24
Views
80
CrossRef citations to date
0
Altmetric
Original Article

The Free Radical Scavenger, α-Lipoic Acid, Protects Against Cerebral Ischemia-Reperfusion Injury in Gerbils

&
Pages 365-370 | Received 16 Aug 1994, Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Fatemeh Seifar, Mohammad Khalili, Habib Khaledyan, Shirin Amiri Moghadam, Azimeh Izadi, Amirreza Azimi & Seied Kazem Shakouri. (2019) α-Lipoic acid, functional fatty acid, as a novel therapeutic alternative for central nervous system diseases: A review. Nutritional Neuroscience 22:5, pages 306-316.
Read now
Ihsan Anik, Sibel Kokturk, Hamza Genc, Burak Cabuk, Kenan Koc, Sadan Yavuz, Sureyya Ceylan, Savas Ceylan, Levent Kamaci & Yonca Anik. (2011) Immunohistochemical analysis of TIMP-2 and collagen types I and IV in experimental spinal cord ischemia–reperfusion injury in rats. The Journal of Spinal Cord Medicine 34:3, pages 257-264.
Read now
Marina A. Lynch. (2001) Lipoic Acid Confers Protection Against Oxidative Injury in Non-neuronal and Neuronal Tissue. Nutritional Neuroscience 4:6, pages 419-438.
Read now
D.S.D. Martin, M. Towey, D.F. Horrobin & M.A. Lynch. (2000) A Diet Enriched in α-Lipoic Acid Reverses the Age-Related Compromise in Antioxidant Defences in Rat Cortical Tissue. Nutritional Neuroscience 3:3, pages 193-206.
Read now

Articles from other publishers (74)

Aparoop Das, Manash Pratim Pathak, Kalyani Pathak, Riya Saikia & Urvashee Gogoi. (2023) Herbal medicine for the treatment of obesity-associated asthma: a comprehensive review. Frontiers in Pharmacology 14.
Crossref
Heena Khan, Thakur Gurjeet Singh, Randhir Singh Dahiya & Mohamed M. Abdel-Daim. (2022) α-Lipoic Acid, an Organosulfur Biomolecule a Novel Therapeutic Agent for Neurodegenerative Disorders: An Mechanistic Perspective. Neurochemical Research 47:7, pages 1853-1864.
Crossref
Yunfeng WANG, Yuanmin DU, Jin LI & Kang XU. (2022) Hydroxysafflor yellow A from safflower (Carthamus tinctorius L.) prevents cerebral ischemia-reperfusion injury in rats. Food Science and Technology 42.
Crossref
Yueming Ding, Yiming Zhang, Wunong Zhang, Jia Shang, Zhenxing Xie & Chaoran Chen. (2021) Effects of Lipoic Acid on Ischemia-Reperfusion Injury. Oxidative Medicine and Cellular Longevity 2021, pages 1-15.
Crossref
Cara L. Field, Sophie T. Whoriskey, Xianguo Zhao & Mark G. Papich. (2021) PHARMACOKINETICS OF SUBCUTANEOUS ALPHA LIPOIC ACID, A PROPOSED THERAPEUTIC AID FOR DOMOIC ACID INTOXICATION IN CALIFORNIA SEA LIONS (ZALOPHUS CALIFORNIANUS). Journal of Zoo and Wildlife Medicine 52:3.
Crossref
Kwanchanok Uppakara, Sopana Jamornwan, Liang-xing Duan, Kai-rui Yue, Chotchanit Sunrat, Erik W Dent, Sheng-biao Wan & Witchuda Saengsawang. (2020) Novel α-Lipoic Acid/3- n -Butylphthalide Conjugate Enhances Protective Effects against Oxidative Stress and 6-OHDA Induced Neuronal Damage . ACS Chemical Neuroscience 11:11, pages 1634-1642.
