1,211
Views
51
CrossRef citations to date
0
Altmetric
Review Article

Angiopoietin-like proteins 3, 4 and 8: regulating lipid metabolism and providing new hope for metabolic syndrome

&
Pages 679-687 | Received 15 Jan 2014, Accepted 22 May 2014, Published online: 24 Jun 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Zhijie Wang, Yuxi Song, Feng Zhang, Chang Zhao, Shixin Fu, Cheng Xia & Yunlong Bai. (2022) Early warning for inactive ovaries based on liver function index, serum MDA, IL-6, FGF21 and ANGPTL8 in dairy cows. Italian Journal of Animal Science 21:1, pages 113-122.
Read now
Wei Huang, Yaqiu Lin, Hua Xiang, Jiangjiang Zhu & Yong Wang. (2022) Angiopoietin-like protein 8, molecular cloning and regulating lipid accumulation in goat intramuscular preadipocytes. Animal Biotechnology 33:5, pages 876-883.
Read now
Yu-Shan Fu, Ji-Hung Wang, Chung-Jen Lee & Bang-Gee Hsu. (2018) Positive correlation of the serum angiopoietin-like protein 3 levels with the aortic augmentation index in patients with coronary artery disease. Therapeutics and Clinical Risk Management 14, pages 231-236.
Read now

Articles from other publishers (47)

Samaneh Mohassel Azadi, Reza Fadaei, Ramtin Omid-Shafaat, Jalil Hosseini & Nariman Moradi. (2023) Elevated angiopoietin-like protein 3 serum levels in diabetic nephropathy patients and its association with renal function and lipid profile. BMC Nephrology 24:1.
Crossref
Reza Fadaei, Samaneh Mohassel Azadi, Ismail Laher & Habibolah Khazaie. (2023) Increased Levels of ANGPTL3 and CTRP9 in Patients With Obstructive Sleep Apnea and Their Relation to Insulin Resistance and Lipid Metabolism and Markers of Endothelial Dysfunction. Laboratory Medicine 54:1, pages 83-89.
Crossref
Nicole Gerwin, Celeste Scotti, Christine Halleux, Mara Fornaro, Jimmy Elliott, Yunyu Zhang, Kristen Johnson, Jian Shi, Sandra Walter, Yufei Li, Carsten Jacobi, Nelly Laplanche, Magali Belaud, Jochen Paul, Gustavo Glowacki, Thomas Peters, Keith A. WhartonJrJr, Igor Vostiar, Florine Polus, Ina Kramer, Sabine Guth, Abdelkader Seroutou, Subhajit Choudhury, Didier Laurent, Joseph Gimbel, Jörg Goldhahn, Matthias Schieker, Sophie Brachat, Ronenn Roubenoff & Michaela Kneissel. (2022) Angiopoietin-like 3-derivative LNA043 for cartilage regeneration in osteoarthritis: a randomized phase 1 trial. Nature Medicine 28:12, pages 2633-2645.
Crossref
Muhammad Sohaib Khan, Choongho Lee & Sang Geon Kim. (2022) Non-alcoholic fatty liver disease and liver secretome. Archives of Pharmacal Research 45:12, pages 938-963.
Crossref
Khairul Anwar Zarkasi, Noraidatulakma Abdullah, Nor Azian Abdul Murad, Norfazilah Ahmad & Rahman Jamal. (2022) Genetic Factors for Coronary Heart Disease and Their Mechanisms: A Meta-Analysis and Comprehensive Review of Common Variants from Genome-Wide Association Studies. Diagnostics 12:10, pages 2561.
Crossref
Andreas Schmid, Hannah Belikan, Alexandra Höpfinger, Andreas Schäffler & Thomas Karrasch. (2021) Impact of oral lipid and glucose tolerance tests on the postprandial concentrations of angiopoietin-like proteins (Angptl) 3 and 4. European Journal of Nutrition 61:4, pages 1919-1929.
Crossref
M. Sahmani, Z. Kianorooz, A. Javadi, N. Gheibi & K. G. Chegini. (2022) A New Insight Into the Anti-Proliferative and Apoptotic Effects of Betatrophin on Human Ovarian Cancer Cell Line Skov-3. Journal of Evolutionary Biochemistry and Physiology 58:3, pages 715-727.
Crossref
Sy-Harn Lian, Bang-Gee Hsu, Ji-Hung Wang & Ming-Chun Chen. (2022) Positive correlation of serum angiopoietin-like protein 3 levels with metabolic syndrome in patients with coronary artery disease. Tzu Chi Medical Journal 34:1, pages 75.
