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Yasukazu Saitoh. (2018) Comments to the article “Artefacts with ascorbate and other redox-active compounds in cell culture: epigenetic modifications, and cell killing due to hydrogen peroxide generation in cell culture media”. Free Radical Research 52:9, pages 910-912.
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Ryouhei Ohwada, Yu Ozeki & Yasukazu Saitoh. (2017) High-dose ascorbic acid induces carcinostatic effects through hydrogen peroxide and superoxide anion radical generation-induced cell death and growth arrest in human tongue carcinoma cells. Free Radical Research 51:7-8, pages 684-692.
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V. Bocci, I. Zanardi & V. Travagli. (2014) A Rational Approach for Improving the Ascorbate Antineoplastic Activity. Cancer Investigation 32:3, pages 81-84.
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Articles from other publishers (44)
Rory S. Carroll, Juan Du, Brianne R. O'Leary, Garett Steers, Prabhat C. Goswami, Garry R. Buettner & Joseph J. Cullen. (2023) Pharmacological ascorbate induces sustained mitochondrial dysfunction. Free Radical Biology and Medicine.
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Sally Temraz, Jana Jabbour, Farah Nassar, Remie El Helou, Ruba Hadla, Maria Mezher, Ahmed El Lakkiss, Maya Charafeddine, Rihab Nasr & Ali Shamseddine. (2023) Can plasma vitamin C predict survival in stage IV colorectal cancer patients? Results of a prospective cohort study. Frontiers in Nutrition 10.
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Senlin Qin, Guoyan Wang, Lei Chen, Huijun Geng, Yining Zheng, Chao Xia, Shengru Wu, Junhu Yao & Lu Deng. (2023) Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression. PLOS Genetics 19:2, pages e1010629.
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Jia Qiu, Tianhong Yang, Yali Long, Peng He, Wanqing Shen, Bing Zhang, Xinchong Shi, Lei Peng, Zhoulei Li & Xiangsong Zhang. (2022) Mitochondrial respiration inhibitor enhances the anti-tumor effect of high-dose ascorbic acid in castration-resistant prostate cancer. Journal of Molecular Medicine 101:1-2, pages 125-138.
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Juan Du, Amanda N. Pope, Brianne R. O’Leary, Brett A. Wagner, Prabhat C. Goswami, Garry R. Buettner & Joseph J. Cullen. (2022) The role of mitochondria in pharmacological ascorbate-induced toxicity. Scientific Reports 12:1.
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Brianne R. O'Leary, Elena K. Ruppenkamp, Garett J. Steers, Juan Du, Rory S. Carroll, Brett A. Wagner, Garry R. Buettner & Joseph J. Cullen. (2022) Pharmacological Ascorbate Enhances Chemotherapies in Pancreatic Ductal Adenocarcinoma. Pancreas 51:6, pages 684-693.
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Yunxia O'Malley, Mitchell C. Coleman, Xingshen Sun, Junying Lei, Jianrong Yao, Casey F. Pulliam, Paige Kluz, Michael L. McCormick, Yaling Yi, Yumi Imai, John F. Engelhardt, Andrew W. Norris, Douglas R. Spitz & Aliye Uc. (2022) Oxidative stress and impaired insulin secretion in cystic fibrosis pig pancreas. Advances in Redox Research 5, pages 100040.
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Garett J. Steers, Gloria Y. Chen, Brianne R. O’Leary, Juan Du, Hannah Van Beek & Joseph J. Cullen. (2022) Auranofin and Pharmacologic Ascorbate as Radiomodulators in the Treatment of Pancreatic Cancer. Antioxidants 11:5, pages 971.
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Luksana Chaiswing, Chontida Yarana, William St. Clair, Artak Tovmasyan, Ines Batinic-Haberle, Ivan Spasojevic & Daret St. Clair. (2022) A Redox-active Mn Porphyrin, MnTnBuOE-2-PyP5+, Synergizes with Carboplatin in Treatment of Chemoresistant Ovarian Cell Line. Oxidative Medicine and Cellular Longevity 2022, pages 1-16.
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Christophe Glorieux & Pedro Buc Calderon. (2021) Vitamin C (Ascorbate) and Redox Topics in Cancer. Antioxidants & Redox Signaling 35:14, pages 1157-1175.
