Citations (69)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (2)
Byung Sun Park, Hyun Woo Jo, Chan Park, Youngbuhm Huh, Junyang Jung & Na Young Jeong. (2015) A novel effect of ethyl pyruvate in Schwann cell de-differentiation and proliferation during Wallerian degeneration. Animal Cells and Systems 19:4, pages 262-268.
Read now
Read now
Robert Antoni OLEK, Wieslaw ZIOLKOWSKI, Jan Jacek KACZOR, Tomasz Henryk WIERZBA & Jedrzej ANTOSIEWICZ. (2011) Higher Hypochlorous Acid Scavenging Activity of Ethyl Pyruvate Compared to Its Sodium Salt. Bioscience, Biotechnology, and Biochemistry 75:3, pages 500-504.
Read now
Read now
Articles from other publishers (67)
Chih-Chien Hsu, Hao-Kai Chuang, Yu-Jer Hsiao, Yuan-Chi Teng, Pin-Hsuan Chiang, Yu-Jun Wang, Ting-Yi Lin, Ping-Hsing Tsai, Chang-Chi Weng, Tai-Chi Lin, De-Kuang Hwang & Ai-Ru Hsieh. (2022) Polygenic Risk Score Improves Cataract Prediction in East Asian Population. Biomedicines 10:8, pages 1920.
Crossref
Crossref
Yan-Yan Zhao, Li-Jun Zhang, Xiang-Yan Liang, Xiao-Chun Zhang, Jin-Rui Chang, Man Shi, Huan Liu, Ying Zhou, Zhuo Sun & Yu-Feng Zhao. (2022) Pyruvate Upregulates Hepatic FGF21 Expression by Activating PDE and Inhibiting cAMP–Epac–CREB Signaling Pathway. International Journal of Molecular Sciences 23:10, pages 5490.
Crossref
Crossref
Tayler F.L. Wishart, Mary Flokis, Daisy Y. Shu, Shannon J. Das & Frank J. Lovicu. (2021) Hallmarks of lens aging and cataractogenesis. Experimental Eye Research 210, pages 108709.
Crossref
Crossref
Elisa Sassetti, Mads H. Clausen & Luca Laraia. (2021) Small-Molecule Inhibitors of Reactive Oxygen Species Production. Journal of Medicinal Chemistry 64:9, pages 5252-5275.
Crossref
Crossref
Hyung-Joo Chung, Muwoong Kim, Junyang Jung & Na Young Jeong. (2019) Inhibition of Neuronal Nitric Oxide Synthase by Ethyl Pyruvate in Schwann Cells Protects Against Peripheral Nerve Degeneration. Neurochemical Research 44:8, pages 1964-1976.
Crossref
Crossref
Hye-Kyung Lee, Ju-Young Park, Hahnbie Lee, Il-Doo Kim, Seung-Woo Kim, Sung-Hwa Yoon & Ja-Kyeong Lee. (2019) Anti-Inflammatory and Neuroprotective Effects of DIPOPA (N,N-Diisopropyl-2-Oxopropanamide), an Ethyl Pyruvate Bioisoster, in the Postischemic Brain. Neurotherapeutics 16:2, pages 523-537.
Crossref
Crossref
Linbo Yao, Chunru Cheng, Xinmin Yang, Chenxia Han, Dan Du, Tingting Liu, Michael Chvanov, John Windsor, Robert Sutton, Wei Huang & Qing Xia. (2019) Ethyl pyruvate and analogs as potential treatments for acute pancreatitis: A review of in vitro and in vivo studies. Pancreatology 19:2, pages 209-216.
Crossref
Crossref
Siqi Zhou & Kazuichi Sakamoto. (2019) Pyruvic acid/ethyl pyruvate inhibits melanogenesis in B16F10 melanoma cells through PI3K/AKT, GSK3β, and ROS-ERK signaling pathways. Genes to Cells 24:1, pages 60-69.
Crossref
Crossref
Jason E. Swain. 2019. In Vitro Fertilization. In Vitro Fertilization
105
119
.
Hye-Kyung Lee, Il-Doo Kim, Seung-Woo Kim, Hahnbie Lee, Ju-Young Park, Sung-Hwa Yoon & Ja-Kyeong Lee. (2017) Anti-inflammatory and anti-excitoxic effects of diethyl oxopropanamide, an ethyl pyruvate bioisoster, exert robust neuroprotective effects in the postischemic brain. Scientific Reports 7:1.
Crossref
Crossref
Jin-Hee Sung, Fawad-Ali Shah, Sang-Ah Gim & Phil-Ok Koh. (2016) Identification of proteins in hyperglycemia and stroke animal models. Journal of Surgical Research 200:1, pages 365-373.
