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Original Article

The Effect of Interferon-α on Beta-1 Integrin Mediated Adhesion and Growth Regulation in Chronic Myelogenous Leukemia

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Pages 241-254 | Received 02 Feb 1997, Published online: 01 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Onyee Chan, Chetasi Talati, Kendra Sweet & Javier Pinilla-Ibarz. (2019) Can increased immunogenicity in chronic myeloid leukemia improve outcomes?. Expert Review of Hematology 12:4, pages 225-233.
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Anne Flörcken, Joachim Kopp, Uwe Kölsch, Christian Meisel, Bernd Dörken, Antonio Pezzutto & Jörg Westermann. (2016) DC generation from peripheral blood mononuclear cells in patients with chronic myeloid leukemia: Influence of interferons on DC yield and functional properties. Human Vaccines & Immunotherapeutics 12:5, pages 1117-1123.
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Hans M. Kvasnicka, Claudia Wickenhauser, Juergen Thiele, Eva Varus, Katharina Hamm, Dietrich W. Beelen & Ullrich W. Schaefer. (2003) Mixed Chimerism of Bone Marrow Vessels (Endothelial Cells, Myofibroblasts) Following Allogeneic Transplantation for Chronic Myelogenous Leukemia. Leukemia & Lymphoma 44:2, pages 321-328.
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Colin D. Weekes, Charles A. Kuszynski & J. Graham Sharp. (2001) VLA-4 Mediated Adhesion to Bone Marrow Stromal Cells Confers Chemoresistance to Adherent Lymphoma Cells. Leukemia & Lymphoma 40:5-6, pages 631-645.
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Randy Fenrick, Lilin Wang, John Nip, Joseph M. Amann, Robert J. Rooney, Jennifer Walker-Daniels, Howard C. Crawford, Diana L. Hulboy, Michael S. Kinch, Lynn M. Matrisian & Scott W. Hiebert. (2000) TEL, a Putative Tumor Suppressor, Modulates Cell Growth and Cell Morphology of Ras-Transformed Cells While Repressing the Transcription of stromelysin-1. Molecular and Cellular Biology 20:16, pages 5828-5839.
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Juergen Thiele, Hans Michael Kvasnicka, Annette Schmitt-Graeff, Thomas Karl Zirbes, Florian Birnbaum, Christian Kressmann, Manuel Melguizo-Grahmann, Holger Frackenpohl, Claudia Sprungmann, Lutz-Dietrich Leder, Volker Diehl, Rudolf Zankovich, Hans Eckart Schaefer, Norbert Niederle & Robert Fischer. (2000) Bone Marrow Features and Clinical Findings in Chronic Myeloid Leukemia - A Comparative, Multicenter, Immunohistological and Morphometric Study on 614 Patients. Leukemia & Lymphoma 36:3-4, pages 295-308.
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Carmine Selleri & Jaroslaw P. Maciejewski. (2000) The Role of FAS-Mediated Apoptosis in Chronic Myelogenous Leukemia. Leukemia & Lymphoma 37:3-4, pages 283-297.
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Articles from other publishers (21)

