Advanced search
Publication Cover
Leukemia & Lymphoma Volume 55, 2014 - Issue 2
Submit an article Journal homepage
1,040
Views
77
CrossRef citations to date
0
Altmetric
Original Articles: Research

A novel three-dimensional stromal-based model for in vitro chemotherapy sensitivity testing of leukemia cells

Omar S. AljitawiHematology/Oncology, Blood and Marrow Transplant ProgramCorrespondence[email protected]
,
Dandan LiDietetics and Nutrition, School of Health Professions
,
Yinghua XiaoHematology/Oncology, Blood and Marrow Transplant Program
,
Da ZhangPathology and Laboratory Medicine
,
Karthik RamachandranDepartment of Physical Therapy and Rehabilitation Science
,
Lisa Stehno-BittelDepartment of Physical Therapy and Rehabilitation Science
,
Peter Van VeldhuizenHematology/Oncology
,
Tara L. LinHematology/Oncology, Blood and Marrow Transplant Program
,
Suman KambhampatiHematology/Oncology
&
Rama GarimellaDietetics and Nutrition, School of Health Professions;Hematology/Oncology;Orthopedic Surgery;Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA
 show all
Pages 378-391 | Received 07 Feb 2013, Accepted 02 Apr 2013, Published online: 15 May 2013

Citations (77)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Anil K Giri & Aleksander Ianevski. (2022) High-throughput screening for drug discovery targeting the cancer cell-microenvironment interactions in hematological cancers. Expert Opinion on Drug Discovery 17:2, pages 181-190.
Read now
Kinan Alhallak, Pilar de la Puente, Amanda Jeske, Jennifer Sun, Barbara Muz, Michael P. Rettig, Ilyas Sahin, Ellen L. Weisberg, James D. Griffin, John L. Reagan, John F. DiPersio & Abdel Kareem Azab. (2021) 3D tissue engineered plasma cultures support leukemic proliferation and induces drug resistance. Leukemia & Lymphoma 62:10, pages 2457-2465.
Read now
Govind Babu, Padmaparna Chaudhuri, Manoj Rajappa, Manjusha Biswas, Bipinesh Sansar, Chethan Rajegowda, Aneesha Radhakrishnan, Jayshree Advani, Biplab Tewary, Padhma Radhakrishnan, Saravanan Thiyagarajan, Aditi Chatterjee, Ram Shankar Upadhayaya & Pradip K Majumder. (2021) JAK-STAT inhibitor as a potential therapeutic opportunity in AML patients resistant to cytarabine and epigenetic therapy. Cancer Biology & Therapy 22:1, pages 66-78.
Read now
Maya S Nair, Ullas Mony, Deepthy Menon, Manzoor Koyakutty, Neeraj Sidharthan, Keechilat Pavithran, Shantikumar V Nair & Krishnakumar N Menon. (2015) Development and molecular characterization of polymeric micro-nanofibrous scaffold of a defined 3-D niche for in vitro chemosensitivity analysis against acute myeloid leukemia cells. International Journal of Nanomedicine 10, pages 3603-3622.
Read now

Articles from other publishers (73)

Dafne Barozzi & Cristina Scielzo. (2023) Emerging Strategies in 3D Culture Models for Hematological Cancers. HemaSphere 7:8, pages e932.
Crossref
Leandro M. Martinez & Monica L. Guzman. (2023) Understanding the interaction between leukaemia stem cells and their microenvironment to improve therapeutic approaches. British Journal of Pharmacology.
Crossref
Igor Pottosin, Miguel Olivas-Aguirre & Oxana Dobrovinskaya. (2023) In vitro simulation of the acute lymphoblastic leukemia niche: a critical view on the optimal approximation for drug testing. Journal of Leukocyte Biology 114:1, pages 21-41.
Crossref
Ewa Krawczyk & Joanna Kitlińska. (2023) Preclinical Models of Neuroblastoma—Current Status and Perspectives. Cancers 15:13, pages 3314.
Crossref
Alejandro de Janon, Athanasios Mantalaris & Nicki Panoskaltsis. (2023) Three-Dimensional Human Bone Marrow Organoids for the Study and Application of Normal and Abnormal Hematoimmunopoiesis. The Journal of Immunology 210:7, pages 895-904.