Crossref
Sheyda ShaafiSoraiya Ebrahimpour-KoujanMohammad Khalili, Seyad Morteza ShamshirgaranMazyar Hashemilar, Aliakbar Taheraghdam, Seyed Kazem Shakouri, Elyar Sadeghi HokmabadiYaeghoub AhmadiMehdi Farhoudi, Nasim RezaeimaneshDaryoush Savadi Osgouei. (2020) Effects of Alpha Lipoic Acid Supplementation on Serum Levels of Oxidative Stress, Inflammatory Markers and Clinical Prognosis among Acute Ischemic Stroke Patients: A Randomized, Double Blind, TNS Trial. Advanced Pharmaceutical Bulletin 10:2, pages 284-289.
Crossref
Zequan Yang, Yikui Tian, Stuart S. Berr & Brent A. French. (2020) Therapeutic Efficacy of Alpha-Lipoic Acid against Acute Myocardial Infarction and Chronic Left Ventricular Remodeling in Mice. Cardiology Research and Practice 2020, pages 1-8.
Crossref
Mahsa Moeinian, Amir Hossein Abdolghaffari, Shekoufeh Nikfar, Saeideh Momtaz & Mohammad Abdollahi. (2018) Effects of alpha lipoic acid and its derivative “andrographolid‐lipoic acid‐1” on ulcerative colitis: A systematic review with meta‐analysis of animal studies. Journal of Cellular Biochemistry 120:4, pages 4766-4782.
Crossref
Ba X. HoangBo HanHoang X. NguyenKhanh T. Dang. (2018) Nutritional Supplement “Bao Khi Khang” as an Adjuvant Therapy in Acute Exacerbations of Chronic Obstructive Pulmonary Disease. Journal of Medicinal Food 21:10, pages 1053-1059.
Crossref
Barry J. Connell, Monique C. Saleh, Desikan Rajagopal & Tarek M. Saleh. (2017) UPEI-400, a conjugate of lipoic acid and scopoletin, mediates neuroprotection in a rat model of ischemia/reperfusion. Food and Chemical Toxicology 100, pages 175-182.
Crossref
Ming-Hsiu Wu, Chao-Ching Huang, Chung-Ching Chio, Kuen-Jer Tsai, Ching-Ping Chang, Nan-Kai Lin & Mao-Tsun Lin. (2015) Inhibition of Peripheral TNF-α and Downregulation of Microglial Activation by Alpha-Lipoic Acid and Etanercept Protect Rat Brain Against Ischemic Stroke. Molecular Neurobiology 53:7, pages 4961-4971.
Crossref
Kang-Ho Choi, Man-Seok Park, Hyung-Seok Kim, Kyung-Tae Kim, Hyeon-Sik Kim, Joon-Tae Kim, Byeong-Chae Kim, Myeong-Kyu Kim, Jong-Tae Park & Ki-Hyun Cho. (2015) Alpha-lipoic acid treatment is neurorestorative and promotes functional recovery after stroke in rats. Molecular Brain 8:1.
Crossref
Mahban Rahimifard, Mona Navaei-Nigjeh, Maryam Baeeri, Faheem Maqbool & Mohammad Abdollahi. (2015) Multiple protective mechanisms of alpha-lipoic acid in oxidation, apoptosis and inflammation against hydrogen peroxide induced toxicity in human lymphocytes. Molecular and Cellular Biochemistry 403:1-2, pages 179-186.
Crossref
Monique C. Saleh, Barry J. Connell, Desikan Rajagopal, Bobby V. Khan, Alaa S. Abd-El-Aziz, Inan Kucukkaya & Tarek M. Saleh. (2014) Co-Administration of Resveratrol and Lipoic Acid, or Their Synthetic Combination, Enhances Neuroprotection in a Rat Model of Ischemia/Reperfusion. PLoS ONE 9:1, pages e87865.
Crossref
Jerome E. Roger & Anand Swaroop. 2014. Vertebrate Photoreceptors. Vertebrate Photoreceptors 275 308 .
Ramasamy Saraswathi & Sivasithamparam Niranjali Devaraj. (2013) Oxidative stress in skeletal muscle impairs mitochondrial function in alloxan induced diabetic rats: Role of alpha lipoic acid. Biomedicine & Preventive Nutrition 3:3, pages 213-219.
