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Original Article

Studies on the Antioxidant and Free Radical Scavenging Properties of Idb 1016 A New Flavanolignan Complex

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Pages 109-115 | Received 15 Dec 1989, Published online: 07 Jul 2009

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Hong-Jun Wang, Yuan-Yuan Jiang, Xiao-Feng Wei, Huai Huang, Shin-Ichi Tashiro, Satoshi Onodera & Takashi Ikejima. (2010) Silibinin induces protective superoxide generation in human breast cancer MCF-7 cells. Free Radical Research 44:1, pages 90-100.
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Manuela Aragno, Elena Tamagno, Giuseppe Poli, Giuseppe Boccuzzi, Enrico Brignardello & Oliviero Danni. (1994) Prevention of Carbon Tetrachloride-Induced Lipid Peroxidation in Liver Microsomes from Dehydroepiandrosterone-Pretreated Rats. Free Radical Research 21:6, pages 427-435.
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E.M. Martinelli, P. Morazzoni, S. Livio & E. Uberti. (1991) Liquid Chromatographic Assay of Silybin in Human Plasma and Urine. Journal of Liquid Chromatography 14:7, pages 1285-1296.
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Articles from other publishers (47)

Hemlata Bhardwaj, Neeru Vasudeva & Sunil Sharma. (2023) Possible Mechanism and Pharmacological Activities of a Flavolignan Silibinin. Current Bioactive Compounds 19:7.
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Václav Tvrdý, Jana Pourová, Eduard Jirkovský, Vladimír Křen, Kateřina Valentová & Přemysl Mladěnka. (2021) Systematic review of pharmacokinetics and potential pharmacokinetic interactions of flavonolignans from silymarin. Medicinal Research Reviews 41:4, pages 2195-2246.
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Motahareh Boozari & Hossein Hosseinzadeh. (2020) Preventing contrast‐induced nephropathy ( CIN ) with herbal medicines: A review . Phytotherapy Research 35:3, pages 1130-1146.
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Murat BOYACIOĞLU. (2019) Protective Effects of Silymarin on Indomethacin-Induced Gastric Ulcer in RatsRatlarda İndometazinle Oluşturulan Gastrik Ülser Üzerine Silimarinin Koruyucu Etkileri. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 16:2, pages 109-114.
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Navaneethakrishnan Polachi, Guirong Bai, Tingyang Li, Yang Chu, Xiangyang Wang, Shuming Li, Ning Gu, Jiang Wu, Wei Li, Yanjun Zhang, Shuiping Zhou, He Sun & Changxiao Liu. (2016) Modulatory effects of silibinin in various cell signaling pathways against liver disorders and cancer – A comprehensive review. European Journal of Medicinal Chemistry 123, pages 577-595.
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Santosh Kumar Jatav, Archana Kulshrestha, Anish Zacharia, Nita Singh, G. Tejovathi, P. S. Bisen & G. B. K. S. Prasad. (2014) Spirulina maxima Protects Liver From Isoniazid and Rifampicin Drug Toxicity . Journal of Evidence-Based Complementary & Alternative Medicine 19:3, pages 189-194.
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Hílton Antônio Mata-Santos, Fabianno Ferreira Dutra, Carolina Carneiro Rocha, Fabiana Gonçalves Lino, Fabiola Ramos Xavier, Leandro Andrade Chinalia, Bryan Hudson Hossy, Morgana Teixeira Lima Castelo-Branco, Anderson Junger Teodoro, Claudia N. Paiva & Alexandre dos Santos Pyrrho. (2014) Silymarin Reduces Profibrogenic Cytokines and Reverses Hepatic Fibrosis in Chronic Murine Schistosomiasis. Antimicrobial Agents and Chemotherapy 58:4, pages 2076-2083.
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A. Y. AU, J. M. HASENWINKEL & C. G. FRONDOZA. (2011) Silybin inhibits interleukin-1β-induced production of pro-inflammatory mediators in canine hepatocyte cultures. Journal of Veterinary Pharmacology and Therapeutics 34:2, pages 120-129.
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Ajay Semalty, Mona Semalty, Mohan Singh Maniyari Rawat & Federico Franceschi. (2010) Supramolecular phospholipids–polyphenolics interactions: The PHYTOSOME® strategy to improve the bioavailability of phytochemicals. Fitoterapia 81:5, pages 306-314.