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András SzarkaOrsolya KapuyTamás LőrinczGábor Bánhegyi. (2021) Vitamin C and Cell Death. Antioxidants & Redox Signaling 34:11, pages 831-844.
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Katharina Hill-Mündel & Donatus Nohr. (2021) Cytotoxic activity of high dose ascorbic acid is enhanced by 2-deoxy-d-glucose in glycolytic melanoma cells. Biochemical and Biophysical Research Communications 546, pages 90-96.
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Cameron M. Cushing, Michael S. Petronek, Kellie L. Bodeker, Sandy Vollstedt, Heather A. Brown, Emyleigh Opat, Nancy J. Hollenbeck, Thomas Shanks, Daniel J. Berg, Brian J. Smith, Mark C. Smith, Varun Monga, Muhammad Furqan, Matthew A. Howard, Jeremy D. Greenlee, Kranti A. Mapuskar, Joel St-Aubin, Ryan T. Flynn, Joseph J. Cullen, Garry R. Buettner, Douglas R. Spitz, John M. Buatti, Bryan G. Allen & Vincent A. Magnotta. (2021) Magnetic resonance imaging (MRI) of pharmacological ascorbate-induced iron redox state as a biomarker in subjects undergoing radio-chemotherapy. Redox Biology 38, pages 101804.
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Michela Codini. (2020) Why Vitamin C Could Be an Excellent Complementary Remedy to Conventional Therapies for Breast Cancer. International Journal of Molecular Sciences 21:21, pages 8397.
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Dieanira T. Erudaitius, Garry R. Buettner & Victor G.J. Rodgers. (2020) The latency of peroxisomal catalase in terms of effectiveness factor for pancreatic and glioblastoma cancer cell lines in the presence of high concentrations of H2O2: Implications for the use of pharmacological ascorbate in cancer therapy. Free Radical Biology and Medicine 156, pages 20-25.
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Naohiro Oka, Akiyoshi Komuro, Hisayuki Amano, Suman Dash, Masahiko Honda, Kazushige Ota, Shunji Nishimura, Takeshi Ueda, Masao Akagi & Hitoshi Okada. (2020) Ascorbate sensitizes human osteosarcoma cells to the cytostatic effects of cisplatin. Pharmacology Research & Perspectives 8:4.
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Julia Kaźmierczak-Barańska, Karolina Boguszewska, Angelika Adamus-Grabicka & Bolesław T. Karwowski. (2020) Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent. Nutrients 12:5, pages 1501.
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Caigui Lin, Jiyang Dong, Zhiliang Wei, Kian-Kai Cheng, Jie Li, Song You, Yueyue Liu, Xiaomin Wang & Zhong Chen. (2020)
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H NMR-Based Metabolic Profiles Delineate the Anticancer Effect of Vitamin C and Oxaliplatin on Hepatocellular Carcinoma Cells
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Margaret L. Musser, Alyssa L. Mahaffey, Melissa A. Fath, Garry R. Buettner, Brett A. Wagner, Benjamin K. Schneider, Yeon-Jung Seo, Jonathan P. Mochel & Chad M. Johannes. (2019) In vitro Cytotoxicity and Pharmacokinetic Evaluation of Pharmacological Ascorbate in Dogs. Frontiers in Veterinary Science 6.
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Joshua D. Schoenfeld, Matthew S. Alexander, Timothy J. Waldron, Zita A. Sibenaller, Douglas R. Spitz, Garry R. Buettner, Bryan G. Allen & Joseph J. Cullen. (2019) Pharmacological Ascorbate as a Means of Sensitizing Cancer Cells to Radio-Chemotherapy While Protecting Normal Tissue. Seminars in Radiation Oncology 29:1, pages 25-32.
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Ana Amélia de Carvalho Melo-Cavalcante, Leonardo da Rocha Sousa, Marcus Vinícius Oliveira Barros Alencar, José Victor de Oliveira Santos, Ana Maria oliveira da Mata, Márcia Fernanda Correia Jardim Paz, Ricardo Melo de Carvalho, Nárcia Mariana Fonseca Nunes, Muhammad Torequl Islam, Anderson Nogueira Mendes, Juan Carlos Ramos Gonçalves, Felipe Cavalcanti Carneiro da Silva, Paulo Michel Pinheiro Ferreira & João Marcelo de Castro e Sousaa. (2019) Retinol palmitate and ascorbic acid: Role in oncological prevention and therapy. Biomedicine & Pharmacotherapy 109, pages 1394-1405.
