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Research Article

Development of chitosan-collagen hydrogel incorporated with lysostaphin (CCHL) burn dressing with anti-methicillin-resistant Staphylococcus aureus and promotion wound healing properties

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Pages 173-180 | Received 30 Mar 2010, Accepted 14 Jul 2010, Published online: 21 Aug 2010

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Paul-Octavian Stanescu, Ionut-Cristian Radu, Rebeca Leu Alexa, Ariana Hudita, Eugenia Tanasa, Jana Ghitman, Oana Stoian, Aristidis Tsatsakis, Octav Ginghina, Catalin Zaharia, Mikhail Shtilman, Yaroslav Mezhuev & Bianca Galateanu. (2021) Novel chitosan and bacterial cellulose biocomposites tailored with polymeric nanoparticles for modern wound dressing development. Drug Delivery 28:1, pages 1932-1950.
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Fahimeh Hajiahmadi, Mohammad Yousef Alikhani, Hanifeh Shariatifar, Mohammad Reza Arabestani & Davoud Ahmadvand. (2019) The bactericidal effect of lysostaphin coupled with liposomal vancomycin as a dual combating system applied directly on methicillin-resistant Staphylococcus aureus infected skin wounds in mice . International Journal of Nanomedicine 14, pages 5943-5955.
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Ruoqiu Fu, Chenwen Li, Caiping Yu, Hong Xie, Sanjun Shi, Zhuoheng Li, Qing Wang & Laichun Lu. (2016) A novel electrospun membrane based on moxifloxacin hydrochloride/poly(vinyl alcohol)/sodium alginate for antibacterial wound dressings in practical application. Drug Delivery 23:3, pages 818-829.
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Wen Zhong. (2015) Efficacy and toxicity of antibacterial agents used in wound dressings. Cutaneous and Ocular Toxicology 34:1, pages 61-67.
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Articles from other publishers (32)