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Richard D. Verschoyle, Karen Brown, William P. Steward & Andreas J. Gescher. (2007) Consumption of silibinin, a flavonolignan from milk thistle, and mammary cancer development in the C3(1) SV40 T,t antigen transgenic multiple mammary adenocarcinoma (TAg) mouse. Cancer Chemotherapy and Pharmacology 62:2, pages 369-372.
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Richard D. Verschoyle, Peter Greaves, Ketan Patel, Debbie A. Marsden, Karen Brown, William P. Steward & Andreas J. Gescher. (2008) Evaluation of the cancer chemopreventive efficacy of silibinin in genetic mouse models of prostate and intestinal carcinogenesis: Relationship with silibinin levels. European Journal of Cancer 44:6, pages 898-906.
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Vaqar M. Adhami, Deeba N. Syed, Naghma Khan & Farrukh Afaq. (2008) Phytochemicals for Prevention of Solar Ultraviolet Radiation-induced Damages. Photochemistry and Photobiology 84:2, pages 489-500.
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Noboru Motohashi & Hiroshi Sakagami. 2008. Bioactive Heterocycles VI. Bioactive Heterocycles VI 1 48 .
Eun-Kyung Kim, Kang-Beom Kwon, Mi-Young Song, Sang-Wan Seo, Sung-Joo Park, Sun-O Ka, Lv Na, Kyung-Ah Kim, Do-Gon Ryu, Hong-Seob So, Raekil Park, Jin-Woo Park & Byung-Hyun Park. (2007) Genistein protects pancreatic β cells against cytokine-mediated toxicity. Molecular and Cellular Endocrinology 278:1-2, pages 18-28.
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Fawn S. Hogan, Naveen K. Krishnegowda, Margarita Mikhailova & Morton S. Kahlenberg. (2007) Flavonoid, Silibinin, Inhibits Proliferation and Promotes Cell-Cycle Arrest of Human Colon Cancer. Journal of Surgical Research 143:1, pages 58-65.
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C. R. FILBURN, R. KETTENACKER & D. W. GRIFFIN. (2007) Bioavailability of a silybin?phosphatidylcholine complex in dogs. Journal of Veterinary Pharmacology and Therapeutics 30:2, pages 132-138.
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C. Nencini, G. Giorgi & L. Micheli. (2007) Protective effect of silymarin on oxidative stress in rat brain. Phytomedicine 14:2-3, pages 129-135.
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Takuji Tanaka & Shigeyuki Sugie. (2007) Inhibition of Colon Carcinogenesis by Dietary Non-Nutritive Compounds. Journal of Toxicologic Pathology 20:4, pages 215-235.
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Gopalakrishnan Ramakrishnan, Hanumantha Rao Balaji Raghavendran, Radhakrishnan Vinodhkumar & Thiruvengadam Devaki. (2006) Suppression of N-nitrosodiethylamine induced hepatocarcinogenesis by silymarin in rats. Chemico-Biological Interactions 161:2, pages 104-114.
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Carmen Hoh, David Boocock, Tim Marczylo, Rajinder Singh, David P. Berry, Ashley R. Dennison, David Hemingway, Andrew Miller, Kevin West, Stephanie Euden, Giuseppe Garcea, Peter B. Farmer, William P. Steward & Andreas J. Gescher. (2006) Pilot Study of Oral Silibinin, a Putative Chemopreventive Agent, in Colorectal Cancer Patients: Silibinin Levels in Plasma, Colorectum, and Liver and Their Pharmacodynamic Consequences. Clinical Cancer Research 12:9, pages 2944-2950.
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Hiroyuki Kohno, Rikako Suzuki, Shigeyuki Sugie, Hiroyuki Tsuda & Takuji Tanaka. (2005) Dietary Supplementation with Silymarin Inhibits 3,2′-Dimethyl-4-Aminobiphenyl–Induced Prostate Carcinogenesis in Male F344 Rats. Clinical Cancer Research 11:13, pages 4962-4967.
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Sleem F'guyer, Farrukh Afaq & Hasan Mukhtar. (2003) Photochemoprevention of skin cancer by botanical agents. Photodermatology, Photoimmunology & Photomedicine 19:2, pages 56-72.
