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Original Article

Resuscitation with Diaspirin Crosslinked Hemoglobin in a Pig Model of Hemorrhagic Shock

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Pages 39-61 | Published online: 11 Jul 2009

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Read on this site (5)

H. W. Kim, J. Tai & A. G. Greenburg. (2004) Active Myogenic Tone: A Requisite for Hemoglobin Mediated Vascular Contraction?. Artificial Cells, Blood Substitutes, and Biotechnology 32:3, pages 339-351.
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H. W. Kim, J. Tai & A. G. Greenburg. (2001) ALPHA ADRENERGIC ACTIVATION AND HEMOGLOBIN MEDIATED CONTRACTION IN THE ISOLATED RAT THORACIC AORTA. Artificial Cells, Blood Substitutes, and Biotechnology 29:5, pages 367-380.
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Harold I. Friedman, Frank Devenuto, Andrew Kerwin, Kevin Carson, Raymond Bynoe. (2000) Hemoglobin Solutions as Blood Substitutes. Journal of Investigative Surgery 13:2, pages 79-94.
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H. W. Kim & A. G. Greenburg. (1997) Ferrrous Hemoglobin Scavenging of Endothelium Derived Nitric Oxide is a Principal Mechanism for Hemoglobin Mediated Vasoactivities in Isolated rat Thoracic Aorta. Artificial Cells, Blood Substitutes, and Biotechnology 25:1-2, pages 121-133.
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Gary Marchand, Elizabeth Dunlap, Liam Farrell, Carmen Nigro & Kenneth Burhop. (1996) Resuscitation with Increasing Doses of Diaspirin Crosslinked Hemoglobin in Swine. Artificial Cells, Blood Substitutes, and Biotechnology 24:5, pages 469-487.
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Articles from other publishers (19)

