Multifactorial Drug-Resistance Phenomenon in Acute Leukemias: Impact of P170-MDR1, LRP56 Protein, Glutathione-Transferases and Metallothionein Systems on Clinical Outcome

References

• Roninson I. B. The role of the MDR1 (P-glycoprotein) gene in multidrug resistance in vitro and in vivo. Biochem. Pharmacol. 1992; 43: 95
   PubMed Web of Science ®Google Scholar
• Roninson I. B. Molecular and cellular biology of multidrug resistance in tumor cells. Plenum, New York, NY 1991
   Google Scholar
• Van Der Valk P., Van Kalken C. K., Ketelaars H., Broxterman H. J., Scheffer G., Kuiper C. M., Tsuruo T., Lankelma J., Meijer C. J., Pinedo H., Scheper R. Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues. Ann. Oncol. 1990; 1: 56
   PubMed Web of Science ®Google Scholar
• Arceci R. J. Clinical signification of P-glycoprotein in multidrug resistance malignancies. Blood 1993; 81: 2215
   PubMed Web of Science ®Google Scholar
• Goldstein L. J., Galski H., Fojo A., Willingham M., Lai S. L., Gazdar A., Pirker R., Green A., Crist W., Brodeur G. M., Lieber M., Cossman I., Gottesman M., Pastan I. Expression of a multidrug gene in human cancers. J. Natl. Cancer Inst. 1989; 81: 116
   PubMed Web of Science ®Google Scholar
• Schneider J., Bak M., Efferth T., Kaufin M., Mattern J., Volm M. P-glycoprotein expression in treated and untreated human breast cancer. Br. J. Cancer 1989; 60: 815
   PubMed Web of Science ®Google Scholar
• Chan H., Thornet P., Haddad G., Ling V. Immunohisto-chemical detection of P-giycoprotein: Prognostic correlation in soft tissue sarcoma of childhood. J. Clin. Oncol. 1990; 8: 689
   PubMed Web of Science ®Google Scholar
• Bourhis J., Benard J., Hartmann O., Boccon G. L., Lemerle J., Riou G. Correlation of MDR1 gene expression with chemotherapy in neuroblastoma. J. Natl. Cancer Inst. 1989; 81: 1401
   PubMed Web of Science ®Google Scholar
• Sato H., Gottesman M. M., Goldstein L. J., Pastan I., Block A. M., Sandberg A. A., Preisler H. D. Expression of the multidrug resistance gene in Myeloid leukemias. Leuk. Res. 1990; 14: 11
   PubMed Web of Science ®Google Scholar
• Sato H., Preisler H., Day R., Raza A., Larson R., Browman G., Goldberg J., Vogler R., Grunwald H., Gottlieb A., Bennett L., Gottesman M., Pastan I. MDR1 transcript levels as an indication of resistant disease in acute myelogenous leukemia. Br. J. Haematol. 1990; 75: 340
   PubMed Web of Science ®Google Scholar
• Musto P., Melillo L., Lombardi G., Matera R., Di Giorgio G., Carotenuto M. High risk of early resistant relapse for leukaemic patients with presence of multidrug resistance associated P-glycoprotein positive cells in complete remission. Br. J. Haematol. 1991; 77: 50
   PubMed Web of Science ®Google Scholar
• Pirker R., Wallner J., Geissler K., Linkesch W., Hass O. A., Bettelheim P., Hopjner M., Scherrer R., Valent P., Havelec L., Ludwig H., Lechner K. MDR1 gene expression and treatment outcome in acute myeloid leukemia. J. Natl. Cancer Inst. 1991; 83: 708
   PubMed Web of Science ®Google Scholar
• Campos L., Guoytat D., Archimbaud E., Calmard O. P., Tsuruo T., Troncy J., Treille D., Fiere D. Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlym-phoblastic leukemia cells at diagnosis. Blood 1992; 79: 473
   PubMed Web of Science ®Google Scholar
• Marie J.-P., Zittoun R., Sikic B. I. Multidrug resistance (mdr1) gene expression in adult acute leukemias: Correlations with treatment outcome and in vitro drug sensitivity. Blood 1991; 78: 586
   PubMed Web of Science ®Google Scholar
• Rottenberg M. L., Mickley L. A., Cole D. E., Balis F. M., Tsuruo T., Poplack D. G., Fojo A. T. Expression of the mdr4/P-170 gene in patients with acute lymphoblastic leukemia. Blood 1989; 74: 1388
   PubMed Web of Science ®Google Scholar
• Pieters R., Hongo T., Loonen A. H., Huismans D. R., Browterman H. J., Halhlen K., Veerman A. J. P. Different types of non-P-glycoprotein mediated multiple drug resistance in children with relapsed acute lymphoblastic leukemia. Br. J. Cancer 1992; 65: 691
