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Original Article

The Effect of the Phenolic Antioxidant Ferulic Acid on the Oxidation of Low Density Lipoprotein Depends on the Pro-oxidant Used

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Pages 337-344 | Received 10 May 1997, Published online: 07 Jul 2009

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Rajagopalan Rukkumani, Kode Aruna, Penumathsa Suresh Varma & Venugopal Padmanabhan Menon. (2005) Ferulic Acid, a Natural Phenolic Antioxidant Modulates Altered Lipid Profiles During Alcohol and Thermally Oxidized Sunflower Oil Induced Toxicity. Journal of Nutraceuticals, Functional & Medical Foods 4:3-4, pages 119-132.
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Barry Halliwell, Kaicun Zhao & Matthew Whiteman. (2000) The gastrointestinal tract: A major site of antioxidant action?. Free Radical Research 33:6, pages 819-830.
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Articles from other publishers (36)

Bo-Hyun Lee, Hyeon-Son Choi & Jungil Hong. (2022) Roles of anti- and pro-oxidant potential of cinnamic acid and phenylpropanoid derivatives in modulating growth of cultured cells. Food Science and Biotechnology 31:4, pages 463-473.
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Danieli Camilo Marcato, Caroline Magnani Spagnol, Hérida Regina Nunes Salgado, Vera Lucia Borges Isaac & Marcos Antonio Corrêa. (2022) New and potential properties, characteristics, and analytical methods of ferulic acid: A review. Brazilian Journal of Pharmaceutical Sciences 58.
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Richa Panwar, Navdeep Raghuwanshi, Amit Kumar Srivastava, Asvene K. Sharma & Vikas Pruthi. (2018) In-vivo sustained release of nanoencapsulated ferulic acid and its impact in induced diabetes. Materials Science and Engineering: C 92, pages 381-392.
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Rebecca A. Chmielowski, Dalia S. Abdelhamid, Jonathan J. Faig, Latrisha K. Petersen, Carol R. Gardner, Kathryn E. Uhrich, Laurie B. Joseph & Prabhas V. Moghe. (2017) Athero-inflammatory nanotherapeutics: Ferulic acid-based poly(anhydride-ester) nanoparticles attenuate foam cell formation by regulating macrophage lipogenesis and reactive oxygen species generation. Acta Biomaterialia 57, pages 85-94.
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Hesham R. El-Seedi, Asmaa M. A. El-Said, Shaden A. M. Khalifa, Ulf Göransson, Lars Bohlin, Anna-Karin Borg-Karlson & Rob Verpoorte. (2012) Biosynthesis, Natural Sources, Dietary Intake, Pharmacokinetic Properties, and Biological Activities of Hydroxycinnamic Acids. Journal of Agricultural and Food Chemistry 60:44, pages 10877-10895.
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Giovanni Scapagnini, Vasto Sonya, Abraham G. Nader, Caruso Calogero, Davide Zella & Galvano Fabio. (2011) Modulation of Nrf2/ARE Pathway by Food Polyphenols: A Nutritional Neuroprotective Strategy for Cognitive and Neurodegenerative Disorders. Molecular Neurobiology 44:2, pages 192-201.
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Nick Emil Gislason, Bruce Lamonte Currie & Andrew Leo Waterhouse. (2011) Novel Antioxidant Reactions of Cinnamates in Wine. Journal of Agricultural and Food Chemistry 59:11, pages 6221-6226.
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Hye-Jin Kim, Seon-Min Jeon, Mi-Kyung Lee, Yun-Young Cho, Eun-Young Kwon, Jin Hee Lee & Myung-Sook Choi. (2010) Comparison of Hesperetin and Its Metabolites for Cholesterol-Lowering and Antioxidative Efficacy in Hypercholesterolemic Hamsters. Journal of Medicinal Food 13:4, pages 808-814.
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Zhaohui Zhao & Mohammed H. Moghadasian. (2009) Bioavailability of hydroxycinnamates: a brief review of in vivo and in vitro studies. Phytochemistry Reviews 9:1, pages 133-145.
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Giovanni Scapagnini, Calogero Caruso & Vittorio Calabrese. 2010. Bio-Farms for Nutraceuticals. Bio-Farms for Nutraceuticals 27 35 .
Din-Wen Huang, Yueh-Hsiung Kuo, Fang-Yi Lin, Yun-Lian Lin & Wenchang Chiang. (2009) Effect of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) Testa and Its Phenolic Components on Cu 2+ -Treated Low-Density Lipoprotein (LDL) Oxidation and Lipopolysaccharide (LPS)-Induced Inflammation in RAW 264.7 Macrophages . Journal of Agricultural and Food Chemistry 57:6, pages 2259-2266.
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E.-S. M. Abdel-Aal & T. H. Gamel. (2008) Effects of Selected Barley Cultivars and Their Pearling Fractions on Inhibition of Human LDL Oxidation In Vitro Using a Modified Conjugated Dienes Method. Cereal Chemistry Journal 85:6, pages 730-737.
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Chatchawan Chotimarkorn & Hideki Ushio. (2008) The effect of trans-ferulic acid and gamma-oryzanol on ethanol-induced liver injury in C57BL mouse. Phytomedicine 15:11, pages 951-958.
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Zhaohui Zhao & Mohammed H. Moghadasian. (2008) Chemistry, natural sources, dietary intake and pharmacokinetic properties of ferulic acid: A review. Food Chemistry 109:4, pages 691-702.
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Ardiansyah, Yusuke Ohsaki, Hitoshi Shirakawa, Takuya Koseki & Michio Komai. (2008) Novel Effects of a Single Administration of Ferulic Acid on the Regulation of Blood Pressure and the Hepatic Lipid Metabolic Profile in Stroke-Prone Spontaneously Hypertensive Rats. Journal of Agricultural and Food Chemistry 56:8, pages 2825-2830.
