906
Views
56
CrossRef citations to date
0
Altmetric
Review Article

Metabolism as a key to histone deacetylase inhibition

, , &
Pages 181-199 | Received 15 Dec 2010, Accepted 21 Jan 2011, Published online: 05 Apr 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Jorge Joven, Vicente Micol, Antonio Segura-Carretero, Carlos Alonso-Villaverde, JavierA. Menéndez & for the Bioactive Food Components Platform . (2014) Polyphenols and the Modulation of Gene Expression Pathways: Can We Eat Our Way Out of the Danger of Chronic Disease?. Critical Reviews in Food Science and Nutrition 54:8, pages 985-1001.
Read now
Lynnette R Ferguson. (2013) Nutrigenetics, nutrigenomics and inflammatory bowel diseases. Expert Review of Clinical Immunology 9:8, pages 717-726.
Read now
Praveen Rajendran, Ariam I. Kidane, Tian-Wei Yu, Wan-Mohaiza Dashwood, William H. Bisson, Christiane V. Löhr, Emily Ho, David E. Williams & Roderick H. Dashwood. (2013) HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics 8:6, pages 612-623.
Read now
Diego Russo, Cosimo Durante, Stefania Bulotta, Cinzia Puppin, Efisio Puxeddu, Sebastiano Filetti & Giuseppe Damante. (2013) Targeting histone deacetylase in thyroid cancer. Expert Opinion on Therapeutic Targets 17:2, pages 179-193.
Read now
Natalie E. Simpson, Volodymyr P. Tryndyak, Marta Pogribna, Frederick A. Beland & Igor P. Pogribny. (2012) Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotype. Epigenetics 7:12, pages 1413-1420.
Read now

Articles from other publishers (51)

Tingting Fan, Ying Yu, Yong‐long Chen, Pan Gu, Stanley Wong, Zheng‐yuan Xia, Jessica Aijia Liu & Chi‐wai Cheung. (2022) Histone deacetylase 5‐induced deficiency of signal transducer and activator of transcription‐3 acetylation contributes to spinal astrocytes degeneration in painful diabetic neuropathy. Glia 71:4, pages 1099-1119.
Crossref
Martina Sandonà, Giorgia Cavioli, Alessandra Renzini, Alessia Cedola, Giuseppe Gigli, Dario Coletti, Timothy A. McKinsey, Viviana Moresi & Valentina Saccone. (2023) Histone Deacetylases: Molecular Mechanisms and Therapeutic Implications for Muscular Dystrophies. International Journal of Molecular Sciences 24:5, pages 4306.
Crossref
Ienglam Lei, Wei HuangPierre Emmanuel Noly, Suyash NaikMiriyam Ghali, Liu LiuFrancis D. Pagani, Ashraf Abou El Ela, Jordan S. Pober, Bertram PittJeffrey L. PlattMarilia CascalhoZhong WangY. Eugene Chen, Richard M. Mortensen & Paul C. Tang. (2023) Metabolic reprogramming by immune-responsive gene 1 up-regulation improves donor heart preservation and function. Science Translational Medicine 15:682.
Crossref
Zheyi Xiang, Le Bai, Jennifer Q. Zhou, Ricardo R. Cevallos, Jonathan R. Sanders, Gang Liu, Karen Bernard & Yan Y. Sanders. (2023) Epigenetic regulation of IPF fibroblast phenotype by glutaminolysis. Molecular Metabolism 67, pages 101655.
Crossref
Sabeeta Kapoor, Elisabetta Damiani, Shan Wang, Ravirajan Dharmanand, Chakrapani Tripathi, Jorge Enrique Tovar Perez, Wan Mohaiza Dashwood, Praveen Rajendran & Roderick Hugh Dashwood. (2022) BRD9 Inhibition by Natural Polyphenols Targets DNA Damage/Repair and Apoptosis in Human Colon Cancer Cells. Nutrients 14:20, pages 4317.