   PubMed Web of Science ®Google Scholar
• Goasguen J. E., Dossot J.-M., Fardel O., Le Mee F., Le Gall E., Leblay R., Le Prise P. Y., Chaperon J., Fauchet R. Expression of the multidrug resistance-associated P-glycoprotein (P-170) in 59 cases of de novo acute lymphoblastic leukemia: prognostic implications. Blood 1993; 81: 2394
   PubMed Web of Science ®Google Scholar
• Beck W. T., Cirtain M. C., Danks M. K., Fested R. L., Sara A. R., Wolverton J. S., Suttle D. P., Trent J. M. Pharmacological, molecular and cytogenetic analysis of “atypical” multidrug-resistant human leukemic cells. Cancer Res. 1987; 47: 5455
   PubMed Web of Science ®Google Scholar
• Baas F., Jongsma A. P., Broxterman H. J., Arceci R. J., Housman D., Scheffer G. L., Reithorst A., Van Groenigen M., Nieuwint A. W., Joenje H. Non-P-glycoprotein mediated mechanism for multidrug resitance precedes P-glycoprotein expression during during in vitro selection for doxorubicin resistance in a human lung cancer cell line. Cancer Res. 1990; 50: 5392
   PubMed Web of Science ®Google Scholar
• Kramer R. A., Zakher J., Kim G. Role of the glutathione redox cyle in acquired and de novo multidrug resistance. Science 1988; 241: 694
   PubMed Web of Science ®Google Scholar
• Lutzky J., Astor M. B., Taub R. N., Baker M. A., Bhalla K., Gervasoni J. E., Rosado M., Stewart V., Krishna S., Hindenburg A. Role of glutathione and dependant enzymes in anthracycline-resistant HL60/AR cells. Cancer Research 1989; 49: 4120
   PubMed Web of Science ®Google Scholar
• Nakagawa K., Saijo N., Tsuchida S., Sakai M., Tsunokawa Y., Yokota J., Muramatsu M., Sato K., Terada M., Tew K. D. Glutathione S-transferase π as a determinant of drug resistance in transfectant cell lines. J. Biol. Chem. 1990; 265: 4296
   PubMed Web of Science ®Google Scholar
• Tidefelt U., Elmhorm-Rosenborg A., Paul C., Hao X. Y., Mannervick B., Erickson L. C. Expression of glutathione transferase π as a predictor for treatment results at different stages of acute nonlymphoblastique leukemia. Cancer Reasearch 1992; 52: 3281
   PubMed Web of Science ®Google Scholar
• Bakka A., Entiresen L., Johnsen A. B. S., Edminson P. D., Rugstad H. E. Resistance against cis-dichlorodiamineplatinium in cultered cells with a high content of metallothionein. Toxicol. Appl. Pharmacol. 1981; 61: 215
   PubMed Web of Science ®Google Scholar
• Kelley S. L., Basu A., Teicher B. A., Hacker M. P., Hamer D. H., Lazo J. S. Overexpression of metallothionein confers resistance to anticancer drugs. Science 1988; 241: 1813
   PubMed Web of Science ®Google Scholar
• Scheper R. J., Broxterman H. J., Sceffer G. L., Kaaijk P., Dalton W. S., Van Heijningen T. H. M., Van Kalken C. K., Slovak M. L., De Vries E. G. E., Van Der Valk P., Meijer C. J. L. M., Pinedo H. M. Overexpression of a Mr 110,000 vesicular-protein in non-P-glycoprotein-mediated multidrug resistance. Cancer Research 1993; 53: 1475
   PubMed Web of Science ®Google Scholar
• List A. F., Spier C. S., Abbaszadegan M., Grogan T. M., Greer J. P., Wolff S. N., Scheper R. J., Dalton W. S. Non P-glycoprotein (PgP) mediated multidrug resistance (MDR) identification of a novel drug resistance phenotype with prognostic relevance in acute myeloid leukemia (AML). Blood 1993; 82 suppl, 1, 1755 (abstract)
   Web of Science ®Google Scholar
• Fenneteau O., Marie J.-P., Lescoeur B., Vilmer E., Schlegel N. Expression of the multidrug resistance-associated P-glycoprotein (P-170) in acute lymphoblastic leukemia (Letter). Blood 1993; 81: 3787
   Google Scholar
• Goasgnen J. E., Ly Sunnaram B., Dossot J.-M., Mordelet E., Fauchet R. Expression of the multidrug resistance-associated P-glycoprotein (P170) in acute lymphoblastic leukemia (Letter). Blood 1993; 81: 3788
   Google Scholar
• Grogan T. M., Dalton W. S., Rybski J., Spier C., Meltzer P., Richter L., Gleason M., Pindur J., Cline A., Scheper R., Tsuruo T., Salmon S. Optimization of immunohistochemical detection of the multidrug transport protein P170 in human normal tissues and malignant lymphomas. Histopathology 1991; 19: 131