Crossref
Jingfei Shi, Yi Liu, Yunxia Duan, Zhishan Sun, Bincheng Wang, Ran Meng & Xunming Ji. (2013) A new idea about reducing reperfusion injury in ischemic stroke: Gradual reperfusion. Medical Hypotheses 80:2, pages 134-136.
Crossref
Andreas N. Kavazis & Scott K. Powers. 2013. Exercise, Energy Balance, and Cancer. Exercise, Energy Balance, and Cancer 7 20 .
Tae Hun Lee, Joon Ha Park, Jong-Dai Kim, Jae-Chul Lee, In Hye Kim, Yongbae Yim, Seul Ki Lee, Bing Chun Yan, Ji Hyeon Ahn, Choong Hyun Lee, Ki-Yeon Yoo, Jung Hoon Choi, In Koo Hwang, Jeong Ho Park & Moo-Ho Won. (2012) Protective Effects of a Novel Synthetic Alpha-Lipoic Acid-Decursinol Hybrid Compound in Experimentally Induced Transient Cerebral Ischemia. Cellular and Molecular Neurobiology 32:7, pages 1209-1221.
Crossref
Jerome E. Roger, Keerthi Ranganath, Lian Zhao, Radu I. Cojocaru, Matthew Brooks, Norimoto Gotoh, Shobi Veleri, Avinash Hiriyanna, Rivka A. Rachel, Maria Mercedes Campos, Robert N. Fariss, Wai T. Wong & Anand Swaroop. (2012) Preservation of Cone Photoreceptors after a Rapid yet Transient Degeneration and Remodeling in Cone-Only Nrl −/− Mouse Retina . The Journal of Neuroscience 32:2, pages 528-541.
Crossref
Barry J. Connell & Tarek M. Saleh. (2012) Co-administration of apocynin with lipoic acid enhances neuroprotection in a rat model of ischemia/reperfusion. Neuroscience Letters 507:1, pages 43-46.
Crossref
Ritesh P. Daya, Mattea L. Tan, Christal D. Sookram, Kevin Skoblenick & Ram K. Mishra. (2011) Alpha-phenyl-N-tert-butylnitrone prevents oxidative stress in a haloperidol-induced animal model of tardive dyskinesia: Investigating the behavioural and biochemical changes. Brain Research 1412, pages 28-36.
Crossref
Scott K. Powers, Li Li Ji, Andreas N. Kavazis & Malcolm J. Jackson. 2011. Comprehensive Physiology. Comprehensive Physiology 941 969 .
Barry J. Connell, Monique Saleh, Bobby V. Khan & Tarek M. Saleh. (2011) Lipoic acid protects against reperfusion injury in the early stages of cerebral ischemia. Brain Research 1375, pages 128-136.
Crossref
Oscar Gonzalez-Perez. 2011. Handbook of Behavior, Food and Nutrition. Handbook of Behavior, Food and Nutrition 1911 1921 .
Hee Sun Park, So Ri Kim, Ju Ock Kim & Yong Chul Lee. (2010) The Roles of Phytochemicals in Bronchial Asthma. Molecules 15:10, pages 6810-6834.
Crossref
Hakan Emmez, Zuhal Yildirim, Aydemir Kale, Mehmet Tönge, Emre Durdağ, Alp Özgün Börcek, Lortlar Neşe Uçankuş, Fikret Doğulu, Nedret Kiliç & M. Kemali Baykaner. (2010) Anti-apoptotic and neuroprotective effects of alpha-lipoic acid on spinal cord ischemia–reperfusion injury in rabbits. Acta Neurochirurgica 152:9, pages 1591-1601.
Crossref
A. K. Mehta, N. Arora, S. N. Gaur & B. P. Singh. (2009) Choline supplementation reduces oxidative stress in mouse model of allergic airway disease. European Journal of Clinical Investigation 39:10, pages 934-941.