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Alpana Tyagi, Neehar Bhatia, Mark S. Condon, Maarten C. Bosland, Chapla Agarwal & Rajesh Agarwal. (2002) Antiproliferative and apoptotic effects of silibinin in rat prostate cancer cells. The Prostate 53:3, pages 211-217.
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Hiroyuki Kohno, Takuji Tanaka, Kunihiro Kawabata, Yoshinobu Hirose, Shigeyuki Sugie, Hiroyuki Tsuda & Hideki Mori. (2002) Silymarin, a naturally occurring polyphenolic antioxidant flavonoid, inhibits azoxymethane‐induced colon carcinogenesis in male F344 rats. International Journal of Cancer 101:5, pages 461-468.
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Pham Quang Vinh, Shigeyuki Sugie, Takuji Tanaka, Akira Hara, Yasuhiro Yamada, Masaki Katayama, Takashi Deguchi & Hideki Mori. (2005) Chemopreventive Effects of a Flavonoid Antioxidant Silymarin on N ‐Butyl‐ N ‐(4‐ hydroxybutyl)nitrosamine‐induced Urinary Bladder Carcinogenesis in Male ICR Mice . Japanese Journal of Cancer Research 93:1, pages 42-49.
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J. Zhao, M. Lahiri-Chatterjee, Y. Sharma & R. Agarwal. (2000) Inhibitory effect of a flavonoid antioxidant silymarin on benzoyl peroxide-induced tumor promotion, oxidative stress and inflammatory responses in SENCAR mouse skin. Carcinogenesis 21:4, pages 811-816.
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Fernando A Crocenzi, Jos? M Pellegrino, Enrique J S?nchez Pozzi, Aldo D Mottino, Emilio A Rodr??guez Garay & Marcelo G Roma. (2000) Effect of silymarin on biliary bile salt secretion in the rat. Biochemical Pharmacology 59:8, pages 1015-1022.
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M. Cuendet & M. Pezzuto. (2000) The Role of Cyclooxygenase and Lipoxygenase in Cancer Chemoprevention. Drug Metabolism and Drug Interactions 17:1-4.
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Neehar Bhatia, Jifu Zhao, Douglas M. Wolf & Rajesh Agarwal. (1999) Inhibition of human carcinoma cell growth and DNA synthesis by silibinin, an active constituent of milk thistle: comparison with silymarin. Cancer Letters 147:1-2, pages 77-84.
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Jifu Zhao, Yogesh Sharma & Rajesh Agarwal. (1999) Significant inhibition by the flavonoid antioxidant silymarin against 12-O-tetradecanoylphorbol 13-acetate-caused modulation of antioxidant and inflammatory enzymes, and cyclooxygenase 2 and interleukin-1? expression in SENCAR mouse epidermis: Implications in the prevention of stage I tumor promotion. Molecular Carcinogenesis 26:4, pages 321-333.
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Goshi Nishimura, Syunsuke Yanoma, Hiromi Mizuno, Koji Kawakami & Mamoru Tsukuda. (2005) An Antioxidant, Probucol, Induces Anti‐angiogenesis and Apoptosis in Athymic Nude Mouse Xenografted Human Head and Neck Squamous Carcinoma Cells. Japanese Journal of Cancer Research 90:11, pages 1224-1230.
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Jifu Zhao & Rajesh Agarwal. (1999) Tissue distribution of silibinin, the major active constituent of silymarin, in mice and its association with enhancement of phase II enzymes: implications in cancer chemoprevention. Carcinogenesis 20:11, pages 2101-2108.
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Nihal Ahmad, Hala Gali, Seema Javed & Rajesh Agarwal. (1998) Skin Cancer Chemopreventive Effects of a Flavonoid Antioxidant Silymarin Are Mediated via Impairment of Receptor Tyrosine Kinase Signaling and Perturbation in Cell Cycle Progression. Biochemical and Biophysical Research Communications 247:2, pages 294-301.
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P. Morazzoni, M. J. Magistretti, C. Giachetti & G. Zanolo. (1992) Comparative bioavailability of Silipide, a new flavanolignan complex, in rats. European Journal of Drug Metabolism and Pharmacokinetics 17:1, pages 39-44.
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