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Receptors and Channels Volume 10, 2004 - Issue 5-6
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Original Article

Effects of Losartan on Blood Pressure, Oxidative Stress, and Nitrate/Nitrite Levels in the Nitric Oxide Deficient Hypertensive Rats

Mahmoud Khattab Department of Pharmacology, College of Pharmacy, King Saud University, Kingdom of Saudi Arabia
,
Mobasher Ahmad Department of Pharmacology, College of Pharmacy, King Saud University, Kingdom of Saudi Arabia
,
Othman A. Al-Shabanah Department of Pharmacology, College of Pharmacy, King Saud University, Kingdom of Saudi Arabia
&
Muhammad Raza Department of Pharmacology, College of Pharmacy, King Saud University, Kingdom of Saudi Arabia
Pages 147-157 | Published online: 04 Dec 2011

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Zhonghui Gai, Zhenxing Wang, Lei Zhang, Jun Ma & Qiao Zhu. (2019) Paeonol protects against hypertension in spontaneously hypertensive rats by restoring vascular endothelium. Bioscience, Biotechnology, and Biochemistry 83:11, pages 1992-1999.
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Yan Wang, Fei Zhang, Yu Liu, Sha Yin, Xuefen Pang, Zhidong Li & Zehui Wei. (2017) Nebivolol alleviates aortic remodeling through eNOS upregulation and inhibition of oxidative stress in l-NAME-induced hypertensive rats. Clinical and Experimental Hypertension 39:7, pages 628-639.
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Amritha A. M., Shakhi Shylesh C. M., Kavyanjana R. Nair, Arya V. S., Thennavan Arumugam, Uma Devi P. & Kanthlal S. K.. (2022) Large Cardamom Extract Enhances Ramipril's Vasoprotective Action by Modulating Endothelial Redox Biology. An Evaluation based on in-silico and in-vitro Research. Current Computer-Aided Drug Design 18:6, pages 440-447.
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Ayobami Dare, Ahmed A Elrashedy, Mahendra L. Channa & Anand Nadar. (2022) Cardioprotective Effects and in-silico Antioxidant Mechanism of L-Ergothioneine in Experimental Type-2 Diabetic Rats. Cardiovascular & Hematological Agents in Medicinal Chemistry 20:2, pages 133-147.
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Metee Iampanichakul, Anuson Poasakate, Prapassorn Potue, Siwayu Rattanakanokchai, Putcharawipa Maneesai, Parichat Prachaney, Wannapa Settheetham-Ishida & Poungrat Pakdeechote. (2022) Nobiletin resolves left ventricular and renal changes in 2K-1C hypertensive rats. Scientific Reports 12:1.
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Prachi Shekhawat, Milind Bagul, Diptee Edwankar & Varsha Pokharkar. (2019) Enhanced dissolution/caco-2 permeability, pharmacokinetic and pharmacodynamic performance of re-dispersible eprosartan mesylate nanopowder. European Journal of Pharmaceutical Sciences 132, pages 72-85.
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Pattanapong Boonprom, Orachorn Boonla, Kanokporn Chayaburakul, Jariya Umka Welbat, Patchareewan Pannangpetch, Upa Kukongviriyapan, Veerapol Kukongviriyapan, Poungrat Pakdeechote & Parichat Prachaney. (2017) Garcinia mangostana pericarp extract protects against oxidative stress and cardiovascular remodeling via suppression of p47 phox and iNOS in nitric oxide deficient rats. Annals of Anatomy - Anatomischer Anzeiger 212, pages 27-36.
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Putcharawipa Maneesai, Patoomporn Prasarttong, Sarawoot Bunbupha, Upa Kukongviriyapan, Veerapol Kukongviriyapan, Panot Tangsucharit, Parichat Prachaney & Poungrat Pakdeechote. (2016) Synergistic Antihypertensive Effect of Carthamus tinctorius L. Extract and Captopril in l-NAME-Induced Hypertensive Rats via Restoration of eNOS and AT1R Expression. Nutrients 8:3, pages 122.
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J. Rincón, D. Correia, J.L. Arcaya, E. Finol, A. Fernández, M. Pérez, K. Yaguas, E. Talavera, M. Chávez, R. Summer & F. Romero. (2015) Role of Angiotensin II type 1 receptor on renal NAD(P)H oxidase, oxidative stress and inflammation in nitric oxide inhibition induced-hypertension. Life Sciences 124, pages 81-90.
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Meenakshi ChaswalShobha DasJagdish PrasadAnju KatyalMohammad Fahim. (2011) Cardiac autonomic function in acutely nitric oxide deficient hypertensive rats: role of the sympathetic nervous system and oxidative stress. Canadian Journal of Physiology and Pharmacology 89:12, pages 865-874.
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Teresa Sousa, Dora Pinho, Manuela Morato, José Marques-Lopes, Eduarda Fernandes, Joana Afonso, Sofia Oliveira, Félix Carvalho & António Albino-Teixeira. (2008) Role of superoxide and hydrogen peroxide in hypertension induced by an antagonist of adenosine receptors. European Journal of Pharmacology 588:2-3, pages 267-276.
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David Bell, YouYou Zhao, Francis McCoy, Adrian Devine & Barbara McDermott. (2008) Differential Effects of an Anti-Oxidant Intervention on Cardiomyocyte Expression of Adrenomedullin and Intermedin and their Receptor Components in Chronic Nitric Oxide Deficiency. Cellular Physiology and Biochemistry 20:5, pages 269-282.
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Soumya Saha, Yuan Li, Georgios Lappas & Madhu B. Anand-Srivastava. (2008) Activation of natriuretic peptide receptor-C attenuates the enhanced oxidative stress in vascular smooth muscle cells from spontaneously hypertensive rats: Implication of Giα protein. Journal of Molecular and Cellular Cardiology 44:2, pages 336-344.
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Eun Seok KangBeom Seok KimChul Hoon KimGi Ho SeoSeung Jin HanSung Wan ChunKyu Yeon HurChul Woo AhnHunjoo HaMankil JungBong Soo ChaHyun Chul Lee. (2008) Protective Effects of Lithospermic Acid B on Diabetic Nephropathy in OLETF Rats Comparing with Amlodipine and Losartan. Korean Diabetes Journal 32:1, pages 10.
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