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Research Article

Nasal Cavity Enzymes Involved in Xenobiotic Metabolism: Effects on the Toxicity of Inhalants

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Pages 345-372 | Published online: 25 Sep 2008

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G.L. Kedderis. 2010. Comprehensive Toxicology. Comprehensive Toxicology 137 151 .
Scott E. Loveless, Brian Slezak, Tessa Serex, Joseph Lewis, Pushkor Mukerji, John C. O’Connor, E. Maria Donner, Steven R. Frame, Stephen H. Korzeniowski & Robert C. Buck. (2009) Toxicological evaluation of sodium perfluorohexanoate. Toxicology 264:1-2, pages 32-44.
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D. Klimmeck, U. Mayer, N. Ungerer, U. Warnken, M. Schnölzer, S. Frings & F. Möhrlen. (2008) Calcium-signaling networks in olfactory receptor neurons. Neuroscience 151:3, pages 901-912.
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Crossref
Pamela Dalton & Richard Opiekum. 2005. Inhalation Toxicology, Second Edition. Inhalation Toxicology, Second Edition 373 403 .
John Morris. 2005. Inhalation Toxicology, Second Edition. Inhalation Toxicology, Second Edition 349 371 .
Virginia McMillan Carr. (2006) Induced and constitutive heat shock protein expression in the olfactory system—A review, new findings, and some perspectives. Journal of Neurocytology 34:3-5, pages 269-293.
Crossref
Christopher B. Rees, Hong Wu & Weiming Li. (2005) Cloning of CYP1A in Atlantic salmon (Salmo salar). Aquaculture 246:1-4, pages 11-23.
Crossref
Plopper Charles G.Harkema Jack R.. 2005. The Laboratory Primate. The Laboratory Primate 503 526 .
Michelle J. Hooth, Ronald A. Herbert, Joseph K. Haseman, Denise P. Orzech, Jerry D. Johnson & John R. Bucher. (2004) Toxicology and carcinogenesis studies of dipropylene glycol in rats and mice. Toxicology 204:2-3, pages 123-140.
Crossref
Anne Hansen & Klaus Reutter. 2004. The Senses of Fish. The Senses of Fish 55 89 .
Ying Chen, Yi-Qing Liu, Ting Su, Xiang Ren, Li Shi, Dazi Liu, Jun Gu, Qing-Yu Zhang & Xinxin Ding. (2003) Immunoblot analysis and immunohistochemical characterization of CYP2A expression in human olfactory mucosa. Biochemical Pharmacology 66:7, pages 1245-1251.
Crossref
Xinxin DingLaurence S. Kaminsky. (2003) Human Extrahepatic Cytochromes P450: Function in Xenobiotic Metabolism and Tissue-Selective Chemical Toxicity in the Respiratory and Gastrointestinal Tracts. Annual Review of Pharmacology and Toxicology 43:1, pages 149-173.
Crossref
Darren A. Robinson, John R. Foster, John A. Nash & Celia J. Reed. (2016) Development of Methodology for the Three-Dimensional Modelling of the Metabolic Capacity of the Rat Nasal Cavity using Glutathione S-Transferase M1 as an Example. Toxicologic Pathology 31:3, pages 332-339.
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Darren A. Robinson, John R. Foster, John A. Nash & Celia J. Reed. (2016) Three-Dimensional Mapping of the Lesions Induced by β-β'-Iminodiproprionitrile, Methyl Iodide and Methyl Methacrylate in the Rat Nasal Cavity. Toxicologic Pathology 31:3, pages 340-347.
Crossref
Tatsuya Kasai, Tomoshi Nishizawa, Heihachiro Arito, Kasuke Nagano, Seigo Yamamoto, Taijiro Matsushima & Toshihiro Kawamoto. (2002) Acute and Subchronic Inhalation Toxicity of Chloroform in Rats and Mice. Journal of Occupational Health 44:4, pages 193-202.
