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Biomaterials, Artificial Cells and Artificial Organs Volume 17, 1989 - Issue 2
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Original Article

Effects of Oral Administration of Artificial Cells Immobilized Phenylalanine Ammonia-Lyase on Intestinal Amino Acids of Phenylketonuric Rats

Louis Bourget Artificial Cells and Organs Research Centre, Departments of Physiology and Medicine, McGill University, 3655 Drummond Street, Montreal, Canada, H3G 1Y6
&
Thomas M.S. Chang Artificial Cells and Organs Research Centre, Departments of Physiology and Medicine, McGill University, 3655 Drummond Street, Montreal, Canada, H3G 1Y6
Pages 161-181 | Published online: 11 Jul 2009

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Read on this site (4)

Binglan Yu & Thomas Ming Swi Chang. (2004) Effects of Combined Oral Administration and Intravenous Injection on Maintaining Decreased Systemic Tyrosine Levels in Rats. Artificial Cells, Blood Substitutes, and Biotechnology 32:1, pages 129-148.
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Sarah Safos. (1995) Enzyme Replacement Therapy in ENU2 Phenylketonuric Mice Using Oral Microencapsulated Phenylalanine Ammonia-Lyase: A Preliminary Report. Artificial Cells, Blood Substitutes, and Biotechnology 23:6, pages 681-692.
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Thomas Ming Swi Chang. (1992) Artificial Cells in Immobilization Biotechnology. Biomaterials, Artificial Cells and Immobilization Biotechnology 20:5, pages 1121-1143.
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. (1990) Literature Alerts. Journal of Microencapsulation 7:3, pages 425-444.
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Articles from other publishers (16)

Yu Jiang, Bingbing Sun, Fenghui Qian, Feng Dong, Chongmao Xu, Wuling Zhong, Rui Huang, Qiwei Zhai, Yu Jiang & Sheng Yang. (2022) Expression of phenylalanine ammonia lyase as an intracellularly free and extracellularly cell surface-immobilized enzyme on a gut microbe as a live biotherapeutic for phenylketonuria. Science China Life Sciences 66:1, pages 127-136.
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Luciana d’Amone, Vikas D. Trivedi, Nikhil U. Nair & Fiorenzo G. Omenetto. (2022) A Silk-Based Platform to Stabilize Phenylalanine Ammonia-lyase for Orally Administered Enzyme Replacement Therapy. Molecular Pharmaceutics 19:12, pages 4625-4630.
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Christina Besada, Abrar Hakami, Gayatri Pillai, Kyle Yetsko, Nhu Truong, Timothy Little, Sharon Pantano & Anil Dmello. (2022) Preformulation Studies with Phenylalanine Ammonia Lyase: Essential Prelude to a Microcapsule Formulation for the Management of Phenylketonuria. Journal of Pharmaceutical Sciences 111:7, pages 1857-1867.
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Marja K. Puurunen, Jerry Vockley, Shawn L. Searle, Stephanie J. Sacharow, John A. PhillipsIIIIII, William S. Denney, Benjamin D. Goodlett, David A. Wagner, Larry Blankstein, Mary J. Castillo, Mark R. Charbonneau, Vincent M. Isabella, Vasu V. Sethuraman, Richard J. Riese, Caroline B. Kurtz & Aoife M. Brennan. (2021) Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study. Nature Metabolism 3:8, pages 1125-1132.
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Els van der Goot, Francjan J. van Spronsen, Joana Falcão Salles & Eddy A. van der Zee. (2020) A Microbial Community Ecology Perspective on the Gut-Microbiome-Brain Axis. Frontiers in Endocrinology 11.
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Vincent M Isabella, Binh N Ha, Mary Joan Castillo, David J Lubkowicz, Sarah E Rowe, Yves A Millet, Cami L Anderson, Ning Li, Adam B Fisher, Kip A West, Philippa J Reeder, Munira M Momin, Christopher G Bergeron, Sarah E Guilmain, Paul F Miller, Caroline B Kurtz & Dean Falb. (2018) Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria. Nature Biotechnology 36:9, pages 857-864.
Crossref
Harvey L. Levy, Christineh N. Sarkissian & Charles R. Scriver. (2018) Phenylalanine ammonia lyase (PAL): From discovery to enzyme substitution therapy for phenylketonuria. Molecular Genetics and Metabolism 124:4, pages 223-229.
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Sean M. Bell, Dan J. Wendt, Yanhong Zhang, Timothy W. Taylor, Shinong Long, Laurie Tsuruda, Bin Zhao, Phillip Laipis & Paul A. Fitzpatrick. (2017) Formulation and PEGylation optimization of the therapeutic PEGylated phenylalanine ammonia lyase for the treatment of phenylketonuria. PLOS ONE 12:3, pages e0173269.
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Woo-Mi Kim. (2009) Development of Modified Phenylalanine Ammonia-lyase for the Treatment of Phenylketonuria. Biomolecules and Therapeutics 17:1, pages 104-110.
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Kiyoshi Takasuna, Chiba Katsuyoshi & Sunao Manabe. (2009) Pre-clinical QT Risk Assessment in Pharmaceutical Companies - Issues of Current QT Risk Assessment -. Biomolecules and Therapeutics 17:1, pages 1-11.
Crossref
B YU & T M S CHANG. 2007. Artificial Cells, Cell Engineering and Therapy. Artificial Cells, Cell Engineering and Therapy 424 432 .
S PRAKASH, J R BHATHENA & H CHEN. 2007. Artificial Cells, Cell Engineering and Therapy. Artificial Cells, Cell Engineering and Therapy 3 41 .
Woomi Kim, Heidi Erlandsen, Sankar Surendran, Raymond C. Stevens, Stephen K. Tyring, Reuben Matalon, Alejandra Gamez & Kimberlee Michols-Matalon. (2004) Trends in Enzyme Therapy for Phenylketonuria. Molecular Therapy 10:2, pages 220-224.
Crossref
Binglan Yu & Thomas Ming Swi Chang. (2004) Effects of long-term oral administration of polymeric microcapsules containing tyrosinase on maintaining decreased systemic tyrosine levels in rats. Journal of Pharmaceutical Sciences 93:4, pages 831-837.
Crossref
Thomas Ming Swi Chang. 1995. Biotechnology Annual Review Volume 1. Biotechnology Annual Review Volume 1 267 295 .
T. M. S. Chang. 1992. Artificial Liver Support. Artificial Liver Support 261 270 .

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