Crossref
Giorgia Melli, Michela Taiana, Francesca Camozzi, Daniela Triolo, Paola Podini, Angelo Quattrini, Franco Taroni & Giuseppe Lauria. (2008) Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy. Experimental Neurology 214:2, pages 276-284.
Crossref
Scott K. Powers & Malcolm J. Jackson. (2008) Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production. Physiological Reviews 88:4, pages 1243-1276.
Crossref
Stuart G. Jarrett, Julie B. Milder, Li-Ping Liang & Manisha Patel. (2008) The ketogenic diet increases mitochondrial glutathione levels. Journal of Neurochemistry 106:3, pages 1044-1051.
Crossref
Philip Lam, Ryan Hamilton, Lester Packer & Derick Han. 2008. Lipoic Acid. Lipoic Acid.
Sethumadhavan Savitha, Balasubramanian Naveen & Chinnakannu Panneerselvam. (2007) Carnitine and lipoate ameliorates lipofuscin accumulation and monoamine oxidase activity in aged rat heart. European Journal of Pharmacology 574:1, pages 61-65.
Crossref
Shyam S. Sharma & Sangeetha Gupta. (2007) Neuroprotective effect of MnTMPyP, a superoxide dismutase/catalase mimetic in global cerebral ischemia is mediated through reduction of oxidative stress and DNA fragmentation. European Journal of Pharmacology 561:1-3, pages 72-79.
Crossref
Jin Won HuhSang Bum HongMi Jung KimChae-Man LimYounsuck Koh. (2007) The Efficacy of α-lipoic Acid on the Endotoxin-induced Acute Lung Injury. Tuberculosis and Respiratory Diseases 62:2, pages 105.
Crossref
Kyung Sun Lee, So Ri Kim, Seoung Ju Park, Kyung Hoon Min, Ka Young Lee, Sun Mi Jin, Wan Hee Yoo & Yong Chul Lee. (2006) Antioxidant Down-Regulates Interleukin-18 Expression in Asthma. Molecular Pharmacology 70:4, pages 1184-1193.
Crossref
Keiichi Komeima, Brian S. Rogers, Lili Lu & Peter A. Campochiaro. (2006) Antioxidants reduce cone cell death in a model of retinitis pigmentosa. Proceedings of the National Academy of Sciences 103:30, pages 11300-11305.
Crossref
Anusuya Devi Muthuswamy, Kokilavani Vedagiri, Murali Ganesan & Panneerselvam Chinnakannu. (2006) Oxidative stress-mediated macromolecular damage and dwindle in antioxidant status in aged rat brain regions: Role of l-carnitine and dl-α-lipoic acid. Clinica Chimica Acta 368:1-2, pages 84-92.
Crossref
S. Savitha & C. Panneerselvam. (2006) Mitochondrial membrane damage during aging process in rat heart: Potential efficacy of l-carnitine and dl α lipoic acid. Mechanisms of Ageing and Development 127:4, pages 349-355.
Crossref
Kumaran Sundaram & Kavin S. Panneerselvam. (2006) Oxidative Stress and DNA Single Strand Breaks in Skeletal Muscle of Aged Rats: Role of Carnitine and Lipoicacid. Biogerontology 7:2, pages 111-118.
Crossref
Oscar Gonzalez-Perez & Rocio E. Gonzalez-Castaneda. (2006) Therapeutic perspectives on the combination of α-lipoic acid and vitamin E. Nutrition Research 26:1, pages 1-5.
Crossref
Kyung Sun Lee, Hee Sun Park, Seoung Ju Park, So Ri Kim, Kyung Hoon Min, Sun Mi Jin, Kwang-Hyun Park, Uh-Hyun Kim, Chan Young Kim & Yong Chul Lee. (2005) A Prodrug of Cysteine, l-2-Oxothiazolidine-4-carboxylic Acid, Regulates Vascular Permeability by Reducing Vascular Endothelial Growth Factor Expression in Asthma. Molecular Pharmacology 68:5, pages 1281-1290.
