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Original Article

Submicron Biodegradable Polymer Membrane Hemoglobin Nanocapsules as Potential Blood Substitutes: A Preliminary Report

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Pages 889-893 | Published online: 11 Jul 2009

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J. Bauer, M. Zähres, A. Zellermann, M. Kirsch, F. Petrat, H. de Groot & C. Mayer. (2010) Perfluorocarbon-filled poly(lactide-co-gylcolide) nano- and microcapsules as artificial oxygen carriers for blood substitutes: a physico-chemical assessment. Journal of Microencapsulation 27:2, pages 122-132.
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Zun Chang Liu & Thomas M.S. Chang. (2008) Long-term Effects on the Histology and Function of Livers and Spleens in Rats after 33% Toploading of PEG-PLA-nano Artificial Red Blood Cells. Artificial Cells, Blood Substitutes, and Biotechnology 36:6, pages 513-524.
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Zun Chang Liu & Thomas M.S. Chang. (2008) Effects of PEG-PLA-nano Artificial Cells Containing Hemoglobin on Kidney Function and Renal Histology in Rats. Artificial Cells, Blood Substitutes, and Biotechnology 36:5, pages 421-430.
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N. Altinbas, C. Fehmer, A. Terheiden, A. Shukla, H. Rehage & C. Mayer. (2006) Alkylcyanoacrylate nanocapsules prepared from mini-emulsions: A comparison with the conventional approach. Journal of Microencapsulation 23:5, pages 567-581.
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Thomas Ming Swi Chang. (2004) Artificial Cell Bioencapsulation in Macro, Micro, Nano, and Molecular Dimensions: Keynote Lecture. Artificial Cells, Blood Substitutes, and Biotechnology 32:1, pages 1-23.
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Fan‐tao Meng, Wan‐zhong Zhang, Guang‐hui Ma & Zhi‐guo Su. (2003) The Preparation and Characterization of Monomethoxypoly(ethylene glycol)‐b‐poly‐DL‐lactide Microcapsules Containing Bovine Hemoglobin. Artificial Cells, Blood Substitutes, and Biotechnology 31:3, pages 279-292.
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M. Wohlgemuth, W. MacHtle, C. Mayer. (2000) Improved preparation and physical studies of polybutylcyanoacrylate nanocapsules. Journal of Microencapsulation 17:4, pages 437-448.
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Thomas Ming Swi Chang. (1997) Recent and Future Developments in Modified Hemoglobin and Microencapsulated Hemoglobin as Red Blood Cell Substitutes. Artificial Cells, Blood Substitutes, and Biotechnology 25:1-2, pages 1-24.
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. (1996) Editorial. Artificial Cells, Blood Substitutes, and Biotechnology 24:4, pages ix-xxiv.
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W. P. Yu & T. M.S. Chang. (1996) Submicron Polymer Membrane Hemoglobin Nanocapsules as Potential Blood Substitutes: Preparation and Characterization. Artificial Cells, Blood Substitutes, and Biotechnology 24:3, pages 169-183.
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Articles from other publishers (26)

