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Original Article

Characterization of the Hemodynamic Response to Intravenous Diaspirin Crosslinked Hemoglobin Solution in Rats

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Pages 91-107 | Published online: 11 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Armin Schubert, Jerome F. O'Hara, Robert J. Przybelski, John E. Tetzlaff, Kenneth E. Marks, Edward Mascha & Andrew C. Novick. (2002) EFFECT OF DIASPIRIN CROSSLINKED HEMOGLOBIN (DCLHb HemAssist™) DURING HIGH BLOOD LOSS SURGERY ON SELECTED INDICES OF ORGAN FUNCTION *. Artificial Cells, Blood Substitutes, and Biotechnology 30:4, pages 259-283.
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Sandra M. Erhart, Daniel J. Cole, Piyush M. Patel, John C. Drummond & Kenneth E. Burhop. (2000) Effect of α-α Diaspirin Crosslinked Hemoglobin (DCLHbTM) on the Potency of Sodium Nitroprusside and Nitroglycerine to Decrease Blood Pressure in Rats: A Dose-Response Study. Artificial Cells, Blood Substitutes, and Biotechnology 28:5, pages 385-396.
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William Sefton, Paul Pudimat, Saiid Bina, Edwin Lojeski, Paul Mongan & Sheila Muldoon. (1999) Inhaled Nitric Oxide Attenuates Increased Pulmonary Artery Pressure Following Diaspirin Crosslinked Hemoglobin (Dclhb) Administration. Artificial Cells, Blood Substitutes, and Biotechnology 27:3, pages 203-213.
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Raluan G. Soltero & John F. Hansbrough. (1999) Comparison of Resuscitation with Diaspirin Crosslinked Hemoglobin (Dclhb) Vs Fresh Blood in A Rat Burn Shock Model. Artificial Cells, Blood Substitutes, and Biotechnology 27:2, pages 135-152.
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Ananda P. Sen, Yumi Dong & Anil Gulati. (1997) Effect of Diaspirin Crosslinked Hemoglobin on Systemic and Regional Blood Circulation in Pregnant Rats. Artificial Cells, Blood Substitutes, and Biotechnology 25:3, pages 275-288.
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Ashok Kumar, Ananda P. Sen, Pramod R. Saxena & Anil Gulati. (1997) Resuscitation with Diaspirin Crosslinked Hemoglobin Increases Cerebral and Renal Blood Perfusion in Hemorrhaged Rats. Artificial Cells, Blood Substitutes, and Biotechnology 25:1-2, pages 85-94.
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Abhijit Barve, Ananda P. Sen, Pramod R. Saxena & Anil Gulati. (1997) Dose Response Effect of Diaspirin Crosslinked Hemoglobin (DCLHb) on Systemic Hemodynamics and Regional Blood Circulation in Rats. Artificial Cells, Blood Substitutes, and Biotechnology 25:1-2, pages 75-84.
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L. F. Poli de Figueiredo, G. I. Elgjo, M. Mathru, M. Rochae Silva & G. C. Kramer. (1997) Hypertonic Acetate-αα Hemoglobin for Small Volume Resuscitation of Hemorrhagic Shock. Artificial Cells, Blood Substitutes, and Biotechnology 25:1-2, pages 61-73.
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Gary Marchand, Elizabeth Dunlap, Liam Farrell, Carmen Nigro & Kenneth Burhop. (1996) Resuscitation with Increasing Doses of Diaspirin Crosslinked Hemoglobin in Swine. Artificial Cells, Blood Substitutes, and Biotechnology 24:5, pages 469-487.
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P. Menu, M. Dormer, B. Faivre, P. Labrude & C. Vigneron. (1995) In Vitro Effect of Dextran-Benzene-Tetra-Carboxylate Hemoglobin on Human Blood Rheological Properties. Artificial Cells, Blood Substitutes, and Biotechnology 23:3, pages 319-330.
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Mark A. Young, Louis Riddez, Bengt Thomas Kjellström, Jenny Bursell, Ford Winslow, Jeffrey Lohman & Robert M. Winslow. (2005) MalPEG-hemoglobin (MP4) improves hemodynamics, acid-base status, and survival after uncontrolled hemorrhage in anesthetized swine. Critical Care Medicine 33:8, pages 1794-1804.
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Ivo P. Torres Filho, Bruce D. Spiess, R Wayne Barbee, Kevin R. Ward, John Oldenhof & Roland N. Pittman. (2005) Systemic Responses to Hemodilution After Transfusion with Stored Blood and with a Hemoglobin-Based Oxygen Carrier. Anesthesia & Analgesia 100:4, pages 912-920.
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D.C.H Cheng, C.D Mazer, R Martineau, A Ralph-Edwards, J Karski, J Robblee, B Finegan, R.I Hall, R Latimer & A Vuylsteke. (2004) A phase II dose-response study of hemoglobin raffimer (Hemolink) in elective coronary artery bypass surgery. The Journal of Thoracic and Cardiovascular Surgery 127:1, pages 79-86.
