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Leukemia & Lymphoma Volume 23, 1996 - Issue 5-6
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Original Article

Multifactorial Drug-Resistance Phenomenon in Acute Leukemias: Impact of P170-MDR1, LRP56 Protein, Glutathione-Transferases and Metallothionein Systems on Clinical Outcome

Jean E. Goasguen The University of Rennes, Laboratoire d'Hématologie et d'Immunologie, Service d'Hématologie, Service d'Hématologie Pédiatrique, Service de Médecine Interne du Centre Hospitalier et Universitaire de Rennes, France
,
Thierry Lamy The University of Rennes, Laboratoire d'Hématologie et d'Immunologie, Service d'Hématologie, Service d'Hématologie Pédiatrique, Service de Médecine Interne du Centre Hospitalier et Universitaire de Rennes, France
,
Christophe Bergeron The University of Rennes, Laboratoire d'Hématologie et d'Immunologie, Service d'Hématologie, Service d'Hématologie Pédiatrique, Service de Médecine Interne du Centre Hospitalier et Universitaire de Rennes, France
,
Béatrice Ly Sunaram The University of Rennes, Laboratoire d'Hématologie et d'Immunologie, Service d'Hématologie, Service d'Hématologie Pédiatrique, Service de Médecine Interne du Centre Hospitalier et Universitaire de Rennes, France
,
Erwan Mordelet The University of Rennes, Laboratoire d'Hématologie et d'Immunologie, Service d'Hématologie, Service d'Hématologie Pédiatrique, Service de Médecine Interne du Centre Hospitalier et Universitaire de Rennes, France
,
Gilles Gorre The University of Rennes, Laboratoire d'Hématologie et d'Immunologie, Service d'Hématologie, Service d'Hématologie Pédiatrique, Service de Médecine Interne du Centre Hospitalier et Universitaire de Rennes, France
,
Jean-Marc Dossot The University of Rennes, Laboratoire d'Hématologie et d'Immunologie, Service d'Hématologie, Service d'Hématologie Pédiatrique, Service de Médecine Interne du Centre Hospitalier et Universitaire de Rennes, France
,
Edouard Le Gall The University of Rennes, Laboratoire d'Hématologie et d'Immunologie, Service d'Hématologie, Service d'Hématologie Pédiatrique, Service de Médecine Interne du Centre Hospitalier et Universitaire de Rennes, France
,
Bernard Grosbois The University of Rennes, Laboratoire d'Hématologie et d'Immunologie, Service d'Hématologie, Service d'Hématologie Pédiatrique, Service de Médecine Interne du Centre Hospitalier et Universitaire de Rennes, France
,
Pierre-Yves Le PrisÉ The University of Rennes, Laboratoire d'Hématologie et d'Immunologie, Service d'Hématologie, Service d'Hématologie Pédiatrique, Service de Médecine Interne du Centre Hospitalier et Universitaire de Rennes, France
&
Renée Fauchet The University of Rennes, Laboratoire d'Hématologie et d'Immunologie, Service d'Hématologie, Service d'Hématologie Pédiatrique, Service de Médecine Interne du Centre Hospitalier et Universitaire de Rennes, France
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Pages 567-576 | Received 10 Mar 1996, Published online: 01 Jul 2009

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Lm Rimsza, K Campbell, Ws Dalton, S Salmon, G. Willcox & Tm Grogan. (1999) The Major Vault Protein (MVP), a New Multidrug Resistance Associated Protein, is Frequently Expressed in Multiple Myeloma. Leukemia & Lymphoma 34:3-4, pages 315-324.
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Articles from other publishers (16)