Crossref
Richard D Mattes, Sylvia B Rowe, Sarah D Ohlhorst, Andrew W Brown, Daniel J Hoffman, DeAnn J Liska, Edith J M Feskens, Jaapna Dhillon, Katherine L Tucker, Leonard H Epstein, Lynnette M Neufeld, Michael Kelley, Naomi K Fukagawa, Roger A Sunde, Steven H Zeisel, Anthony J Basile, Laura E Borth & Emahlea Jackson. (2022) Valuing the Diversity of Research Methods to Advance Nutrition Science. Advances in Nutrition 13:4, pages 1324-1393.
Crossref
Jacob King, Maya Patel & Sriram Chandrasekaran. (2021) Metabolism, HDACs, and HDAC Inhibitors: A Systems Biology Perspective. Metabolites 11:11, pages 792.
Crossref
Muhammet Mesut Nezir ENGİN, Esra ÖZEN ENGİN, Recep ERÖZ, Gorkem DULGER & Hüseyin YÜCE. (2021) Effects of Epigenetic Regulation on CancerEpigenetik Düzenlemenin Kanser Üzerine Etkileri. Journal of Biotechnology and Strategic Health Research 5:1, pages 1-7.
Crossref
Elisabetta Damiani, Munevver N. Duran, Nivedhitha Mohan, Praveen Rajendran & Roderick H. Dashwood. (2020) Targeting Epigenetic ‘Readers’ with Natural Compounds for Cancer Interception. Journal of Cancer Prevention 25:4, pages 189-203.
Crossref
Steven H. Zeisel. (2020) Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Annual Review of Food Science and Technology 11:1, pages 71-92.
Crossref
Javier A. Menendez, Elisabet Cuyàs, Núria Folguera-Blasco, Sara Verdura, Begoña Martin-Castillo, Jorge Joven & Tomás Alarcón. (2019) In silico clinical trials for anti-aging therapies. Aging 11:16, pages 6591-6601.
Crossref
Steven H. Zeisel. (2019) A Conceptual Framework for Studying and Investing in Precision Nutrition. Frontiers in Genetics 10.
Crossref
Alla Klyuyeva, Alina Tuganova, Natalia Kedishvili & Kirill M. Popov. (2019) Tissue-specific kinase expression and activity regulate flux through the pyruvate dehydrogenase complex. Journal of Biological Chemistry 294:3, pages 838-851.
Crossref
Takeo Kubota & Kazuki Mochizuki. 2019. Handbook of Nutrition, Diet, and Epigenetics. Handbook of Nutrition, Diet, and Epigenetics 935 948 .
María C. Ovejero‐Benito, Alejandra Reolid, Patricia Sánchez‐Jiménez, Miriam Saiz‐Rodríguez, Ester Muñoz‐Aceituno, Mar Llamas‐Velasco, Samuel Martín‐Vilchez, Teresa Cabaleiro, Manuel Román, Dolores Ochoa, Esteban Daudén & Francisco Abad‐Santos. (2018) Histone modifications associated with biological drug response in moderate‐to‐severe psoriasis. Experimental Dermatology 27:12, pages 1361-1371.
Crossref
Pan Pan, Kiyoko Oshima, Yi-Wen Huang, Kimberle A. Agle, William R. Drobyski, Xiao Chen, Jianying Zhang, Martha M. Yearsley, Jianhua Yu & Li-Shu Wang. (2018) Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors. International Journal of Cancer 143:4, pages 886-896.
Crossref
Folami Y. Ideraabdullah & Steven H. Zeisel. (2018) Dietary Modulation of the Epigenome. Physiological Reviews 98:2, pages 667-695.
Crossref
Xiaoying S. Zhong, John H. Winston, Xiuju Luo, Kevin T. Kline, Syed Z. Nayeem, Yingzi Cong, Tor C. Savidge, Roderick H. Dashwood, Don W. Powell & Qingjie Li. (2018) Neonatal Colonic Inflammation Epigenetically Aggravates Epithelial Inflammatory Responses to Injury in Adult Life. Cellular and Molecular Gastroenterology and Hepatology 6:1, pages 65-78.
