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Drug Delivery Volume 23, 2016 - Issue 4: Liposome- and lipid-based drug delivery
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Research Article

A new approach for treatment of precancerous lesions with curcumin solid–lipid nanoparticle-loaded gels: in vitro and clinical evaluation

Heba A. HazzahDepartment of Pharmaceutics, Faculty of Pharmacy and Drug Manufacturing, Pharos University in Alexandria, Alexandria, Egypt, Correspondence[email protected]
,
Ragwa M. FaridDepartment of Pharmaceutics, Faculty of Pharmacy and Drug Manufacturing, Pharos University in Alexandria, Alexandria, Egypt,
,
Maha M. A. NasraDepartment of Pharmaceutics, Faculty of Pharmacy, and
,
Mennatallah ZakariaDepartment of Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dentistry, Alexandria University, Alexandria, Egypt
,
Yousria GawishDepartment of Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dentistry, Alexandria University, Alexandria, Egypt
,
Magda A. El-MassikDepartment of Pharmaceutics, Faculty of Pharmacy and Drug Manufacturing, Pharos University in Alexandria, Alexandria, Egypt,
&
Ossama Y. AbdallahDepartment of Pharmaceutics, Faculty of Pharmacy, and
show all
Pages 1409-1419 | Received 08 May 2015, Accepted 21 Jun 2015, Published online: 06 Jul 2015

