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Leukemia & Lymphoma Volume 19, 1995 - Issue 1-2
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Original Article

A Controlled Trial of Tranexamic Acid Therapy for the Reduction of Bleeding During Treatment of Acute Myeloid Leukemia

O. Shpilberg The Institute of Hematology, Department of Hematology, Hadassah University Hospital, Jerusalem
,
R. Blumenthal The Institute of Hematology, Department of Hematology, Hadassah University Hospital, Jerusalem
,
O. Sofer The Institute of Hematology, Department of Hematology, Hadassah University Hospital, Jerusalem
,
Y. Katz The Institute of Hematology, Department of Hematology, Hadassah University Hospital, Jerusalem
,
A. Chetrit The Institute of Hematology, Department of Clinical Epidemiology, The Chaim Sheba Medical Center, Tel-Hashomer and Sackler School of Medicine. Tel-Aviv University, Jerusalem
,
B. Ramot The Institute of Hematology, Department of Hematology, Hadassah University Hospital, Jerusalem
,
A. Eldor The Institute of Hematology, Department of Hematology, Hadassah University Hospital, Jerusalem
&
I. Ben-Bassat
 show all
Pages 141-144 | Received 25 Nov 1994, Published online: 01 Jul 2009

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Stamatis J. Karakatsanis, Stamatis S. Papadatos & Konstantinos N. Syrigos. (2019) Hypoplastic thrombocytopenia and platelet transfusion: therapeutic goals. Hospital Practice 47:1, pages 16-23.
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Joan Cid & Miguel Lozano. (2010) Platelet dose for prophylactic platelet transfusions. Expert Review of Hematology 3:4, pages 397-400.
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Articles from other publishers (41)

Søren Thorgaard Bønløkke, Marianne Tang Severinsen, Hans Beier Ommen, Christian Fenger Eriksen & Anne‐Mette Hvas. (2023) Prophylaxis with low dose tranexamic acid in acute myeloid leukemia patients undergoing intensive chemotherapy. eJHaem 4:3, pages 690-694.
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Anton Ilich, Terry B. Gernsheimer, Darrell J. Triulzi, Heather Herren, Siobhan P. Brown, Lori A. Holle, Andrew T. Lucas, Bas de Laat, Nahed El Kassar, Alisa S. Wolberg, Susanne May & Nigel S. Key. (2023) Absence of hyperfibrinolysis may explain lack of efficacy of tranexamic acid in hypoproliferative thrombocytopenia. Blood Advances 7:6, pages 900-908.
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Jeffrey I. Zwicker. (2022) Tranexamic acid as a stopgap for low platelets?. Blood 140:11, pages 1185-1186.
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Christopher S. Graffeo, Lucas P. Carlstrom, Salomon Cohen Cohen, Avital Perry, Garret Choby & Jamie J. Van Gompel. (2021) Perioperative Tranexamic Acid for ACTH-Secreting Pituitary Adenomas: Implementation Protocol Results and Trial Prospectus. World Neurosurgery 153, pages e359-e364.
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Nicole Relke, Nicholas L.J. Chornenki & Michelle Sholzberg. (2021) Tranexamic acid evidence and controversies: An illustrated review. Research and Practice in Thrombosis and Haemostasis 5:5, pages e12546.
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Avi Leader, Liron Hofstetter & Galia Spectre. (2021) Challenges and Advances in Managing Thrombocytopenic Cancer Patients. Journal of Clinical Medicine 10:6, pages 1169.
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Darrell J. Triulzi. (2020) How well do platelets prevent bleeding?. Hematology 2020:1, pages 518-522.
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Tzu‐Fei Wang, Robert S. Makar, Darko Antic, Jerrold H. Levy, James D. Douketis, Jean M. Connors, Marc Carrier & Jeffrey I. Zwicker. (2020) Management of hemostatic complications in acute leukemia: Guidance from the SSC of the ISTH. Journal of Thrombosis and Haemostasis 18:12, pages 3174-3183.
