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Research Article

Oral Protein Drug Delivery

Pages 195-232 | Received 12 Apr 1996, Accepted 01 Jul 1996, Published online: 20 Oct 2008

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Read on this site (5)

Shiming He, Zhongcheng Liu & Donggang Xu. (2019) Advance in oral delivery systems for therapeutic protein. Journal of Drug Targeting 27:3, pages 283-291.
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Ping Li, Hanne Mørck Nielsen & Anette Müllertz. (2012) Oral delivery of peptides and proteins using lipid-based drug delivery systems. Expert Opinion on Drug Delivery 9:10, pages 1289-1304.
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Nevin Çelebi, Gülay Yetkin, Çiğdem Özer, Alp Can & Nahide Gökçora. (2012) Evaluation of microemulsion and liposomes as carriers for oral delivery of transforming growth factor alpha in rats. Journal of Microencapsulation 29:6, pages 539-548.
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Girishchandra B. Patel & G. Dennis Sprott. (1999) Archaeobacterial Ether Lipid Liposomes (Archaeosomes) as Novel Vaccine and Drug Delivery Systems. Critical Reviews in Biotechnology 19:4, pages 317-357.
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Isabel Gomez-Orellana & Duncan R Paton. (1998) Advances in the oral delivery of proteins. Expert Opinion on Therapeutic Patents 8:3, pages 223-234.
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Articles from other publishers (54)

