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Research Article

Natural Bcl-2 inhibitor (−)– gossypol induces protective autophagy via reactive oxygen species–high mobility group box 1 pathway in Burkitt lymphoma

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Pages 2263-2268 | Received 01 Oct 2012, Accepted 07 Feb 2013, Published online: 13 Mar 2013

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Tao Ren, Jinlu Shan, Mengxia Li, Yi Qing, Chengyuan Qian, Guangjie Wang, Qing Li, Guoshou Lu, Chongyi Li, Yu Peng, Hao Luo, Shiheng Zhang, Yuxing Yang, Yi Cheng, Dong Wang & Shu-Feng Zhou. (2015) Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung cancer. Drug Design, Development and Therapy 9, pages 2887-2910.
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Xiaofang Sun & Daolin Tang. (2014) HMGB1-dependent and -independent autophagy. Autophagy 10:10, pages 1873-1876.
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Dilipkumar Pal, Pooja Sahu, Gautam Sethi, Carly E. Wallace & Anupam Bishayee. (2022) Gossypol and Its Natural Derivatives: Multitargeted Phytochemicals as Potential Drug Candidates for Oncologic Diseases. Pharmaceutics 14:12, pages 2624.
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Ogochukwu O. Izuegbuna. (2022) Polyphenols: Chemoprevention and therapeutic potentials in hematological malignancies. Frontiers in Nutrition 9.
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Olga Renner, Mascha Mayer, Christian Leischner, Markus Burkard, Alexander Berger, Ulrich M. Lauer, Sascha Venturelli & Stephan C. Bischoff. (2022) Systematic Review of Gossypol/AT-101 in Cancer Clinical Trials. Pharmaceuticals 15:2, pages 144.
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Yuan-dong Sun, Hao Zhang, Ye-qiang Chen, Chun-xue Wu, Jian-bo Zhang, Hui-rong Xu, Jing-zhou Liu & Jian-jun Han. (2020) HMGB1, the Next Predictor of Transcatheter Arterial Chemoembolization for Liver Metastasis of Colorectal Cancer?. Frontiers in Oncology 10.
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Yun Zeng, Jingwen Ma, Liang Xu & Daocheng Wu. (2019) Natural Product Gossypol and its Derivatives in Precision Cancer Medicine. Current Medicinal Chemistry 26:10, pages 1849-1873.
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Mojgan Djavaheri-Mergny, Sylvie Giuriato, Mario P. Tschan & Magali Humbert. (2019) Therapeutic Modulation of Autophagy in Leukaemia and Lymphoma. Cells 8:2, pages 103.
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Ying Wang, Ya Wang, Ji Wang, Wan Lei, Ke Li, Daocheng Wu & Xiaojuan Wang. (2018) Pharmacokinetics, biodistribution, and bioavailability of gossypol-loaded Pluronic ® F127 nanoparticles. Journal of Drug Delivery Science and Technology 45, pages 388-396.
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Han Zhang. (2018) Targeting autophagy in lymphomas: a double-edged sword?. International Journal of Hematology 107:5, pages 502-512.
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Nan Zhang, Yaran Wu, Xilin Lyu, Bo Li, Xiaojing Yan, Haojun Xiong, Xinzhe Li, Gang Huang, Yijun Zeng, Yan Zhang, Jiqin Lian, Zhenhong Ni & Fengtian He. (2017) HSF1 upregulates ATG4B expression and enhances epirubicin-induced protective autophagy in hepatocellular carcinoma cells. Cancer Letters 409, pages 81-90.
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Afshin Amini, Samar Masoumi-Moghaddam & David L. MorrisAfshin Amini, Samar Masoumi-Moghaddam & David L. Morris. 2016. Utility of Bromelain and N-Acetylcysteine in Treatment of Peritoneal Dissemination of Gastrointestinal Mucin-Producing Malignancies. Utility of Bromelain and N-Acetylcysteine in Treatment of Peritoneal Dissemination of Gastrointestinal Mucin-Producing Malignancies 99 158 .
Jens Mani, Stefan Vallo, Stefanie Rakel, Patrick Antonietti, Florian Gessler, Roman Blaheta, Georg Bartsch, Martin Michaelis, Jindrich Cinatl, Axel Haferkamp & Donat Kögel. (2015) Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (−)-Gossypol (AT-101). BMC Cancer 15:1.
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Rui Kang, Ruochan Chen, Qiuhong Zhang, Wen Hou, Sha Wu, Lizhi Cao, Jin Huang, Yan Yu, Xue-gong Fan, Zhengwen Yan, Xiaofang Sun, Haichao Wang, Qingde Wang, Allan Tsung, Timothy R. Billiar, Herbert J. ZehIIIIII, Michael T. Lotze & Daolin Tang. (2014) HMGB1 in health and disease. Molecular Aspects of Medicine 40, pages 1-116.
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Bin Wang, Linfeng Chen, Zhenhong Ni, Xufang Dai, Liyan Qin, Yaran Wu, Xinzhe Li, Liang Xu, Jiqin Lian & Fengtian He. (2014) Hsp90 inhibitor 17-AAG sensitizes Bcl-2 inhibitor (-)-gossypol by suppressing ERK-mediated protective autophagy and Mcl-1 accumulation in hepatocellular carcinoma cells. Experimental Cell Research 328:2, pages 379-387.
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Ryan S. Soderquist, Alexey V. Danilov & Alan Eastman. (2014) Gossypol Increases Expression of the Pro-apoptotic BH3-only Protein NOXA through a Novel Mechanism Involving Phospholipase A2, Cytoplasmic Calcium, and Endoplasmic Reticulum Stress. Journal of Biological Chemistry 289:23, pages 16190-16199.
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Zhenhong Ni, Bin Wang, Xufang Dai, Wen Ding, Ting Yang, Xinzhe Li, Seth Lewin, Liang Xu, Jiqin Lian & Fengtian He. (2014) HCC cells with high levels of Bcl-2 are resistant to ABT-737 via activation of the ROS?JNK?autophagy pathway. Free Radical Biology and Medicine 70, pages 194-203.
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Daolin Tang, Rui Kang, Bennett Van Houten, Herbert J. Zeh, Timothy R. Billiar & Michael T. Lotze. (2014) High Mobility Group Box 1 (HMGB1) Phenotypic Role Revealed with Stress. Molecular Medicine 20:1, pages 359-362.
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Le Yu & Shuwen Liu. (2013) Autophagy contributes to modulating the cytotoxicities of Bcl-2 homology domain-3 mimetics. Seminars in Cancer Biology 23:6, pages 553-560.
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Séverine Lorin, Ahmed Hamaï, Maryam Mehrpour & Patrice Codogno. (2013) Autophagy regulation and its role in cancer. Seminars in Cancer Biology 23:5, pages 361-379.
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