Radiotracer studies of cyclamate-¹⁴C in experimental animals. Abbott Laboratories. 1966, unpublished report
   Google Scholar
• Ward V. L., Zeman F. J. Distribution of14C-cyclamate in the lactating rat. J. Nutr. 1971; 101: 1635
   PubMed Web of Science ®Google Scholar
• Wiegand R. G. ¹⁴C-Cyclamate distribution in milk of lactating dogs. Abbott Laboratories. 1967, unpublished report
   Google Scholar
• Klaverkamp J. F., Dixon R. L. Studies of the renal secretion of PAH and cyclamate in rats. Proc. West Pharmacol., Soc. 1969; 12: 75
   PubMedGoogle Scholar
• Oser B. L., Carson S., Vogin E. E., Sonders R. C. Conversion of cyclamate to cyclohexylamine in rats. Nature (London) 1968; 220: 178
   PubMed Web of Science ®Google Scholar
• Bickel M. H. Conditions of cyclohexylamine formation in rats chronically ingesting cyclamate. Experientia 1972; 28: 741
   Google Scholar
• Bickel M. H. Metabolism and disposition of Na-cyclamate in the rat as a function of duration of exposure. Int. Cong. Pharmacol. 1972; 5: 22
   Google Scholar
• Bickel M. H., Burkard B., Meier-Strasser E., Van den Broek-Boot M. Entero-bacterial formation of cyclohexylamine in rats ingesting cyclamate. Xenobiotica 1974; 4: 425
   PubMed Web of Science ®Google Scholar
• Collings A. J. The metabolism of sodium cyclamate. Sweetness and Sweeteners, G. G. Birch, L. F. Green, C. B. Coulson. Applied Science Publishers, London 1971; 51
   Google Scholar
• Dalderup L. M., Keller G. H. M., Schouten F. Cyclamate and cyclohexylamine. Lancet 1970; 1: 845
   PubMed Web of Science ®Google Scholar
• Ichibagase H., Kojima S., Suenaga A., Inoue K. Studies on synthetic sweetening agents. XVI. Metabolism of sodium cyclamate. 5. The metabolism of sodium cyclamate in rabbits and rats after prolonged administration of sodium cyclamate. Chem. Pharm. Bull. 1972; 20: 1093
   PubMed Web of Science ®Google Scholar
• Kojima S., Ichibagase H. Studies on synthetic sweetening agents. XIII. Metabolism of sodium cyclamate. 2. Detection of metabolites of sodium cyclamate in rabbit and rat by gas-liquid chromatography. Chem. Pharm. Bull. 1968; 16: 1851
   PubMed Web of Science ®Google Scholar
• Prosky L., O'Dell R. G. In vivo conversion of14C-labeled cyclamate to cyclohexylamine. J. Pharm. Sci. 1971; 60: 1341
   PubMed Web of Science ®Google Scholar
• Renwick A. G. Microbial metabolism of drugs. Drug Metabolism, From Microbe to Man, D. V. Parke, R. L. Smith. Taylor and Francis, London 1976; 169
   Google Scholar
• Asahina M. Participation of bacteria in the metabolism of sodium cyclamate in guinea pigs. J. Food Hyg. Soc. Jpn. 1972; 13: 133
   Google Scholar
• Asahina M., Yamaha T., Sarrazin G., Watanabe K. Conversion of cyclamate to cyclohexylamine in guinea pig. Chem. Pharm. Bull. 1972; 20: 102
   PubMed Web of Science ®Google Scholar
• Suenaga A., Kojima S., Ichibagase H. Studies on synthetic sweetening agents. XVII. Metabolism of sodium cyclamate. 6. Influences of neomycin and sulfaguanidine on metabolism of sodium cyclamate. Chem. Pharm. Bull. 1972; 20: 1357
   PubMed Web of Science ®Google Scholar
• Golberg L., Parekh C., Patti A., Soike K. Cyclamate degradation in mammals and in vitro. Toxicol. Appl. Pharmacol. 1969; 14: 654
   Web of Science ®Google Scholar
• Hayashi N., Iwahara S., Tanimura A., Furuya T., Kawamata K., Kaneko T. Studies on metabolism of sodium cyclohexylsulfamate. 1. On urinary excretion of cyclohexylamine in monkey and effect of administration of feces of cyclohexylamine excreting monkey and commercial diet to rabbit, guinea pig and rat. Natl. Inst. Hyg. Sci. Bull. 1973; 91: 11
   Google Scholar
• Asahina M., Yamaha T., Watanabe K., Sarrazin G. Excretion of cyclohexylamine, a metabolite of cyclamate in human urine. Chem. Pharm. Bull. 1971; 19: 628
   PubMed Web of Science ®Google Scholar
• Blumberg A. G., Heaton A. M. The occurrence of cyclohexylamine in urines studied for drug use by thin-layer chromatography. J. Chromatog. 1970; 48: 565
   PubMedGoogle Scholar
• Davis T. R. A., Adler N., Opsahl J. C. Excretion of cyclohexylamine in subjects ingesting sodium cyclamate. Toxicol. Appl. Pharmacol. 1969; 15: 106
