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Original Article

Increased Vascular Resistance with Hemoglobin-Based Oxygen Carriers

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Pages 361-372 | Published online: 11 Jul 2009

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Charles D. Conover, Rita Linberg, Kwok L. Shum & Robert G. L. Shorr. (1999) The Ability of Polyethylene Glycol Conjugated Bovine Hemoglobin (PEG-Hb) To Adequately Deliver Oxygen in Both Exchange Transfusion and Top-Loaded Rat Models. Artificial Cells, Blood Substitutes, and Biotechnology 27:2, pages 93-107.
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Jan Simoni, Grace Simoni, Charles D. Lox, Samuel D. Prien & G. Tom Shires. (1997) Modified Hemoglobin Solution, with Desired Pharmacological Properties, Does not Activate Nuclear Transcription Factor NF-kappa B in Human Vascular Endothelial Cells. Artificial Cells, Blood Substitutes, and Biotechnology 25:1-2, pages 193-210.
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H. W. Kim & A. G. Greenburg. (1997) Ferrrous Hemoglobin Scavenging of Endothelium Derived Nitric Oxide is a Principal Mechanism for Hemoglobin Mediated Vasoactivities in Isolated rat Thoracic Aorta. Artificial Cells, Blood Substitutes, and Biotechnology 25:1-2, pages 121-133.
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J. R. Hess. (1995) Review of Modified Hemoglobin Research at Letterman: Attempts to Delineate the Toxicity of Cell-Free Tetrameric Hemoglobin. Artificial Cells, Blood Substitutes, and Biotechnology 23:3, pages 277-289.
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Articles from other publishers (25)