Crossref
Siriporn Keeratichamroen, Thiwaree Sornprachum, Lukana Ngiwsara, Narittira Ornnork & Jisnuson Svasti. (2023) p‑STAT3 influences doxorubicin and etoposide resistance of A549 cells grown in an in vitro 3D culture model. Oncology Reports 49:4.
Crossref
Katerina E. Miari & Mark T. S. Williams. (2023) Stromal bone marrow fibroblasts and mesenchymal stem cells support acute myeloid leukaemia cells and promote therapy resistance. British Journal of Pharmacology.
Crossref
Basil Al-Kaabneh, Benjamin Frisch & Omar S. Aljitawi. (2022) The Potential Role of 3D In Vitro Acute Myeloid Leukemia Culture Models in Understanding Drug Resistance in Leukemia Stem Cells. Cancers 14:21, pages 5252.
Crossref
Myriam Salazar-Terreros & Jean-Paul Vernot. (2022) In Vitro and In Vivo Modeling of Normal and Leukemic Bone Marrow Niches: Cellular Senescence Contribution to Leukemia Induction and Progression. International Journal of Molecular Sciences 23:13, pages 7350.
Crossref
Sabrina Zippel, Nadine Dilger, Chandralekha Chatterjee, Annamarija Raic, Gerald Brenner-Weiß, Patrik Schadzek, Bastian E Rapp & Cornelia Lee-Thedieck. (2022) A parallelized, perfused 3D triculture model of leukemia for in vitro drug testing of chemotherapeutics. Biofabrication 14:3, pages 035011.
Crossref
Shyam A. Patel. (2022) Functional genomic approaches in acute myeloid leukemia: Insights into disease models and the therapeutic potential of reprogramming. Cancer Letters 533, pages 215579.
Crossref
Isabella Maria Mayer, Andrea Hoelbl-Kovacic, Veronika Sexl & Eszter Doma. (2022) Isolation, Maintenance and Expansion of Adult Hematopoietic Stem/Progenitor Cells and Leukemic Stem Cells. Cancers 14:7, pages 1723.
Crossref
Cornelia Lee-Thedieck, Peter Schertl & Gerd Klein. (2022) The extracellular matrix of hematopoietic stem cell niches. Advanced Drug Delivery Reviews 181, pages 114069.
Crossref
Drew E. Glaser, Matthew B. Curtis, Peter A. Sariano, Zachary A. Rollins, Bhupinder S. Shergill, Aravind Anand, Alyssa M. Deely, Venktesh S. Shirure, Leif Anderson, Jeremy M. Lowen, Natalie R. Ng, Katherine Weilbaecher, Daniel C. Link & Steven C. George. (2022) Organ-on-a-chip model of vascularized human bone marrow niches. Biomaterials 280, pages 121245.
Crossref
Emmanuel C. Asante, Nikitha K. Pallegar, Alicia M. Viloria-Petit & Sherri L. Christian. 2022. Cancer Cell Biology. Cancer Cell Biology 69 77 .
Rhiannon David, Sarah Gee, Kainat Khan, Amy Wilson & Ann Doherty. (2021) Three dimensional and microphysiological bone marrow models detect in vivo positive compounds. Scientific Reports 11:1.
Crossref
Andrés García-García, Thibaut KleinGordian BornMorgane HilpertArnaud Scherberich, Claudia LengerkeRadek C. SkodaPaul E. Bourgine & Ivan Martin. (2021) Culturing patient-derived malignant hematopoietic stem cells in engineered and fully humanized 3D niches. Proceedings of the National Academy of Sciences 118:40.
Crossref
Teresa Franchi-Mendes, Rodrigo Eduardo, Giacomo Domenici & Catarina Brito. (2021) 3D Cancer Models: Depicting Cellular Crosstalk within the Tumour Microenvironment. Cancers 13:18, pages 4610.
Crossref
Chandralekha Chatterjee, Peter Schertl, Miriam Frommer, Anita Ludwig-Husemann, Anna Mohra, Nadine Dilger, Toufik Naolou, Sophia Meermeyer, Timna Claire Bergmann, Alejandro Alonso Calleja & Cornelia Lee-Thedieck. (2021) Rebuilding the hematopoietic stem cell niche: Recent developments and future prospects. Acta Biomaterialia 132, pages 129-148.
Crossref
Yoonhee Bae, Chanyang Joo, Kyoung Hwan Park, Sun-Woong Kang, Kang Moo Huh & Joon Sig Choi. (2021) Preparation and characterization of 3D human glioblastoma spheroids using an N-octanoyl glycol chitosan hydrogel. International Journal of Biological Macromolecules 185, pages 87-97.