Crossref
E Dybing, J Doe, J Groten, J Kleiner, J O'Brien, A.G Renwick, J Schlatter, P Steinberg, A Tritscher, R Walker & M Younes. (2002) Hazard characterisation of chemicals in food and diet. Food and Chemical Toxicology 40:2-3, pages 237-282.
Crossref
Eliane Fuseau, Olivier Petricoul, Katy HP Moore, Andrew Barrow & Tim Ibbotson. (2002) Clinical Pharmacokinetics of Intranasal Sumatriptan. Clinical Pharmacokinetics 41:11, pages 801-811.
Crossref
Sandra Marini, Vincenzo Longo, Cinzia Zaccaro, Francesco De Matteis & Pier Giovanni Gervasi. (2001) Selective inactivation of rat and bovine olfactory cytochrome P450 by three haloethanes. Toxicology Letters 124:1-3, pages 83-90.
Crossref
Jean-Marie Heydel, Séverine Leclerc, Pascal Bernard, Hélène Pelczar, Daniela Gradinaru, Jacques Magdalou, Alain Minn, Yves Artur & Hervé Goudonnet. (2001) Rat olfactory bulb and epithelium UDP-glucuronosyltransferase 2A1 (UGT2A1) expression: in situ mRNA localization and quantitative analysis. Molecular Brain Research 90:1, pages 83-92.
Crossref
Virginian McMillan Carr, Bert Ph.M. Menco, Maya P. Yankova, Richard I. Morimoto & Albert I. Farbman. (2001) Odorants as cell-type specific activators of a heat shock response in the rat olfactory mucosa. The Journal of Comparative Neurology 432:4, pages 425-439.
Crossref
Paul M. Hext, Patricia J. Pinto & Barbara A. Gaskell. (2001) Methyl methacrylate toxicity in rat nasal epithelium: investigation of the time course of lesion development and recovery from short term vapour inhalation. Toxicology 156:2-3, pages 119-128.
Crossref
Richard L. Doty. 2001. Functional Neurobiology of Aging. Functional Neurobiology of Aging 647 658 .
Fuqiang Xu, Ikuhiro Kida, Fahmeed Hyder & Robert G. Shulman. (2000) Assessment and discrimination of odor stimuli in rat olfactory bulb by dynamic functional MRI. Proceedings of the National Academy of Sciences 97:19, pages 10601-10606.
Crossref
H. Riechelmann. (2018) The Nose versus the Environment: 1982 and Today. American Journal of Rhinology 14:5, pages 291-298.
Crossref
Jun Gu, Ting Su, Ying Chen, Qing-Yu Zhang & Xinxin Ding. (2000) Expression of Biotransformation Enzymes in Human Fetal Olfactory Mucosa: Potential Roles in Developmental Toxicity. Toxicology and Applied Pharmacology 165:2, pages 158-162.
Crossref
J.D Kilgour, S.A Simpson, D.J Alexander & C.J Reed. (2000) A rat nasal epithelial model for predicting upper respiratory tract toxicity: in vivo–in vitro correlations. Toxicology 145:1, pages 39-49.
Crossref
Jack R. Harkema, Charles G. Plopper & Kent E. Pinkerton. 2000. Pulmonary Immunotoxicology. Pulmonary Immunotoxicology 1 59 .
Jun Gu, Carol Dudley, Ting Su, David C. Spink, Qing-Yu Zhang, Robert L. Moss & Xinxin Ding. (1999) Cytochrome P450 and Steroid Hydroxylase Activity in Mouse Olfactory and Vomeronasal Mucosa. Biochemical and Biophysical Research Communications 266:1, pages 262-267.
Crossref
Gene E. Schulze, Jim E. Proctor, Mark A. Dominick, Amy E. Weiss, Oliver P. Flint, Nuggehally R. Srinivas, Stephen K. Durham & Beth E. Schilling. (2016) Intranasal Toxicity of BMS-181885, A Novel 5-HT1 Agonist. International Journal of Toxicology 18:5, pages 285-296.