Munishwar Nath Gupta & Vladimir N. Uversky. (2024) Biological importance of arginine: A comprehensive review of the roles in structure, disorder, and functionality of peptides and proteins. International Journal of Biological Macromolecules 257, pages 128646.
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Ruth Martis, Caroline A Crowther, Emily Shepherd, Jane Alsweiler, Michelle R Downie & Julie Brown. (2018) Treatments for women with gestational diabetes mellitus: an overview of Cochrane systematic reviews. Cochrane Database of Systematic Reviews 2018:8.
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Sandra Soares, Ana Costa, Pedro Fonte & Bruno Sarmento. 2017. Drug Delivery. Drug Delivery 101 146 .
Ruth Martis, Julie Brown, Jane Alsweiler, Michelle R Downie & Caroline A Crowther. (2016) Treatments for women with gestational diabetes mellitus: an overview of Cochrane systematic reviews. Cochrane Database of Systematic Reviews.
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Wenbin Zhao, Yangyang Li, Wenhui Liu, Ding Ding, Yingchun Xu, Liqiang Pan & Shuqing Chen. (2016) Transcytosis, Antitumor Activity and Toxicity of Staphylococcal Enterotoxin C2 as an Oral Administration Protein Drug. Toxins 8:6, pages 185.
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M.J. Ansari. (2015) Oral Delivery of Insulin for Treatment of Diabetes: Classical Challenges and Current Opportunities. Journal of Medical Sciences 15:5, pages 209-220.
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Ajay Banga. 2015. Therapeutic Peptides and Proteins. Therapeutic Peptides and Proteins 233 262 .
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Hanne Mørck Nielsen. 2014. Mucosal Delivery of Biopharmaceuticals. Mucosal Delivery of Biopharmaceuticals 99 122 .
Manal F. Abou Taleb. (2013) Radiation synthesis of multifunctional polymeric hydrogels for oral delivery of insulin. International Journal of Biological Macromolecules 62, pages 341-347.
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Guiying Zhang, Tao Wang, Lijun Gao & Dongqin Quan. (2013) Oral delivery of oil-based formulation for a novel synthetic cationic peptide of GnRH (gonadotropin-releasing hormone) antagonist for prostate cancer treatment. International Journal of Pharmaceutics 450:1-2, pages 138-144.
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Yeonhee Yun, Yong Woo Cho & Kinam Park. (2013) Nanoparticles for oral delivery: Targeted nanoparticles with peptidic ligands for oral protein delivery. Advanced Drug Delivery Reviews 65:6, pages 822-832.
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Mehrdad Mahkam & Asrin Pakravan. (2012) Synthesis and Characterization of pH‐Sensitive Positive‐charge Silica Nanoparticles for Oral Anionic Drug Delivery. Journal of the Chinese Chemical Society 60:3, pages 293-296.
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Yan Hu, Tianming Yang & Xianming Hu. (2011) Novel polysaccharides-based nanoparticle carriers prepared by polyelectrolyte complexation for protein drug delivery. Polymer Bulletin 68:4, pages 1183-1199.
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BT Griffin & CM O’Driscoll. (2011) Opportunities and challenges for oral delivery of hydrophobic versus hydrophilic peptide and protein-like drugs using lipid-based technologies. Therapeutic Delivery 2:12, pages 1633-1653.
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Laura D.R. Davis, William J. Spencer, Van Thong Pham, Tonya L. Ward, David R. Blais, David R. Mack, Harvey Kaplan & Illimar Altosaar. (2011) 14C radiolabeling of proteins to monitor biodistribution of ingested proteins. Analytical Biochemistry 410:1, pages 57-61.
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Gaurang Patel & Ambikanandan Misra. 2011. Challenges in Delivery of Therapeutic Genomics and Proteomics. Challenges in Delivery of Therapeutic Genomics and Proteomics 481 529 .
Sanjay Kalra, Bharti Kalra & Navneet Agrawal. (2010) Oral Insulin. Diabetology & Metabolic Syndrome 2:1.
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Harish Iyer, Anand Khedkar & Manish Verma. (2010) Oral insulin – a review of current status. Diabetes, Obesity and Metabolism 12:3, pages 179-185.
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Shirui Mao, Dongmei Cun & Yoshiaki Kawashima. 2009. Delivery Technologies for Biopharmaceuticals. Delivery Technologies for Biopharmaceuticals 29 67 .
Mehrdad Mahkam. (2009) Starch-based polymeric carriers for oral-insulin delivery. Journal of Biomedical Materials Research Part A 9999A, pages NA-NA.
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XingYi Li, XiangYe Kong, Shuai Shi, XiuLing Zheng, Gang Guo, YuQuan Wei & ZhiYong Qian. (2008) Preparation of alginate coated chitosan microparticles for vaccine delivery. BMC Biotechnology 8:1.
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Rajesh Singh, Shailesh Singh & James W. Lillard. (2008) Past, Present, and Future Technologies for Oral Delivery of Therapeutic Proteins. Journal of Pharmaceutical Sciences 97:7, pages 2497-2523.
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Anne des Rieux, Virginie Fievez, Marie Garinot, Yves-Jacques Schneider & Véronique Préat. (2006) Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach. Journal of Controlled Release 116:1, pages 1-27.
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Yun Bai & Wei-Chiang Shen. (2006) Improving the Oral Efficacy of Recombinant Granulocyte Colony-Stimulating Factor and Transferrin Fusion Protein by Spacer Optimization. Pharmaceutical Research 23:9, pages 2116-2121.
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M. MahkamM. Allahverdipoor, R. Mohammadi, S. O. Ranaei-Siadat, M. R. Rashidi, S. Davaran, M. Barshan & S. E. Ranaei-Siadat. (2016) An Oral Delivery System for Insulin. Journal of Bioactive and Compatible Polymers 21:2, pages 135-148.
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Christineh N. Sarkissian & Alejandra Gámez. (2005) Phenylalanine ammonia lyase, enzyme substitution therapy for phenylketonuria, where are we now?. Molecular Genetics and Metabolism 86, pages 22-26.
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Mehrdad Mahkam. (2005) Using pH-sensitive hydrogels containing cubane as a crosslinking agent for oral delivery of insulin. Journal of Biomedical Materials Research Part B: Applied Biomaterials 75B:1, pages 108-112.
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Gesine E. Hildebrand & Stephan Harnisch. 2005. Modern Biopharmaceuticals. Modern Biopharmaceuticals 1360 1391 .