   PubMed Web of Science ®Google Scholar
• Mannervick B., Alin P., Guthenberg C., Jensson H., Tahir M. K., Warholm M., Jornvall H. Identification of three classes of cytosolic transferases common to several mammalian species: correlation between structural data and enzymatic properties. Proc. Natl. Acad. Sci. USA 1985; 82: 7202
   PubMed Web of Science ®Google Scholar
• Wolf C. R., Wareing D. J., Blask S., Hayes J. D. GST in resistance to chemotherapeutic drugs. Glutathione-S-transferases and drug resistance, I. D. Hayes, C. B. Pickett, T. J. Mantle. Taylor and Francis, LondonUK 1990; 295
   Google Scholar
• Clapper M., Buller A., Smith T., Tew K. GST in alkylating agent resistant cells. Glutathione-S-transferases and carcinogenesis, T. J. Mantle, C. B. Pickett, J. D. Hayes. Taylor and Francis, LondonUK 1987; 213
   Google Scholar
• Moscow J. A., Fairchild C. R., Madden M. J., Ranson D. T., Wieand H. S., O'Brian E. E., Poplack D. G., Gossman J., Myers C. E., Cowan K. H. Expression of anionic glutathion-S-transferases and P-glycoprotein genes in human tissues and tumors. Cancer Research 1989; 49: 1422
   PubMed Web of Science ®Google Scholar
• Shea T., Hennet W. GST-pi in human tumors. Glutathione-S-transferases and carcinogenesis, T. J. Mantle, C. B. Pickett, J. D. Hayes. Taylor and Francis, London 1987; 227
   Google Scholar
• Tew K. D. The involvement of glutathione-S-transferases in drug resistance. Anticancer drugs. (Colloque INSERM), H. Tapiero, J. Robert, T. Lampidis. Paris F. John Libbey Eurotexte Ltd, INSERM, London UK 1989; 1–103
   Google Scholar
• Tew K. D., Shisselbauer M., Clapper M., Kuzmich S. GST and resistance to alkylating agents. Glutathione-S-transferases and drug resistance, J. D. Hayes, C. B. Pickett, T. J. Mantle. Taylor and Francis, London UK 1990; 309
   Google Scholar
• Bahnson R. R., Basu A., Lazo J. S. The role of metallothioneins in the anticancer drug resistance. Molecular and clinical advances in anticancer drug resistance. Kluwer academic publishers, Boston MA 1991; 251
   Google Scholar
• Karim M. Metallothioneins: proteins in search of function. Cell 1985; 41: 9
   PubMed Web of Science ®Google Scholar
• Klug A., Rhodes D. “Zinc fingers”: a novel protein motif for nucleic acid recognition. Trends Biochern. Sci. 1987; 12: 464
   Web of Science ®Google Scholar
• Endressen L., Bakka A., Rugstad H. E. Increased resistance to chlorambueil in cultured cells with a high concentration of cytoplasmic metallothionein. Cancer Research 1983; 43: 2918
   PubMed Web of Science ®Google Scholar
• Holmes J., Wareing C., Jacobs A., Hayes I. D., Paduar A., Wolff C. R. GST-pi expression in leukemia: a comparative analysis with MDR-1 data. Br. J. Cancer 1990; 62: 209
   PubMed Web of Science ®Google Scholar
• McQuaid S., Mc Cann S., Daly P., Lawlor S., Humphries P. Observations of the transcriptional activity of the GST-pi gene in human haematological malignancies and in the peripheral leukocytes of cancer patients under chemotherapy. Br. J. Cancer 1989; 50: 540
   Web of Science ®Google Scholar
• Koberda J., Hellmann A. GST activity of leukemic cells as a prognostic factor for response to chemotherapy in acute leukemias. Med. Oncol. an Tumor pharmacoter. 1991; 8: 35
   PubMed Web of Science ®Google Scholar
• Teicher B. A., Holden S. A., Kelley M. J., Shea T. C., Cucchi C. A., Rosowsky A, Henner W. D., Frei E. Characterization of a human squamous carcinoma cell line resistant to cis-diaminedichloroplatinium. Cancer Research 1987; 47: 388
   PubMed Web of Science ®Google Scholar
• Andrews P. A., Murphy M. P., Howell S. B. Metallothionein mediated cisplatin resistance in human ovarian carcinoma cells. Cancer Chemother. Pharmacol 1987; 19: 149
   Web of Science ®Google Scholar
• Webber M. M., Maseehur Rehman S. M., James G. T. Metallothionein induction and deinduction in human prostatic carcinoma cells: relationship with resistance and sensitivity to adriamycin. Cancer Research 1988; 48: 4503
   PubMed Web of Science ®Google Scholar