Crossref
Nicoleta Andreescu, Maria Puiu & Mihai Niculescu. 2018. Cancer Epigenetics for Precision Medicine. Cancer Epigenetics for Precision Medicine 121 139 .
Ying-Shiuan Chen, Rong Wang, Wan-Mohaiza Dashwood, Christiane V. Löhr, David E. Williams, Emily Ho, Susanne Mertens-Talcott & Roderick H. Dashwood. (2017) A miRNA signature for an environmental heterocyclic amine defined by a multi-organ carcinogenicity bioassay in the rat. Archives of Toxicology 91:10, pages 3415-3425.
Crossref
Takeo Kubota & Kazuki Mochizuki. 2017. Handbook of Nutrition, Diet, and Epigenetics. Handbook of Nutrition, Diet, and Epigenetics 1 14 .
Zachary T. Schug, Johan Vande Voorde & Eyal Gottlieb. (2016) The metabolic fate of acetate in cancer. Nature Reviews Cancer 16:11, pages 708-717.
Crossref
Carmen SapienzaJean-Pierre Issa. (2016) Diet, Nutrition, and Cancer Epigenetics. Annual Review of Nutrition 36:1, pages 665-681.
Crossref
Walter H. Moos, Eleni Maneta, Carl A. Pinkert, Michael H. Irwin, Michelle E. Hoffman, Douglas V. Faller & Kosta Steliou. (2016) Epigenetic Treatment of Neuropsychiatric Disorders: Autism and Schizophrenia. Drug Development Research 77:2, pages 53-72.
Crossref
Mona Mischke & Torsten Plösch. 2016. Microbiota of the Human Body. Microbiota of the Human Body 33 44 .
Praveen Rajendran, Wan-Mohaiza Dashwood, Li Li, Yuki Kang, Eunah Kim, Gavin Johnson, Kay A. Fischer, Christiane V. Löhr, David E. Williams, Emily Ho, Masayuki Yamamoto, David A. Lieberman & Roderick H. Dashwood. (2015) Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon. Clinical Epigenetics 7:1.
Crossref
Christian Busch, Markus Burkard, Christian Leischner, Ulrich M. Lauer, Jan Frank & Sascha Venturelli. (2015) Epigenetic activities of flavonoids in the prevention and treatment of cancer. Clinical Epigenetics 7:1.
Crossref
Alain Khaiat & Claude Saliou. 2015. Cosmeceuticals and Active Cosmetics, Third Edition. Cosmeceuticals and Active Cosmetics, Third Edition 385 402 .
Vidar GundersenJon Storm-MathisenLinda Hildegard Bergersen. (2015) Neuroglial Transmission. Physiological Reviews 95:3, pages 695-726.
Crossref
Rommel A. Mathias, Amanda J. Guise & Ileana M. Cristea. (2015) Post-translational Modifications Regulate Class IIa Histone Deacetylase (HDAC) Function in Health and Disease. Molecular & Cellular Proteomics 14:3, pages 456-470.
Crossref
Kerstin Klein & Steffen Gay. (2015) Epigenetics in rheumatoid arthritis. Current Opinion in Rheumatology 27:1, pages 76-82.
Crossref
Federico Andreoli & Alberto Del Rio. (2015) Computer-aided Molecular Design of Compounds Targeting Histone Modifying Enzymes. Computational and Structural Biotechnology Journal 13, pages 358-365.
Crossref
Y Kang, H Nian, P Rajendran, E Kim, W M Dashwood, J T Pinto, L A Boardman, S N Thibodeau, P J Limburg, C V Löhr, W H Bisson, D E Williams, E Ho & R H Dashwood. (2014) HDAC8 and STAT3 repress BMF gene activity in colon cancer cells. Cell Death & Disease 5:10, pages e1476-e1476.
Crossref
Shalome Bassett & Matthew Barnett. (2014) The Role of Dietary Histone Deacetylases (HDACs) Inhibitors in Health and Disease. Nutrients 6:10, pages 4273-4301.