Peter Bedőcs & János Szebeni. (2020) The Critical Choice of Animal Models in Nanomedicine Safety Assessment: A Lesson Learned From Hemoglobin-Based Oxygen Carriers. Frontiers in Immunology 11.
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Hugh W F Kingston, Aniruddha Ghose, Voravut Rungpradubvong, Sudarat Satitthummanid, M Trent Herdman, Katherine Plewes, Haruhiko Ishioka, Stije J Leopold, Ipsita Sinha, Benjamas Intharabut, Kim Piera, Yvette McNeil, Sanjib Mohanty, Richard J Maude, Nicholas J White, Nicholas P J Day, Tsin W Yeo, Md Amir Hossain, Nicholas M Anstey & Arjen M Dondorp. (2019) Cell-Free Hemoglobin Is Associated With Increased Vascular Resistance and Reduced Peripheral Perfusion in Severe Malaria. The Journal of Infectious Diseases.
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Ann M. Peruski, Edward S. Cooper & Amy L. Butler. (2014) Microcirculatory effects of a hyperviscous hemoglobin-based solution administered intravenously in dogs with experimentally induced hemorrhagic shock. American Journal of Veterinary Research 75:1, pages 77-84.
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Robert M. Van Haren, Chad M. Thorson, Col Lorne H. Blackbourne & Kenneth G. Proctor. 2013. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics 127 138 .
Robert P. Hebbel. (2011) Reconstructing sickle cell disease: A data‐based analysis of the “hyperhemolysis paradigm” for pulmonary hypertension from the perspective of evidence‐based medicine. American Journal of Hematology 86:2, pages 123-154.
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David Irwin, Paul W. Buehler, Abdu I. Alayash, Yiping Jia, Joe Bonventura, Ben Foreman, Molly White, Robert Jacobs, Brian Piteo, Martha C. TissotvanPatot, Karyn L. Hamilton & Robert W. Gotshall. (2010) Mixed S-Nitrosylated Polymerized Bovine Hemoglobin Species Moderate Hemodynamic Effects in Acutely Hypoxic Rats. American Journal of Respiratory Cell and Molecular Biology 42:2, pages 200-209.
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Ronald Kluger, Jonathan S. Foot & Adelle A. Vandersteen. (2010) Protein–protein coupling and its application to functional red cell substitutes. Chemical Communications 46:8, pages 1194.
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Peter C. Minneci, Katherine J. Deans, Sruti Shiva, Huang Zhi, Steven M. Banks, Steven Kern, Charles Natanson, Steven B. Solomon & Mark T. Gladwin. (2008) Nitrite reductase activity of hemoglobin as a systemic nitric oxide generator mechanism to detoxify plasma hemoglobin produced during hemolysis. American Journal of Physiology-Heart and Circulatory Physiology 295:2, pages H743-H754.
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Jan Simoni. 2005. Artificial Oxygen Carrier. Artificial Oxygen Carrier 75 126 .
Paul W. Buehler & Abdu I. Alayash. (2004) Toxicities of hemoglobin solutions: in search of in-vitro and in-vivo model systems. Transfusion 44:10, pages 1516-1530.
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Mark T. Gladwin, Jack H. Crawford & Rakesh P. Patel. (2004) The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation. Free Radical Biology and Medicine 36:6, pages 707-717.
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John S. Olson, Erin W. Foley, Corina Rogge, Ah-Lim Tsai, Michael P. Doyle & Douglas D. Lemon. (2004) No scavenging and the hypertensive effect of hemoglobin-based blood substitutes. Free Radical Biology and Medicine 36:6, pages 685-697.
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William W. Muir & Maxey L. Wellman. (2003) Hemoglobin Solutions and Tissue Oxygenation. Journal of Veterinary Internal Medicine 17:2, pages 127-135.
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Robert A. Maxwell, Jeffrey B. Gibson, Timothy C. Fabian & Kenneth G. Proctor. (2000) Resuscitation of Severe Chest Trauma with Four Different Hemoglobin-Based Oxygen-Carrying Solutions. The Journal of Trauma: Injury, Infection, and Critical Care 49:2, pages 200-211.
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Charles D. Conover, Rita Linberg, Laura Lejeune, Melissa Nagy & Kwok L. Shum. (2004) PEG‐Hemoglobin as a Resuscitation Solution in the Treatment of Hypovolemic Shock in the Anesthetized Rat. Artificial Organs 23:12, pages 1088-1098.
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Lawrence T. Goodnough, Mitchell G. Scott & Terri G. Monk. (1998) Oxygen Carriers as Blood Substitutes. Clinical Orthopaedics and Related Research 357, pages 89-100.
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Kunihiko Nakai, Ichiro Sakuma, Toshio Ohta, Joji Ando, Akira Kitabatake, Yoshikazu Nakazato & Tsuneo A. Takahashi. (1998) Permeability characteristics of hemoglobin derivatives across cultured endothelial cell monolayers. Journal of Laboratory and Clinical Medicine 132:4, pages 313-319.
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Alex L. Loeb, Laura J. McIntosh, Nichelle R. Raj & David E. Longnecker. (1998) Resuscitation after hemorrhage using recombinant human hemoglobin (rHb1.1) in rats. Critical Care Medicine 26:6, pages 1071-1080.
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Mark W. Vaughn, Lih Kuo & James C. Liao. (1998) Effective diffusion distance of nitric oxide in the microcirculation. American Journal of Physiology-Heart and Circulatory Physiology 274:5, pages H1705-H1714.
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Charles D. Conover, Rita Linberg, Carl W. Gilbert, Kwok L. Shum & Robert G.L. Shorr. (2008) Effect of Polyethylene Glycol Conjugated Bovine Hemoglobin in Both Top‐Load and Exchange Transfusion Rat Models. Artificial Organs 21:10, pages 1066-1075.
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Mitchell G Scott, Dennis F Kucik, Lawrence T Goodnough & Terri G Monk. (1997) Blood substitutes: evolution and future applications. Clinical Chemistry 43:9, pages 1724-1731.
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Charles D. Conover, Laura Lejeune, Kwok Shum, Carl Gilbert & Robert G. L. Shorr. (2008) Physiological Effect of Polyethylene Glycol Conjugation on Stroma‐Free Bovine Hemoglobin in the Conscious Dog After Partial Exchange Transfusion. Artificial Organs 21:5, pages 369-378.
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Kunihiko Nakai, Toshio Ohta, Ichiro Sakuma, Kazuhiro Akama, Yuki Kobayashi, Satoru Tokuyama, Akira Kitabatake, Yoshikazu Nakazato, Tsuneo A. Takahashi & Sekiguchi Sadayoshi. (1996) Inhibition of Endothelium-Dependent Relaxation by Hemoglobin in Rabbit Aortic Strips: Comparison Between Acellular Hemoglobin Derivatives and Cellular Hemoglobins. Journal of Cardiovascular Pharmacology 28:1, pages 115-123.
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Larry W. Hunter, Gertrude M. Tyce & Duane K. Rorie. (1996) Norepinephrine release during vasoconstriction induced by cross-linked hemoglobin. Life Sciences 59:2, pages 131-140.
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Ronald J. Rohlfs & Kim D. Vandegriff. 1996. Blood Substitutes. Blood Substitutes 163 184 .

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