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Research Article

Formulation and evaluation of flurbiprofen-loaded genipin cross-linked gelatin microspheres for intra-articular delivery

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Pages 200-210 | Received 11 Sep 2012, Accepted 28 Oct 2012, Published online: 19 Dec 2012

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Gangliang Huang, Yang Liu & Ling Chen. (2017) Chitosan and its derivatives as vehicles for drug delivery. Drug Delivery 24:2, pages 108-113.
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Courtney Morrish, Shahla Teimouri & Stefan Kasapis. (2023) Structural manipulation of the gelatin/genipin network to inform the molecular transport of caffeine. Food Hydrocolloids 140, pages 108616.
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Farnaz Jaberifard, Nasser Arsalani, Marjan Ghorbani & Hossein Mostafavi. (2022) Incorporating halloysite nanotube/carvedilol nanohybrids into gelatin microsphere as a novel oral pH-sensitive drug delivery system. Colloids and Surfaces A: Physicochemical and Engineering Aspects 637, pages 128122.
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Hagar I. Mohamed, Amal H. El-Kamel, Ghada O. Hammad & Lamia A. Heikal. (2022) Design of Targeted Flurbiprofen Biomimetic Nanoparticles for Management of Arthritis: In Vitro and In Vivo Appraisal. Pharmaceutics 14:1, pages 140.
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Shahla Teimouri, Chaitali Dekiwadia & Stefan Kasapis. (2021) Decoupling diffusion and macromolecular relaxation in the release of vitamin B6 from genipin-crosslinked whey protein networks. Food Chemistry 346, pages 128886.
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Zuoxiang Dong, Xinyue Meng, Wei Yang, Jinfeng Zhang, Peng Sun, Huawei Zhang, Xing Fang, Dong-An Wang & Changjiang Fan. (2021) Progress of gelatin-based microspheres (GMSs) as delivery vehicles of drug and cell. Materials Science and Engineering: C 122, pages 111949.
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Malihe Pooresmaeil & Hassan Namazi. (2020) pH-sensitive ternary Fe3O4/GQDs@G hybrid microspheres; Synthesis, characterization and drug delivery application. Journal of Alloys and Compounds 846, pages 156419.
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Shamsul Bin Sulaiman, Ruszymah Binti Haji Idrus & Ng Min Hwei. (2020) Gelatin Microsphere for Cartilage Tissue Engineering: Current and Future Strategies. Polymers 12:10, pages 2404.
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Nuran Işıklan & Ümit Haydar Erol. (2020) Design and evaluation of temperature-responsive chitosan/hydroxypropyl cellulose blend nanospheres for sustainable flurbiprofen release. International Journal of Biological Macromolecules 159, pages 751-762.
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Alexandros Nakas, Athanasia M. Dalatsi, Afroditi Kapourani, Konstantinos N. Kontogiannopoulos, Andreana N. Assimopoulou & Panagiotis Barmpalexis. (2020) Quality Risk Management and Quality by Design for the Development of Diclofenac Sodium Intra-articular Gelatin Microspheres. AAPS PharmSciTech 21:4.
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Felicity A. Whitehead, Simon A. Young & Stefan Kasapis. (2019) Structural relaxation and glass transition in high-solid gelatin systems crosslinked with genipin. International Journal of Biological Macromolecules 141, pages 867-875.
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Lisa Bacher, Michael Maskos & Anna Musyanovych. (2019) Gelatin‐Based Capsules through Interfacial Polymerization: Batch and Continuous Flow Synthesis. Chemical Engineering & Technology 42:10, pages 2119-2126.
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Parinaz Nezhad-Mokhtari, Nasser Arsalani, Siamak Javanbakht & Ahmad Shaabani. (2019) Development of gelatin microsphere encapsulated Cu-based metal-organic framework nanohybrid for the methotrexate delivery. Journal of Drug Delivery Science and Technology 50, pages 174-180.