Wentao Jiang, Ziyu Wu, Zheng Gao, Mimi Wan, Min Zhou, Chun Mao & Jian Shen. (2022) Artificial Cells: Past, Present and Future. ACS Nano 16:10, pages 15705-15733.
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Ruifen Xu, Jianwei Zhang, Panghu Zhou, Rui Yang, Xuyang Feng & Lixian Xu. (2015) A novel artificial red blood cell substitute: grafted starch-encapsulated hemoglobin. RSC Advances 5:54, pages 43845-43853.
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Feroz Alam, Neha Yadav, Murad Ahmad & Mariyam Shadan. (2013) Blood Substitutes: Possibilities with Nanotechnology. Indian Journal of Hematology and Blood Transfusion 30:3, pages 155-162.
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Thomas Ming Swi Chang. 2013. Biomaterials Science. Biomaterials Science 811 827 .
Yun Wang & Thomas M. S. Chang. (2012) Nanobiotechnological Nanocapsules Containing Polyhemoglobin-Tyrosinase: Effects on Murine B16F10 Melanoma Cell Proliferation and Attachment. Journal of Skin Cancer 2012, pages 1-9.
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Thomas Ming Swi Chang. (2010) Blood replacement with nanobiotechnologically engineered hemoglobin and hemoglobin nanocapsules. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2:4, pages 418-430.
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Yan Sheng, Changsheng Liu, Yuan Yuan, Xiaolan Zhang, Xiaoqian Shan & Feng Xu. (2009) Porosity and semipermeability of hemoglobin‐loaded polymeric nanoparticles as potential blood substitutes. Journal of Biomedical Materials Research Part B: Applied Biomaterials 91B:2, pages 631-642.
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Yan Sheng, Yuan Yuan, Changsheng Liu, Xinyi Tao, Xiaoqian Shan & Feng Xu. (2009) In vitro macrophage uptake and in vivo biodistribution of PLA–PEG nanoparticles loaded with hemoglobin as blood substitutes: effect of PEG content. Journal of Materials Science: Materials in Medicine 20:9, pages 1881-1891.
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T.M.S. Chang. (2009) Nanobiotechnology for Hemoglobin-based Blood Substitutes. Critical Care Clinics 25:2, pages 373-382.
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Thomas Ming Swi Chang. (2008) Nanobiotechnological modification of hemoglobin and enzymes from this laboratory. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1784:10, pages 1435-1440.
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Luca Ronda, Stefano Bruno, Stefania Abbruzzetti, Cristiano Viappiani & Stefano Bettati. (2008) Ligand reactivity and allosteric regulation of hemoglobin-based oxygen carriers. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1784:10, pages 1365-1377.
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T M S CHANG. 2007. Artificial Cells, Cell Engineering and Therapy. Artificial Cells, Cell Engineering and Therapy 321 332 .
S PRAKASH, J R BHATHENA & H CHEN. 2007. Artificial Cells, Cell Engineering and Therapy. Artificial Cells, Cell Engineering and Therapy 3 41 .
Thomas Ming Swi Chang. 2006. Blood Substitutes. Blood Substitutes 523 531 .
C. Mayer. (2018) Nanocapsules as Drug Delivery Systems. The International Journal of Artificial Organs 28:11, pages 1163-1171.
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Thomas Ming Swi Chang. 2005. Scaffolding In Tissue Engineering. Scaffolding In Tissue Engineering 473 480 .
Thomas Ming Swi Chang. (2005) Therapeutic applications of polymeric artificial cells. Nature Reviews Drug Discovery 4:3, pages 221-235.
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Thomas Ming Swi Chang. (2004) Artificial Cells for Cell and Organ Replacements. Artificial Organs 28:3, pages 265-270.
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M Wohlgemuth & C Mayer. (2003) Pulsed field gradient NMR on polybutylcyanoacrylate nanocapsules. Journal of Colloid and Interface Science 260:2, pages 324-331.
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Brian Corrigan. (2002) Beyond EPO. Clinical Journal of Sport Medicine 12:4, pages 242-244.
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C. Mayer. (2002) Nuclear magnetic resonance on dispersed nanoparticles. Progress in Nuclear Magnetic Resonance Spectroscopy 40:4, pages 307-366.
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T.M.S. Chang, F. D’Agnillo, W.P. Yu & S. Razack. (2000) Two future generations of blood substitutes based on polyhemoglobin–SOD–catalase and nanoencapsulation. Advanced Drug Delivery Reviews 40:3, pages 213-218.
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T. Frietsch, C. Lenz & K. F. Waschke. (1998) Artificial oxygen carriers. European Journal of Anaesthesiology 15:5, pages 571-584.
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David D. Rose & Christopher Grande. (1998) A historical overview and military perspective on fluid resuscitation, blood salvaging techniques, and blood substitutes. Seminars in Anesthesia, Perioperative Medicine and Pain 17:3, pages 239-251.
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T.M.S. Chang. 1998. Biotechnolgy Annual Review. Biotechnolgy Annual Review 75 112 .
T.M.S. Chang & W.P. Yu. 1998. Blood Substitutes, Present and Future Perspectives. Blood Substitutes, Present and Future Perspectives 161 169 .

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