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Original Article

Differential Substrate Recognition Capabilities of Janus Family Protein Tyrosine Kinases Within the Interleukin 2 Receptor (I12R) System: Jak3 as a Potential Molecular Target for Treatment of Leukemias with a Hyperactive Jak-Stat Signaling Machinery

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Pages 289-297 | Received 10 Apr 1998, Published online: 05 Aug 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Arturo Valle-Mendiola, Benny Weiss-Steider, Leticia Rocha-Zavaleta & Isabel Soto-Cruz. (2014) IL-2 Enhances Cervical Cancer Cells Proliferation and JAK3/STAT5 Phosphorylation at Low Doses, While at High Doses IL-2 Has Opposite Effects. Cancer Investigation 32:4, pages 115-125.
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Fatih M Uckun, Jason Pitt & Sanjive Qazi. (2011) JAK3 pathway is constitutively active in B-lineage acute lymphoblastic leukemia. Expert Review of Anticancer Therapy 11:1, pages 37-48.
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Yong-Jie Zhou, Kelly S. Magnuson, Tammy P. Cheng, Massimo Gadina, David M. Frucht, Jerome Galon, Fabio Candotti, Robert L. Geahlen, Paul S. Changelian & John J. O'Shea. (2000) Hierarchy of Protein Tyrosine Kinases in Interleukin-2 (IL-2) Signaling: Activation of Syk Depends on Jak3; However, Neither Syk nor Lck Is Required for IL-2-Mediated STAT Activation. Molecular and Cellular Biology 20:12, pages 4371-4380.
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Articles from other publishers (19)

Juqi Zhang, Wenhui Li, Mingli Gong, Yanlun Gu, Hanxu Zhang, Bingqi Dong, Qi Guo, Xiaocong Pang, Qian Xiang, Xu He & Yimin Cui. (2023) Risk of venous thromboembolism with janus kinase inhibitors in inflammatory immune diseases: a systematic review and meta-analysis. Frontiers in Pharmacology 14.
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Alice H. Grant, Alejandro C. Rodriguez, Omar J. Rodriguez Moncivais, Shengjie Sun, Lin Li, Jonathon E. Mohl, Ming-Ying Leung, Robert A. Kirken & Georgialina Rodriguez. (2023) JAK1 Pseudokinase V666G Mutant Dominantly Impairs JAK3 Phosphorylation and IL-2 Signaling. International Journal of Molecular Sciences 24:7, pages 6805.
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Przemysław J. Kotyla, Małgorzata Engelmann, Joanna Giemza-Stokłosa, Bartosz Wnuk & Md Asiful Islam. (2021) Thromboembolic Adverse Drug Reactions in Janus Kinase (JAK) Inhibitors: Does the Inhibitor Specificity Play a Role?. International Journal of Molecular Sciences 22:5, pages 2449.
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Gemma Moncunill, Anja Scholzen, Maximillian Mpina, Augusto NhabombaAurore Bouyoukou HounkpatinLourdes OsabaRaquel VallsJoseph J. Campo, Hèctor SanzChenjerai JairoceNana Aba Williams, Erica M. PasiniDavid ArtetaJoan MaynouLourdes PalaciosMiquel Duran-FrigolaJohn J. Aponte, Clemens H. M. KockenSelidji Todagbe AgnandjiJosé Manuel MasBenjamin Mordmüller, Claudia Daubenberger, Robert Sauerwein & Carlota Dobaño. (2020) Antigen-stimulated PBMC transcriptional protective signatures for malaria immunization. Science Translational Medicine 12:543.
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Uddalak Bharadwaj, Moses M. Kasembeli, Prema Robinson & David J. Tweardy. (2020) Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution. Pharmacological Reviews 72:2, pages 486-526.
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Geoffrey A Smith, Kenji Uchida, Arthur Weiss & Jack Taunton. (2016) Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling. Nature Chemical Biology 12:5, pages 373-379.
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Arturo Valle-Mendiola, Adriana Gutiérrez-Hoya, María del Carmen Lagunas-Cruz, Benny Weiss-Steider & Isabel Soto-Cruz. (2016) Pleiotropic Effects of IL-2 on Cancer: Its Role in Cervical Cancer. Mediators of Inflammation 2016, pages 1-11.
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Nicola M. Heller, Xiulan Qi, Franck Gesbert & Achsah D. Keegan. (2012) The Extracellular and Transmembrane Domains of the γC and Interleukin (IL)-13 Receptor α1 Chains, Not Their Cytoplasmic Domains, Dictate the Nature of Signaling Responses to IL-4 and IL-13. Journal of Biological Chemistry 287:38, pages 31948-31961.
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Karen L. Wu, Hui Miao & Shenaz Khan. (2007) JAK kinases promote invasiveness in VHL-mediated renal cell carcinoma by a suppressor of cytokine signaling-regulated, HIF-independent mechanism. American Journal of Physiology-Renal Physiology 293:6, pages F1836-F1846.
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Nikolai Engedal, Tone Gjevik, Rune Blomhoff & Heidi Kiil Blomhoff. (2006) All- trans Retinoic Acid Stimulates IL-2-Mediated Proliferation of Human T Lymphocytes: Early Induction of Cyclin D3 . The Journal of Immunology 177:5, pages 2851-2861.
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Tadashi Matsuda, Jian Feng, Bruce A. Witthuhn, Yuichi Sekine & James N. Ihle. (2004) Determination of the transphosphorylation sites of Jak2 kinase. Biochemical and Biophysical Research Communications 325:2, pages 586-594.
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Kent E. Nybakken, Christoph W. Turck, David J. Robbins & J. Michael Bishop. (2002) Hedgehog-stimulated Phosphorylation of the Kinesin-related Protein Costal2 Is Mediated by the Serine/Threonine Kinase Fused. Journal of Biological Chemistry 277:27, pages 24638-24647.
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Giovanna Scapin. (2002) Structural biology in drug design: selective protein kinase inhibitors. Drug Discovery Today 7:11, pages 601-611.
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Karen B. O'Brien, John J. O'Shea & Christin Carter-Su. (2002) SH2-B Family Members Differentially Regulate JAK Family Tyrosine Kinases. Journal of Biological Chemistry 277:10, pages 8673-8681.
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Jonathan M. Ellery & Peter J. Nicholls. (2002) Alternate signalling pathways from the interleukin-2 receptor. Cytokine & Growth Factor Reviews 13:1, pages 27-40.
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Heather E. Tibbles, Alexei Vassilev, Heather Wendorf, Dawn Schonhoff, Dan Zhu, David Lorenz, Barbara Waurzyniak, Xing-Ping Liu & Fatih M. Uckun. (2001) Role of a JAK3-dependent Biochemical Signaling Pathway in Platelet Activation and Aggregation. Journal of Biological Chemistry 276:21, pages 17815-17822.
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N GEIJSEN, L KOENDERMAN & P COFFER. (2001) Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family. Cytokine & Growth Factor Reviews 12:1, pages 19-25.
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Jonathan M Ellery, Sarah J Kempshall & Peter J Nicholls. (2000) Activation of the interleukin 2 receptor. Cellular Signalling 12:6, pages 367-373.
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Ravi Malaviya, DeMin Zhu, Ilker Dibirdik & Fatih M. Uckun. (1999) Targeting Janus Kinase 3 in Mast Cells Prevents Immediate Hypersensitivity Reactions and Anaphylaxis. Journal of Biological Chemistry 274:38, pages 27028-27038.
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