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Hui Xie, Shengtao Tian, Li Cui, Jieyu Yan, Yanhua Bai, Xiaohui Li, Maoqiang Wang, Fangfang Zhang & Feng Duan. (2019) Adjuvant trans-arterial chemoembolization after hepatectomy significantly improves the prognosis of low-risk patients with R0-stage hepatocellular carcinoma. Cancer Management and Research 11, pages 4065-4073.
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Heba F. Salem, Rasha M. Kharshoum, Heba A. Abou-Taleb, Hisham A. AbouTaleb & Kariman M. AbouElhassan. (2019) Progesterone-loaded nanosized transethosomes for vaginal permeation enhancement: formulation, statistical optimization, and clinical evaluation in anovulatory polycystic ovary syndrome. Journal of Liposome Research 29:2, pages 183-194.
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Slavomira Doktorovova, Eliana B. Souto & Amélia M. Silva. (2018) Hansen solubility parameters (HSP) for prescreening formulation of solid lipid nanoparticles (SLN): in vitro testing of curcumin-loaded SLN in MCF-7 and BT-474 cell lines. Pharmaceutical Development and Technology 23:1, pages 96-105.
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Mohammed H. Elkomy, Shahira F. El Menshawe, Heba A. Abou-Taleb & Marwa H. Elkarmalawy. (2017) Loratadine bioavailability via buccal transferosomal gel: formulation, statistical optimization, in vitro/in vivo characterization, and pharmacokinetics in human volunteers. Drug Delivery 24:1, pages 781-791.
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Maha M. A. Nasra, Heba M. Khiri, Heba A. Hazzah & Ossama Y. Abdallah. (2017) Formulation, in-vitro characterization and clinical evaluation of curcumin in-situ gel for treatment of periodontitis. Drug Delivery 24:1, pages 133-142.
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Yatian Wang, Boxin Zhao, Shengqi Wang, Qianying Liang, Yun Cai, Fuheng Yang & Guofeng Li. (2016) Formulation and evaluation of novel glycyrrhizic acid micelles for transdermal delivery of podophyllotoxin. Drug Delivery 23:5, pages 1623-1635.
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Hossein Omidian, Renae L. Wilson & Sumana Dey Chowdhury. (2023) Enhancing Therapeutic Efficacy of Curcumin: Advances in Delivery Systems and Clinical Applications. Gels 9:8, pages 596.
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Isha Mutreja, Dhiraj Kumar, Ajeet Kaushik & Yogendra Kumar Mishra. (2023) Lipid nanoparticle-based formulations for high-performance dentistry applications. Journal of Materials Chemistry B 11:26, pages 5990-6023.
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Yuan Liu, Honglian Guo, Rengui Xu & Wei Chen. (2022) Smart intraoral systems for advanced drug delivery. MedComm – Biomaterials and Applications 1:2.
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Yining Xu, Thibaut Fourniols, Yasmine Labrak, Véronique Préat, Ana Beloqui & Anne des Rieux. (2022) Surface Modification of Lipid-Based Nanoparticles. ACS Nano 16:5, pages 7168-7196.
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Shery Jacob, Anroop B. Nair, Sai H. S. Boddu, Bapi Gorain, Nagaraja Sreeharsha & Jigar Shah. (2021) An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems. Pharmaceutics 13:8, pages 1206.
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Sosmitha Girisa, Aviral Kumar, Varsha Rana, Dey Parama, Uzini Devi Daimary, Saman Warnakulasuriya, Alan Prem Kumar & Ajaikumar B. Kunnumakkara. (2021) From Simple Mouth Cavities to Complex Oral Mucosal Disorders—Curcuminoids as a Promising Therapeutic Approach. ACS Pharmacology & Translational Science 4:2, pages 647-665.
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Xiu Lin, Rui Wang, Sujuan Pan, Hongqin Yang & Yiru Peng. (2021) Three components encapsulated nanoparticles: Preparation and photophysical property. Arabian Journal of Chemistry 14:3, pages 103023.
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Salman Ahmad Mustfa, Eleonora Maurizi, John McGrath & Ciro Chiappini. (2020) Nanomedicine Approaches to Negotiate Local Biobarriers for Topical Drug Delivery. Advanced Therapeutics 4:1, pages 2000160.
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Ana S. Macedo, Pedro M. Castro, Luís Roque, Natália G. Thomé, Catarina P. Reis, Manuela E. Pintado & Pedro Fonte. (2020) Novel and revisited approaches in nanoparticle systems for buccal drug delivery. Journal of Controlled Release 320, pages 125-141.
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Marcos Luciano Bruschi, Sabrina Barbosa de Souza Ferreira & Jéssica Bassi da Silva. 2020. Nanotechnology for Oral Drug Delivery. Nanotechnology for Oral Drug Delivery 77 141 .
Helena Rouco, Patricia Diaz-Rodriguez, Carmen Remuñán-López & Mariana Landin. 2020. Nanomaterials for Clinical Applications. Nanomaterials for Clinical Applications 213 247 .
Phuong H.L. Tran, Wei Duan & Thao T.D. Tran. (2019) Recent developments of nanoparticle-delivered dosage forms for buccal delivery. International Journal of Pharmaceutics 571, pages 118697.
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Carmelo Puglia, Rosario Pignatello, Virginia Fuochi, Pio Maria Furneri, Maria Rosaria Lauro, Debora Santonocito, Rita Cortesi & Elisabetta Esposito. (2019) Lipid Nanoparticles and Active Natural Compounds: A Perfect Combination for Pharmaceutical Applications. Current Medicinal Chemistry 26:24, pages 4681-4696.
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Samet Özdemir, Burak Çelik & Melike Üner. 2019. Materials for Biomedical Engineering. Materials for Biomedical Engineering 457 505 .
Usha Subbiah, Sonaa Elango & Raghavendra Jayesh. 2019. Nanobiomaterials in Clinical Dentistry. Nanobiomaterials in Clinical Dentistry 617 646 .
Yuhua Wang, Zhihui Luo, Zhengchao Wang, Minghai You, Shusen Xie, Yiru Peng & Hongqin Yang. (2018) Effect of curcumin-loaded nanoparticles on mitochondrial dysfunctions of breast cancer cells. Journal of Nanoparticle Research 20:10.
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Darine Abozaid, Alyaa Ramadan, Heba Barakat & Nawal Khalafallah. (2018) Acyclovir lipid nanocapsules gel for oromucosal delivery: A preclinical evidence of efficacy in the chicken pouch membrane model. European Journal of Pharmaceutical Sciences 121, pages 228-235.
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Bruno Fonseca-Santos & Marlus Chorilli. (2018) An overview of polymeric dosage forms in buccal drug delivery: State of art, design of formulations and their in vivo performance evaluation. Materials Science and Engineering: C 86, pages 129-143.
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Michelle Franz-Montan, Daniele Ribeiro de Araújo, Lígia Nunes de Morais Ribeiro, Nathalie Ferreira Silva de Melo & Eneida de Paula. 2017. Nanostructures for Oral Medicine. Nanostructures for Oral Medicine 87 121 .
Slavomira Doktorovova, Ranjita Shegokar & Eliana B. Souto. 2017. Nanostructures for Novel Therapy. Nanostructures for Novel Therapy 811 843 .

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