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Johnny Cai, Jessica Ribkoff, Sven Olson, Vikram Raghunathan, Hanny Al‐Samkari, Thomas G. DeLoughery & Joseph J. Shatzel. (2019) The many roles of tranexamic acid: An overview of the clinical indications for TXA in medical and surgical patients. European Journal of Haematology 104:2, pages 79-87.
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Nikita Mehra & Venkatraman Radhakrishnan. (2020) Tranexamic acid-induced acute renal failure in a pediatric patient with acute myeloid leukemia: A cautionary note. Cancer Research, Statistics, and Treatment 3:3, pages 634.
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Lise J. Estcourt, Zoe McQuilten, Gillian Powter, Claire Dyer, Eleanor Curnow, Erica M. Wood & Simon J. Stanworth. (2019) The TREATT Trial (TRial to EvaluAte Tranexamic acid therapy in Thrombocytopenia): safety and efficacy of tranexamic acid in patients with haematological malignancies with severe thrombocytopenia: study protocol for a double-blind randomised controlled trial. Trials 20:1.
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Nicholas L. Jackson Chornenki, Kevin J. Um, Pablo A. Mendoza, Ashkan Samienezhad, Vidushi Swarup, Chatree Chai-Adisaksopha & Deborah M. Siegal. (2019) Risk of venous and arterial thrombosis in non-surgical patients receiving systemic tranexamic acid: A systematic review and meta-analysis. Thrombosis Research 179, pages 81-86.
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Martina C. Murphy & Harvey G. Klein. 2019. Consultative Hemostasis and Thrombosis. Consultative Hemostasis and Thrombosis 540 572 .
Joshua Montroy, Nicholas A Fergusson, Brian Hutton, Luke T Lavallée, Chris Morash, Ilias Cagiannos, Sonya Cnossen, Dean A Fergusson & Rodney H Breau. (2017) The Safety and Efficacy of Lysine Analogues in Cancer Patients: A Systematic Review and Meta-Analysis. Transfusion Medicine Reviews 31:3, pages 141-148.
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Ariela Marshall, Ang Li, Adrienne Drucker & Walter Dzik. (2016) Aminocaproic acid use in hospitalized patients with hematological malignancy: a case series. Hematological Oncology 34:3, pages 147-153.
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Gemma L. Crighton, Lise J. Estcourt, Erica M. Wood & Simon J. Stanworth. (2016) Platelet Transfusions in Patients with Hypoproliferative Thrombocytopenia. Hematology/Oncology Clinics of North America 30:3, pages 541-560.
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Lise J Estcourt, Patricia M Fortin, Marialena Trivella & Sally Hopewell. (2016) Preoperative blood transfusions for sickle cell disease. Cochrane Database of Systematic Reviews.
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Lise J Estcourt, Michael Desborough, Susan J Brunskill, Carolyn Doree, Sally Hopewell, Michael F Murphy & Simon J Stanworth. (2016) Antifibrinolytics (lysine analogues) for the prevention of bleeding in people with haematological disorders. Cochrane Database of Systematic Reviews.
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M. Lozano & J. Cid. (2016) Alternative strategies to platelet transfusion. ISBT Science Series 11:S1, pages 93-99.
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Arturo J Martí-Carvajal, Vidhu Anand & Ivan Solà. (2015) Treatment for disseminated intravascular coagulation in patients with acute and chronic leukemia. Cochrane Database of Systematic Reviews.
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Arturo J Martí-Carvajal, Vidhu Anand & Ivan Solà. (2015) Janus kinase-1 and Janus kinase-2 inhibitors for treating myelofibrosis. Cochrane Database of Systematic Reviews.
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Howard A. Liebman. (2014) Thrombocytopenia in cancer patients. Thrombosis Research 133, pages S63-S69.