Crossref
Ali Golchin, Sina Farzaneh, Bahareh Porjabbar, Fatemeh Sadegian, Masoumeh Estaji, Parviz Ranjbarvan, Mohammad Kanafimahbob, Javad Ranjbari, Nasim Salehi-Nik & Simzar Hosseinzadeh. (2021) Regenerative Medicine Under the Control of 3D Scaffolds: Current State and Progress of Tissue Scaffolds. Current Stem Cell Research & Therapy 16:2, pages 209-229.
Crossref
Cristina Scielzo & Paolo Ghia. (2020) Modeling the Leukemia Microenviroment In Vitro. Frontiers in Oncology 10.
Crossref
Dasharatham Janagama & Susanta K. Hui. (2020) 3-D Cell Culture Systems in Bone Marrow Tissue and Organoid Engineering, and BM Phantoms as In Vitro Models of Hematological Cancer Therapeutics—A Review. Materials 13:24, pages 5609.
Crossref
Tomonori Harada, Isao Tsuboi, Mizuki Utsunomiya, Masahiro Yasuda & Shin Aizawa. (2020) Kinetics of leukemic cells in 3D culture with stromal cells and with arginine deprivation stress. Journal of Bioscience and Bioengineering 130:6, pages 650-658.
Crossref
D.G.J. Cucchi, R.W.J. Groen, J.J.W.M. Janssen & J. Cloos. (2020) Ex vivo cultures and drug testing of primary acute myeloid leukemia samples: Current techniques and implications for experimental design and outcome. Drug Resistance Updates 53, pages 100730.
Crossref
Kamil Wierzchowski, Iwona Grabowska & Maciej Pilarek. (2020) Efficient propagation of suspended HL-60 cells in a disposable bioreactor supporting wave-induced agitation at various Reynolds number. Bioprocess and Biosystems Engineering 43:11, pages 1973-1985.
Crossref
Marco V. Haselager, Arnon P. Kater & Eric Eldering. (2020) Proliferative Signals in Chronic Lymphocytic Leukemia; What Are We Missing?. Frontiers in Oncology 10.
Crossref
Le-Ping Yan, Irene Mencía Castaño, Rukmani Sridharan, Domhnall Kelly, Mark Lemoine, Brenton L. Cavanagh, Nicholas J. Dunne, Helen O. McCarthy & Fergal J. O'Brien. (2020) Collagen/GAG scaffolds activated by RALA-siMMP-9 complexes with potential for improved diabetic foot ulcer healing. Materials Science and Engineering: C 114, pages 111022.
Crossref
Ashley K. Nguyen & Kristopher A. Kilian. (2020) Physicochemical Tools for Visualizing and Quantifying Cell-Generated Forces. ACS Chemical Biology 15:7, pages 1731-1746.
Crossref
Margaux Deynoux, Nicola Sunter, Elfi Ducrocq, Hassan Dakik, Roseline Guibon, Julien Burlaud-Gaillard, Lucie Brisson, Florence Rouleux-Bonnin, Louis-Romée le Nail, Olivier Hérault, Jorge Domenech, Philippe Roingeard, Gaëlle Fromont & Frédéric Mazurier. (2020) A comparative study of the capacity of mesenchymal stromal cell lines to form spheroids. PLOS ONE 15:6, pages e0225485.
Crossref
Sukhraj Pal S. Dhami, Andrea Tirincsi, Denis Baev, Janusz Krawczyk, John Quinn, Mary R. Cahill, Dimitrios Zeugolis & Eva Szegezdi. (2020) Theranostic drug test incorporating the bone‐marrow microenvironment can predict the clinical response of acute myeloid leukaemia to chemotherapy. British Journal of Haematology 189:6.
Crossref
Aurimas Stulpinas, Aušra Imbrasaitė, Natalija Krestnikova & Audronė Valerija Kalvelytė. 2020. Tumor Progression and Metastasis. Tumor Progression and Metastasis.
Miguel Mateu-Sanz, Juan Tornín, Bénédicte Brulin, Anna Khlyustova, Maria-Pau Ginebra, Pierre Layrolle & Cristina Canal. (2020) Cold Plasma-Treated Ringer’s Saline: A Weapon to Target Osteosarcoma. Cancers 12:1, pages 227.