Crossref
Crossref
Soon Min, Sandeep More, Ju-Young Park, Sae-Bom Jeon, Shin Park, Eun-Jung Park, Sung-Hwa Yoon & Dong-Kug Choi. (2014) EOP, a Newly Synthesized Ethyl Pyruvate Derivative, Attenuates the Production of Inflammatory Mediators via p38, ERK and NF-κB Pathways in Lipopolysaccharide-Activated BV-2 Microglial Cells. Molecules 19:12, pages 19361-19375.
Crossref
Crossref
Antonella Cotoia, Rosella Scrima, Julia V. Gefter, Claudia Piccoli, Gilda Cinnella, Michele Dambrosio, Mitchell P. Fink & Nazzareno Capitanio. (2014) p-Hydroxyphenylpyruvate, an Intermediate of the Phe/Tyr Catabolism, Improves Mitochondrial Oxidative Metabolism under Stressing Conditions and Prolongs Survival in Rats Subjected to Profound Hemorrhagic Shock. PLoS ONE 9:3, pages e90917.
Crossref
Crossref
Seung-Woo Kim, Hye-Kyung Lee, Joo-Hyun Shin & Ja-Kyeong Lee. (2013) Up-down Regulation of HO-1 and iNOS Gene Expressions by Ethyl Pyruvate via Recruiting p300 to Nrf2 and Depriving It from p65. Free Radical Biology and Medicine 65, pages 468-476.
Crossref
Crossref
Jason E. Swain & Thomas B. Pool. 2013. Clinical Embryology. Clinical Embryology
63
83
.
Jeong-Soo Park. (2012) Safe Nuclear Factor-kappa B Inhibitor for Cachexia Management. Journal of Korean Biological Nursing Science 14:2, pages 129-138.
Crossref
Crossref
Akiva Leibowitz, Matthew Boyko, Yoram Shapira & Alexander Zlotnik. (2012) Blood Glutamate Scavenging: Insight into Neuroprotection. International Journal of Molecular Sciences 13:8, pages 10041-10066.
Crossref
Crossref
Zheng-Gang Luan, Hao Zhang, Xiao-Chun Ma, Cheng Zhang & Ren-Xuan Guo. (2012) Therapeutic Treatment With Ethyl Pyruvate Attenuates the Severity of Liver Injury in Rats With Severe Acute Pancreatitis. Pancreas 41:5, pages 729-737.
Crossref
Crossref
Miguel A Perez-Pinzon, R Anne Stetler & Gary Fiskum. (2012) Novel Mitochondrial Targets for Neuroprotection. Journal of Cerebral Blood Flow & Metabolism 32:7, pages 1362-1376.
Crossref
Crossref
Gary Fiskum & Melissa Laird. 2012. Mitochondrial Signaling in Health and Disease. Mitochondrial Signaling in Health and Disease
469
492
.
Pratip Mitra & Robert M. Brownstone. (2012) An in vitro spinal cord slice preparation for recording from lumbar motoneurons of the adult mouse. Journal of Neurophysiology 107:2, pages 728-741.
Crossref
Crossref
Jason E. Swain & Thomas B. Pool. 2012. Practical Manual of In Vitro Fertilization. Practical Manual of In Vitro Fertilization
79
90
.
Jia Liu, Lawrence Litt, Mark R. Segal, Mark J. S. Kelly, Jeffrey G. Pelton & Myungwon Kim. (2011) Metabolomics of Oxidative Stress in Recent Studies of Endogenous and Exogenously Administered Intermediate Metabolites. International Journal of Molecular Sciences 12:10, pages 6469-6501.
Crossref
Crossref
Ching-Wen Kung, Yen-Mei Lee, Pao-Yun Cheng, Yi-Jen Peng & Mao-Hsiung Yen. (2011) Ethyl Pyruvate Reduces Acute Lung Injury Via Regulation of iNOS and HO-1 Expression in Endotoxemic Rats. Journal of Surgical Research 167:2, pages e323-e331.
Crossref
Crossref
Hyun-Ji Kim, Seung-Woo Kim, Ja-Kyeong Lee & Sung-Hwa Yoon. (2011) A Simple and Sensitive High Performance Liquid Chromatography-Electrospray Ionization/Mass Spectrometry Method for the Quantification of Ethyl Pyruvate in Rat Plasma. Bulletin of the Korean Chemical Society 32:4, pages 1221-1227.
Crossref
Crossref
Daolin TangRui KangHerbert J. ZehIIIIIIMichael T. Lotze. (2011) High-Mobility Group Box 1, Oxidative Stress, and Disease. Antioxidants & Redox Signaling 14:7, pages 1315-1335.
