Advanced search
Publication Cover
Leukemia & Lymphoma Volume 56, 2015 - Issue 12
Submit an article Journal homepage
293
Views
25
CrossRef citations to date
0
Altmetric
Original Articles: Clinical

Obatoclax in combination with fludarabine and rituximab is well-tolerated and shows promising clinical activity in relapsed chronic lymphocytic leukemia

Jennifer R. BrownDepartment of Medical Oncology, Boston, MA, USA;Department of Medicine, Harvard Medical School, Boston, MA, USACorrespondence[email protected]
,
Bethany TesarDepartment of Medical Oncology, Boston, MA, USA;Department of Medicine, Harvard Medical School, Boston, MA, USA
,
Lijian YuDepartment of Medical Oncology, Boston, MA, USA;Department of Medicine, Harvard Medical School, Boston, MA, USA
,
Lillian WernerDepartment of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA
,
Naoko TakebeInvestigational Drug Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
,
Evgeny MiklerDepartment of Medical Oncology, Boston, MA, USA
,
Hazel M. ReynoldsDepartment of Medical Oncology, Boston, MA, USA
,
Christina ThompsonDepartment of Medical Oncology, Boston, MA, USA
,
David C. FisherDepartment of Medical Oncology, Boston, MA, USA;Department of Medicine, Harvard Medical School, Boston, MA, USA
,
Donna NeubergDepartment of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA
&
A. S. FreedmanDepartment of Medical Oncology, Boston, MA, USA;Department of Medicine, Harvard Medical School, Boston, MA, USA
 show all
Pages 3336-3342 | Received 31 Dec 2014, Accepted 12 Apr 2015, Published online: 18 Jun 2015

Citations (25)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Binli Mao, Vu Thuy Khanh Le-Trilling, Kai Wang, Denise Mennerich, Jie Hu, Zhenyu Zhao, Jiaxin Zheng, Yingying Deng, Benjamin Katschinski, Shilei Xu, Guiji Zhang, Xuefei Cai, Yuan Hu, Jianwei Wang, Mengji Lu, Ailong Huang, Ni Tang, Mirko Trilling & Yong Lin. (2022) Obatoclax inhibits SARS-CoV-2 entry by altered endosomal acidification and impaired cathepsin and furin activity in vitro. Emerging Microbes & Infections 11:1, pages 483-497.
Read now
Elisa Tomat. (2016) Coordination Chemistry of Linear Tripyrroles: Promises and Perils. Comments on Inorganic Chemistry 36:6, pages 327-342.
Read now

Articles from other publishers (23)