   PubMed Web of Science ®Google Scholar
• Glogner P. The metabolism of tolbutamide and cyclamate. Humangenetik 1970; 9: 230
   PubMedGoogle Scholar
• Kojima S., Ichibagase H. Studies on synthetic sweetening agents. XIV. Metabolism of sodium cyclamate. 3. On metabolites of sodium cyclamate in human. Chem. Pharm. Bull. 1969; 17: 2620
   PubMed Web of Science ®Google Scholar
• Leahy J. S., Taylor T., Rudd C. J. Cyclohexylamine excretors among human volunteers given cyclamate. Inform. Bull. B.I.B.R.A. 1967; 6: 333
   Google Scholar
• Food Cosmet. Toxicol. 1967; 5: 595
   PubMedGoogle Scholar
• Leahy J. S., Wakefield M., Taylor T. Urinary excretion of cyclohexylamine following oral administration of sodium cyclamate to man. Inform. Bull. B.I.B.R.A. 1966; 5: 669
   Google Scholar
• Food Cosmet. Toxicol. 1967; 5: 447
   Google Scholar
• Pawan G. L. S. Dietary cyclamate and cyclohexylamine excretion in man. Proc. Nutr. Soc. 1970; 20: 10A
   Google Scholar
• Renwick A. G., Williams R. T. Gut bacteria and the metabolism of cyclamate in the rat. Biochem. J. 1969; 114: 78P
   Web of Science ®Google Scholar
• Drasar B. S., Renwick A. G., Williams R. T. The conversion of cyclamate into cyclohexylamine by gut bacteria. Biochem. J. 1971; 123: 26P
   Web of Science ®Google Scholar
• Drasar B. S., Renwick A. G., Williams R. T. The role of the gut flora in the metabolism of cyclamate. Biochem. J. 1972; 129: 881
   PubMed Web of Science ®Google Scholar
• Asahina M., Niimura T., Yamaha T., Takahashi T. Formation of cyclohexylamine and cyclohexanone from cyclamate by microorganisms isolated from the feces of the guinea pig. Agric. Biol. Chem. 1972; 36: 711
   Web of Science ®Google Scholar
• Matsui M., Hayashi N., Konuma H., Tanimura A., Kurata H. Studies on the metabolism of food additives by microorganisms inhabiting the gastrointestinal tract. V. Detection of cyclohexylamine-forming bacteria from the intestinal tract of rabbit and guinea pig after oral administration of sodium cyclamate. J. Food Hyg. Soc. Jpn. 1980; 21: 129
   Google Scholar
• Matsui M., Tanimura A., Kurata H. Identification of cyclamate-converting bacteria. Studies on the metabolism of food additives by microorganisms inhabiting the gastrointestinal tract, VI. J. Food Hyg. Soc. Jpn. 1981; 22: 215
   Google Scholar
• Niimura T., Tokieda T., Yamaha T. Partial purification and some properties of cyclamate sulfatamase. J. Biochem. 1974; 75: 407
   PubMed Web of Science ®Google Scholar
• Tsuchiya (nee Tokieda) T. Studies on the metabolism of sodium cyclamate by intestinal bacteria. Mem. Tokyo U. Agric. 1981; 23: 1
   Google Scholar
• Tokieda T., Niimura T., Yamaha T., Hasegawa T., Suzuki T. Anaerobic deamination of cyclohexylamine by intestinal microorganisms in rabbits. Agric. Biol. Chem. 1979; 43: 25
   Web of Science ®Google Scholar
• Matsui M., Hayashi N., Konuma H., Tanimura A., Kurata H. Studies on metabolism of food additives by microorganisms inhabiting the gastrointestinal tract. IV. Fate of fecal flora in monkey administered orally sodium cyclamate and detection of sodium cyclamate assimilating bacteria in vitro by anaerobic culture. J. Food Hyg. Soc. Jpn. 1976; 17: 54
   Google Scholar
• Matsui M., Hayashi N., Tanimura A., Kurata H. Studies on metabolism of food additives by microorganisms inhabiting the gastrointestinal tract. III. Suitable medium for the production of cyclohexylamine from sodium cyclamate by sodium cyclamate assimilating bacteria under anaerobic culture condition. J. Food Hyg. Soc. Jpn. 1976; 17: 48
   Google Scholar
• Roxon J. J., Tesoriero A. A. Effect of cysteine on cyclamate metabolism by rat intestinal microorganisms. Austr. J. Pharm. Sci. 1974; NS3: 26
   Google Scholar
• Tesoriero A. A., Roxon J. J. [35S]Cyclamate metabolism: incorporation of35S into proteins of intestinal bacteria in vitro and production of volatile35S-containing compounds. Xenobiotica 1975; 5: 25
   PubMed Web of Science ®Google Scholar