Crossref
Crossref
Robert A. Frost, Erika Pereyra & Charles H. Lang. (2011) Ethyl Pyruvate Preserves IGF-I Sensitivity toward mTOR Substrates and Protein Synthesis in C2C12 Myotubes. Endocrinology 152:1, pages 151-163.
Crossref
Crossref
Ruy J. CruzJr.Jr., Tomoyuki Harada, Eizaburo Sasatomi & Mitchell P. Fink. (2011) Effects of Ethyl Pyruvate and Other α-Keto Carboxylic Acid Derivatives in a Rat Model of Multivisceral Ischemia and Reperfusion. Journal of Surgical Research 165:1, pages 151-157.
Crossref
Crossref
Nobuhiro Moro & Richard L. Sutton. (2010) Beneficial effects of sodium or ethyl pyruvate after traumatic brain injury in the rat. Experimental Neurology 225:2, pages 391-401.
Crossref
Crossref
Kenneth K. Kao & Mitchell P. Fink. (2010) The biochemical basis for the anti-inflammatory and cytoprotective actions of ethyl pyruvate and related compounds. Biochemical Pharmacology 80:2, pages 151-159.
Crossref
Crossref
Mark F. McCarty, Jorge Barroso-Aranda & Francisco Contreras. (2010) Oxidative stress therapy for solid tumors – A proposal. Medical Hypotheses 74:6, pages 1052-1054.
Crossref
Crossref
Hongxia Shen, Xiaoming Hu, Can Liu, Suping Wang, Wenting Zhang, Hui Gao, R. Anne Stetler, Yanqin Gao & Jun Chen. (2010) Ethyl pyruvate protects against hypoxic-ischemic brain injury via anti-cell death and anti-inflammatory mechanisms. Neurobiology of Disease 37:3, pages 711-722.
Crossref
Crossref
Brian P. Suffoletto, David D. Salcido, Eric S. Logue, Timothy W. Caprio & James J. Menegazzi. (2009) Ethyl pyruvate enhances intra-resuscitation hemodynamics in prolonged ventricular fibrillation arrest. Resuscitation 80:12, pages 1411-1416.
Crossref
Crossref
Alexander Zlotnik, Shaun E. Gruenbaum, Alan A. Artru, Irene Rozet, Michael Dubilet, Sergey Tkachov, Evgeny Brotfain, Yael Klin, Yoram Shapira & Vivian I. Teichberg. (2009) The Neuroprotective Effects of Oxaloacetate in Closed Head Injury in Rats is Mediated by its Blood Glutamate Scavenging Activity. Journal of Neurosurgical Anesthesiology 21:3, pages 235-241.
Crossref
Crossref
Runkuan Yang, Angel L. Shaufl, Meaghan E. Killeen & Mitchell P. Fink. (2009) Ethyl Pyruvate Ameliorates Liver Injury Secondary to Severe Acute Pancreatitis. Journal of Surgical Research 153:2, pages 302-309.
Crossref
Crossref
Rosanna Di Paola, Emanuela Mazzon, Tiziana Genovese, Concetta Crisafulli, Placido Bramanti, Rocco Caminiti, Emanuela Esposito, Mitchell P. Fink & Salvatore Cuzzocrea. (2009) Ethyl pyruvate reduces the development of zymosan-induced generalized inflammation in mice. Critical Care Medicine 37:1, pages 270-282.
Crossref
Crossref
Jia Liu, Kiyoshi Hirai & Lawrence Litt. (2008) Fructose-1,6-bisphosphate does not preserve ATP in hypoxic–ischemic neonatal cerebrocortical slices. Brain Research 1238, pages 230-238.
Crossref
Crossref
Alexander Zlotnik, Boris Gurevich, Evgenia Cherniavsky, Sergei Tkachov, Angela Matuzani-Ruban, Avner Leon, Yoram Shapira & Vivian I. Teichberg. (2007) The Contribution of the Blood Glutamate Scavenging Activity of Pyruvate to its Neuroprotective Properties in a Rat Model of Closed Head Injury. Neurochemical Research 33:6, pages 1044-1050.
Crossref
Crossref
Yu Ou, Gao-Yong Liao & Wu-Tong Wu. (2008) Potential use of hirudin in diabetic cataract: A study of galactose mediated human lens epithelial cells injury. Chemico-Biological Interactions 173:2, pages 141-147.
Crossref
Crossref
Mitchell P Fink. (2008) Ethyl pyruvate. Current Opinion in Anaesthesiology 21:2, pages 160-167.