Crossref
Brittany Balhouse, Jill Ivey, Zerin M. Khan & Scott S. Verbridge. 2020. Three-Dimensional Microfabrication Using Two-Photon Polymerization. Three-Dimensional Microfabrication Using Two-Photon Polymerization 625 670 .
Nikitha K. Pallegar & Sherri L. Christian. 2020. Tumor Microenvironment. Tumor Microenvironment 1 13 .
Adeeb Shehzad, Vijaya Ravinayagam, Hamad AlRumaih, Meneerah Aljafary, Dana Almohazey, Sarah Almofty, Noor A. Al-Rashid & Ebtesam A. Al-Suhaimi. (2019) Application of Three-dimensional (3D) Tumor Cell Culture Systems and Mechanism of Drug Resistance. Current Pharmaceutical Design 25:34, pages 3599-3607.
Crossref
Mosfera A. Chowdury, Khalil L. Heileman, Thomas A. Moore & Edmond W.K. Young. (2019) Biomicrofluidic Systems for Hematologic Cancer Research and Clinical Applications. SLAS Technology 24:5, pages 457-476.
Crossref
Justin Ham, Lauren Lever, Maura Fox & Michaela R Reagan. (2019) In Vitro 3D Cultures to Reproduce the Bone Marrow Niche. JBMR Plus 3:10.
Crossref
Xiyuan Lu, Alessia Lodi, Marina Konopleva & Stefano Tiziani. (2019) Three-Dimensional Leukemia Co-Culture System for In Vitro High-Content Metabolomics Screening. SLAS Discovery 24:8, pages 817-828.
Crossref
Donna M. Cartledge Wolf & Sigrid A. Langhans. (2019) Moving Myeloid Leukemia Drug Discovery Into the Third Dimension. Frontiers in Pediatrics 7.
Crossref
Hong Nam Kim, Nicole L. Habbit, Chia‐Yi Su, Nakwon Choi, Eun Hyun Ahn, Elizabeth A. Lipke & Deok‐Ho Kim. (2019) Microphysiological Systems as Enabling Tools for Modeling Complexity in the Tumor Microenvironment and Accelerating Cancer Drug Development. Advanced Functional Materials 29:22, pages 1807553.
Crossref
Antonella Sola, Jessika Bertacchini, Daniele D'Avella, Laura Anselmi, Tullia Maraldi, Sandra Marmiroli & Massimo Messori. (2019) Development of solvent-casting particulate leaching (SCPL) polymer scaffolds as improved three-dimensional supports to mimic the bone marrow niche. Materials Science and Engineering: C 96, pages 153-165.
Crossref
Nikitha K. Pallegar, Chantae J. Garland, Mathepan Mahendralingam, Alicia M. Viloria-Petit & Sherri L. Christian. (2018) A Novel 3-Dimensional Co-culture Method Reveals a Partial Mesenchymal to Epithelial Transition in Breast Cancer Cells Induced by Adipocytes. Journal of Mammary Gland Biology and Neoplasia 24:1, pages 85-97.
Crossref
Alan Chramiec & Gordana Vunjak-Novakovic. (2019) Tissue engineered models of healthy and malignant human bone marrow. Advanced Drug Delivery Reviews 140, pages 78-92.
Crossref
Cassandra Ringuette-Goulet, Stéphane Bolduc & Frédéric Pouliot. (2018) Modeling human bladder cancer. World Journal of Urology 36:11, pages 1759-1766.
Crossref
Mahroo Karimpoor, Eranka IIlangakoon, Alistair G. Reid, Simone Claudiani, Mohan Edirisinghe & Jamshid S. Khorashad. (2018) Development of artificial bone marrow fibre scaffolds to study resistance to anti-leukaemia agents. British Journal of Haematology 182:6, pages 924-927.
Crossref
Mahroo Karimpoor, Eva Yebra-Fernandez, Maryam Parhizkar, Mine Orlu, Duncan Craig, Jamshid S. Khorashad & Mohan Edirisinghe. (2018) Alginate foam-based three-dimensional culture to investigate drug sensitivity in primary leukaemia cells. Journal of The Royal Society Interface 15:141, pages 20170928.
Crossref
Eddy-Tim Verjans, Jordi Doijen, Walter Luyten, Bart Landuyt & Liliane Schoofs. (2018) Three-dimensional cell culture models for anticancer drug screening: Worth the effort?. Journal of Cellular Physiology 233:4, pages 2993-3003.