Arnab Sarkar, Abhik Paul, Tanmoy Banerjee, Avik Maji, Sanjukta Saha, Anupam Bishayee & Tapan Kumar Maity. (2023) Therapeutic advancements in targeting BCL-2 family proteins by epigenetic regulators, natural, and synthetic agents in cancer. European Journal of Pharmacology 944, pages 175588.
Crossref
Jennifer K. Lue & Owen A. O'Connor. 2023. Precision Cancer Therapies, Volume 1 ‐ Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies. Precision Cancer Therapies, Volume 1 ‐ Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies 151 164 .
Peishan Li, Shufen He, Xuejiao Zhang, Qi Gao, Yanan Liu & Liwei Liu. (2022) Structures, biosynthesis, and bioactivities of prodiginine natural products. Applied Microbiology and Biotechnology 106:23, pages 7721-7735.
Crossref
Haiming Dai, X. Wei Meng, Kaiqin Ye, Jia Jia & Scott H. Kaufmann. 2022. Mechanisms of Cell Death and Opportunities for Therapeutic Development. Mechanisms of Cell Death and Opportunities for Therapeutic Development 197 260 .
Jingye Li, Jinrong Xu & Zhibing Li. (2021) Obatoclax, the pan-Bcl-2 inhibitor sensitizes hepatocellular carcinoma cells to promote the anti-tumor efficacy in combination with immune checkpoint blockade. Translational Oncology 14:8, pages 101116.
Crossref
Xue Li, Junwei Dou, Qidong You & Zhengyu Jiang. (2021) Inhibitors of BCL2A1/Bfl-1 protein: Potential stock in cancer therapy. European Journal of Medicinal Chemistry 220, pages 113539.
Crossref
Linlin Zhang, Zaiming Lu & Xiangxuan Zhao. (2021) Targeting Bcl-2 for cancer therapy. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1876:1, pages 188569.
Crossref
Lena Berning, David Schlütermann, Annabelle Friedrich, Niklas Berleth, Yadong Sun, Wenxian Wu, María José Mendiburo, Jana Deitersen, Hannah U. C. Brass, Margaretha A. Skowron, Michèle J. Hoffmann, Günter Niegisch, Jörg Pietruszka & Björn Stork. (2021) Prodigiosin Sensitizes Sensitive and Resistant Urothelial Carcinoma Cells to Cisplatin Treatment. Molecules 26:5, pages 1294.
Crossref
Finny Varghese, Esther van Woudenbergh, Gijs Overheul, Marc Eleveld, Lisa Kurver, Niels van Heerbeek, Arjan van Laarhoven, Pascal Miesen, Gerco den Hartog, Marien de Jonge & Ronald van Rij. (2021) Berberine and Obatoclax Inhibit SARS-Cov-2 Replication in Primary Human Nasal Epithelial Cells In Vitro. Viruses 13:2, pages 282.
Crossref
Magdalena Klanova & Pavel Klener. (2020) BCL-2 Proteins in Pathogenesis and Therapy of B-Cell Non-Hodgkin Lymphomas. Cancers 12:4, pages 938.
Crossref
Natalie Yan Li Ngoi, Clarice Choong, Joanne Lee, Gregory Bellot, Andrea LA Wong, Boon Cher Goh & Shazib Pervaiz. (2020) Targeting Mitochondrial Apoptosis to Overcome Treatment Resistance in Cancer. Cancers 12:3, pages 574.
Crossref
Nikolay V. Pervushin, Viacheslav V. Senichkin, Boris Zhivotovsky & Gelina S. Kopeina. 2020. Cell Death Regulation in Health and Disease - Part A. Cell Death Regulation in Health and Disease - Part A 23 55 .
Mei Lan Tan, Shahrul Bariyah Sahul Hamid, Muhammad Asyraf Abduraman & Heng Kean Tan. 2020. Cancer Immunology. Cancer Immunology 307 353 .
Adam S. Kittai & Jennifer A. Woyach. (2019) Resistance Mechanisms to Targeted Agents in Chronic Lymphocytic Leukemia. The Cancer Journal 25:6, pages 428-435.
Crossref
Vasanti Suvarna, Vikas Singh & Manikanta Murahari. (2019) Current overview on the clinical update of Bcl-2 anti-apoptotic inhibitors for cancer therapy. European Journal of Pharmacology 862, pages 172655.
Crossref
Fevzi F. Yalniz & William G. Wierda. (2019) Targeting BCL2 in Chronic Lymphocytic Leukemia and Other Hematologic Malignancies. Drugs 79:12, pages 1287-1304.
Crossref
Rebecca Valentin, Stephanie Grabow & Matthew S. Davids. (2018) The rise of apoptosis: targeting apoptosis in hematologic malignancies. Blood 132:12, pages 1248-1264.
Crossref
Yichao Wan, Ningning Dai, Zilong Tang & Hao Fang. (2018) Small-molecule Mcl-1 inhibitors: Emerging anti-tumor agents. European Journal of Medicinal Chemistry 146, pages 471-482.
Crossref
Erika A.K. Fletcher, Mohamed Eltahir, Frida Lindqvist, Jonas Rieth, Gunilla Törnqvist, Justyna Leja-Jarblad & Sara M. Mangsbo. (2018) Extracorporeal human whole blood in motion, as a tool to predict first-infusion reactions and mechanism-of-action of immunotherapeutics. International Immunopharmacology 54, pages 1-11.
Crossref
Matthew S. Davids. (2017) Targeting BCL-2 in B-cell lymphomas. Blood 130:9, pages 1081-1088.
Crossref
Benjamin L. Lampson & Matthew S. Davids. (2017) The Development and Current Use of BCL-2 Inhibitors for the Treatment of Chronic Lymphocytic Leukemia. Current Hematologic Malignancy Reports 12:1, pages 11-19.
Crossref
Taira Maekawa. 2017. Chemotherapy for Leukemia. Chemotherapy for Leukemia 343 361 .
Mingping Wang, Wei Tian, Chongqing Wang, Shihai Lu, Chao Yang, Juan Wang, Yunlong Song, Youjun Zhou, Ju Zhu, Zhiyu Li & Canhui Zheng. (2016) Design, synthesis, and activity evaluation of selective inhibitors of anti-apoptotic Bcl-2 proteins: The effects on the selectivity of the P1 pockets in the active sites. Bioorganic & Medicinal Chemistry Letters 26:21, pages 5207-5211.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.