Crossref
Yani Ke, Shan Liu, Zheyuan Zhang & Jie Hu. (2021) Circulating angiopoietin-like proteins in metabolic-associated fatty liver disease: a systematic review and meta-analysis. Lipids in Health and Disease 20:1.
Crossref
Huajie Zou, Yongping Xu, Xiaoyu Meng, Danpei Li, Xi Chen, Tingting Du, Yan Yang, Yong Chen, Shiying Shao, Gang Yuan, Xinrong Zhou, Shuhong Hu, Wentao He, Delin Ma, Junhui Xie, Benping Zhang, Jianhua Zhang, Wenjun Li, Zhelong Liu & Xuefeng Yu. (2021) Circulating ANGPTL8 levels and risk of kidney function decline: Results from the 4C Study. Cardiovascular Diabetology 20:1.
Crossref
Maryam Navaeian, Hossein Ahmadpour-Yazdi, Samieh Asadian & Nematollah Gheibi. (2021) The effect of ANGPTL8 protein on proliferation and apoptosis in HepG2 hepatocellular carcinoma cell line. Gene Reports 25, pages 101306.
Crossref
Chang Guo, Chenxi Wang, Xia Deng, Jianqiang He, Ling Yang & Guoyue Yuan. (2021) ANGPTL8 in metabolic homeostasis: more friend than foe?. Open Biology 11:9.
Crossref
Chatchon Kaewkrasaesin, Waralee Chatchomchuan, Suwanna Muanpetch & Weerapan Khovidhunkit. (2021) ANGPTL3 and ANGPTL8 in Thai subjects with hyperalphalipoproteinemia and severe hypertriglyceridemia. Journal of Clinical Lipidology 15:5, pages 752-759.
Crossref
Huixia Yang, Xiaoyan Han & Zengping Hao. (2021) An Immune-Gene-Based Classifier Predicts Prognosis in Patients With Cervical Squamous Cell Carcinoma. Frontiers in Molecular Biosciences 8.
Crossref
Sanjay Kalra, Saptarshi Bhattacharya & Pawan Rawal. (2021) Hepatocrinology. Medical Sciences 9:2, pages 39.
Crossref
Xuefeng Wei, Yunchang Zhu, Jie Du, Xiaojie Ma, Xue Zhao, Yaoyao Ma, Shuang Han & Yun Ma. (2021) Analysis of ANGPTL8 promoter activity and screening of related transcription factors in bovine. Gene 784, pages 145594.
Crossref
Maryam Navaeian, Samieh Asadian, Hossein Ahmadpour Yazdi & Nematollah Gheibi. (2021) ANGPTL8 roles in proliferation, metabolic diseases, hypothyroidism, polycystic ovary syndrome, and signaling pathways. Molecular Biology Reports 48:4, pages 3719-3731.
Crossref
Barbara S. Wiggins. (2021) Human Angiopoietin-like Protein 3/ANGPTL3 Antibodies: Adding to the Armamentarium in the Management of Dyslipidemia. Journal of Cardiovascular Pharmacology 78:5, pages e631-e640.
Crossref
Juan Li, Yunyun Yang, Xiaolu Jiao, Huahui Yu, Yunhui Du, Ming Zhang, Chaowei Hu, Yongxiang Wei & Yanwen Qin. (2020) The Clinical Role of Angiopoietin-Like Protein 3 in Evaluating Coronary Artery Disease in Patients with Obstructive Sleep Apnea. Cardiovascular Drugs and Therapy 34:6, pages 773-780.
Crossref
Mohamed Abu-Farha, Anindya Ghosh, Irina Al-Khairi, S.R. Murthy Madiraju, Jehad Abubaker & Marc Prentki. (2020) The multi-faces of Angptl8 in health and disease: Novel functions beyond lipoprotein lipase modulation. Progress in Lipid Research 80, pages 101067.
Crossref
Xiaolu Jiao, Yunyun Yang, Linyi Li, Huahui Yu, Yunxiao Yang, Juan Li, Yunhui Du, Jing Zhang, Chaowei Hu & Yanwen Qin. (2020) Angiopoietin-like protein 8 accelerates atherosclerosis in ApoE−/− mice. Atherosclerosis 307, pages 63-71.
Crossref
Farzad Rahmani, Malihe Hasanzadeh, Seyed Mahdi Hassanian, Majid Khazaei, Habibollah Esmaily, seyed Ami Asef-Agah, Alireza Naghipour, Gordon A Ferns & Amir Avan. (2020) Association of a genetic variant in the angiopoietin-like protein 4 gene with cervical cancer. Pathology - Research and Practice 216:7, pages 153011.
