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Original Article

The Use of Semifluorinated Alkanes in Blood-Substitutes

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Pages 583-595 | Published online: 11 Jul 2009

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Charalambos Tsagogiorgas, Friedrich Anger, Grietje Beck, Annette Breedijk, Benito Yard & Simone Hoeger. (2019) Impact of different emulsifiers on biocompatibility and inflammatory potential of Perfluorohexyloctane (F6H8) emulsions for new intravenous drug delivery systems. Drug Design, Development and Therapy 13, pages 2097-2110.
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Stefan Kegel, Jorge Chacon-Caldera, Charalambos Tsagogiorgas, Bastian Theisinger, Gerhard Glatting & Lothar R. Schad. (2016) 19F Oximetry with semifluorinated alkanes. Artificial Cells, Nanomedicine, and Biotechnology 44:8, pages 1861-1866.
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Articles from other publishers (17)

Claudio Gatto, Paolo Ruzza, Laura Giurgola, Claudia Honisch, Orietta Rossi, Mario R. Romano, Eugenio Ragazzi & Jana D’Amato Tóthová. (2022) Comparison of Perfluorocarbon Liquids Cytotoxicity Tests: Direct Contact Versus the Test on Liquid Extracts. ACS Omega 8:1, pages 365-372.
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Neal Stolowich, Jason Vittitow, Robert Kissling & Douglas Borchman. (2023) Oxygen-Carrying Capacity of Perfluorohexyloctane, a Novel Eye Drop for Dry Eye Disease. Current Therapeutic Research 98, pages 100705.
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Matthias Otto, Jörg Krebs, Peter Welker, René Holm, Manfred Thiel, Luciano Gattinoni, Michael Quintel & Charalambos Tsagogiorgas. (2021) Inhalationally Administered Semifluorinated Alkanes (SFAs) as Drug Carriers in an Experimental Model of Acute Respiratory Distress Syndrome. Pharmaceutics 13:3, pages 431.
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Dirk-Henning Menz, Nicolas Feltgen, Thorsten Lechner, Helge Menz, Bernd-Kristof Müller, Joachim Dresp & Hans Hoerauf. (2019) Hydrofluoric Acid and Other Impurities in Toxic Perfluorooctane Batches. Translational Vision Science & Technology 8:3, pages 24.
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Anna Runnsjö, Vitaly Kocherbitov, Gesche Graf, Anthony Pettigrew, Dieter Scherer, Kell Mortensen & Johan Engblom. (2017) Semifluorinated alkanes and alkanes: A phase study of the perfluorohexyloctane – Tetradecane system. The Journal of Chemical Thermodynamics 105, pages 352-361.
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Antigoni Theodoratou, Ulrich Jonas, Benoit Loppinet, Thomas Geue, Rene Stangenberg, Rabea Keller, Dan Li, Rüdiger Berger, Jan Vermant & Dimitris Vlassopoulos. (2016) Semifluorinated Alkanes at the Air–Water Interface: Tailoring Structure and Rheology at the Molecular Scale. Langmuir 32:13, pages 3139-3151.
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Francesco Morescalchi, Ciro Costagliola, Sarah Duse, Elena Gambicorti, Barbara Parolini, Barbara Arcidiacono, Mario R. Romano & Francesco Semeraro. (2014) Heavy Silicone Oil and Intraocular Inflammation. BioMed Research International 2014, pages 1-16.
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C. Tsagogiorgas, T. Jung, J. Krebs, B. Theisinger, G. Beck, B.A. Yard & M. Quintel. (2012) Aerosolized semifluorinated alkanes as excipients are suitable for inhalative drug delivery—A pilot study. International Journal of Pharmaceutics 422:1-2, pages 194-201.
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A. Zaggia, L. Conte, G. Padoan & F. Ceretta. (2010) Synthesis and characterization of partially fluorinated ethers. Journal of Fluorine Chemistry 131:8, pages 844-851.
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Heide Brandhorst, Sana Asif, Karin Andersson, Bastian Theisinger, Helene H. Andersson, Maria Felldin, Aksel Foss, Kaija Salmela, Annika Tibell, Gunnar Tufveson, Olle Korsgren & Daniel Brandhorst. (2010) A New Oxygen Carrier for Improved Long-Term Storage of Human Pancreata Before Islet Isolation. Transplantation 89:2, pages 155-160.
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L. Conte, A. Zaggia, A. Sassi & R. Seraglia. (2007) Synthesis and characterization of tri-block fluorinated-n-alkanes. Journal of Fluorine Chemistry 128:5, pages 493-499.
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Jerzy Mackiewicz, Kristel Maaijwee, Christoph Lüke, Norbert Kociok, Wilfried Hiebl, Hasso Meinert & Antonia M. Joussen. (2006) Effect of gravity in long-term vitreous tamponade: in vivo investigation using perfluorocarbon liquids and semi-fluorinated alkanes. Graefe's Archive for Clinical and Experimental Ophthalmology 245:5, pages 665-675.
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Antonia M. Joussen & Bernd Kirchhof. 2007. Retinal Vascular Disease. Retinal Vascular Disease 260 273 .
A.M.A. Dias, C.M.B. Gonçalves, J.L. Legido, J.A.P. Coutinho & I.M. Marrucho. (2005) Solubility of oxygen in substituted perfluorocarbons. Fluid Phase Equilibria 238:1, pages 7-12.
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M. Broniatowski, I. Sandez Macho, J. MiñonesJr.Jr. & P. Dynarowicz-Łątka. (2005) Properties of Langmuir monolayers from semifluorinated alkanes. Applied Surface Science 246:4, pages 342-347.
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Jean G. Riess. (2001) Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some Physiology Blut ist ein ganz besondrer Saft . Chemical Reviews 101:9, pages 2797-2920.
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M. Napoli. (1996) Diblock and triblock semifluorinated n-alkanes: preparations, structural aspects and applications. Journal of Fluorine Chemistry 79:1, pages 59-69.
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