Crossref
V. S. Deshpande, M. B. Genter, C. Jung & P. B. Desai. (1999) Characterization of lidocaine metabolism by rat nasal microsomes: implications for nasal drug delivery. European Journal of Drug Metabolism and Pharmacokinetics 24:2, pages 177-182.
Crossref
Jan Born, Reinhard Pietrowsky & Horst L. Fehm. 1999. Advances in Brain Vasopressin. Advances in Brain Vasopressin 619 642 .
S. Bleich, F. Hapla & R. Sprung. (1998) Zur möglichen Kausalität methanol- und methylacetathaltiger Holzstäube an der Entstehung von malignen NasentumorenPossible risk to develop nasal cancer by occupational exposure to wood dust containing methanol and methylacetate. Holz als Roh- und Werkstoff 56:6, pages 367-372.
Crossref
Carina C. Ferrari, Hernán J. Aldana Marcos, Pablo D. Carmanchahi & Jorge M. Affanni. (1998) Olfactory mucosa of the South American armadilloChaetophractus villosus: An ultrastructural study. The Anatomical Record 252:3, pages 325-339.
Crossref
John B. Morris. (1998) Invited Editorial on “Comparison between the uptake of nitrous oxide and nitric oxide in the human nose”. Journal of Applied Physiology 85:4, pages 1201-1202.
Crossref
Jianhua Zhang & Xinxin Ding. (1998) Identification and Characterization of a Novel Tissue-specific Transcriptional Activating Element in the 5′-Flanking Region of theCYP2A3 Gene Predominantly Expressed in Rat Olfactory Mucosa. Journal of Biological Chemistry 273:36, pages 23454-23462.
Crossref
Shim-Mo Hayashi, Ikuo Mori & Takashi Nonoyama. (2016) Spontaneous Proliferative Lesions in the Nasopharyngeal Meatus of F344 Rats. Toxicologic Pathology 26:3, pages 419-427.
Crossref
Steven H. Yoshida & M. Eric Gershwin. (1998) Immunity, infection, and nasal disease. Clinical Reviews in Allergy & Immunology 16:1-2, pages 3-24.
Crossref
J.R Thornton-Manning & A.R Dahl. (1997) Metabolic capacity of nasal tissue. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 380:1-2, pages 43-59.
Crossref
Jun Gu, Vernon E. Walker, Thomas W. Lipinskas, Dale M. Walker & Xinxin Ding. (1997) Intraperitoneal Administration of Coumarin Causes Tissue-Selective Depletion of Cytochromes P450 and Cytotoxicity in the Olfactory Mucosa. Toxicology and Applied Pharmacology 146:1, pages 134-143.
Crossref
Pia Larsson, Wojciech Cybulski & Hans Tjälve. (2009) Binding of 3 H‐Metronidazole in Olfactory, Respiratory and Alimentary Epithelia in Rats . Pharmacology & Toxicology 81:2, pages 65-73.
Crossref
J.S. Kimbell, M.N. Godo, E.A. Gross, D.R. Joyner, R.B. Richardson & K.T. Morgan. (1997) Computer Simulation of Inspiratory Airflow in All Regions of the F344 Rat Nasal Passages. Toxicology and Applied Pharmacology 145:2, pages 388-398.
Crossref
Susan L. Starcevic & Barbara S. Zielinski. (1997) Glutathione and GlutathioneS-Transferase in the Rainbow Trout Olfactory Mucosa during Retrograde Degeneration and Regeneration of the Olfactory Nerve. Experimental Neurology 146:2, pages 331-340.
Crossref
Kevin T. Morgan. (2016) Review Article: A Brief Review of Formaldehyde Carcinogenesis in Relation to Rat Nasal Pathology and Human Health Risk Assessment. Toxicologic Pathology 25:3, pages 291-305.
