18
Views
50
CrossRef citations to date
0
Altmetric
Original Article

Studies on the Antioxidant and Free Radical Scavenging Properties of Idb 1016 A New Flavanolignan Complex

, , , , , , , , & show all
Pages 109-115 | Received 15 Dec 1989, Published online: 07 Jul 2009

References

  • Wagner H. Antihepatotoxic flavonoids. Plant Flavonoids in Biology and Medicine: Biochemical, Pharmacological and Structure-Activity, V. Cody, E. Middleton, J. B. Harborne. A.R. Liss Inc., New York 1986; 14–35
  • Bindoli B., Cavallini L., Siliprandi N. Inhibitory action of silymarin of lipid peroxide formation in rat liver mitochondria and microsomes. Biochemical Pharmacology 1977; 26: 2405–2409
  • Valenzuela A., Guerra R. Differential effect of silybin on the Fe3+-ADP and t-butyl hydroperoxide-induced microsomal lipid peroxidation. Experientia 1986; 42: 139–141
  • Valenzuela A., Lagos C., Schmidt K., Videla L. A. Silymarin protection against hepatic lipid peroxidation induced by acute ethanol intoxication in the rat. Biochemical Pharmacology 1985; 34: 2209–2212
  • Valenzuela A., Barria T., Guerra R., Garrido A. Inhibitory effect of the flavonoid silymarin on the erythrocyte haemolysis induced by phenylhydrazine. Biochemical and Biophysical Research Communications 1985; 126: 712–718
  • Desplaces A., Choppin J., Vogel G., Trost W. Histochemical study on the treatment of the liver damage by phalloidine with silymarin, the active principle of the seed of Silybum Marianum. Digestion 1974; 10: 343–344
  • Morazzoni P., Magistretti M. J., Zanolo G., Poletti P. Comparative bioavailability of IdB 1016 a new flavanolignan complex in the rat. Abstract of 37th Annual Congress on Medicinal Plant Research. Thieme Verlag, Stutgart 1989; 78
  • Barzaghi N., Perucca G., Pifferi G., Crema A. Single-dose pharmacokinetic study of IdB 1016, a new flavanolignan complex in man. European Journal of Clinical Pharmacology 1989; 36(suppl.)A110
  • Slater T. F., Sawyer B. C. Stimulatory effect of carbon tetrachloride and other halogenoalkanes on peroxidative reactions in rat liver fractions in vitro: general features of the system used. Biochemical Journal 1971; 123: 815–822
  • Albano E., Cheeseman K. H., Tomasi A., Carini R., Dianzani M. U., Slater T. F. Effect of spin traps in isolated hepatocytes and liver microsomes. Biochemical Pharmacology 1986; 35: 3955–3960
  • Poli G., Gravela E., Albano E., Dianzani M. U. Studies on fatty liver with isolated hepatocytes II. The action of carbon tetrachloride on lipid peroxidation, protein and triglyceride synthesis and secretion. Experimental in Molecular Pathology 1979; 30: 116–127
  • Poli G., Albano E., Tomasi A., Cheeseman K. H., Chiarpotto E., Parola M., Biocca M. E., Slater T. F., Dianzani M. U. Electron spin resonance studies on isolated hepatocytes treated with ferrous or ferric iron. Free Radical Research Communications 1987; 3: 251–255
  • Albano E., Tomasi A., Goria-Gatti L., Iannone A. Free radical activation of monomethyl and dimethyl hydrazines in isolated hepatocytes and liver microsomes. Free Radical in Biology and Medicine 1989; 6: 3–8
  • Albano E., Lott K. A.K., Slater T. F., Stier A., Syraons M. R.C., Tomasi A. Spin trapping studies on the free-radical products formed by metabolic activation of carbon tetrachloride in rat liver microsomal fractions, isolated hepatocytes and in vivo in the rat. Biochemical Journal 1982; 204: 593–603
  • Bors W., Saran M. Radical scavenging by flavonoid antioxidants. Free Radical Research Communications 1987; 2: 289–294
  • Robak J., Griglewski R. Flavonoids are scavengers of superoxide anions. Biochemical Pharmacology 1988; 37: 837–841
  • Valenzuela A., Guerra R. Protective effect of the flavonoid silybin dihemisuccinate on the toxicity of phenyl-hydrazine on rat liver. FEBS Letters 1985; 181: 291–294

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.