Crossref
Crossref
Donatella Fedeli, Giancarlo Falcioni, Robert A. Olek, Maurizio Massi, Carlo Cifani, Carlo Polidori & Rosita Gabbianelli. (2007) Protective effect of ethyl pyruvate on msP rat leukocytes damaged by alcohol intake. Journal of Applied Toxicology 27:6, pages 561-570.
Crossref
Crossref
Rosita Gabbianelli, Carlo Cifani, Maurizio Massi, Carlo Polidori & Giancarlo Falcioni. (2007) Oxidative damage in rat erythrocyte membranes following ethanol intake: Effect of ethyl pyruvate. Chemico-Biological Interactions 169:2, pages 122-131.
Crossref
Crossref
Caroline Martin, Hervé Dubouchaud, Laurent Mosoni, Jean-Michel Chardigny, Alexandra Oudot, Eric Fontaine, Catherine Vergely, Christiane Keriel, Luc Rochette, Xavier Leverve & Luc Demaison. (2007) Abnormalities of mitochondrial functioning can partly explain the metabolic disorders encountered in sarcopenic gastrocnemius. Aging Cell 6:2, pages 165-177.
Crossref
Crossref
M. P. Fink. (2007) Ethyl pyruvate: a novel anti-inflammatory agent. Journal of Internal Medicine 261:4, pages 349-362.
Crossref
Crossref
Ke Yao, Jian Tan, Wei-zhong Gu, Pan-Pan Ye & Kai-jun Wang. (2007) Reactive oxygen species mediates the apoptosis induced by transforming growth factor β2 in human lens epithelial cells. Biochemical and Biophysical Research Communications 354:1, pages 278-283.
Crossref
Crossref
Thomas C. Vary, Wiley W. Souba & Christopher J. Lynch. 2007. Mitochondria. Mitochondria
117
150
.
Ik-Hyun Cho, Seung-Woo Kim, Jung-Bin Kim, Tae-Kyung Kim, Kang-Woo Lee, Pyung-Lim Han & Ja-Kyeong Lee. (2006) Ethyl pyruvate attenuates kainic acid-induced neuronal cell death in the mouse hippocampus. Journal of Neuroscience Research 84:7, pages 1505-1511.
Crossref
Crossref
Penny L. Sappington, Ruy J. CruzJr.Jr., Tomoyuki Harada, Runkuan Yang, Yusheng Han, Joshua A. Englert, Alfred A. Ajami, Meaghan E. Killeen, Russell L. Delude & Mitchell P. Fink. (2005) The ethyl pyruvate analogues, diethyl oxaloproprionate, 2-acetamidoacrylate, and methyl-2-acetamidoacrylate, exhibit anti-inflammatory properties in vivo and/or in vitro. Biochemical Pharmacology 70:11, pages 1579-1592.
Crossref
Crossref
Jung-Bin Kim, Young-Mi Yu, Seung-Woo Kim & Ja-Kyeong Lee. (2005) Anti-inflammatory mechanism is involved in ethyl pyruvate-mediated efficacious neuroprotection in the postischemic brain. Brain Research 1060:1-2, pages 188-192.
Crossref
Crossref
Robert T. Mallet, Jie Sun, E. Marty Knott, Arti B. Sharma & Albert H. Olivencia-Yurvati. (2016) Metabolic Cardioprotection by Pyruvate: Recent Progress. Experimental Biology and Medicine 230:7, pages 435-443.
Crossref
Crossref
Matthew D. Taylor, Todd J. Grand, Jeffrey E. Cohen, Vivien Hsu, George P. Liao, Suzanne Zentko, Mark F. Berry, Timothy J. Gardner & Y. Joseph Woo. (2005) Ethyl Pyruvate Enhances ATP Levels, Reduces Oxidative Stress and Preserves Cardiac Function in a Rat Model of Off-Pump Coronary Bypass. Heart, Lung and Circulation 14:1, pages 25-31.
Crossref
Crossref
Gerhard Schultheiss, Sarah L�n Kocks & Martin Diener. (2004) Stimulation of colonic anion secretion by monochloramine: action sites. Pfl�gers Archiv - European Journal of Physiology 449:6, pages 553-563.
Crossref
Crossref
Li-Zhen Wang, Wan-Chun Sun & Xing-Zu Zhu. (2005) Ethyl pyruvate protects PC12 cells from dopamine-induced apoptosis. European Journal of Pharmacology 508:1-3, pages 57-68.