Ningjuan Han, Huanle Fang & Rui Niu. (2023) Nanosphere and Microsphere-Based Drug Delivery Systems for Wound Healing Applications: A Review. Science of Advanced Materials 15:4, pages 441-456.
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Xin Liu, Zhiwen Jiang, Dejun Xing, Yan Yang, Zhiying Li & Zhiqiang Sun. (2022) Recent progress in nanocomposites of carbon dioxide fixation derived reproducible biomedical polymers. Frontiers in Chemistry 10.
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Jian Zha, Jingyuan Li, Zheng Su, Nuraly Akimbekov & Xia Wu. (2022) Lysostaphin: Engineering and Potentiation toward Better Applications. Journal of Agricultural and Food Chemistry 70:37, pages 11441-11457.
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Mohammad Javad Fatemi, Soheila Naderi Garahgheshlagh, Tayyeb Ghadimi, Shahla Jamili, Mohammad Reza Nourani, Ali Mohammad Sharifi, Mohsen Saberi, Naser Amini, Vahid Hosseinpour Sarmadi & Seyed Yasin Yazdi-Amirkhiz. (2021) Investigating the Impact of Collagen-Chitosan Derived from Scomberomorus Guttatus and Shrimp Skin on Second-Degree Burn in Rats Model. Regenerative Therapy 18, pages 12-20.
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Xiuhui Lin, Jian He, Wanlin Li, Yuchen Qi, Huiqun Hu, Dongxiao Zhang, Feng Xu, Xiaoyuan Chen & Min Zhou. (2021) Lung-Targeting Lysostaphin Microspheres for Methicillin-Resistant Staphylococcus aureus Pneumonia Treatment and Prevention . ACS Nano 15:10, pages 16625-16641.
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Pranav P. Kalelkar, Milan Riddick & Andrés J. García. (2021) Biomaterial-based antimicrobial therapies for the treatment of bacterial infections. Nature Reviews Materials 7:1, pages 39-54.
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J. Jayakumar, V.A. Kumar, L. Biswas & R. Biswas. (2021) Therapeutic applications of lysostaphin against Staphylococcus aureus . Journal of Applied Microbiology 131:3, pages 1072-1082.
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Joanna Skopinska-Wisniewska, Silvia De la Flor & Justyna Kozlowska. (2021) From Supramolecular Hydrogels to Multifunctional Carriers for Biologically Active Substances. International Journal of Molecular Sciences 22:14, pages 7402.
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Olga Urbanek, Alicja Wysocka, Paweł Nakielski, Filippo Pierini, Elżbieta Jagielska & Izabela Sabała. (2021) Staphylococcus aureus Specific Electrospun Wound Dressings: Influence of Immobilization Technique on Antibacterial Efficiency of Novel Enzybiotic. Pharmaceutics 13:5, pages 711.
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Guizi Ye, Jinjiang Huang, Guodong Li, Jien Zhang, Yongxue Sun, Dongping Zeng, Wenbin Bao, Jiang Zhong & Qingshan Huang. (2021) Clinical efficacy of intravaginal recombinant lysostaphin administration on endometritis in sows. Veterinary Medicine and Science 7:3, pages 746-754.
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Soheila Naderi Gharehgheshlagh, Mohammad Javad Fatemi, Shahla Jamili, Mohammad Reza Nourani, Ali Mohammad Sharifi, Mohsen Saberi, Naser Amini & Fatemeh Ganji. (2020) A Dermal Gel Made of Rutilus Kutum Skin Collagen-Chitosan for Deep Burn Healing. International Journal of Peptide Research and Therapeutics 27:1, pages 317-328.
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Maria do Carmo de Freire Bastos, Felipe Miceli de Farias, Patrícia Carlin Fagundes & Marcus Lívio Varella Coelho. (2020) Staphylococcins: an update on antimicrobial peptides produced by staphylococci and their diverse potential applications. Applied Microbiology and Biotechnology 104:24, pages 10339-10368.
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Aneta Pietraszek, Gabriela Ledwójcik, Joanna Lewandowska-Łańcucka, Wojciech Horak, Radosław Lach, Anna Łatkiewicz & Anna Karewicz. (2020) Bioactive hydrogel scaffolds reinforced with alkaline-phosphatase containing halloysite nanotubes for bone repair applications. International Journal of Biological Macromolecules 163, pages 1187-1195.
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Jinhua Li, Chengtie Wu, Paul K. Chu & Michael Gelinsky. (2020) 3D printing of hydrogels: Rational design strategies and emerging biomedical applications. Materials Science and Engineering: R: Reports 140, pages 100543.
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Zoe Harrison, Leslie Pace, Rukhsana Awais & J. Amber Jennings. 2020. Racing for the Surface. Racing for the Surface 477 510 .
Diogo Ribeiro, Alexsander Carvalho Júnior, Gustavo Vale de Macedo, Vitor Chagas, Lucas Silva, Brenda Cutrim, Deivid Santos, Bruno Soares, Adrielle Zagmignan, Rita de Miranda, Priscilla de Albuquerque & Luís Nascimento da Silva. (2019) Polysaccharide-Based Formulations for Healing of Skin-Related Wound Infections: Lessons from Animal Models and Clinical Trials. Biomolecules 10:1, pages 63.
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Ana Luiza R. de Souza, Mariana Fonseca, Leonardo Miziara Barboza Ferreira, Suzy S.S. Kurokawa, Charlene P. Kiill, Natália N. Ferreira, Alexandre dos Santos Pyrrho, Victor H.V. Sarmento, Amélia M. Silva, Maria Palmira D. Gremião & Clóvis A. Ribeiro. (2019) Meglumine-based supra-amphiphile self-assembled in water as a skin drug delivery system: Influence of unfrozen bound water in the system bioadhesiveness. Colloids and Surfaces B: Biointerfaces 184, pages 110523.
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Anna Mądry, Agnieszka Jendroszek, Grzegorz Dubin & Benedykt Wladyka. (2019) Production of Lysostaphin by Nonproprietary Method Utilizing a Promoter from Toxin–Antitoxin System. Molecular Biotechnology 61:10, pages 774-782.
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Tamer I.M. Ragab, Ahmed A. Nada, Eman A. Ali, Al Shimaa Gamal Shalaby, Ahmed A.F. Soliman, Mahmoud Emam & Mohamed A. El Raey. (2019) Soft hydrogel based on modified chitosan containing P. granatum peel extract and its nano-forms: Multiparticulate study on chronic wounds treatment. International Journal of Biological Macromolecules 135, pages 407-421.
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Christopher T. Johnson, Mary Caitlin P. Sok, Karen E. Martin, Pranav P. Kalelkar, Jeremy D. Caplin, Edward A. Botchwey & Andrés J. García. (2019) Lysostaphin and BMP-2 co-delivery reduces S. aureus infection and regenerates critical-sized segmental bone defects . Science Advances 5:5, pages eaaw1228.
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Hans Merzendorfer & Ephraim Cohen. 2019. Extracellular Sugar-Based Biopolymers Matrices. Extracellular Sugar-Based Biopolymers Matrices 541 624 .
Qian-Qian Ouyang, Zhang Hu, Zhen-Peng Lin, Wei-Yan Quan, Yi-Feng Deng, Si-Dong Li, Pu-Wang Li & Yu Chen. (2018) Chitosan hydrogel in combination with marine peptides from tilapia for burns healing. International Journal of Biological Macromolecules 112, pages 1191-1198.
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Sumit Mishra, Priti Rani, Gautam Sen & Kartick Prasad Dey. 2018. Hydrogels. Hydrogels 145 173 .
A. Oryan, E. Alemzadeh & A. Moshiri. (2017) Burn wound healing: present concepts, treatment strategies and future directions. Journal of Wound Care 26:1, pages 5-19.
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Aiswaria Padmanabhan & Lakshmi S. Nair. 2016. Chitin and Chitosan for Regenerative Medicine. Chitin and Chitosan for Regenerative Medicine 3 40 .
Vuk Uskoković. (2015) When 1 + 1 > 2: Nanostructured composites for hard tissue engineering applications. Materials Science and Engineering: C 57, pages 434-451.
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P. Szweda, G. Gorczyca, R. Tylingo, J. Kurlenda, J. Kwiecinski & S. Milewski. (2014) Chitosan-protein scaffolds loaded with lysostaphin as potential antistaphylococcal wound dressing materials. Journal of Applied Microbiology 117:3, pages 634-642.
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Elena P. Ivanova, Kateryna Bazaka & Russell J. Crawford. 2014. New Functional Biomaterials for Medicine and Healthcare. New Functional Biomaterials for Medicine and Healthcare 32 70 .
Hai-Rong Lu, Mei-Gang Gu, Qiang Huang, Jin-Jiang Huang, Wan-Ying Lu, Hong Lu & Qing-Shan Huang. (2013) Hydrogen/Deuterium Exchange Mass Spectrometry and Site-Directed Disulfide Cross-Linking Suggest an Important Dynamic Interface between the Two Lysostaphin Domains. Antimicrobial Agents and Chemotherapy 57:4, pages 1872-1881.
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