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Free Radical Research Volume 44, 2010 - Issue 9
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Research Article

The antioxidant edaravone attenuates ER-stress-mediated cardiac apoptosis and dysfunction in rats with autoimmune myocarditis

Hiroko Shimazaki Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City 956-8603, Japan
,
Kenichi Watanabe Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City 956-8603, JapanCorrespondence[email protected]
,
Punniyakoti T. Veeraveedu Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City 956-8603, Japan
,
Meilei Harima Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City 956-8603, Japan
,
Rajarajan A. Thandavarayan Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City 956-8603, Japan
,
Wawaimuli Arozal Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City 956-8603, Japan
,
Hitoshi Tachikawa First Department of Internal Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan
,
Makoto Kodama First Department of Internal Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan
&
Yoshifusa Aizawa First Department of Internal Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan
 show all
Pages 1082-1090 | Received 26 Feb 2010, Published online: 06 Sep 2010

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Zhao-Yin Fu, Zhi-Jiang Wu, Jun-Hui Zheng, Nuo Li, Jun-Yu Lu & Meng-Hua Chen. (2020) Edaravone Ameliorates Renal Warm Ischemia-Reperfusion Injury by Downregulating Endoplasmic Reticulum Stress in a Rat Resuscitation Model. Drug Design, Development and Therapy 14, pages 175-183.
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Yan-Yan Wang, Chen-Guang Wang, Shou-Nan Qi, Zao-Xia Liu, Guan-Fang Su & Ya-Juan Zheng. (2019) 3,5-Dimethoxy-4-hydroxy myricanol ameliorates photoreceptor cell degeneration in Pde6b10 mouse model. Cutaneous and Ocular Toxicology 38:1, pages 36-43.
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Somasundaram Arumugam, Rajarajan A. Thandavarayan, Wawaimuli Arozal, Flori R. Sari, Vijayasree V. Giridharan, Vivian Soetikno, Suresh S. Palaniyandi, Meilei Harima, Kenji Suzuki, Masaki Nagata, Ritsuo Tagaki, Makoto Kodama & Kenichi Watanabe. (2012) Quercetin offers cardioprotection against progression of experimental autoimmune myocarditis by suppression of oxidative and endoplasmic reticulum stress via endothelin-1/MAPK signalling. Free Radical Research 46:2, pages 154-163.
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Qiujie Du, Xi Zhang, Tianyun Wang & Xiaoyin Wang. (2022) Effects and mechanisms of animal-free hydrolysates on recombination protein yields in CHO cells. Applied Microbiology and Biotechnology 106:22, pages 7387-7396.
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He Chang, Yue Wang, Yang Wu, Ping Ma, Ying Song, Chunxiao Liu, Ying Ye, Jian-Hua Qi & Zhi Qi. (2020) Cardiac apoptosis caused by elevated cholesterol level in experimental autoimmune myocarditis. Experimental Cell Research 395:1, pages 112169.
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Qini Zhao, Liquan Yin, Lirong Zhang, Dongli Jiang, Long Liu & Hong Ji. (2020) Chitoheptaose Promotes Heart Rehabilitation in a Rat Myocarditis Model by Improving Antioxidant, Anti-Inflammatory, and Antiapoptotic Properties. Oxidative Medicine and Cellular Longevity 2020, pages 1-13.
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Aiqun Pan, Yuying Tan, Zhihao Wang & Guoliang Xu. (2019) STAT4 silencing underlies a novel inhibitory role of microRNA-141-3p in inflammation response of mice with experimental autoimmune myocarditis. American Journal of Physiology-Heart and Circulatory Physiology 317:3, pages H531-H540.
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Durgalakshmi Sivasankar, Melvin George & Damal Kandadai Sriram. (2018) Novel approaches in the treatment of diabetic cardiomyopathy. Biomedicine & Pharmacotherapy 106, pages 1039-1045.
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Tae Kwang Ha, Anders Holmgaard Hansen, Stefan Kol, Helene Faustrup Kildegaard & Gyun Min Lee. (2018) Baicalein Reduces Oxidative Stress in CHO Cell Cultures and Improves Recombinant Antibody Productivity. Biotechnology Journal 13:3, pages 1700425.
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Chunlian Zhong, Yang Wu, He Chang, Chunxiao Liu, Li Zhou, Jun Zou & Zhi Qi. (2017) Effect of PKC inhibitor on experimental autoimmune myocarditis in Lewis rats. Oncotarget 8:33, pages 54187-54198.
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Vengadeshprabhu Karuppagounder, Somasundaram Arumugam, Sahana Suresh Babu, Suresh S. Palaniyandi, Kenichi Watanabe, John P. Cooke & Rajarajan A. Thandavarayan. (2017) The senescence accelerated mouse prone 8 (SAMP8): A novel murine model for cardiac aging. Ageing Research Reviews 35, pages 291-296.