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Luksana ChaiswingWilliam H. St. ClairDaret K. St. Clair. (2018) Redox Paradox: A Novel Approach to Therapeutics-Resistant Cancer. Antioxidants & Redox Signaling 29:13, pages 1237-1272.
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Nicola Baillie, Anitra Carr & Selene Peng. (2018) The Use of Intravenous Vitamin C as a Supportive Therapy for a Patient with Glioblastoma Multiforme. Antioxidants 7:9, pages 115.
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Margreet C. M. Vissers & Andrew B. Das. (2018) Potential Mechanisms of Action for Vitamin C in Cancer: Reviewing the Evidence. Frontiers in Physiology 9.
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Joshua D. Schoenfeld, Zita A. Sibenaller, Kranti A. Mapuskar, Megan D. Bradley, Brett A. Wagner, Garry R. Buettner, Varun Monga, Mohammed Milhem, Douglas R. Spitz & Bryan G. Allen. (2018) Redox active metals and H2O2 mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models. Redox Biology 14, pages 417-422.
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Brianne R. O'Leary, Frederick K. Houwen, Chase L. Johnson, Bryan G. Allen, James J. Mezhir, Daniel J. Berg, Joseph J. Cullen & Douglas R. Spitz. (2018) Pharmacological Ascorbate as an Adjuvant for Enhancing Radiation-Chemotherapy Responses in Gastric Adenocarcinoma. Radiation Research 189:5, pages 456.
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Enlong Ma, Ping Chen, Heather M. Wilkins, Tao Wang, Russell H. Swerdlow & Qi Chen. (2017) Pharmacologic ascorbate induces neuroblastoma cell death by hydrogen peroxide mediated DNA damage and reduction in cancer cell glycolysis. Free Radical Biology and Medicine 113, pages 36-47.
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Bin Zhang, Sharath Kandhi, Yang-Ming Yang, Yicong Le, Wensheng Deng, Jun Qin, Houli Jiang, Ghezal Froogh, Dong Sun & An Huang. (2017) A novel mechanism of ascorbate direct modulation of soluble epoxide hydrolase. Prostaglandins & Other Lipid Mediators 131, pages 59-66.
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Joshua D. Schoenfeld, Zita A. Sibenaller, Kranti A. Mapuskar, Brett A. Wagner, Kimberly L. Cramer-Morales, Muhammad Furqan, Sonia Sandhu, Thomas L. Carlisle, Mark C. Smith, Taher Abu Hejleh, Daniel J. Berg, Jun Zhang, John Keech, Kalpaj R. Parekh, Sudershan Bhatia, Varun Monga, Kellie L. Bodeker, Logan Ahmann, Sandy Vollstedt, Heather Brown, Erin P. Shanahan Kauffman, Mary E. Schall, Ray J. Hohl, Gerald H. Clamon, Jeremy D. Greenlee, Matthew A. Howard, Michael K. Schultz, Brian J. Smith, Dennis P. Riley, Frederick E. Domann, Joseph J. Cullen, Garry R. Buettner, John M. Buatti, Douglas R. Spitz & Bryan G. Allen. (2017) O 2 ⋅− and H 2 O 2 -Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate. Cancer Cell 31:4, pages 487-500.e8.
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Dieanira Erudaitius, Andrew Huang, Sarah Kazmi, Garry R. Buettner & Victor G. J. Rodgers. (2017) Peroxiporin Expression Is an Important Factor for Cancer Cell Susceptibility to Therapeutic H2O2: Implications for Pharmacological Ascorbate Therapy. PLOS ONE 12:1, pages e0170442.
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Claire M. Doskey, Visarut Buranasudja, Brett A. Wagner, Justin G. Wilkes, Juan Du, Joseph J. Cullen & Garry R. Buettner. (2016) Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacological ascorbate in cancer therapy. Redox Biology 10, pages 274-284.