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B. T. Kjellstrom. (2003) Blood substitutes: where do we stand today?. Journal of Internal Medicine 253:5, pages 495-497.
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Eishun Tsuchida, Teruyuki Komatsu, Yasuko Matsukawa, Akito Nakagawa, Hiromi Sakai, Koichi Kobayashi & Makoto Suematsu. (2002) Human serum albumin incorporating synthetic heme: Red blood cell substitute without hypertension by nitric oxide scavenging. Journal of Biomedical Materials Research Part A 64A:2, pages 257-261.
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R. Ferrera, G. Hadour, P. Chiari, P. Montagna, O. Jegaden, K. Burhop & J. J. Lehot. (2002) Effect of diaspirin cross-linked haemoglobin (DCLHbtm) on mean arterial pressure during cardiopulmonary bypass in swine. Transfusion Medicine 12:5, pages 311-316.
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Luiz A. Vane, J. Sean Funston, Robert Kirschner, Don Harper, Donald J. Deyo, Daniel L. Traber, Lillian L. Traber & George C. Kramer. (2002) Comparison of transfusion with DCLHb or pRBCs for treatment of intraoperative anemia in sheep. Journal of Applied Physiology 92:1, pages 343-353.
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Armin Schubert. (2001) Hemoglobin-based oxygen carriers, blood substitutes, and their relevance to high-volume blood loss. Seminars in Anesthesia, Perioperative Medicine and Pain 20:1, pages 78-84.
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Mark R. Forrest, Adrian H. Chester & David Royston. (2001) The Effects of Diaspirin Cross-Linked Hemoglobin on the Tone of Human Saphenous Vein. Anesthesia & Analgesia 92:2, pages 324-328.
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Mark R. Forrest, Adrian H. Chester & David Royston. (2001) The Effects of Diaspirin Cross-Linked Hemoglobin on the Tone of Human Saphenous Vein. Anesthesia and Analgesia, pages 324-328.
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Hiromi Sakai, Hiroyuki Hara, Minako Yuasa, Amy G. Tsai, Shinji Takeoka, Eishun Tsuchida & Marcos Intaglietta. (2000) Molecular dimensions of Hb-based O 2 carriers determine constriction of resistance arteries and hypertension . American Journal of Physiology-Heart and Circulatory Physiology 279:3, pages H908-H915.
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Robert M. Winslow. (2000) alphaalpha-Crosslinked Hemoglobin: Was Failure Predicted by Preclinical Testing?. Vox Sanguinis 79:1, pages 1-20.
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F. J. Lou Carmichael, Arlene C. Y. Ali, Janet A. Campbell, Susan F. Langlois, George P. Biro, Andrew R. Willan, Charles H. Pierce & A. Gerson Greenburg. (2000) A phase I study of oxidized raffinose cross-linked human hemoglobin. Critical Care Medicine 28:7, pages 2283-2292.
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Xavier M. Mueller, Hendrik T. Tevaearai, David Jegger, Iker Mallabiabarrena, Jean Patrice Gardaz & Ludwig K. von Segesser. (2000) Hemoglobin Substitute and Cardiopulmonary Bypass. ASAIO Journal 46:4, pages 403-408.
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Rameshraja Palaparthy, Huashan Wang & Anil Gulati. (2000) Current aspects in pharmacology of modified hemoglobins. Advanced Drug Delivery Reviews 40:3, pages 185-198.
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Robert J. Przybelski, Elaine K. Daily, Jean Micheels, Edward Sloan, Pierre Mols, Luc Corne, Max D. Koenigsberg, William H. Bickell, Dan R. Thompson, Jay D. Harviel & Stephen M. Cohn. (2012) A Safety Assessment of Diaspirin Cross-Linked Hemoglobin (DCLHb) in the Treatment of Hemorrhagic, Hypovolemic Shock. Prehospital and Disaster Medicine 14:4, pages 47-60.
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Francis Rioux, Nathalie Harvey, Steve Moisan, Richard Larivière, Marcel Lebel, John H Grose & Kenneth Burhop. (1999) Nonpeptide endothelin receptor antagonists attenuate the pressor effect of diaspirin-crosslinked hemoglobin in rat. Canadian Journal of Physiology and Pharmacology 77:3, pages 188-194.
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Patrick Menu, Dan Longrois, Béatrice Faivre, Mireille Donner, Pierre Labrude, Jean-François Stoltz & Claude Vigneron. (1999) Rheological behaviour of red blood cells suspended in hemoglobin solutions.. Transfusion Science 20:1, pages 5-16.
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Anil Gulati, Abhijit Barve & Ananda P. Sen. (1999) Pharmacology of hemoglobin therapeutics. Journal of Laboratory and Clinical Medicine 133:2, pages 112-119.
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S. R. Fischer & D. L. Traber. 1999. Shock, Sepsis, and Organ Failure. Shock, Sepsis, and Organ Failure 273 293 .
