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Original Articles: Research

Matrine induces apoptosis of human multiple myeloma cells via activation of the mitochondrial pathway

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Pages 1337-1346 | Received 17 Jan 2010, Accepted 21 Apr 2010, Published online: 08 Jun 2010

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Jae Hee Jung, Gi Byoung Hwang, Sun Young Park, Jung Eun Lee, Chu Won Nho, Byung Uk Lee & Gwi-Nam Bae. (2011) Antimicrobial Air Filtration Using Airborne Sophora Flavescens Natural-Product Nanoparticles. Aerosol Science and Technology 45:12, pages 1510-1518.
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SANGRAM SINGH, MOIN UDDIN, M. MASROOR A. KHAN, SARIKA SINGH, AMAN SOBIA CHISHTI & UROOJ HASSAN BHAT. (2022) THERAPEUTIC PROPERTIES OF CAPSAICIN: A MEDICINALLY IMPORTANT BIO-ACTIVE CONSTITUENT OF CHILLI PEPPER. Asian Journal of Pharmaceutical and Clinical Research, pages 47-58.
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Jianyou Gu, Xiao Wang, Ling Zhang, Jingjing Xiang, Jingya Li, Zheng Chen, Yu Zhang, Junfa Chen & Jianping Shen. (2021) Matrine suppresses cell growth of diffuse large B-cell lymphoma via inhibiting CaMKIIγ/c-Myc/CDK6 signaling pathway. BMC Complementary Medicine and Therapies 21:1.
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Amin Thawabteh, Salma Juma, Mariam Bader, Donia Karaman, Laura Scrano, Sabino Bufo & Rafik Karaman. (2019) The Biological Activity of Natural Alkaloids against Herbivores, Cancerous Cells and Pathogens. Toxins 11:11, pages 656.
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Beomku Kang, Hyunmin Park & Bonglee Kim. (2019) Anticancer Activity and Underlying Mechanism of Phytochemicals against Multiple Myeloma. International Journal of Molecular Sciences 20:9, pages 2302.
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Haroon ur Rashid, Yiming Xu, Yaseen Muhammad, Lisheng Wang & Jun Jiang. (2019) Research advances on anticancer activities of matrine and its derivatives: An updated overview. European Journal of Medicinal Chemistry 161, pages 205-238.
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Valentina Laghezza Masci, Stefano Bernardini, Lorenzo Modesti, Elisa Ovidi & Antonio Tiezzi. 2019. Medically Important Plant Biomes: Source of Secondary Metabolites. Medically Important Plant Biomes: Source of Secondary Metabolites 85 113 .
Junqing Wu, Gang Hu, Yuqing Dong, Ruye Ma, Zhijie Yu, Songfu Jiang, Yixiang Han, Kang Yu & Shenghui Zhang. (2017) Matrine induces Akt/mTOR signalling inhibition-mediated autophagy and apoptosis in acute myeloid leukaemia cells. Journal of Cellular and Molecular Medicine 21:6, pages 1171-1181.
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Qi An, Chao Han, Yubing Zhou, Feng Li, Duolu Li, Xiaojian Zhang, Zujiang Yu, Zhenfeng Duan & Quancheng Kan. (2016) Matrine induces cell cycle arrest and apoptosis with recovery of the expression of miR-126 in the A549 non-small cell lung cancer cell line. Molecular Medicine Reports.
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Yixiang Han, Aifang Ye, Yan Zhang, Zhimin Cai, Wei Wang, Lan Sun, Songfu Jiang, Jianbo Wu, Kang Yu & Shenghui Zhang. (2015) Musashi-2 Silencing Exerts Potent Activity against Acute Myeloid Leukemia and Enhances Chemosensitivity to Daunorubicin. PLOS ONE 10:8, pages e0136484.
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ZHIYUN CAO, XUZHENG CHEN, WEI LIN, JINYAN ZHAO, LIANGPU ZHENG, HONGZHI YE, LIANMING LIAO & JIAN DU. (2015) Jiedu Xiaozheng Yin decoction inhibits hepatoma cell proliferation by inducing apoptosis via the mitochondrial-mediated pathway. Molecular Medicine Reports 12:2, pages 2800-2806.
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SHAN-BU XIE, XING-XING HE & SHU-KUN YAO. (2015) Matrine-induced autophagy regulated by p53 through AMP-activated protein kinase in human hepatoma cells. International Journal of Oncology 47:2, pages 517-526.
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Nanmu Yang, Feng Han, Hong Cui, Jinxi Huang, Tao Wang, Yi Zhou & Jinxue Zhou. (2015) Matrine suppresses proliferation and induces apoptosis in human cholangiocarcinoma cells through suppression of JAK2/STAT3 signaling. Pharmacological Reports 67:2, pages 388-393.
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Gong-Ping Xu, Wei Zhao, Jin-Peng Zhuang, Jia-Ning Zu, Duan-Yang Wang, Fei Han, Zhi-Peng Zhang & Jing-Long Yan. (2014) Matrine inhibits the growth and induces apoptosis of osteosarcoma cells in vitro by inactivating the Akt pathway. Tumor Biology 36:3, pages 1653-1659.
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Jian-Lan Yu, Jun-Hua Li, Rong-Gui Chengz, Yan-Mei Ma, Xiao-Juan Wang & Jing-Chun Liu. (2014) Effect of matrine on transforming growth factor ?1 and hepatocyte growth factor in rat liver fibrosis model. Asian Pacific Journal of Tropical Medicine 7:5, pages 390-393.
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Qingliang Shao, Xiaxia Zhao & Li Yao. (2014) Matrine inhibits the growth of retinoblastoma cells (SO-Rb50) by decreasing proliferation and inducing apoptosis in a mitochondrial pathway. Molecular Biology Reports 41:5, pages 3475-3480.
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Feng Yan, Yang Liu & Wenbo Wang. (2013) Matrine inhibited the growth of rat osteosarcoma UMR-108 cells by inducing apoptosis in a mitochondrial–caspase-dependent pathway. Tumor Biology 34:4, pages 2135-2140.
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Hui Jin, Yu Sun, Shuiying Wang & Xiaodong Cheng. (2013) Matrine Activates PTEN to Induce Growth Inhibition and Apoptosis in V600EBRAF Harboring Melanoma Cells. International Journal of Molecular Sciences 14:8, pages 16040-16057.
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YUMIN LI, JUNQIANG ZHANG, HAIZHEN MA, XIAOHUI CHEN, TAO LIU, ZUOYI JIAO, WENTING HE, FURONG WANG, XIAOKANG LIU & XIANGTING ZENG. (2013) Protective role of autophagy in matrine-induced gastric cancer cell death. International Journal of Oncology 42:4, pages 1417-1426.
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Cheng Zhen Liang, Jia Kai Zhang, Zhongli Shi, Bing Liu, Chengchun Q. Shen & Hui Min Tao. (2011) Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2. Cancer Chemotherapy and Pharmacology 69:2, pages 317-331.
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Jin-Jian Lu, Jiao-Lin Bao, Xiu-Ping Chen, Min Huang & Yi-Tao Wang. (2012) Alkaloids Isolated from Natural Herbs as the Anticancer Agents. Evidence-Based Complementary and Alternative Medicine 2012, pages 1-12.
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Jae Hee Jung, Sun Young Park, Jung Eun Lee, Chu Won Nho, Byung Uk Lee & Gwi Nam Bae. (2011) Electrohydrodynamic nano-spraying of ethanolic natural plant extracts. Journal of Aerosol Science 42:10, pages 725-736.
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