Crossref
Fatima el Bahhaj, Frank J. Dekker, Nadine Martinet & Philippe Bertrand. (2014) Delivery of epidrugs. Drug Discovery Today 19:9, pages 1337-1352.
Crossref
Inga Wessels. (2014) Epigenetics and Metal Deficiencies. Current Nutrition Reports 3:3, pages 196-203.
Crossref
Shujuan Sun, Yingyan Han, Jia Liu, Yong Fang, Yuan Tian, Jianfeng Zhou, Ding Ma & Peng Wu. (2014) Trichostatin A Targets the Mitochondrial Respiratory Chain, Increasing Mitochondrial Reactive Oxygen Species Production to Trigger Apoptosis in Human Breast Cancer Cells. PLoS ONE 9:3, pages e91610.
Crossref
Nadia Mazarakis & Tom C. Karagiannis. 2014. Molecular mechanisms and physiology of disease. Molecular mechanisms and physiology of disease 427 444 .
Taylor Chomiak, Nathanael Turner & Bin Hu. (2013) What We Have Learned about Autism Spectrum Disorder from Valproic Acid. Pathology Research International 2013, pages 1-8.
Crossref
Heidi R FullerEmma L Humphrey & Glenn E Morris. (2013) Naturally occurring plant polyphenols as potential therapies for inherited neuromuscular diseases. Future Medicinal Chemistry 5:17, pages 2091-2101.
Crossref
N. D. Turner, L. E. Ritchie, R. S. Bresalier & R. S. Chapkin. (2013) The Microbiome and Colorectal Neoplasia: Environmental Modifiers of Dysbiosis. Current Gastroenterology Reports 15:9.
Crossref
Anika Eva Wagner, Anna Maria Terschluesen & Gerald Rimbach. (2013) Health Promoting Effects of Brassica-Derived Phytochemicals: From Chemopreventive and Anti-Inflammatory Activities to Epigenetic Regulation. Oxidative Medicine and Cellular Longevity 2013, pages 1-12.
Crossref
Bishambar Dayal, Vineela Reddy Yannamreddy, Chandran Ragunath, Narayanan Ramasubbu, Trinava Roy, Ritesh Amin, Swayam. P. Nirujogi & Michael A. Lea. 2013. Advances in Applied Nanotechnology for Agriculture. Advances in Applied Nanotechnology for Agriculture 177 191 .
John M. Denu. 2013. Environmental Epigenomics in Health and Disease. Environmental Epigenomics in Health and Disease 163 187 .
David M Hockenbery, Mark Tom, Cori Abikoff & Daciana Margineantu. 2013. Cell Death Signaling in Cancer Biology and Treatment. Cell Death Signaling in Cancer Biology and Treatment 35 51 .
Kosta SteliouMichael S. BoosalisSusan P. PerrineJosé SangermanDouglas V. Faller. (2012) Butyrate Histone Deacetylase Inhibitors. BioResearch Open Access 1:4, pages 192-198.
Crossref
Laura M. Beaver, David E. Williams, Roderick H. Dashwood & Emily Ho. 2012. Nutrition, Diet and Cancer. Nutrition, Diet and Cancer 49 81 .
Praveen Rajendran, Emily Ho, David E Williams & Roderick H Dashwood. (2011) Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells. Clinical Epigenetics 3:1.
Crossref
Praveen Rajendran, Barbara Delage, W Mohaiza Dashwood, Tian-Wei Yu, Bradyn Wuth, David E Williams, Emily Ho & Roderick H Dashwood. (2011) Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly. Molecular Cancer 10:1.
Crossref
Emily Ho, Laura M. Beaver, David E. Williams & Roderick H. Dashwood. (2011) Dietary Factors and Epigenetic Regulation for Prostate Cancer Prevention. Advances in Nutrition 2:6, pages 497-510.
Crossref
Thomas Prates Ong, Fernando Salvador Moreno & Sharon Ann Ross. (2011) Targeting the Epigenome with Bioactive Food Components for Cancer Prevention. Journal of Nutrigenetics and Nutrigenomics 4:5, pages 275-292.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.