Crossref
Crossref
Y.Joseph Woo, Matthew D Taylor, Jeffrey E Cohen, Vasant Jayasankar, Lawrence T Bish, Jeffrey Burdick, Timothy J Pirolli, Mark F Berry, Vivian Hsu & Todd Grand. (2004) Ethyl pyruvate preserves cardiac function and attenuates oxidative injury after prolonged myocardial ischemia. The Journal of Thoracic and Cardiovascular Surgery 127:5, pages 1262-1269.
Crossref
Crossref
Kota V Ramana, Deepak Chandra, Nancy K Wills, Aruni Bhatnagar & Satish K Srivastava. (2004) Oxidative stress-induced up-regulation of the chloride channel and Na+/Ca2+ exchanger during cataractogenesis in diabetic rats. Journal of Diabetes and its Complications 18:3, pages 177-182.
Crossref
Crossref
Mingchen Song, John A. Kellum, Hoda Kaldas & Mitchell P. Fink. (2004) Evidence That Glutathione Depletion Is a Mechanism Responsible for the Anti-Inflammatory Effects of Ethyl Pyruvate in Cultured Lipopolysaccharide-Stimulated RAW 264.7 Cells. Journal of Pharmacology and Experimental Therapeutics 308:1, pages 307-316.
Crossref
Crossref
Mitchell P. Fink. (2008) The Therapeutic Potential of Ethyl Pyruvate for the Management of Ischemia/Reperfusion Syndromes, Sepsis and Sepsis‐Related Organ Dysfunction, and Other Conditions Associated With Excessive Inflammation. Transfusion Alternatives in Transfusion Medicine 5:4, pages 432-436.
Crossref
Crossref
Xue Qing Wang, Ai Ying Xiao, Christian Sheline, Krzystztof Hyrc, Aizhen Yang, Mark P. Goldberg, Dennis W. Choi & Shan Ping Yu. (2003) Apoptotic insults impair Na+, K+-ATPase activity as a mechanism of neuronal death mediated by concurrent ATP deficiency and oxidant stress. Journal of Cell Science 116:10, pages 2099-2110.
Crossref
Crossref
Penny L. Sappington, Xiaonan Han, Runkuan Yang, Russell L. Delude & Mitchell P. Fink. (2003) Ethyl Pyruvate Ameliorates Intestinal Epithelial Barrier Dysfunction in Endotoxemic Mice and Immunostimulated Caco-2 Enterocytic Monolayers. Journal of Pharmacology and Experimental Therapeutics 304:1, pages 464-476.
Crossref
Crossref
Mitchell P. Fink. (2003) Ethyl pyruvate: A novel anti-inflammatory agent. Critical Care Medicine 31:Supplement, pages S51-S56.
Crossref
Crossref
Ramesh Venkataraman, John A. Kellum, Mingchen Song & Mitchell P. Fink. (2002) Resuscitation with Ringer's Ethyl Pyruvate Solution Prolongs Survival and Modulates Plasma Cytokine and Nitrite/Nitrate Concentrations in a Rat Model of Lipopolysaccharide-Induced Shock. Shock 18:6, pages 507-512.
Crossref
Crossref
Ed W. J. van Niel, Karin Hofvendahl & Bärbel Hahn-Hägerdal. (2002)
Formation and Conversion of Oxygen Metabolites by
Lactococcus lactis
subsp.
lactis
ATCC 19435 under Different Growth Conditions
. Applied and Environmental Microbiology 68:9, pages 4350-4356.
Crossref
Crossref
Runkuan YangDavid J. Gallo, Jeffrey J. Baust, Takashi UchiyamaSimon K. Watkins, Russell L. Delude & Mitchell P. Fink. (2002) Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock. American Journal of Physiology-Gastrointestinal and Liver Physiology 283:1, pages G212-G221.
Crossref
Crossref
Mitchell P. Fink. (2002) Reactive oxygen species as mediators of organ dysfunction caused by sepsis, acute respiratory distress syndrome, or hemorrhagic shock: potential benefits of resuscitation with Ringerʼs ethyl pyruvate solution. Current Opinion in Clinical Nutrition and Metabolic Care 5:2, pages 167-174.
Crossref
Crossref
M. P. Fink. 2002. Yearbook of Intensive Care and Emergency Medicine 2002. Yearbook of Intensive Care and Emergency Medicine 2002
435
445
.
M. P. Fink. 2002. Intensive Care Medicine. Intensive Care Medicine
435
445
.
Carrie A. Sims, Somkiat Wattanasirichaigoon, Michael J. Menconi, Alfred M. Ajami & Mitchell P. Fink. (2001) Ringer’s ethyl pyruvate solution ameliorates ischemia/reperfusion-induced intestinal mucosal injury in rats. Critical Care Medicine 29:8, pages 1513-1518.
Crossref
Crossref