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Original Article

Vitamin K, 2,3-Epoxide And Quinone Reduction: Mechanism And Inhibition

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Pages 401-415 | Received 06 Dec 1989, Published online: 07 Jul 2009

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Read on this site (3)

Werner Cordier & Vanessa Steenkamp. (2012) Herbal remedies affecting coagulation: A review. Pharmaceutical Biology 50:4, pages 443-452.
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Nicholas Au & Allan E. Rettie. (2008) Pharmacogenomics of 4-Hydroxycoumarin Anticoagulants. Drug Metabolism Reviews 40:2, pages 355-375.
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David Ross. (2004) Quinone Reductases Multitasking in the Metabolic World. Drug Metabolism Reviews 36:3-4, pages 639-654.
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Articles from other publishers (25)

Tao Xiao, Ke Liu, Qiwen Gao, Manyun Chen, Young S. Kim, Shouguang Jin, Yousong Ding & Robert W. HuigensIIIIII. (2023) Design, Synthesis, and Evaluation of Carbonate-Linked Halogenated Phenazine-Quinone Prodrugs with Improved Water-Solubility and Potent Antibacterial Profiles. ACS Infectious Diseases 9:4, pages 899-915.
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Lubna ABDALLAH, Ibtihaj SURAKJI, Tarteel QAWASME, Dania AYYASH, Ruba SHHADEH, Ghadeer OMAR & Ali BARAKAT. (2022) <i>In Vitro</i> Activity of Some Medicinal Plants on Blood Coagulation. Turkish Journal of Pharmaceutical Sciences 19:3, pages 330-335.
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David Ross & David Siegel. (2021) The diverse functionality of NQO1 and its roles in redox control. Redox Biology 41, pages 101950.
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Céline Rivière & Thierry Hennebelle. 2021. Handbook of Dietary Phytochemicals. Handbook of Dietary Phytochemicals 1201 1324 .
G. Omar, L. Abdallah, A. Barakat, R. Othman & H. Bourinee. (2020) In vitro haemostatic efficacy of aqueous, methanol and ethanol plant extracts of three medicinal plant species in Palestine. Brazilian Journal of Biology 80:4, pages 763-768.
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Elyse M. Digby, Oleg Sadovski & Andrew A. Beharry. (2020) An Activatable Photosensitizer Targeting Human NAD(P)H: Quinone Oxidoreductase 1. Chemistry – A European Journal 26:12, pages 2713-2718.
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Céline Rivière & Thierry Hennebelle. 2020. Handbook of Dietary Phytochemicals. Handbook of Dietary Phytochemicals 1 125 .
Mark A. Rishavy, Kevin W. Hallgren, Lee Wilson, Savita Singh, Kurt W. Runge & Kathleen L. Berkner. (2018) Warfarin alters vitamin K metabolism: a surprising mechanism of VKORC1 uncoupling necessitates an additional reductase. Blood 131:25, pages 2826-2835.
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Michael Caspers, Katrin J. Czogalla, Kerstin Liphardt, Jens Müller, Philipp Westhofen, Matthias Watzka & Johannes Oldenburg. (2015) Two enzymes catalyze vitamin K 2,3-epoxide reductase activity in mouse: VKORC1 is highly expressed in exocrine tissues while VKORC1L1 is highly expressed in brain. Thrombosis Research 135:5, pages 977-983.
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Gergely Kiss, Csaba Konrad, Issa Pour‐Ghaz, Josef J. Mansour, Béata Németh, Anatoly A. Starkov, Vera Adam‐Vizi & Christos Chinopoulos. (2014) Mitochondrial diaphorases as NAD + donors to segments of the citric acid cycle that support substrate‐level phosphorylation yielding ATP during respiratory inhibition . The FASEB Journal 28:4, pages 1682-1697.
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Martin J. Shearer & Paul Newman. (2014) Recent trends in the metabolism and cell biology of vitamin K with special reference to vitamin K cycling and MK-4 biosynthesis. Journal of Lipid Research 55:3, pages 345-362.
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Brian O. IngramJared L. TurbyfillPeggy J. BledsoeAnil K. JaiswalDarrel W. Stafford. (2013) Assessment of the contribution of NAD(P)H-dependent quinone oxidoreductase 1 (NQO1) to the reduction of vitamin K in wild-type and NQO1-deficient mice. Biochemical Journal 456:1, pages 47-54.
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Werner Cordier, Allan D Cromarty, Elsabie Botha & Vanessa Steenkamp. (2011) Effects of selected South African plant extracts on haemolysis and coagulation. Human & Experimental Toxicology 31:3, pages 250-257.
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Jian-Ke Tie, Da-Yun Jin, David L. Straight & Darrel W. Stafford. (2011) Functional study of the vitamin K cycle in mammalian cells. Blood 117:10, pages 2967-2974.
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Jian?Ke Tie & Darrel W. Stafford. 2008. Vitamin K. Vitamin K 103 130 .
Xing Gong, Ramana Gutala & Anil K. Jaiswal. 2008. Vitamin K. Vitamin K 85 101 .
Yan-Mei SunDa-Yun JinRodney M. CamireDarrel W. Stafford. (2005) Vitamin K epoxide reductase significantly improves carboxylation in a cell line overexpressing factor X. Blood 106:12, pages 3811-3815.
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Jian-Ke Tie, Christopher Nicchitta, Gunnar von Heijne & Darrel W. Stafford. (2005) Membrane Topology Mapping of Vitamin K Epoxide Reductase by in Vitro Translation/Cotranslocation. Journal of Biological Chemistry 280:16, pages 16410-16416.
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David Ross & David Siegel. 2004. Quinones and Quinone Enzymes, Part B. Quinones and Quinone Enzymes, Part B 115 144 .
R. Aguilar Hernández, M. J. Sánchez De Las Matas, C. Arriagada, C. Barcia, P. Caviedes, M. T. Herrero & J. Segura-Aguilar. (2003) MPP+-induced degeneration is potentiated by dicoumarol in cultures of the RCSN-3 dopaminergic cell line. Implications of neuromelanin in oxidative metabolism of dopamine neurotoxicity. Neurotoxicity Research 5:6, pages 407-410.
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Shiuan Chen, Kebin Wu, Di Zhang, Mark Sherman, Richard Knox & Chung S. Yang. (1999) Molecular Characterization of Binding of Substrates and Inhibitors to DT-Diaphorase: Combined Approach Involving Site-Directed Mutagenesis, Inhibitor-Binding Analysis, and Computer Modeling. Molecular Pharmacology 56:2, pages 272-278.
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F. von Bruchhausen, S. Ebel, E. Hackenthal, G. Dannhardt, A. W. Frahm, U. Holzgrabe, K. Keller, E. Nürnberg, H. Rimpler, G. Schneider, P. Surmann, H. U. Wolf & G. Wurm. 1993. Hagers Handbuch der Pharmazeutischen Praxis. Hagers Handbuch der Pharmazeutischen Praxis 1 163 .
Peter C. Preusch. (1992) Is thioredoxin the physiological vitamin K epoxide reducing agent?. FEBS Letters 305:3, pages 257-259.
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Enrique Cadenas, Paul Hochstein & Lars Ernster. 1992. Advances in Enzymology and Related Areas of Molecular Biology. Advances in Enzymology and Related Areas of Molecular Biology 97 146 .
Peter C. Preusch, David Siegel, Neil W. Gibson & David Ross. (1991) A note on the inhibition of DT-diaphorase by dicoumarol. Free Radical Biology and Medicine 11:1, pages 77-80.
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