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Drug Delivery Volume 23, 2016 - Issue 1
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Research Article

PEGylation alleviates the non-specific toxicities of Alpha-Momorcharin and preserves its antitumor efficacy in vivo

Nian-hua DengDepartment of Immunology, College of Preclinical and Forensic Medicine, Sichuan University, Chengdu, PR China, ;School of Medical Laboratory Science, Chengdu Medical College, Chengdu, PR China,
,
Ling WangSchool of Medical Laboratory Science, Chengdu Medical College, Chengdu, PR China,
,
Qian-chuan HePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, and
,
Jue-cun ZhengSchool of Medical Laboratory Science, Chengdu Medical College, Chengdu, PR China,
,
Yao MengSchool of Medical Laboratory Science, Chengdu Medical College, Chengdu, PR China,
,
Yan-Fa MengKey Laboratory of Bio-Resources and Eco-Environment Ministry of Education/Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Science, Sichuan University, Chengdu, PR ChinaCorrespondence[email protected]
,
Chong-Jie ZhangDepartment of Immunology, College of Preclinical and Forensic Medicine, Sichuan University, Chengdu, PR China, Correspondence[email protected]
&
Fu-bing ShenSchool of Medical Laboratory Science, Chengdu Medical College, Chengdu, PR China, Correspondence[email protected]
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Pages 95-100 | Received 08 Feb 2014, Accepted 14 Mar 2014, Published online: 30 Apr 2014

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Nianhua Deng, Yun Sun, Mengling Liu, Qianchuan He, Ling Wang, Yu Zhang, Wenkui Sun, Ning Lei, Yang Liu, Yingxia Luo & Fubing Shen. (2019) Alpha-momorcharin regulates cytokine expression and induces apoptosis in monocytes. Immunopharmacology and Immunotoxicology 41:2, pages 258-266.
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Liang Pang, Chun Zhang, Jing Qin, Limei Han, Ruixiang Li, Chao Hong, Huining He & Jianxin Wang. (2017) A novel strategy to achieve effective drug delivery: exploit cells as carrier combined with nanoparticles. Drug Delivery 24:1, pages 83-91.
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Iason Psilopatis, Kleio Vrettou, Constantinos Giaginis & Stamatios Theocharis. (2023) The Role of Bitter Melon in Breast and Gynecological Cancer Prevention and Therapy. International Journal of Molecular Sciences 24:10, pages 8918.
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Zi-Wei Cai, Ting Ye, Pei-Wen Jiang, Yu-Jiao Liao, Lin Wang, Qing-Liang Zhang, Wen-Qian Du, Min Huang, Ping Yang & Min-Hui Li. (2023) MAPK Cascade Signaling Is Involved in α-MMC Induced Growth Inhibition of Multiple Myeloma MM.1S Cells via G2 Arrest and Mitochondrial-Pathway-Dependent Apoptosis In Vitro. Pharmaceuticals 16:1, pages 124.
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Bin Liu, Zhonglin Zhang, Shiyong Lu, Qianchuan He, Nianhua Deng, Hao Meng, Chenling Pan, Huanhuan Li, Mengling Liu, Axiu Huang & Fubing Shen. (2020) In-silico analysis of ligand-receptor binding patterns of α-MMC, TCS and MAP30 protein to LRP1 receptor. Journal of Molecular Graphics and Modelling 98, pages 107619.
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Jia-Qi Lu, Zhen-Ning Zhu, Yong-Tang Zheng & Pang-Chui Shaw. (2020) Engineering of Ribosome-inactivating Proteins for Improving Pharmacological Properties. Toxins 12:3, pages 167.
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Meng‐Jie Tan, Xue‐Wei Cao, Peng‐Fei Li, Yi‐Zhou Zhai, Yu Zhou, Ye‐Jun Liu, Jian Zhao & Fu‐Jun Wang. (2017) Effectively enhancing cytotoxic and apoptotic effects of alpha‐momorcharin by integrating a heparin‐binding peptide. Biotechnology and Applied Biochemistry 64:6, pages 918-926.
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Ling Wang, Fubing Shen, Min Zhang, Qianchuan He, Hui Zhao, Xiaoping Yu, Shuxia Yang, Yang Liu, Nianhua Deng, Juecun Zheng, Lixia Zhu & Xiaolan Liu. (2016) Cytotoxicity mechanism of α-MMC in normal liver cells through LRP1 mediated endocytosis and JNK activation. Toxicology 357-358, pages 33-43.
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W. Roy Jackson, Eva M. Campi & Milton T. W. Hearn. (2016) Closing Pandora's box: chemical products should be designed to preserve efficacy of function while reducing toxicity. Green Chemistry 18:15, pages 4140-4144.
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Dongliang Cao, Yun Sun, Ling Wang, Qianchuan He, Juecun Zheng, Fei Deng, Shanshan Deng, ShuChing Chang, XiaoPing Yu, Minhui Li, Yao Meng, Jiagui Jin & Fubing Shen. (2015) Alpha-momorcharin (α-MMC) exerts effective anti-human breast tumor activities but has a narrow therapeutic window in vivo. Fitoterapia 100, pages 139-149.
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