• Spillane W. J., Benson G. A., McGlinchey G. Metabolic studies with non-nutritive sweeteners cyclooctylsulfamate and 4-methylcyclohexylsulfamate. J. Pharm. Sci. 1979; 68: 372
   PubMed Web of Science ®Google Scholar
• Spillane W. J., Benson G. A. Metabolic studies of the non-nutritive sweeteners cyclopentyl-methylsulfamate and cyclopentylsulfamate: determination of metabolites in rat urine. J. Pharm. Sci. 1978; 67: 226
   PubMedGoogle Scholar
• Benson G. A., Spillane W. J. Determination of the nonnutritive sweetener sodium cyclopentylsulfamate and three of its metabolites, cyclopentylamine, cyclopentanone, and cyclopentanol, in urine of rats and rabbits. J. Pharm. Sci. 1976; 65: 1841
   PubMed Web of Science ®Google Scholar
• Benson G. A., Spillane W. J. Metabolic studies with the non-nutritive sweetener cycloheptylsulfamate. J. Pharm. Sci. 1977; 66: 881
   PubMed Web of Science ®Google Scholar
• Matsui M., Tanimura A., Kurata H., Ozaki A., Benno Y., Mitsuoka T. Studies on the metabolism of food additives by microorganisms inhabiting the gastrointestinal tract. VII. Formation of cyclohexylamine from sodium cyclamate in germ free and conventional mice administered with cyclamate converting bacteria. J. Food Hyg. Soc. Jpn. 1982; 23: 270
   Google Scholar
• Hengstmann J. H., Dengler H. J., Geipert F. The conversion of cyclamate to cyclohexylamine in 255 diabetic and obese patients. N.-S. Arch. Pharmakol. 1974; 282(Suppl.)R31
   Google Scholar
• Hill M. J., Crowther J. S., Drasar B. S., Hawksworth G., Aries V., Williams R. E. O. Bacteria and aetiology of cancer of large bowel. Lancet 1971; 1: 95
   PubMed Web of Science ®Google Scholar
• Renwick A. G. (1983) The fate of cyclamate in man and rat. Proc. European Toxicology Forum. October 18–23, 1983, 301, The Toxicology Forum
   Google Scholar
• Renwick A. G., Williams R. T. The metabolites of cyclohexylamine in man and certain animals. Biochem. J. 1972; 129: 857
   PubMed Web of Science ®Google Scholar
• Suenaga A., Wada T., Ichibagase H. Studies on synthetic sweetening agents. XVIII. Metabolism of sodium cyclamate. 7. Dicyclohexylamine, a metabolite of sodium cyclamate in rabbit and rat. Chem. Pharm. Bull. 1983; 31: 2079
   PubMed Web of Science ®Google Scholar
• Sonders R. C. Further investigations into the metabolism of CHA in the dog. Abbott Laboratories. 1969, unpublished report
   Google Scholar
• Sonders R. C., Estep C. B., Wiegand R. G. Metabolism of cyclohexylamine. Fed. Proc. 1968; 27: 238, and unpublished report, Abbott Laboratories, 1967
   Google Scholar
• Estep C. B., Wiegand R. G. Final report on the distribution of cyclohexylamine at equilibrium in the rat. Abbott Laboratories. 1967, unpublished report
   Google Scholar
• Elliott T. H., Lee-Yoong N. Y., Tao R. C. C. The metabolism of cyclohexylamine in rabbits. Biochem. J. 1968; 109: 11P
   Web of Science ®Google Scholar
• Tokieda T., Niimura T., Takamura F., Yamaha T. Purification and some properties of cyclohexylamine oxidase from a Pseudomonas sp. J. Biochem. 1977; 81: 851
   PubMed Web of Science ®Google Scholar
• Sarkar S., Banerjee R., Ise M. S., Zeller E. A. Uber die Wirkung von 2-Phenylcyclopropylaminen auf die Monoamin-oxydase und andere Enzymsysteme. Helv. Chim. Acta 1960; 43: 439
   Web of Science ®Google Scholar
• Kurebayashi H., Tanaka A., Yamaha T. Oxidative deamination of cyclohexylamine and its homologs by rabbit liver microsomes. Biochem. Pharmacol. 1979; 28: 1719
   PubMed Web of Science ®Google Scholar
• Leighty E. G., Fentiman A. F., Jr. Conjugation of metabolites of cyclamate to fatty acids. Pharmacologist 1982; 24: 168
   Google Scholar
• Leighty E. G., Fentiman A. F., Jr. Fatty acid conjugation with cyclamate metabolites as a possible mechanism for ultimate retention. Food Chem. Toxicol. 1983; 21: 251
   PubMed Web of Science ®Google Scholar
• Theivagt J. G., Helgren P. F., Leubke D. R. Cyclohexylamine. Encycl. Ind. Chem. Anal. 1971; 11: 209
   Google Scholar
• Theivagt J. G., Helgren P. F., Luebke D. R. Cyclohexylamine derivatives. Encycl. Ind. Chem. Anal. 1971; 11: 220
   Google Scholar