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Remya Sreedhar, Vijayasree V. Giridharan, Somasundaram Arumugam, Vengadeshprabhu Karuppagounder, Suresh S. Palaniyandi, Prasanna Krishnamurthy, Joao Quevedo, Kenichi Watanabe, Tetsuya Konishi & Rajarajan A. Thandavarayan. (2016) Role of MAPK-mediated endoplasmic reticulum stress signaling in the heart during aging in senescence-accelerated prone mice. BioFactors 42:4, pages 368-375.
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Kai Kang, Matthew J. Tarchick, Xiaoshan Yu, Craig Beight, Ping Bu & Minzhong Yu. (2016) Carnosic acid slows photoreceptor degeneration in the Pde6brd10 mouse model of retinitis pigmentosa. Scientific Reports 6:1.
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Kazuaki Kajimoto, Yoshitaka Minami & Hideyoshi Harashima. (2014) Cytoprotective role of the fatty acid binding protein 4 against oxidative and endoplasmic reticulum stress in 3T3-L1 adipocytes. FEBS Open Bio 4:1, pages 602-610.
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Somasundaram Arumugam, Sayaka Mito, Rajarajan A. Thandavarayan, Vijayasree V. Giridharan, Vigneshwaran Pitchaimani, Vengadeshprabhu Karuppagounder, Meilei Harima, Mayumi Nomoto, Kenji Suzuki & Kenichi Watanabe. (2013) Mulberry Leaf Diet Protects Against Progression of Experimental Autoimmune Myocarditis to Dilated Cardiomyopathy Via Modulation of Oxidative Stress and MAPK-Mediated Apoptosis. Cardiovascular Therapeutics 31:6, pages 352-362.
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Kiyoshi Kikuchi, Salunya Tancharoen, Nobuyuki Takeshige, Munetake Yoshitomi, Motohiro Morioka, Yoshinaka Murai & Eiichiro Tanaka. (2013) The Efficacy of Edaravone (Radicut), a Free Radical Scavenger, for Cardiovascular Disease. International Journal of Molecular Sciences 14:7, pages 13909-13930.
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Yung-Mei ChaoMing-Derg LaiJulie Y.H. Chan. (2013) Redox-Sensitive Endoplasmic Reticulum Stress and Autophagy at Rostral Ventrolateral Medulla Contribute to Hypertension in Spontaneously Hypertensive Rats. Hypertension 61:6, pages 1270-1280.
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Marc A. Lafleur, James L. Stevens & Jeffrey W. Lawrence. (2013) Xenobiotic Perturbation of ER Stress and the Unfolded Protein Response. Toxicologic Pathology 41:2, pages 235-262.
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Somasundaram Arumugam, Rajarajan A. Thandavarayan, Punniyakoti T. Veeraveedu, Vijayasree V. Giridharan, Vivian Soetikno, Meilei Harima, Kenji Suzuki, Masaki Nagata, Ritsuo Tagaki, Makoto Kodama & Kenichi Watanabe. (2012) Involvement of AMPK and MAPK signaling during the progression of experimental autoimmune myocarditis in rats and its blockade using a novel antioxidant. Experimental and Molecular Pathology 93:2, pages 183-189.
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Somasundaram Arumugam, Rajarajan A. Thandavarayan, Punniyakoti T. Veeraveedu, Takashi Nakamura, Wawaimuli Arozal, Flori R. Sari, Vijayasree V. Giridharan, Vivian Soetikno, Suresh S. Palaniyandi, Meilei Harima, Kenji Suzuki, Masaki Nagata, Makoto Kodama & Kenichi Watanabe. (2012) Beneficial effects of edaravone, a novel antioxidant, in rats with dilated cardiomyopathy. Journal of Cellular and Molecular Medicine 16:9, pages 2176-2185.
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Honorata Kraskiewicz & Una FitzGerald. (2012) InterfERing with endoplasmic reticulum stress. Trends in Pharmacological Sciences 33:2, pages 53-63.
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KIYOSHI KIKUCHI, NOBUYUKI TAKESHIGE, NAOKI MIURA, YOKO MORIMOTO, TAKASHI ITO, SALUNYA TANCHAROEN, KEI MIYATA, CHIEMI KIKUCHI, NARUMI IIDA, HISAAKI UCHIKADO, NAOHISA MIYAGI, NAOTO SHIOMI, TERUKAZU KURAMOTO, IKURO MARUYAMA, MOTOHIRO MORIOKA & KO-ICHI KAWAHARA. (2012) Beyond free radical scavenging: Beneficial effects of edaravone (Radicut) in various diseases (Review). Experimental and Therapeutic Medicine 3:1, pages 3-8.
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Yanti Octavia, Hans Peter Brunner-La Rocca & An L. Moens. (2012) NADPH oxidase-dependent oxidative stress in the failing heart: From pathogenic roles to therapeutic approach. Free Radical Biology and Medicine 52:2, pages 291-297.
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Joo Hee Chung, Hee Jung Choi, Soo Young Kim, Kwan Soo Hong, Soo Kee Min, Myung Hee Nam, Chan Wha Kim, Young Ho Koh & Jong Bok Seo. (2011) Proteomic and biochemical analyses reveal the activation of unfolded protein response, ERK-1/2 and ribosomal protein S6 signaling in experimental autoimmune myocarditis rat model. BMC Genomics 12:1.
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