Crossref
Zichun Hua, Qing-yu Zhang, Ting Su, Thomas W. Lipinskas & Xinxin Ding. (1997) cDNA Cloning, Heterologous Expression, and Characterization of Mouse CYP2G1, an Olfactory-Specific Steroid Hydroxylase. Archives of Biochemistry and Biophysics 340:2, pages 208-214.
Crossref
Kulwinder K. Banger, Edward A. Lock & Celia J. Reed. (1996) Regulation of rat olfactory glutathione S-transferase expression. Biochemical Pharmacology 52:5, pages 801-808.
Crossref
Reinhard Pietrowsky, Christel Strüben, Matthias Mölle, Horst L. Fehm & Jan Born. (1996) Brain potential changes after intranasal vs. intravenous administration of vasopressin: evidence for a direct nose-brain pathway for peptide effects in humans. Biological Psychiatry 39:5, pages 332-340.
Crossref
Kevin T. Morgan & Jack R. Harkema. 1996. Respiratory System. Respiratory System 87 104 .
Kevin T. Morgan & Jack R. Harkema. 1996. Respiratory System. Respiratory System 28 43 .
Jack R. Harkema & Kevin T. Morgan. 1996. Respiratory System. Respiratory System 3 17 .
Steven H. Yoshida & M. Eric Gershwin. 1996. Diseases of the Sinuses. Diseases of the Sinuses 367 379 .
Matthew S. Bogdanffy & Annie M. Jarabek. (1995) Understanding mechanisms of inhaled toxicants: implications for replacing default factors with chemical-specific data. Toxicology Letters 82-83, pages 919-932.
Crossref
Roger McClellan & Rogene HendersonDonald Dungworth, Fletcher Hahn & Kristen Nikula. 1995. Concepts In Inhalation Toxicology. Concepts In Inhalation Toxicology 535 578 .
Roger McClellan & Rogene HendersonAlan Dahl. 1995. Concepts In Inhalation Toxicology. Concepts In Inhalation Toxicology 175 190 .
Mary Beth Genter, Nora J. Deamer, Bonita L. Blake, Deborah S. Wesley & Patricia E. Levi. (2016) Olfactory Toxicity of Methimazole: Dose-Response and Structure-Activity Studies and Characterization of Flavin-Containing Monooxygenase Activity in the Long-Evans Rat Olfactory Mucosa. Toxicologic Pathology 23:4, pages 477-486.
Crossref
M.N. Godo, K.T. Morgan, R.B. Richardson & J.S. Kimbell. (1995) Reconstruction of complex passageways for simulations of transport phenomena: development of a graphical user interface for biological applications. Computer Methods and Programs in Biomedicine 47:2, pages 97-112.
Crossref
Catalina Eriksson & Eva B. Brittebo. (1995) Dichlobenil in the fetal and neonatal mouse olfactory mucosa. Toxicology 96:2, pages 93-104.
Crossref
David C. Dorman, Kevin T. Morgan & Marc Bonnefoi. 1995. Neurotoxicology. Neurotoxicology 67 79 .
Susan L. Starcevic & Barbara S. Zielinski. (1995) Immunohistochemical localization of glutathione S-transferase pi in rainbow trout olfactory receptor neurons. Neuroscience Letters 183:3, pages 175-178.
Crossref
G. Monod, D. Saucier, E. Perdu-Durand, M. Diallo, J.-P. Cravedi & L. Astic. (1995) Catalytic and immunocytochemical detection of xenobiotic metabolizing enzymes in the olfactory organ of rainbow trout (Oncorhynchus mykiss). Marine Environmental Research 39:1-4, pages 39-43.
Crossref
Pia Larsson & Hans Tjälve. (1995) Extrahepatic bioactivation of aflatoxin B1 in fetal, infant and adult rats. Chemico-Biological Interactions 94:1, pages 1-19.
