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Review Article

Bile salts-containing vesicles: promising pharmaceutical carriers for oral delivery of poorly water-soluble drugs and peptide/protein-based therapeutics or vaccines

Pages 1847-1867 | Received 24 Sep 2014, Accepted 11 Oct 2014, Published online: 12 Nov 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (18)

Nabil K Alruwaili, Ameeduzzafar Zafar, Omar Awad Alsaidan, Mohd Yasir, Ehab M. Mostafa, Sultan F. Alnomasy, Alenazy Rawaf, Ali Alquraini & Fadhel A. Alomar. (2022) Development of surface modified bilosomes for the oral delivery of quercetin: optimization, characterization in-vitro antioxidant, antimicrobial, and cytotoxicity study. Drug Delivery 29:1, pages 3035-3050.
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Mohammed H. Elkomy, Hussein M. Eid, Mohammed Elmowafy, Khaled Shalaby, Ameeduzzafar Zafar, Mohamed A. Abdelgawad, Mostafa E. Rateb, Mohammed R.A. Ali, Izzeddin Alsalahat & Heba A. Abou-Taleb. (2022) Bilosomes as a promising nanoplatform for oral delivery of an alkaloid nutraceutical: improved pharmacokinetic profile and snowballed hypoglycemic effect in diabetic rats. Drug Delivery 29:1, pages 2694-2704.
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Haidy Abbas, Yasmin A. El-Feky, Majid Mohammad Al-Sawahli, Nehal M. EL-Deeb, Hala Bakr El-Nassan & Mariam Zewail. (2022) Development and optimization of curcumin analog nano-bilosomes using 21.31 full factorial design for anti-tumor profiles improvement in human hepatocellular carcinoma: in-vitro evaluation, in-vivo safety assay. Drug Delivery 29:1, pages 714-727.
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Mohamed El-Nabarawi, Mohamed Nafady, Shahira Elmenshawe, Marwa Elkarmalawy & Mahmoud Teaima. (2021) Liver Targeting of Daclatasvir via Tailoring Sterically Stabilized Bilosomes: Fabrication, Comparative In Vitro/In Vivo Appraisal and Biodistribution Studies. International Journal of Nanomedicine 16, pages 6413-6426.
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Mahmoud Teaima, Rehab Abdelmonem, Yomna A Adel, Mohamed A El-Nabarawi & Tayseer M El-Nawawy. (2021) Transdermal Delivery of Telmisartan: Formulation, in vitro, ex vivo, Iontophoretic Permeation Enhancement and Comparative Pharmacokinetic Study in Rats. Drug Design, Development and Therapy 15, pages 4603-4614.
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Noemi Lupo, Christian Steinbring, Julian David Friedl, Bao Le-Vinh & Andreas Bernkop-Schnürch. (2021) Impact of bile salts and a medium chain fatty acid on the physical properties of self-emulsifying drug delivery systems. Drug Development and Industrial Pharmacy 47:1, pages 22-35.
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Ameeduzzafar Zafar, Nabil K. Alruwaili, Syed Sarim Imam, Omar Awad Alsaidan, Mohd Yasir, Mohammed M. Ghoneim, Sultan Alshehri, Md. Khalid Anwer, Alanood S. Almurshedi & Abdullah S. Alanazi. (2021) Development and evaluation of luteolin loaded pegylated bilosome: optimization, in vitro characterization, and cytotoxicity study. Drug Delivery 28:1, pages 2562-2573.
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Ailing Zhang, Jianbo Li, Shuaishuai Wang, Yaru Xu, Qinglian Li, Zhe Wu, Chenxu Wang, Haiyang Meng & Jinjie Zhang. (2021) Rapid and improved oral absorption of N-butylphthalide by sodium cholate-appended liposomes for efficient ischemic stroke therapy. Drug Delivery 28:1, pages 2469-2479.
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Sadek Ahmed, Mohamed Aly Kassem & Sinar Sayed. (2020) Bilosomes as Promising Nanovesicular Carriers for Improved Transdermal Delivery: Construction, in vitro Optimization, ex vivo Permeation and in vivo Evaluation. International Journal of Nanomedicine 15, pages 9783-9798.