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. 2014. Mollison's Blood Transfusion in Clinical Medicine. Mollison's Blood Transfusion in Clinical Medicine 800 845 .
Douglas Wardrop, Lise J Estcourt, Susan J Brunskill, Carolyn Doree, Marialena Trivella, Simon Stanworth & Michael F Murphy. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Osama A. Albirmawy, Magdy E. Saafan, Emad M. Shehata, Ahmed S. Basuni & Ahmed A. Eldaba. (2013) Topical application of tranexamic acid after adenoidectomy: A double-blind, prospective, randomized, controlled study. International Journal of Pediatric Otorhinolaryngology 77:7, pages 1139-1142.
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Charles D. Bolan & Harvey G. Klein. 2013. Consultative Hemostasis and Thrombosis. Consultative Hemostasis and Thrombosis 496 525 .
Douglas Wardrop, Lise Estcourt, Carolyn Doree, Sally Hopewell, Susan J Brunskill, Simon Stanworth & Michael F Murphy. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Scott E. Lentz. 2011. Gynecologic Oncology. Gynecologic Oncology 509 537 .
Hartmut DöhnerElihu H. EsteySergio AmadoriFrederick R. AppelbaumThomas BüchnerAlan K. BurnettHervé DombretPierre FenauxDavid GrimwadeRichard A. LarsonFrancesco Lo-CocoTomoki NaoeDietger NiederwieserGert J. OssenkoppeleMiguel A. SanzJorge SierraMartin S. TallmanBob Löwenberg & Clara D. Bloomfield. (2010) Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 115:3, pages 453-474.
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Jaime Pereira. 2009. Coagulation in Cancer. Coagulation in Cancer 305 326 .
Theodore Athanasiadis, Achim G. Beule & Peter J. Wormald. (2018) Effects of Topical Antifibrinolytics in Endoscopic Sinus Surgery: A Pilot Randomized Controlled Trial. American Journal of Rhinology 21:6, pages 737-742.
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Wen-Chi Chou, Chang-Hsien Lu, Gigin Lin, Yu-Shin Hong, Ping-Tsung Chen, Hung-Chih Hsu, Jen-Shi Chen, Kun-Yun Yeh, Hung-Ming Wang & Chuang-Chi Liaw. (2007) Transcutaneous arterial embolization to control massive tumor bleeding in head and neck cancer: 63 patients’ experiences from a single medical center. Supportive Care in Cancer 15:10, pages 1185-1190.
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Charles D. Bolan & Harvey G. Klein. 2007. Consultative Hemostasis and Thrombosis. Consultative Hemostasis and Thrombosis 461 490 .
Nancy Robitaille & Heather A. Hume. 2006. Pediatric Hematology. Pediatric Hematology 691 723 .
. 2005. Mollison's Blood Transfusion in Clinical Medicine. Mollison's Blood Transfusion in Clinical Medicine 810 844 .
Jose Pereira & Tien Phan. (2004) Management of Bleeding in Patients with Advanced Cancer. The Oncologist 9:5, pages 561-570.
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Roger Ladouceur. (2004) Utilisation des antifibrinolytiques pour les saignements : un traitement m?connu. M?decine Palliative : Soins de Support - Accompagnement - ?thique 3:2, pages 71-77.
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. (2003) Guidelines for the use of platelet transfusions. British Journal of Haematology 122:1, pages 10-23.
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M.H. Ellis & Y. Beyth. (1999) Abnormal vaginal bleeding in adolescence as the presenting symptom of a bleeding diathesis. Journal of Pediatric and Adolescent Gynecology 12:3, pages 127-131.
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Barbara Holmes Gobel. (1999) Disseminated intravascular coagulation. Seminars in Oncology Nursing 15:3, pages 174-182.
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Bruno Gagnon, Isabelle Mancini, Jose Pereira & Eduardo Bruera. (2019) Palliative Management of Bleeding Events in Advanced Cancer Patients. Journal of Palliative Care 14:4, pages 50-54.
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