Crossref
Ming-Chun Chen, Bang-Gee Hsu, Chung-Jen Lee & Ji-Hung Wang. (2020) High-Serum Angiopoietin-Like Protein 3 Levels Associated with Cardiovascular Outcome in Patients with Coronary Artery Disease. International Journal of Hypertension 2020, pages 1-7.
Crossref
Sepideh Kaviani, Caroline M. Taylor, Jada L. Stevenson, Jamie A. Cooper & Chad M. Paton. (2019) A 7-day high-PUFA diet reduces angiopoietin-like protein 3 and 8 responses and postprandial triglyceride levels in healthy females but not males: a randomized control trial. BMC Nutrition 5:1.
Crossref
Naohiko Akimoto, Ryuichi Wada, Katsuhiko Iwakiri & Zenya Naito. (2019) Histology and molecular biology studies on the expression and localization of angiopoietin‑like protein 8 in human tissues. Biomedical Reports.
Crossref
Felipe Vendrame, Leticia Olops, Sara Teresinha Olalla Saad, Fernando Ferreira Costa & Kleber Yotsumoto Fertrin. (2019) Hypocholesterolemia and dysregulated production of angiopoietin-like proteins in sickle cell anemia patients. Cytokine 120, pages 88-91.
Crossref
Xinli Han, Rufeng Dai, Yihui Zhai, Qian Shen, Li Sun, Haimei Liu & Hong Xu. (2019) Anti-proteinuria effect of antibody against ANGPTL3 coil-coiled domain on adriamycin-induced nephropathy in mice. Biochemical and Biophysical Research Communications 516:3, pages 812-818.
Crossref
Xuefeng Wei, Shuang Han, Shuzhe Wang, Quizhi Zheng, Xin Li, Jie Du, Jinhui Zhao, Fei Li & Yun Ma. (2019) ANGPTL8 regulates adipocytes differentiation and adipogenesis in bovine. Gene 707, pages 93-99.
Crossref
Hendra Susanto, Dwi Listyorini, Ahmad Taufiq, Viol Dhea Kharisma, Adeodatus Yuda Handaya, Melati Putri Pertiwi, Silmy Aulia Rufiatin Nisa & Elhah Nailul Khasna. (2019) Betatrophin/Lipasin/C19orf80: In Silico Approach for Protein-Based Biomaterial Marker in Metabolic Syndrome and Colorectal Cancer Through Computational-Based Study. IOP Conference Series: Materials Science and Engineering 515, pages 012094.
Crossref
Aspen R. Gutgsell, Swapnil V. Ghodge, Albert A. Bowers & Saskia B. Neher. (2019) Mapping the sites of the lipoprotein lipase (LPL)–angiopoietin-like protein 4 (ANGPTL4) interaction provides mechanistic insight into LPL inhibition. Journal of Biological Chemistry 294:8, pages 2678-5366.
Crossref
Clara Yongjoo Park, Jiyoung Moon, Garam Jo, Juhee Lee, Oh Yoen Kim, Hannah Oh, Hyunjung Lim & Min-Jeong Shin. (2019) The association between genetic variants of angiopoietin-like 3 and risk of diabetes mellitus is modified by dietary factors in Koreans. Scientific Reports 9:1.
Crossref
Song Yang, Xiaolu Jiao, Xiaoguang Huo, Miaomiao Zhu, Yi Wang, Xiangnan Fang, Yunyun Yang, Weidong Yue & Yanwen Qin. (2018) Association between circulating full-length angiopoietin-like protein 8 and non-high-density lipoprotein cholesterol levels in Chinese non-diabetic individuals: a cross-sectional study. Lipids in Health and Disease 17:1.
Crossref
Xiaolu Jiao, Jiqiang He, Yunyun Yang, Song Yang, Juan Li & Yanwen Qin. (2018) Associations between circulating full-length angiopoietin-like protein 8 levels and severity of coronary artery disease in Chinese non-diabetic patients: a case–control study. Cardiovascular Diabetology 17:1.
Crossref
Manuel Castro Cabezas, Benjamin Burggraaf & Boudewijn Klop. (2018) Dyslipidemias in clinical practice. Clinica Chimica Acta 487, pages 117-125.
Crossref
M A M Abuzahra, Jakaria, K Listyarini, A Furqon, C Sumantri, M J Uddin & A Gunawan. (2018) Variant discovery in the sheepmeat odour and flavour in javanese fat tailed sheep using RNA sequencing. IOP Conference Series: Earth and Environmental Science 157, pages 012030.