T. N. Estep. 2013. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics 621 646 .
Mark A. Young, Louis Riddez, B Thomas Kjellström & Robert M. Winslow. (2007) Effect of Maleimide-Polyethylene Glycol Hemoglobin (MP4) on Hemodynamics and Acid-Base Status After Uncontrolled Hemorrhage in Anesthetized Swine: Comparison With Crystalloid and Blood. Journal of Trauma: Injury, Infection & Critical Care 63:6, pages 1234-1244.
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Mark A. Young, Ashok Malavalli, Nancy Winslow, Kim D. Vandegriff & Robert M. Winslow. (2007) Toxicity and hemodynamic effects after single dose administration of MalPEG-hemoglobin (MP4) in rhesus monkeys. Translational Research 149:6, pages 333-342.
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Mark A. Young, Louis Riddez, Bengt Thomas Kjellström, Jenny Bursell, Ford Winslow, Jeffrey Lohman & Robert M. Winslow. (2005) MalPEG-hemoglobin (MP4) improves hemodynamics, acid-base status, and survival after uncontrolled hemorrhage in anesthetized swine. Critical Care Medicine 33:8, pages 1794-1804.
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Y. Smani, Béatrice Faivre, Sandra Audonnet-Blaise, P. Labrude & C. Vigneron. (2005) Hemoglobin-Based Oxygen Carrier Distribution Inside Vascular Wall and Arterial Pressure Evolution: Is There a Relationship?. European Surgical Research 37:1, pages 1-8.
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A. Pape, M. Kleen, G. Kemming, F. Meisner, J. Meier & O. Habler. (2004) Fluid resuscitation from severe hemorrhagic shock using diaspirin cross-linked hemoglobin fails to improve pancreatic and renal perfusion. Acta Anaesthesiologica Scandinavica 48:10, pages 1328-1337.
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Hae Won Kim & A. Gerson Greenburg. (2004) Artificial Oxygen Carriers as Red Blood Cell Substitutes: A Selected Review and Current Status. Artificial Organs 28:9, pages 813-828.
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Dan Drobin, B. Thomas Kjellstrom, Elisabeth Malm, Ashok Malavalli, Jeff Lohman, Kim D. Vandegriff, Mark A. Young & Robert M. Winslow. (2004) Hemodynamic response and oxygen transport in pigs resuscitated with maleimide-polyethylene glycol-modified hemoglobin (MP4). Journal of Applied Physiology 96:5, pages 1843-1853.
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Jean G. Riess. (2001) Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some Physiology Blut ist ein ganz besondrer Saft . Chemical Reviews 101:9, pages 2797-2920.
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H.W. Kim & A.G. Greenburg. (2000) Pharmacodynamic characterization of hemoglobin-induced vasoactivity in isolated rat thoracic aorta. Journal of Laboratory and Clinical Medicine 135:2, pages 180-187.
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Stefanie R. Fischer, Michael Burnet, Daniel L. Traber, Donald S. Prough & George C. Kramer. (1999) Plasma volume expansion with solutions of hemoglobin, albumin, and Ringer lactate in sheep. American Journal of Physiology-Heart and Circulatory Physiology 276:6, pages H2194-H2203.
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Mat Van Iterson, Michiel Sinaasappel, Ken Burhop, Adrianus Trouwborst & Can Ince. (1998) Low-volume resuscitation with a hemoglobin-based oxygen carrier after hemorrhage improves gut microvascular oxygenation in swine. Journal of Laboratory and Clinical Medicine 132:5, pages 421-431.
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Kunihiko Nakai, Ichiro Sakuma, Toshio Ohta, Joji Ando, Akira Kitabatake, Yoshikazu Nakazato & Tsuneo A. Takahashi. (1998) Permeability characteristics of hemoglobin derivatives across cultured endothelial cell monolayers. Journal of Laboratory and Clinical Medicine 132:4, pages 313-319.
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T.M.S. Chang. 1998. Biotechnolgy Annual Review. Biotechnolgy Annual Review 75 112 .
Luiz F. Poli de Figueiredo, Mali Mathru, Daneshvari Solanki, Victor W. Macdonald, John Hess & George C. Kramer. (1997) Pulmonary Hypertension and Systemic Vasoconstriction May Offset the Benefits of Acellular Hemoglobin Blood Substitutes. The Journal of Trauma: Injury, Infection, and Critical Care 42:5, pages 847-856.
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Lan Xu, Liying Sun, Florence M. Rollwagen, Yingyue Li, Nancy D. Pacheco, Emmanouil Pikoulis, Ari Leppaniemi, Raluan Soltero, David Burris, Diana Malcolm & Thor B. Nielsen. (1997) Cellular Responses to Surgical Trauma, Hemorrhage, and Resuscitation with Diaspirin Cross-Linked Hemoglobin in Rats. The Journal of Trauma: Injury, Infection, and Critical Care 42:1, pages 32-41.
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John R. Hess & Robert F. Reiss. (1996) Resuscitation and the limited utility of the present generation of blood substitutes. Transfusion Medicine Reviews 10:4, pages 276-285.
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Kunihiko Nakai, Toshio Ohta, Ichiro Sakuma, Kazuhiro Akama, Yuki Kobayashi, Satoru Tokuyama, Akira Kitabatake, Yoshikazu Nakazato, Tsuneo A. Takahashi & Sekiguchi Sadayoshi. (1996) Inhibition of Endothelium-Dependent Relaxation by Hemoglobin in Rabbit Aortic Strips: Comparison Between Acellular Hemoglobin Derivatives and Cellular Hemoglobins. Journal of Cardiovascular Pharmacology 28:1, pages 115-123.
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Bradley J. Hindman, Franklin Dexter, Johann Cutkomp & Tom Smith. (1995) Diaspirin Cross-linked Hemoglobin Does Not Increase Brain Oxygen Consumption during Hypothermic Cardiopulmonary Bypass in Rabbits. Anesthesiology 83:6, pages 1302-1311.
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