A. ?ilek, N. ?elebi, F. T?rnaks?z & A. Tay. (2005) A lecithin-based microemulsion of rh-insulin with aprotinin for oral administration: Investigation of hypoglycemic effects in non-diabetic and STZ-induced diabetic rats. International Journal of Pharmaceutics 298:1, pages 176-185.
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C. Martin, J. Thongborisute, H. Takeuchi, H. Yamamoto, Y. Kawashima & H.O. Alpar. (2005) Cholesterol?bile salt vesicles as potential delivery vehicles for drug and vaccine delivery. International Journal of Pharmaceutics 298:2, pages 339-343.
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Yu-Hsin Lin, Hsiang-Fa Liang, Ching-Kuang Chung, Mei-Chin Chen & Hsing-Wen Sung. (2005) Physically crosslinked alginate/N,O-carboxymethyl chitosan hydrogels with calcium for oral delivery of protein drugs. Biomaterials 26:14, pages 2105-2113.
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C. Martin, S. Somavarapu & H.O. Alpar. (2005) Mucosal delivery of diphtheria toxoid using polymer-coated-bioadhesive liposomes as vaccine carriers. Journal of Drug Delivery Science and Technology 15:4, pages 301-306.
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Monette M. Cotreau, Lucille Stonis, Andrew Strahs & Ullrich S. Schwertschlag. (2004) A multiple‐dose, safety, tolerability, pharmacokinetics and pharmacodynamic study of oral recombinant human interleukin‐11 (oprelvekin). Biopharmaceutics & Drug Disposition 25:7, pages 291-296.
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Hsiang-Fa Liang, Min-Hao Hong, Rong-Ming Ho, Ching-Kuang Chung, Yu-Hsin Lin, Chun-Hung Chen & Hsing-Wen Sung. (2004) Novel Method Using a Temperature-Sensitive Polymer (Methylcellulose) to Thermally Gel Aqueous Alginate as a pH-Sensitive Hydrogel. Biomacromolecules 5:5, pages 1917-1925.
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Reem Smoum, Abraham Rubinstein & Morris Srebnik. (2003) A study of the effect on nucleophilic hydrolytic activity of pancreatic elastase, trypsin, chymotrypsin, and leucine aminopeptidase by boronic acids in the presence of arabinogalactan: a subsequent study on the hydrolytic activity of chymotrypsin by boronic acids in the presence of mono-, di-, and trisaccharides. Bioorganic Chemistry 31:6, pages 464-474.
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V.R. Sinha & Aman Trehan. (2003) Biodegradable microspheres for protein delivery. Journal of Controlled Release 90:3, pages 261-280.
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S Eiamtrakarn, Y Itoh, J Kishimoto, Y Yoshikawa, N Shibata, M Murakami & K Takada. (2002) Gastrointestinal mucoadhesive patch system (GI-MAPS) for oral administration of G-CSF, a model protein. Biomaterials 23:1, pages 145-152.
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Anurag Sood & Ramesh Panchagnula. (2001) Peroral Route:  An Opportunity for Protein and Peptide Drug Delivery . Chemical Reviews 101:11, pages 3275-3304.
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F Veuillez, Y.N Kalia, Y Jacques, J Deshusses & P Buri. (2001) Factors and strategies for improving buccal absorption of peptides. European Journal of Pharmaceutics and Biopharmaceutics 51:2, pages 93-109.
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Wei Wang. (2000) Lyophilization and development of solid protein pharmaceuticals. International Journal of Pharmaceutics 203:1-2, pages 1-60.
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Paul Burke & Scott Putney. 2000. Sustained-Release Injectable Products. Sustained-Release Injectable Products 371 407 .
Andrea Leone-Bay, Duncan R. Paton & John J. Weidner. (2000) The Development of Delivery Agents that Facilitate the Oral Absorption of Macromolecular Drugs. Medicinal Research Reviews 20:2, pages 169-186.
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D.D Breimer. (1999) Future challenges for drug delivery. Journal of Controlled Release 62:1-2, pages 3-6.
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Sy-Juen Wu & Joseph R Robinson. (1999) Transport of human growth hormone across Caco-2 cells with novel delivery agents: evidence for P-glycoprotein involvement. Journal of Controlled Release 62:1-2, pages 171-177.
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A.M. Lowman, M. Morishita, M. Kajita, T. Nagai & N.A. Peppas. (1999) Oral delivery of insulin using pH‐responsive complexation gels. Journal of Pharmaceutical Sciences 88:9, pages 933-937.
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István TóthJohn P. MalkinsonNicholas S. FlinnBruno DrouillatAnikó HorváthJudith ÉrchegyiMiklós IdeiAnikó VenetianerPer ArturssonLucia LazorovaBéla SzendeGyörgy Kéri. (1999) Novel Lipoamino Acid- and Liposaccharide-Based System for Peptide Delivery:  Application for Oral Administration of Tumor-Selective Somatostatin Analogues. Journal of Medicinal Chemistry 42:19, pages 4010-4013.
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Wei Wang. (1999) Instability, stabilization, and formulation of liquid protein pharmaceuticals. International Journal of Pharmaceutics 185:2, pages 129-188.
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Ann L. Daugherty & Randall J. Mrsny. (1999) Transcellular uptake mechanisms of the intestinal epithelial barrier Part one. Pharmaceutical Science & Technology Today 2:4, pages 144-151.
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Gerardo P Carino & Edith Mathiowitz. (1999) Oral insulin delivery1Abbreviations: GI, gastrointestinal; IDDM, insulin-dependent diabetes mellitus; IU, international units; NIDDM, non-insulin-dependent diabetes mellitus; PIN, phase inversion nanoencapsulation; ZOT, zona occludens toxin.1. Advanced Drug Delivery Reviews 35:2-3, pages 249-257.
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Udaya B. Kompella. 1999. Biopharmaceutical Drug Design and Development. Biopharmaceutical Drug Design and Development 239 273 .
Dean K Pettit & Wayne R Gombotz. (1998) The development of site-specific drug-delivery systems for protein and peptide biopharmaceuticals. Trends in Biotechnology 16:8, pages 343-349.
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David J Brayden & Daniel J O'Mahony. (1998) Novel oral drug delivery gateways for biotechnology products: polypeptides and vaccines. Pharmaceutical Science & Technology Today 1:7, pages 291-299.
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D Breimer. (1998) Future challenges for drug delivery research. Advanced Drug Delivery Reviews 33:3, pages 265-268.
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