Crossref
Alessandro Poggi, Serena Varesano & Maria Raffaella Zocchi. (2018) How to Hit Mesenchymal Stromal Cells and Make the Tumor Microenvironment Immunostimulant Rather Than Immunosuppressive. Frontiers in Immunology 9.
Crossref
Marta Pokrywczyńska, Tomasz Kloskowski, Daria Balcerczyk, Monika Buhl, Arkadiusz Jundziłł, Maciej Nowacki, Kaja Męcińska‐Jundziłł & Tomasz Drewa. (2017) Stem cells and differentiated cells differ in their sensitivity to urine in vitro. Journal of Cellular Biochemistry 119:2, pages 2307-2319.
Crossref
Eirini G. Velliou, Eleni Pefani, Susana Brito dos Santos, Maria Fuentes‐Gari, Ruth Misener, Nicki Panoskaltsis, Athanasios Mantalaris, Michael C. Georgiadis & Efstratios N. Pistikopoulos. 2017. Modelling Optimization and Control of Biomedical Systems. Modelling Optimization and Control of Biomedical Systems 233 264 .
Luís P. Ferreira, Vítor M. Gaspar, Rui Henrique, Carmen Jerónimo & João F. Mano. (2017) Mesenchymal Stem Cells Relevance in Multicellular Bioengineered 3D In Vitro Tumor Models. Biotechnology Journal 12:12, pages 1700079.
Crossref
Rachael A. Wyatt, Nhu P. V. Trieu & Bryan D. Crawford. (2017) Zebrafish Xenograft: An Evolutionary Experiment in Tumour Biology. Genes 8:9, pages 220.
Crossref
Patrick Aouad, Melody Saikali, Rana Abdel-Samad, Sabreen Fostok, Leeanna El-Houjeiri, Claudio Pisano, Rabih Talhouk & Nadine Darwiche. (2017) Antitumor activities of the synthetic retinoid ST1926 in two-dimensional and three-dimensional human breast cancer models. Anti-Cancer Drugs 28:7, pages 757-770.
Crossref
Brile Chung, Ali A. Esmaeili, Sailesh Gopalakrishna-Pillai, John P. Murad, Emily S. Andersen, Naveen Kumar Reddy, Gayathri Srinivasan, Brian Armstrong, Caleb Chu, Young Kim, Tommy Tong, James Waisman, John H. Yim, Behnam Badie & Peter P. Lee. (2017) Human brain metastatic stroma attracts breast cancer cells via chemokines CXCL16 and CXCL12. npj Breast Cancer 3:1.
Crossref
Mohammad HoushmandMasoud SoleimaniAmir AtashiGiuseppe SaglioMohammad AbdollahiMahin Nikougoftar Zarif. (2017) Mimicking the Acute Myeloid Leukemia Niche for Molecular Study and Drug Screening. Tissue Engineering Part C: Methods 23:2, pages 72-85.
Crossref
Yong Yang, Kai Wang, Xiaosong Gu & Kam W. Leong. (2017) Biophysical Regulation of Cell Behavior—Cross Talk between Substrate Stiffness and Nanotopography. Engineering 3:1, pages 36-54.
Crossref
Helen C. Owen, Sandra Appiah, Noor Hasan, Lucy Ghali, Ghada Elayat & Celia Bell. 2017. Neurobiology of Chinese Herb Medicine. Neurobiology of Chinese Herb Medicine 249 278 .
B.A. Pereira, N.L. Lister, E.M. De-Juan-Pardo, G.P. Risbridger & S.J. Ellem. 2017. Comprehensive Biomaterials II. Comprehensive Biomaterials II 303 328 .
Peter Horvath, Nathalie Aulner, Marc Bickle, Anthony M. Davies, Elaine Del Nery, Daniel Ebner, Maria C. Montoya, Päivi Östling, Vilja Pietiäinen, Leo S. Price, Spencer L. Shorte, Gerardo Turcatti, Carina von Schantz & Neil O. Carragher. (2016) Screening out irrelevant cell-based models of disease. Nature Reviews Drug Discovery 15:11, pages 751-769.
Crossref
Sukhraj Pal S. Dhami, Shanthi S. Kappala, Alexander Thompson & Eva Szegezdi. (2016) Three-dimensional ex vivo co-culture models of the leukaemic bone marrow niche for functional drug testing. Drug Discovery Today 21:9, pages 1464-1471.