Joan M. Przybocki, Thomas A. McCalden, John M. Collier & Ruth E. Billings. (1998) Hepatic inflammatory responses to αα-cross-linked hemoglobin infusion in rats. Journal of Laboratory and Clinical Medicine 131:5, pages 432-441.
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K. Nakai, I. Sakuma & A. Kitabatake. 1998. Blood Substitutes, Present and Future Perspectives. Blood Substitutes, Present and Future Perspectives 251 264 .
Stefanie R. Fischer, Hans G. Bone, W. Cameron Powell, Roy McGuire, Lillian D. Traber & Daniel L. Traber. (1997) Pyridoxalated hemoglobin polyoxyethylene conjugate does not restore hypoxic pulmonary vasoconstriction in ovine sepsis. Critical Care Medicine 25:9, pages 1551-1559.
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Gary Reah, Andrew R. Bodenham, Abhiram Mallick, Elaine K. Daily & Robert J. Przybelski. (1997) Initial evaluation of diaspirin cross-linked hemoglobin (DCLHb[trademark symbol]) as a vasopressor in critically ill patients. Critical Care Medicine 25:9, pages 1480-1488.
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Dirk Nolte, Peter Steinhauser, Sven Pickelmann, Steffen Berger, Roger Hartl & Konrad Messmer. (1997) Effects of diaspirin-cross-linked hemoglobin (dclhbtm) on local tissue oxygen tension in striated skin muscle: An efficacy study in the hamster. Journal of Laboratory and Clinical Medicine 130:3, pages 328-338.
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Hans G. Bone, Paul J. Schenarts, Michael Booke, Roy McGuire, Donald Harper, Lillian D. Traber & Daniel L. Traber. (1997) Oxalated pyridoxalated hemoglobin polyoxyethylene conjugate normalizes the hyperdynamic circulation in septic sheep. Critical Care Medicine 25:6, pages 1010-1018.
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Zaid Abassi, Shaban Kotob, Federico Pieruzzi, Majd Abouassali, Harry R. Keiser, Joseph C. Fratantoni & Abdu I. Alayash. (1997) Effects of polymerization on the hypertensive action of diaspirin cross-linked hemoglobin in rats. Journal of Laboratory and Clinical Medicine 129:6, pages 603-610.
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Luiz F. Poli de Figueiredo, Mali Mathru, Daneshvari Solanki, Victor W. Macdonald, John Hess & George C. Kramer. (1997) Pulmonary Hypertension and Systemic Vasoconstriction May Offset the Benefits of Acellular Hemoglobin Blood Substitutes. The Journal of Trauma: Injury, Infection, and Critical Care 42:5, pages 847-856.
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S. R. Fischer, H. G. Bone & D. L. Traber. 1997. Yearbook of Intensive Care and Emergency Medicine 1997. Yearbook of Intensive Care and Emergency Medicine 1997 424 441 .
R. G. Kilbourn, J. DeAngelo & J. Bonaventura. 1997. Yearbook of Intensive Care and Emergency Medicine 1997. Yearbook of Intensive Care and Emergency Medicine 1997 230 239 .
Stefan-Mario Kasper, Michael Walter, Frank Grune, Albrecht Bischoff, Heide Erasmi & Walter Buzello. (1996) Effects of a Hemoglobin-Based Oxygen Carrier (HBOC-201) on Hemodynamics and Oxygen Transport in Patients Undergoing Preoperative Hemodilution for Elective Abdominal Aortic Surgery. Anesthesia & Analgesia 83:5, pages 912-927.
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Stefan-Mario Kasper, Michael Walter, Frank Grune, Albrecht Bischoff, Heide Erasmi & Walter Buzello. (1996) Effects of a Hemoglobin-Based Oxygen Carrier (HBOC-201) on Hemodynamics and Oxygen Transport in Patients Undergoing Preoperative Hemodilution for Elective Abdominal Aortic Surgery. Anesthesia & Analgesia 83:5, pages 912-927.
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Ari Leppaniemi, Raluan Soltero, David Burris, Emmanouil Pikoulis, Jennifer Ratigan, Christine Waasdorp, Howard Hufnagel & Diana Malcolm. (1996) Early Resuscitation with Low-Volume PolyDCLHb Is Effective in the Treatment of Shock Induced by Penetrating Vascular Injury. The Journal of Trauma: Injury, Infection, and Critical Care 40:2, pages 242-248.
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Stephen M. Cohn & Thomas J. Farrell. (1995) Diaspirin Cross-Linked Hemoglobin Resuscitation of Hemorrhage. The Journal of Trauma: Injury, Infection, and Critical Care 39:2, pages 210-217.
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Anil Gulati, Govind Singh, Sam Rebello & Avadhesh C. Sharma. (1995) Effect of diaspirin crosslinked and stroma-reduced hemoglobin on mean arterial pressure and endothelin-1 concentration in rats. Life Sciences 56:17, pages 1433-1442.
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