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Siamak Javanbakht, Parinaz Nezhad-Mokhtari, Ahmad Shaabani, Nasser Arsalani & Marjan Ghorbani. (2019) Incorporating Cu-based metal-organic framework/drug nanohybrids into gelatin microsphere for ibuprofen oral delivery. Materials Science and Engineering: C 96, pages 302-309.
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Abhijit Pawar, Shreya Thakkar & Manju Misra. (2018) A bird's eye view of nanoparticles prepared by electrospraying: advancements in drug delivery field. Journal of Controlled Release 286, pages 179-200.
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Khandmaa Dashnyam, Jung-Hwan Lee, Nandin Mandakhbayar, Guang-Zhen Jin, Hae-Hyoung Lee & Hae-Won Kim. (2018) Intra-articular biomaterials-assisted delivery to treat temporomandibular joint disorders. Journal of Tissue Engineering 9, pages 204173141877651.
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Riccardo A.A. Muzzarelli, Mohamad El Mehtedi, Carlo Bottegoni & Antonio Gigante. (2016) Physical properties imparted by genipin to chitosan for tissue regeneration with human stem cells: A review. International Journal of Biological Macromolecules 93, pages 1366-1381.
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Ki-Su Park, Chaeyeon Kim, Jin-Oh Nam, Sung-Min Kang & Chang-Soo Lee. (2016) Synthesis and characterization of thermosensitive gelatin hydrogel microspheres in a microfluidic system. Macromolecular Research 24:6, pages 529-536.
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Riccardo Muzzarelli, Mohamad El Mehtedi, Carlo Bottegoni, Alberto Aquili & Antonio Gigante. (2015) Genipin-Crosslinked Chitosan Gels and Scaffolds for Tissue Engineering and Regeneration of Cartilage and Bone. Marine Drugs 13:12, pages 7314-7338.
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Fakhar ud Din, Omer Mustapha, Dong Wuk Kim, Rehmana Rashid, Jong Hyuck Park, Ju Yeon Choi, Sae Kwang Ku, Chul Soon Yong, Jong Oh Kim & Han-Gon Choi. (2015) Novel dual-reverse thermosensitive solid lipid nanoparticle-loaded hydrogel for rectal administration of flurbiprofen with improved bioavailability and reduced initial burst effect. European Journal of Pharmaceutics and Biopharmaceutics 94, pages 64-72.
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Fakhar ud Din, Rehmana Rashid, Omer Mustapha, Dong Wuk Kim, Jong Hyuck Park, Sae Kwang Ku, Yu-Kyoung Oh, Jong Oh Kim, Yu Seok Youn, Chul Soon Yong & Han-Gon Choi. (2015) Development of a novel solid lipid nanoparticles-loaded dual-reverse thermosensitive nanomicelle for intramuscular administration with sustained release and reduced toxicity. RSC Advances 5:54, pages 43687-43694.
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Maarten Janssen, George Mihov, Tim Welting, Jens Thies & Pieter Emans. (2014) Drugs and Polymers for Delivery Systems in OA Joints: Clinical Needs and Opportunities. Polymers 6:3, pages 799-819.
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Yuan Yang, Haihao Tang, Alexander Köwitsch, Karsten Mäder, Gerd Hause, Joachim Ulrich & Thomas Groth. (2013) Novel mineralized heparin–gelatin nanoparticles for potential application in tissue engineering of bone. Journal of Materials Science: Materials in Medicine 25:3, pages 669-680.
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Grzegorz Gorczyca, Robert Tylingo, Piotr Szweda, Ewa Augustin, Maria Sadowska & Sławomir Milewski. (2014) Preparation and characterization of genipin cross-linked porous chitosan–collagen–gelatin scaffolds using chitosan–CO2 solution. Carbohydrate Polymers 102, pages 901-911.
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Li Cui, Junfang Jia, Yi Guo, Yun Liu & Ping Zhu. (2014) Preparation and characterization of IPN hydrogels composed of chitosan and gelatin cross-linked by genipin. Carbohydrate Polymers 99, pages 31-38.
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