Crossref
Agua Sobrino, Duc T. T. Phan, Rupsa Datta, Xiaolin Wang, Stephanie J. Hachey, Mónica Romero-López, Enrico Gratton, Abraham P. Lee, Steven C. George & Christopher C. W. Hughes. (2016) 3D microtumors in vitro supported by perfused vascular networks. Scientific Reports 6:1.
Crossref
D Pal, H J Blair, A Elder, K Dormon, K J Rennie, D J L Coleman, J Weiland, K S Rankin, A Filby, O Heidenreich & J Vormoor. (2016) Long-term in vitro maintenance of clonal abundance and leukaemia-initiating potential in acute lymphoblastic leukaemia. Leukemia 30:8, pages 1691-1700.
Crossref
Michaël Barbier, Steffen Jaensch, Frans Cornelissen, Suzana Vidic, Kjersti Gjerde, Ronald de Hoogt, Ralph Graeser, Emmanuel Gustin & Yolanda T. Chong. (2016) Ellipsoid Segmentation Model for Analyzing Light-Attenuated 3D Confocal Image Stacks of Fluorescent Multi-Cellular Spheroids. PLOS ONE 11:6, pages e0156942.
Crossref
Andrew Goodspeed, Laura M. Heiser, Joe W. Gray & James C. Costello. (2016) Tumor-Derived Cell Lines as Molecular Models of Cancer Pharmacogenomics. Molecular Cancer Research 14:1, pages 3-13.
Crossref
Suil Shin, Muhammad Ikram, Fazli Subhan, Hae Yeong Kang, Yeseon Lim, Rira Lee, Songwan Jin, Young Hun Jeong, Jong-Young Kwak, Yong-Jin Na & Sik Yoon. (2016) Alginate–marine collagen–agarose composite hydrogels as matrices for biomimetic 3D cell spheroid formation. RSC Advances 6:52, pages 46952-46965.
Crossref
Brittany Balhouse, Jill Ivey & Scott S. Verbridge. 2016. Three-Dimensional Microfabrication Using Two-photon Polymerization. Three-Dimensional Microfabrication Using Two-photon Polymerization 417 445 .
Allison Bruce, Rebecca Evans, Ryan Mezan, Lin Shi, Blake S. Moses, Karen H. Martin, Laura F. Gibson & Yong Yang. (2015) Three-Dimensional Microfluidic Tri-Culture Model of the Bone Marrow Microenvironment for Study of Acute Lymphoblastic Leukemia. PLOS ONE 10:10, pages e0140506.
Crossref
Megan C. Cox, Laura M. Reese, Lissett R. Bickford & Scott S. Verbridge. (2015) Toward the Broad Adoption of 3D Tumor Models in the Cancer Drug Pipeline. ACS Biomaterials Science & Engineering 1:10, pages 877-894.
Crossref
Guanqun Li, Xujun Liu, Qian Du, Mei Gao & Jing An. (2015) Three dimensional de novo micro bone marrow and its versatile application in drug screening and regenerative medicine . Experimental Biology and Medicine 240:8, pages 1029-1038.
Crossref
Eirini G. Velliou, Susana Brito Dos Santos, Maria M. Papathanasiou, Maria Fuentes-Gari, Ruth Misener, Nicki Panoskaltsis, Efstratios N. Pistikopoulos & Athanasios Mantalaris. (2015) Towards unravelling the kinetics of an acute myeloid leukaemia model system under oxidative and starvation stress: a comparison between two- and three-dimensional cultures. Bioprocess and Biosystems Engineering 38:8, pages 1589-1600.
Crossref
Kambez H. BenamStephanie Dauth, Bryan Hassell, Anna HerlandAbhishek JainKyung-Jin JangKatia Karalis, Hyun Jung KimLuke MacQueen, Roza Mahmoodian, Samira MusahYu-suke TorisawaAndries D. van der MeerRemi VillenaveMoran Yadid, Kevin K. Parker & Donald E. Ingber. (2015) Engineered In Vitro Disease Models. Annual Review of Pathology: Mechanisms of Disease 10:1, pages 195-262.
Crossref
Jennifer L. Wilding & Walter F. Bodmer. (2014) Cancer Cell Lines for Drug Discovery and Development. Cancer Research 74:9, pages 2377-2384.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.