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Mohamed Ahmed El-Nabarawi, Rehab Nabil Shamma, Faten Farouk & Samar Mohamed Nasralla. (2020) Bilosomes as a novel carrier for the cutaneous delivery for dapsone as a potential treatment of acne: preparation, characterization and in vivo skin deposition assay. Journal of Liposome Research 30:1, pages 1-11.
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Marianne Joseph Naguib, Amira Moustafa Kamel, Ahmed Thabet Negmeldin, Ahmed Hassen Elshafeey & Ibrahim Elsayed. (2020) Molecular docking and statistical optimization of taurocholate-stabilized galactose anchored bilosomes for the enhancement of sofosbuvir absorption and hepatic relative targeting efficiency. Drug Delivery 27:1, pages 996-1009.
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Rofida Albash, Mohamed A El-Nabarawi, Hanan Refai & Aly A Abdelbary. (2019) Tailoring of PEGylated bilosomes for promoting the transdermal delivery of olmesartan medoxomil: in-vitro characterization, ex-vivo permeation and in-vivo assessment. International Journal of Nanomedicine 14, pages 6555-6574.
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Abdul Ahad, Mohammad Raish, Ajaz Ahmad, Fahad I. Al-Jenoobi & Abdullah M. Al-Mohizea. (2018) Development and biological evaluation of vesicles containing bile salt of telmisartan for the treatment of diabetic nephropathy. Artificial Cells, Nanomedicine, and Biotechnology 46:sup1, pages 532-539.
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Azza Abdelmageed Matloub, Alaa Hamed Salama, Hadeer Ahmed Aglan, Mona Mahmoud AbouSamra, Sahar Salah Mohamed ElSouda & Hanaa Hamdy Ahmed. (2018) Exploiting bilosomes for delivering bioactive polysaccharide isolated from Enteromorpha intestinalis for hacking hepatocellular carcinoma. Drug Development and Industrial Pharmacy 44:4, pages 523-534.
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Amira Mohamed Mohsen, Marwa Hasanein Asfour & Abeer A. A. Salama. (2017) Improved hepatoprotective activity of silymarin via encapsulation in the novel vesicular nanosystem bilosomes. Drug Development and Industrial Pharmacy 43:12, pages 2043-2054.
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Heba M. Aboud, Adel Ahmed Ali, Shahira F. El-Menshawe & Ahmed Abd Elbary. (2016) Nanotransfersomes of carvedilol for intranasal delivery: formulation, characterization and in vivo evaluation. Drug Delivery 23:7, pages 2471-2481.
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Yosra SR Elnaggar. (2015) Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine. International Journal of Nanomedicine 10, pages 3955-3971.
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Vidya Sabale, Manjusha Charde, Nitin Dumore & Ujwala Mahajan. (2023) Recent Developments in Proniosomal Transdermal Drug Delivery: An Overview. Current Drug Delivery 20:6, pages 683-693.
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V. Anoop Narayanan, Ankitha Sharma, Rajesh K. S., Arunraj T. R., Gururaj M. P., Parasuraman S. & Anish John. (2022) Bilosomes as a Potential Carrier to Enhance Cognitive Effects of Bacopa monnieri Extract on Oral Administration. Journal of Health and Allied Sciences NU 13:03, pages 421-430.
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Sindy Müller, Kai Gruhle, Annette Meister, Gerd Hause & Simon Drescher. (2019) Bolalipid-Doped Liposomes: Can Bolalipids Increase the Integrity of Liposomes Exposed to Gastrointestinal Fluids?. Pharmaceutics 11:12, pages 646.
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Amira A. Boseila, Hassan M. Rashed, Tamer M. Sakr, Amal Y. Abdel-Reheem & Emad B. Basalious. (2019) Superiority of DEAE-Dx-Stabilized Cationic Bile-Based Vesicles over Conventional Vesicles for Enhanced Hepatic Delivery of Daclatasvir. Molecular Pharmaceutics 16:10, pages 4190-4199.
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