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Gow-Chin Yen, Pin-Der Duh, Din-Wen Huang, Chin-Lin Hsu & Timothy Yu-Chi Fu. (2008) Protective effect of pine (Pinus morrisonicola Hay.) needle on LDL oxidation and its anti-inflammatory action by modulation of iNOS and COX-2 expression in LPS-stimulated RAW 264.7 macrophages. Food and Chemical Toxicology 46:1, pages 175-185.
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Jonathan E. Brown & Mary F. Kelly. (2007) Inhibition of lipid peroxidation by anthocyanins, anthocyanidins and their phenolic degradation products. European Journal of Lipid Science and Technology 109:1, pages 66-71.
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T. Wegener & H. Wagner. (2006) The active components and the pharmacological multi-target principle of STW 5 (Iberogast®). Phytomedicine 13, pages 20-35.
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Hafiz Mohmmad Abdul & D. Allan Butterfield. (2005) Protection against amyloid beta-peptide (1–42)-induced loss of phospholipid asymmetry in synaptosomal membranes by tricyclodecan-9-xanthogenate (D609) and ferulic acid ethyl ester: Implications for Alzheimer's disease. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1741:1-2, pages 140-148.
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YongZhong Hou, Jie Yang, GuangRong Zhao & YingJin Yuan. (2004) Ferulic acid inhibits endothelial cell proliferation through NO down-regulating ERK1/2 pathway. Journal of Cellular Biochemistry 93:6, pages 1203-1209.
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J. Milde, E.F. Elstner & J. Graßmann. (2004) Synergistic inhibition of low-density lipoprotein oxidation by rutin, γ-terpinene, and ascorbic acid. Phytomedicine 11:2-3, pages 105-113.
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Jitka Psotová, Jan Lasovský & Jaroslav Vičar. (2003) Metal-chelating properties, electrochemical behavior, scavenging and cytoprotective activities of six natural phenolics. Biomedical Papers 147:2, pages 147-153.
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Rebecca A. Patterson, Elizabeth T.M. Horsley & David S. Leake. (2003) Prooxidant and antioxidant properties of human serum ultrafiltrates toward LDL: important role of uric acid. Journal of Lipid Research 44:3, pages 512-521.
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G.M. Nardi, R. Felippi, S. DalBó, J.M. Siqueira-Junior, D.C. Arruda, F. Delle Monache, A.K. Timbola, M.G. Pizzolatti, K. Ckless & R.M. Ribeiro-do-Valle. (2003) Anti-inflammatory and antioxidant effects of Croton celtidifolius bark. Phytomedicine 10:2-3, pages 176-184.
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D.Allan Butterfield, Alessandra Castegna, Chava B. Pocernich, Jennifer Drake, Giovanni Scapagnini & Vittorio Calabrese. (2002) Nutritional approaches to combat oxidative stress in Alzheimer’s disease. The Journal of Nutritional Biochemistry 13:8, pages 444-461.
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Jaroslaw Kanski, Marina Aksenova, Antonia Stoyanova & D.Allan Butterfield. (2002) Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: structure-activity studies. The Journal of Nutritional Biochemistry 13:5, pages 273-281.
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K.A. Youdim, J.P.E. Spencer, H. Schroeter & C. Rice-Evans. (2002) Dietary Flavonoids as Potential Neuroprotectants. Biological Chemistry 383:3-4.
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Sergio Eduardo SOARES. (2002) Ácidos fenólicos como antioxidantes. Revista de Nutrição 15:1, pages 71-81.
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Chun Hu, Ying Zhang & David D. Kitts. (2000) Evaluation of Antioxidant and Prooxidant Activities of Bamboo Phyllostachys nigra Var. Henonis Leaf Extract in Vitro . Journal of Agricultural and Food Chemistry 48:8, pages 3170-3176.
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Garry G. Duthie, Susan J. Duthie & Janet A. M. Kyle. (2007) Plant polyphenols in cancer and heart disease: implications as nutritional antioxidants. Nutrition Research Reviews 13:1, pages 79-106.
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Heike Jacobi, Marie-Luise Hinrichsen, Doris Weß & Irene Witte. (1999) Induction of lipid peroxidation in human fibroblasts by the antioxidant propyl gallate in combination with copper(II). Toxicology Letters 110:3, pages 183-190.
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Antonella Saija, Antonio Tomaino, Rossella Lo Cascio, Domenico Trombetta, Anna Proteggente, Anna De Pasquale, Nicola Uccella & Francesco Bonina. (1999) Ferulic and caffeic acids as potential protective agents against photooxidative skin damage. Journal of the Science of Food and Agriculture 79:3, pages 476-480.
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Louise C. Bourne & Catherine A. Rice-Evans. 1999. Oxidants and Antioxidants Part A. Oxidants and Antioxidants Part A 91 106 .
Catherine Rice-Evans. 1999. Antioxidant Food Supplements in Human Health. Antioxidant Food Supplements in Human Health 239 253 .
Louise C. Bourne & Catherine Rice-Evans. (1998) Bioavailability of Ferulic Acid. Biochemical and Biophysical Research Communications 253:2, pages 222-227.
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