Crossref
G. Monod, D. Saucier, E. Perdu-Durand, M. Diallo, J. -P. Cravedi & L. Astic. (1994) Biotransformation enzyme activities in the olfactory organ of rainbow trout (Oncorhynchus mykiss). Immunocytochemical localization of cytochrome P4501A1 and its induction by β-naphthoflavone. Fish Physiology and Biochemistry 13:6, pages 433-444.
Crossref
Virginia McMillan Carr, Shawn P. Murphy, Richard I. Morimoto & Albert I. Farbman. (2004) Small subclass of rat olfactory neurons with specific bulbar projections is reactive with monoclonal antibodies to the HSP70 heat shock protein. Journal of Comparative Neurology 348:1, pages 150-160.
Crossref
MAHMOUD AMINLARI & MEHRDAD SHAHBAZI. (1994) Rhodanese (Thiosulfate:Cyanide Sulfurtransferase) Distribution in the Digestive Tract of Chicken. Poultry Science 73:9, pages 1465-1469.
Crossref
Stéphane Mery, Elizabeth A. Gross, Donald R. Joyner, Matthew Godo & Kevin T. Morgan. (2016) Nasal Diagrams: A Tool for Recording the Distribution of Nasal Lesions in Rats and Mice. Toxicologic Pathology 22:4, pages 353-372.
Crossref
Kerry T. Blanchard & John B. Morris. (1994) Effects of m-xylene on rat nasal cytochrome P450 mixed function oxidase activities. Toxicology Letters 70:2, pages 253-259.
Crossref
M. B. Genter, N. J. Deamer, Y. Cao & P. E. Levi. (2006) Effects of P450 inhibition and induction on the olfactory toxicity of β, β′‐iminodipropionitrile (IDPN) in the rat. Journal of Biochemical Toxicology 9:1, pages 31-39.
Crossref
R.J. Richards & V.I.C. Oreffo. (1993) Respiratory tract epithelium and neoplasia. Respiratory Medicine 87:3, pages 175-181.
Crossref
James A. Bond. (1993) Metabolism and Elimination of Inhaled Drugs and Airborne Chemicals from the Lungs. Pharmacology & Toxicology 72, pages 36-47.
Crossref
K. Vähäkangas & O. Pelkonen. 1993. Nicotine and Related Alkaloids. Nicotine and Related Alkaloids 111 127 .
X. Ding & M. J. Coon. 1993. Cytochrome P450. Cytochrome P450 351 361 .
E.A. Lock & E.S. Harpur. (2016) Toxicology of Sensory Systems: A Perspective. Human & Experimental Toxicology 11:6, pages 442-448.
Crossref
Susanna S.T. Lee & Jeffrey G. Scott. (1992) Tissue distribution of microsomal cytochrome P-450 monooxygenases and their inducibility by phenobarbital in house fly, Musca domestica L.. Insect Biochemistry and Molecular Biology 22:7, pages 699-711.
Crossref
Rebecca Bascom. (2018) Multiple Chemical Sensitivity: A Respiratory Disorder?. Toxicology and Industrial Health 8:4, pages 221-228.
Crossref
J. L. Lewis, C. E. Rhoades, D. E. Bice, J. R. Harkema, J. A. Hotchkiss, D. M. Sylvester & A. R. Dahl. (2005) Interspecies comparison of cellular localization of the cyanide metabolizing enzyme rhodanese within olfactory mucosa. The Anatomical Record 232:4, pages 620-627.
Crossref
Paul J. Boor, Margaret B. Trent, Geoffrey A. Lyles, Ming Tao & G.A.S. Ansari. (1992) Methylamine metabolism to formaldehyde by vascular semicarbazide-sensitive amine oxidase. Toxicology 73:3, pages 251-258.
Crossref
Jack R. Harkema. (2017) Comparative Aspects of Nasal Airway Anatomy: Relevance to Inhalation Toxicology *1 . Toxicologic Pathology 19:4_part_1, pages 321-336.
Crossref

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