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Ana Salomé Pires, Cláudia Raquel Marques, João Carlos Encarnação, Ana Margarida Abrantes, Ana Catarina Mamede, Mafalda Laranjo, Ana Cristina Gonçalves, Ana Bela Sarmento-Ribeiro & Maria Filomena Botelho. (2016) Ascorbic acid and colon cancer: an oxidative stimulus to cell death depending on cell profile. European Journal of Cell Biology 95:6-7, pages 208-218.
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Helder T. Soares, Joana R. S. Campos, Lígia C. Gomes-da-Silva, Fábio A. Schaberle, Janusz M. Dabrowski & Luis G. Arnaut. (2016) Pro-oxidant and Antioxidant Effects in Photodynamic Therapy: Cells Recognise that Not All Exogenous ROS Are Alike. ChemBioChem 17:9, pages 836-842.
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Qi ChenKishore PolireddyPing ChenRuochen Dong. (2015) The unpaved journey of vitamin C in cancer treatment. Canadian Journal of Physiology and Pharmacology 93:12, pages 1055-1063.
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Juan Du, John A. CieslakIIIIII, Jessemae L. Welsh, Zita A. Sibenaller, Bryan G. Allen, Brett A. Wagner, Amanda L. Kalen, Claire M. Doskey, Robert K. Strother, Anna M. Button, Sarah L. Mott, Brian Smith, Susan Tsai, James Mezhir, Prabhat C. Goswami, Douglas R. Spitz, Garry R. Buettner & Joseph J. Cullen. (2015) Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer. Cancer Research 75:16, pages 3314-3326.
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Juan Du, Brett A. Wagner, Garry R. Buettner & Joseph J. Cullen. (2015) Role of labile iron in the toxicity of pharmacological ascorbate. Free Radical Biology and Medicine 84, pages 289-295.
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John A. Cieslak, Robert K. Strother, Malvika Rawal, Juan Du, Claire M. Doskey, Samuel R. Schroeder, Anna Button, Brett A. Wagner, Garry R. Buettner & Joseph J. Cullen. (2015) Manganoporphyrins and ascorbate enhance gemcitabine cytotoxicity in pancreatic cancer. Free Radical Biology and Medicine 83, pages 227-237.
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Edward Folk, Tracy M. Downs & Alfred Roc Ordman. (2015) Two Grams BID Is an Oral Dosage of Vitamin C to Reduce the Risk of Recurrence of Superficial Bladder Carcinoma. Journal of Cancer Therapy 06:02, pages 169-176.
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Carole Grasso, Marie-Sophie Fabre, Sarah V. Collis, M. Leticia Castro, Cameron S. Field, Nanette Schleich, Melanie J. McConnell & Patries M. Herst. (2014) Pharmacological Doses of Daily Ascorbate Protect Tumors from Radiation Damage after a Single Dose of Radiation in an Intracranial Mouse Glioma Model. Frontiers in Oncology 4.
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Dongsheng Zhang, Juan Li, Fengzhen Wang, Jun Hu, Shuwei Wang & Yueming Sun. (2014) 2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy. Cancer Letters 355:2, pages 176-183.
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Marija Mojić, Jelena Bogdanović Pristov, Danijela Maksimović-Ivanić, David R. Jones, Marina Stanić, Sanja Mijatović & Ivan Spasojević. (2014) Extracellular iron diminishes anticancer effects of vitamin C: An in vitro study. Scientific Reports 4:1.
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Jie Dai, Mingwei Liu, Qing Ai, Ling Lin, Kunwei Wu, Xinyu Deng, Yuping Jing, Mengying Jia, Jingyuan Wan & Li Zhang. (2014) Involvement of catalase in the protective benefits of metformin in mice with oxidative liver injury. Chemico-Biological Interactions 216, pages 34-42.
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Justin C. Moser, Malvika Rawal, Brett A. Wagner, Juan Du, Joseph J. Cullen & Garry R. Buettner. (2014) Pharmacological ascorbate and ionizing radiation (IR) increase labile iron in pancreatic cancer. Redox Biology 2, pages 22-27.
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Malvika Rawal, Samuel R. Schroeder, Brett A. Wagner, Cameron M. Cushing, Jessemae L. Welsh, Anna M. Button, Juan Du, Zita A. Sibenaller, Garry R. Buettner & Joseph J. Cullen. (2013) Manganoporphyrins Increase Ascorbate-Induced Cytotoxicity by Enhancing H2O2 Generation. Cancer Research 73:16, pages 5232-5241.
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