Crossref
Yun Huang, Xin Chen, Xiaohong Chen, Yu Feng, Heming Guo, Sicheng Li, Ting Dai, Rong Jiang, Xiaoyan Zhang, Chen Fang & Ji Hu. (2017) Angiopoietin-like protein 8 in early pregnancy improves the prediction of gestational diabetes. Diabetologia 61:3, pages 574-580.
Crossref
Antwi-Boasiako Oteng, Asmita Bhattacharya, Susanne Brodesser, Ling Qi, Nguan Soon Tan & Sander Kersten. (2017) Feeding Angptl4−/− mice trans fat promotes foam cell formation in mesenteric lymph nodes without leading to ascites. Journal of Lipid Research 58:6, pages 1100-1113.
Crossref
Mohamed Abu-Farha, Preethi Cherian, Irina Al-Khairi, Dhanya Madhu, Ali Tiss, Samia Warsam, Asma Alhubail, Devarajan Sriraman, Faisal Al-Refaei & Jehad Abubaker. (2017) Plasma and adipose tissue level of angiopoietin-like 7 (ANGPTL7) are increased in obesity and reduced after physical exercise. PLOS ONE 12:3, pages e0173024.
Crossref
Mohamed Abu-Farha, Jehad Abubaker, Irina Al-Khairi, Preethi Cherian, Fiona Noronha, Sina Kavalakatt, Abdelkrim Khadir, Kazem Behbehani, Monira Alarouj, Abdullah Bennakhi & Naser Elkum. (2016) Circulating angiopoietin-like protein 8 (betatrophin) association with HsCRP and metabolic syndrome. Cardiovascular Diabetology 15:1.
Crossref
A. Zieli?ska, R. Maciulewski, K. Siewko, A. Pop?awska-Kita, D. Lipi?ska, G. Koz?owska, M. G?rska & M. Szelachowska. (2016) Levels of betatrophin decrease during pregnancy despite increased insulin resistance, beta-cell function and triglyceride levels. Diabetes & Metabolism 42:6, pages 409-415.
Crossref
Haoyu Wang, Yaxin Lai, Cheng Han, Aihua Liu, Chenling Fan, Hong Wang, Hongmei Zhang, Shuangning Ding, Weiping Teng & Zhongyan Shan. (2016) The Effects of Serum ANGPTL8/betatrophin on the Risk of Developing the Metabolic Syndrome – A Prospective Study. Scientific Reports 6:1.
Crossref
A B Crujeiras, M A Zulet, I Abete, M Amil, M C Carreira, J A Martínez & F F Casanueva. (2015) Interplay of atherogenic factors, protein intake and betatrophin levels in obese–metabolic syndrome patients treated with hypocaloric diets. International Journal of Obesity 40:3, pages 403-410.
Crossref
EnXu Li, Masanori Nakata, Atsumi Shinozaki, Yifei Yang, Boyang Zhang & Toshihiko Yada. (2016) Betatrophin expression is promoted in obese hyperinsulinemic type 2 but not type 1 diabetic mice. Endocrine Journal 63:7, pages 611-619.
Crossref
Mohamed Hassan. (2015) ANGPLT3: A novel modulator of lipid metabolism. Global Cardiology Science and Practice 2015:5, pages 65.
Crossref
Jinmi Lee, Seok-Woo Hong, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park & Won-Young Lee. (2015) AMP-activated protein kinase suppresses the expression of LXR/SREBP-1 signaling-induced ANGPTL8 in HepG2 cells. Molecular and Cellular Endocrinology 414, pages 148-155.
Crossref
R.K. Chilukoti, A. Giese, W. Malenke, G. Homuth, A. Bukowska, A. Goette, S.B. Felix, J. Kanaan, H.-G. Wollert, K. Evert, S. Verheule, P. Jais, S.N. Hatem, U. Lendeckel & C. Wolke. (2015) Atrial fibrillation and rapid acute pacing regulate adipocyte/adipositas-related gene expression in the atria. International Journal of Cardiology 187, pages 604-613.
Crossref
Tomoyoshi Koyama, Katsunori Ogawara, Atsushi Kasamatsu, Atsushi Okamoto, Hiroki Kasama, Yasuyuki Minakawa, Ken Shimada, Hidetaka Yokoe, Masashi Shiiba, Hideki Tanzawa & Katsuhiro Uzawa. (2015) ANGPTL3 is a novel biomarker as it activates ERK/MAPK pathway in oral cancer. Cancer Medicine 4:5, pages 759-769.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.