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Free Radical Research Volume 46, 2012 - Issue 2
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Research Articles

Ascorbic acid supplementation down-regulates the alcohol induced oxidative stress, hepatic stellate cell activation, cytotoxicity and mRNA levels of selected fibrotic genes in guinea pigs

P. A. AbhilashDepartment of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram, Kerala, India
,
R. HarikrishnanDepartment of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram, Kerala, India
&
M. IndiraDepartment of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram, Kerala, IndiaCorrespondence[email protected]
Pages 204-213 | Received 21 Oct 2011, Accepted 05 Dec 2011, Published online: 23 Jan 2012

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S. H. Priyanka, S. Syam Das, Saritha S. Nair, Arun A. Rauf & M. Indira. (2019) All trans retinoic acid modulates TNF-α and CYP2E1 pathways and enhances regression of ethanol-induced fibrosis markers in hepatocytes and HSCs in abstaining rodent model. Archives of Physiology and Biochemistry 125:4, pages 302-310.
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Ya Zhang, Hang Zhao, Hua Li, Wei Cao, Fang Wang, Tian Zhang & Si-Wang Wang. (2017) Protective Effects of Amarogentin against Carbon Tetrachloride-Induced Liver Fibrosis in Mice. Molecules 22:5, pages 754.
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Ping Qiu, Yu Dong, Bo Li, Xian-jie Kang, Chao Gu, Tao Zhu, Yun-yun Luo, Min-xia Pang, Wei-feng Du & Wei-hong Ge. (2017) Dihydromyricetin modulates p62 and autophagy crosstalk with the Keap-1/Nrf2 pathway to alleviate ethanol-induced hepatic injury. Toxicology Letters 274, pages 31-41.
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Zeinab Ghorbani, Masoomeh Hajizadeh & Azita Hekmatdoost. (2016) Dietary supplementation in patients with alcoholic liver disease: a review on current evidence. Hepatobiliary & Pancreatic Diseases International 15:4, pages 348-360.
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Lina Gu, Xufeng Tao, Youwei Xu, Xu Han, Yan Qi, Lina Xu, Lianhong Yin & Jinyong Peng. (2016) Dioscin alleviates BDL- and DMN-induced hepatic fibrosis via Sirt1/Nrf2-mediated inhibition of p38 MAPK pathway. Toxicology and Applied Pharmacology 292, pages 19-29.
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Yuehua Wang, Bin Li, Jinyan Zhu, Qi Zhang, Xiuyan Zhang, Li Li, Yan Ma & Xianjun Meng. (2016) Lonicera caerulea berry extract suppresses lipopolysaccharide-induced inflammation via Toll-like receptor and oxidative stress-associated mitogen-activated protein kinase signaling. Food & Function 7:10, pages 4267-4277.
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Eva Crosas-Molist & Isabel Fabregat. (2015) Role of NADPH oxidases in the redox biology of liver fibrosis. Redox Biology 6, pages 106-111.
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Jasmohan S. Bajaj, Naga S. Betrapally, Phillip B. Hylemon, Douglas M. Heuman, Kalyani Daita, Melanie B. White, Ariel Unser, Leroy R. Thacker, Arun J. Sanyal, Dae Joong Kang, Masoumeh Sikaroodi & Patrick M Gillevet. (2015) Salivary microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy. Hepatology 62:4, pages 1260-1271.
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Xiaoling Zhang, Youwei Xu, Yan Qi, Xu Han, Lianhong Yin, Lina Xu, Kexin Liu & Jinyong Peng. (2015) Potent effects of dioscin against thioacetamide-induced liver fibrosis through attenuating oxidative stress in turn inhibiting inflammation, TGF-β/Smad and MAPK signaling pathways. Journal of Functional Foods 16, pages 436-447.
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Teresa Arrigo. (2015) Role of the diet as a link between oxidative stress and liver diseases. World Journal of Gastroenterology 21:2, pages 384.
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Jin-Hee Kim, Young-Joo Jeong, Jun-Man Hong, Hang-Rae Kim, Jae Seung Kang, Wang Jae Lee & Young-il Hwang. (2014) Chronic vitamin C insufficiency aggravated thioacetamide-induced liver fibrosis in gulo-knockout mice. Free Radical Biology and Medicine 67, pages 81-90.
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P.A. Abhilash, R. Harikrishnan & M. Indira. (2014) Ascorbic acid suppresses endotoxemia and NF-κB signaling cascade in alcoholic liver fibrosis in guinea pigs: A mechanistic approach. Toxicology and Applied Pharmacology 274:2, pages 215-224.
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R. Harikrishnan, P. A. Abhilash, S. Syam Das, P. Prathibha, S. Rejitha, Febi John, S. Kavitha & M. Indira. (2013) Protective effect of ascorbic acid against ethanol-induced reproductive toxicity in male guinea pigs. British Journal of Nutrition 110:4, pages 689-698.
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Xiaoming Li, Xiaoli Wang, Cuiyan Han, Xiaoli Wang, Guihua Xing, Li Zhou, Gang Li & Yingcai Niu. (2013) Astragaloside IV suppresses collagen production of activated hepatic stellate cells via oxidative stress-mediated p38 MAPK pathway. Free Radical Biology and Medicine 60, pages 168-176.
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M Jin, A Ande, A Kumar & S Kumar. (2013) Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway. Cell Death & Disease 4:3, pages e554-e554.
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Isabel Fabregat & Patricia Sancho. 2013. TGF-β in Human Disease. TGF-β in Human Disease 255 277 .

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