Rosanna K. Jackson, Julie A. E. Irving & Gareth J. Veal. (2016) Personalization of dexamethasone therapy in childhood acute lymphoblastic leukaemia. British Journal of Haematology 173:1, pages 13-24.
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Raffaella Franca, Paola Rebora, Giuseppe Basso, Andrea Biondi, Giovanni Cazzaniga, Sergio Crovella, Giuliana DecortiFranca Fagioli, Emanuela Giarin, Franco Locatelli, Vincenzo Poggi, Maria Grazia Valsecchi & Marco Rabusin. (2012) Glutathione S -transferase homozygous deletions and relapse in childhood acute lymphoblastic leukemia: a novel study design in a large Italian AIEOP cohort . Pharmacogenomics 13:16, pages 1905-1916.
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Mikael Herlevsen, Gary Oxford, Charles R. Owens, Mark Conaway & Dan Theodorescu. (2007) Depletion of major vault protein increases doxorubicin sensitivity and nuclear accumulation and disrupts its sequestration in lysosomes. Molecular Cancer Therapeutics 6:6, pages 1804-1813.
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Tomotaka Kobayashi, Tatsuhiro Ishida, Yurie Okada, Saori Ise, Hideyoshi Harashima & Hiroshi Kiwada. (2007) Effect of transferrin receptor-targeted liposomal doxorubicin in P-glycoprotein-mediated drug resistant tumor cells. International Journal of Pharmaceutics 329:1-2, pages 94-102.
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Monique L. den Boer & Rob Pieters. 2010. Childhood Leukemias. Childhood Leukemias 414 438 .
L Moureau-Zabotto, S Ricci, J P Lefranc, F Coulet, C Genestie, M Antoine, S Uzan, J P Lotz, E Touboul & R Lacave. (2006) Prognostic impact of multidrug resistance gene expression on the management of breast cancer in the context of adjuvant therapy based on a series of 171 patients. British Journal of Cancer 94:4, pages 473-480.
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Nathalie Grandgirard, Beatrice Ly-Sunnaram, Dominique Ferrant, Virginie Gandemer, Christine Edan, Edouard Le Gall, Jacques-Phillipe Moulinoux, Emmanuelle Leray & Jean E. Goasguen. (2004) Impact of Topoisomerase II alpha and Spermine on the clinical outcome of children with acute lymphoblastic leukemia. Leukemia Research 28:5, pages 479-486.
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R. Pieters & M. L. den Boer. (2003) Molecular Pharmacodynamics in Childhood Leukemia. International Journal of Hematology 78:5, pages 402-413.
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Marieke H Mossink, Arend van Zon, Rik J Scheper, Pieter Sonneveld & Erik AC Wiemer. (2003) Vaults: a ribonucleoprotein particle involved in drug resistance?. Oncogene 22:47, pages 7458-7467.
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Béatrice Ly Sunnaram, Virginie Gandemer, Martine Sebillot, Nathalie Grandgirard, Laurence Amiot, Emmanuelle Leray & Jean E. Goasguen. (2003) LRP overexpression in monocytic lineage. Leukemia Research 27:8, pages 755-759.
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Maria Ilaria Del Principe, Giovanni Del Poeta, Luca Maurillo, Francesco Buccisano, Adriano Venditti, Anna Tamburini, Antonio Bruno, Maria Christina Cox, Giovanna Suppo, Andrea Tendas, Laura Giannì, Massimiliano Postorino, Mario Masi, Domenico Del Principe & Sergio Amadori. (2003) P-glycoprotein and BCL-2 levels predict outcome in adult acute lymphoblastic leukaemia. British Journal of Haematology 121:5, pages 730-738.
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Daniela Damiani, Angela Michelutti, Mariagrazia Michieli, Paola Masolini, Raffaella Stocchi, Antonella Geromin, Anna Ermacora, Domenico Russo, Renato Fanin & Michele Baccarani. (2002) P-glycoprotein, lung resistance-related protein and multidrug resistance-associated protein in de novo adult acute lymphoblastic leukaemia . British Journal of Haematology 116:3, pages 519-527.
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Pieter Sonneveld & Alan F. List. (2001) Chemotherapy resistance in acute myeloid leukaemia. Best Practice & Research Clinical Haematology 14:1, pages 211-233.
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George L. Scheffer, Anouk B Schroeijers, Miguel A. Izquierdo, Erik A.C. Wiemer & Rik J. Scheper. (2000) Lung resistance-related protein/major vault protein and vaults in multidrug-resistant cancer. Current Opinion in Oncology 12:6, pages 550-556.
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Anton G. Borg, Robert Burgess, Linda M. Green, Rik J. Scheper & John A. Liu Yin. (2002) Overexpression of lung‐resistance protein and increased P‐glycoprotein function in acute myeloid leukaemia cells predict a poor response to chemotherapy and reduced patient survival. British Journal of Haematology 103:4, pages 1083-1091.
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Thierry Lamy, Bernard Drenou, Olivier Fardel, Laurence Amiot, Isabelle Grulois, Pierre-Yves Le Prise, Thomas P. Loughran & Renee Fauchet. (1998) Multidrug resistance analysis in lymphoproliferative disease of large granular lymphocytes. British Journal of Haematology 100:3, pages 509-515.
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