Moshe Talpaz, Jessica Mercer & Rüdiger Hehlmann. 2021. Chronic Myeloid Leukemia. Chronic Myeloid Leukemia 197 226 .
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Tim R. Randolph. 2020. Rodak's Hematology. Rodak's Hematology 555 588 .
Moshe Talpaz, Jessica Mercer & Rüdiger Hehlmann. 2016. Chronic Myeloid Leukemia. Chronic Myeloid Leukemia 207 230 .
Moshe Talpaz, Jessica Mercer & Rüdiger Hehlmann. (2015) The interferon-alpha revival in CML. Annals of Hematology 94:S2, pages 195-207.
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C Riether, C M Schürch & A F Ochsenbein. (2014) Regulation of hematopoietic and leukemic stem cells by the immune system. Cell Death & Differentiation 22:2, pages 187-198.
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M Talpaz, R Hehlmann, A Quintás-Cardama, J Mercer & J Cortes. (2012) Re-emergence of interferon-α in the treatment of chronic myeloid leukemia. Leukemia 27:4, pages 803-812.
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François Guilhot, Lydia Roy, Pierre-Jean Saulnier & Joëlle Guilhot. (2009) Interferon in chronic myeloid leukaemia: past and future. Best Practice & Research Clinical Haematology 22:3, pages 315-329.
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Lisa A. Kujawski & Moshe Talpaz. (2007) The role of interferon-alpha in the treatment of chronic myeloid leukemia. Cytokine & Growth Factor Reviews 18:5-6, pages 459-471.
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Amy Meyer, Cynthia M. van Golen, Bhumsoo Kim, Kenneth L. van Golen & Eva L. Feldman. (2004) Integrin Expression Regulates Neuroblastoma Attachment and Migration. Neoplasia 6:4, pages 332-342.
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Ruibao Ren. (2002) The molecular mechanism of chronic myelogenous leukemia and its therapeutic implications: studies in a murine model. Oncogene 21:56, pages 8629-8642.
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Juergen Thiele, Hans M. Kvasnicka, Annette Schmitt-Graeff, Dilek Goekce, Volker Diehl, Rudolf Zankovich & Hans E. Schaefer. (2001) Therapy-Related Changes of CD34 + Progenitor Cells in Chronic Myeloid Leukemia: A Morphometric Study on Sequential Trephine Biopsies . Journal of Hematotherapy & Stem Cell Research 10:6, pages 827-836.
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Yu‐Chen Gu, Jan Fredrik Talts, Donald Gullberg, Rupert Timpl & Marja Ekblom. (2002) Glucocorticoids down‐regulate the extracellular matrix proteins fibronectin, fibulin‐1 and fibulin‐2 in bone marrow stroma. European Journal of Haematology 67:3, pages 176-184.
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Ming DengGeorge Q. Daley. (2001) Expression of interferon consensus sequence binding protein induces potent immunity against BCR/ABL-induced leukemia. Blood 97:11, pages 3491-3497.
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Qin WangYoshitaka MiyakawaNorma FoxKenneth Kaushansky. (2000) Interferon-α directly represses megakaryopoiesis by inhibiting thrombopoietin-induced signaling through induction of SOCS-1. Blood 96:6, pages 2093-2099.
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J Thiele, HM Kvasnicka, DW Beelen, TK Zirbes, F Jung, D Reske, LD Leder & UW Schaefer. (2000) Relevance and dynamics of myelofibrosis regarding hematopoietic reconstitution after allogeneic bone marrow transplantation in chronic myelogenous leukemia – a single center experience on 160 patients. Bone Marrow Transplantation 26:3, pages 275-281.
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Juergen Thiele, Hans Michael Kvasnicka, Annette Schmitt-Graeff, Gabriela Cvetanovska, Nicole Blum & Hans Eckart Schaefer. (2000) Therapy-related Changes of CD20+ and CD45RO+ Lymphocyte Subsets in Chronic Myeloid Leukemia (CML): An Immunohistochemical and Morphometric Study on Sequential Trephine Biopsies of the Bone Marrow. Modern Pathology 13:8, pages 888-896.
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IA Voutsadakis. (2000) Interferon-alpha and the pathogenesis of myeloproliferative disorders. Medical Oncology 17:4, pages 249-257.
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Juergen Thiele, Hans M. Kvasnicka, Annette Schmitt-Graeff, Susanne Bundschuh, Teresa Biermann, Gernod Roessler, Maria Wasmus, Volker Diehl, Rudolf Zankovich & Hans E. Schaefer. (2000) Effects of Chemotherapy (Busulfan-Hydroxyurea) and Interferon-Alfa on Bone Marrow Morphologic Features in Chronic Myelogenous Leukemia. American Journal of Clinical Pathology 114:1, pages 57-65.
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Claudia Wickenhauser, Beate Schmitz, Barbara Selbach, Carina Brockbals, Oliver Manske & Jürgen Thiele. (2008) Interferon α2b directly induces fibroblast proliferation and transforming growth factor β secretion of macrophages. British Journal of Haematology 109:2, pages 296-304.
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U. Raymond Osarogiagbon & Philip B. McGlave. (1999) Chronic myelogenous leukemia. Current Opinion in Hematology 6:4, pages 241.
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