Crossref
Jacinto Santiago-Mejia, Monica Fuentes-Vargas, Camilo Rios, Horacio Vidrio & Rodolfo Rodriguez. (2004) Effect of ascorbic acid, dihydrolipoic acid,t-Butylhydroquinone, and phenylbutylnitrone on mortality and neurological impairment induced by sequential common carotid artery sectioning in mice. Drug Development Research 63:4, pages 212-218.
Crossref
You Sook Cho, Jaechun Lee, Tae-Hoon Lee, Eun Young Lee, Ki-Up Lee, Joong Yeol Park & Hee-Bom Moon. (2004) α-Lipoic acid inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma. Journal of Allergy and Clinical Immunology 114:2, pages 429-435.
Crossref
Z Kyselova, M Stefek & V Bauer. (2004) Pharmacological prevention of diabetic cataract. Journal of Diabetes and its Complications 18:2, pages 129-140.
Crossref
L. Pari & P. Murugavel. (2004) Protective effect of α ‐lipoic acid against chloroquine‐induced hepatotoxicity in rats . Journal of Applied Toxicology 24:1, pages 21-26.
Crossref
Joaquin Garcia-Estrada, Oscar Gonzalez-Perez, Rocio Elizabeth Gonzalez-Castaneda, Alicia Martinez-Contreras, Sonia Luquin, Pedro Garzon de la Mora & Alicia Navarro-Ruiz. (2003) An alpha-lipoic acid–vitamin E mixture reduces post-embolism lipid peroxidation, cerebral infarction, and neurological deficit in rats. Neuroscience Research 47:2, pages 219-224.
Crossref
Otoni Cardoso do Vale, Daniel Sá Roriz Fonteles, Francisco Romero Cabral & Manassés Claudino Fonteles. (2003) A dual action of alpha-lipoic acid in the brain: an electrophysiological evaluation. Arquivos de Neuro-Psiquiatria 61:3B, pages 738-745.
Crossref
Palaniappan Arivazhagan, Thangaswamy Thilakavathy, Kadirvel Ramanathan, Sundaram Kumaran & Chinnakkannu Panneerselvam. (2002) Effect of DL-α-lipoic acid on the status of lipid peroxidation and protein oxidation in various brain regions of aged rats. The Journal of Nutritional Biochemistry 13:10, pages 619-624.
Crossref
P Arivazhagan, S Shila, S Kumaran & C Panneerselvam. (2002) Effect of DL-α-lipoic acid on the status of lipid peroxidation and antioxidant enzymes in various brain regions of aged rats. Experimental Gerontology 37:6, pages 803-811.
Crossref
O. Gonzalez-Perez, R.E. Gonzalez-Castañeda, M. Huerta, S. Luquin, U. Gomez-Pinedo, E. Sanchez-Almaraz, A. Navarro-Ruiz & J. Garcia-Estrada. (2002) Beneficial effects of α-lipoic acid plus vitamin E on neurological deficit, reactive gliosis and neuronal remodeling in the penumbra of the ischemic rat brain. Neuroscience Letters 321:1-2, pages 100-104.
Crossref
J. W. Phillis. 2002. CNS Neuroprotection. CNS Neuroprotection 245 280 .
M.F. McCarty. (2001) Versatile cytoprotective activity of lipoic acid may reflect its ability to activate signalling intermediates that trigger the heat-shock and phase II responses. Medical Hypotheses 57:3, pages 313-317.
Crossref
M.F. McCarty. (2000) Monoselenolipoic acid may be an outstanding pharmaceutical antioxidant with direct thioredoxin-like activity. Medical Hypotheses 55:3, pages 185-186.
Crossref
Ippolita Cantuti‐Castelvetri, Barbara Shukitt‐Hale & James A. Joseph. (2000) Neurobehavioral aspects of antioxidants in aging. International Journal of Developmental Neuroscience 18:4-5, pages 367-381.
Crossref
Silvia Alvarez & Alberto Boveris. (2000) Antioxidant adaptive response of human mononuclear cells to UV-B: effect of lipoic acid. Journal of Photochemistry and Photobiology B: Biology 55:2-3, pages 113-119.
Crossref
Gidö, Cronberg & Wieloch. (2001) The effect of α‐phenyl‐tert‐butyl nitrone (PBN) on free radical formation in transient focal ischaemia measured by microdialysis and 3,4‐dihydroxybenzoate formation. Acta Physiologica Scandinavica 168:2, pages 277-285.
Crossref
Richard Berger & Yves Garnier. (2000) Perinatal brain injury. Journal of Perinatal Medicine 28:4.
Crossref
John K. Lodge & Lester Packer. 2000. Nutrition and Immunology. Nutrition and Immunology 97 106 .
Bernadette M. McGahon, Donen S.D. Martin, David F. Horrobin & Marina A. Lynch. (1999) Age-related changes in LTP and antioxidant defenses are reversed by an α-lipoic acid-enriched diet. Neurobiology of Aging 20:6, pages 655-664.
Crossref
Burton M. Berkson. (1999) A conservative triple antioxidant approach to the treatment of hepatitis CEine konservative dreifache antioxidante Methode zur Behandlung von Hepatitis C. Eine Kombination von Alpha-Liponsäure (thioctic acid), Silymarin und Selenium: Drei Krankenberichte. Medizinische Klinik 94:S3, pages 84-89.
Crossref
Richard Berger & Yves Garnier. (1999) Pathophysiology of perinatal brain damage. Brain Research Reviews 30:2, pages 107-134.
Crossref
F Block. (1999) Global ischemia and behavioural deficits. Progress in Neurobiology 58:3, pages 279-295.
Crossref
Yoshiyuki Mitsui, James D. Schmelzer, Paula J. Zollman, Manami Mitsui, Hans J. Tritschler & Phillip A. Low. (1999) Alpha-lipoic acid provides neuroprotection from ischemia-reperfusion injury of peripheral nerve. Journal of the Neurological Sciences 163:1, pages 11-16.
Crossref
Michael Gassen & M. B. H. Youdim. 1999. Diagnosis and Treatment of Parkinson’s Disease — State of the Art. Diagnosis and Treatment of Parkinson’s Disease — State of the Art 193 210 .
Toshihiko Ozawa, Kouichi Tatsumi & Tada-aki HoriLester Packer. 1998. Biodefence Mechanisms Against Environmental Stress. Biodefence Mechanisms Against Environmental Stress 33 46 .
Derick HanChandan K. SenSashwati RoyMichael S. KobayashiHans J. Tritschler & Lester Packer. (1997) Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 273:5, pages R1771-R1778.
Crossref
Gerreke Ph. Biewenga, Guido R.M.M. Haenen & Aalt Bast. (1997) The pharmacology of the antioxidant lipoic acid. General Pharmacology: The Vascular System 29:3, pages 315-331.
Crossref
Sashwati Roy, Chandan K. Sen, Hans J. Tritschler & Lester Packer. (1997) Modulation of cellular reducing equivalent homeostasis by α-lipoic acid. Biochemical Pharmacology 53:3, pages 393-399.
Crossref
Gerald Scott. 1997. Antioxidants in Science, Technology, Medicine and Nutrition. Antioxidants in Science, Technology, Medicine and Nutrition 262 308 .
Lester Packer, Hans J. Tritschler & Klaus Wessel. (1997) Neuroprotection by the Metabolic Antioxidant α-Lipoic Acid. Free Radical Biology and Medicine 22:1-2, pages 359-378.
Crossref
Matthias Schweizer & Christoph Richter. (1996) Stimulation of Ca2+ release from rat liver mitochondria by the dithiol reagent α-lipoic acid. Biochemical Pharmacology 52:12, pages 1815-1820.
Crossref
Manas Panigrahi, Yarasi Sadguna, Bangalore R. Shivakumar, Sastry V.R. Kolluri, Sashwati Roy, Lester Packer & Vijayalakshmi Ravindranath. (1996) α-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats. Brain Research 717:1-2, pages 184-188.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.