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Artificial Cells, Blood Substitutes, and Biotechnology Volume 23, 1995 - Issue 3
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Original Article

Use of Oxygent™, A Perfluorochemical-Based Oxygen Carrier, as An Alternative to Intraoperative Blood Transfusion

Peter E. Keipert Alliance Pharmaceutical Corp., 3040 Science Park Road, San Diego, CA, 92121
Pages 381-394 | Published online: 11 Jul 2009

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Stephanie Dinkelmann, Wolfgang Röhlke, Hasso Meinert & Hinnak Northoff. (2001) A SYSTEM ESTABLISHING COMPATIBILITY PROFILES FOR ARTIFICIAL OXYGEN CARRIERS AND OTHER SUBSTANCES. Artificial Cells, Blood Substitutes, and Biotechnology 29:1, pages 57-70.
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Articles from other publishers (48)

Thore Dietrich, Stephan Theodor Bujak, Thorsten Keller, Bernhard Schnackenburg, Riad Bourayou, Rolf Gebker, Kristof Graf & Eckart Fleck. (2023) In Vivo Fluorine Imaging Using 1.5 Tesla MRI for Depiction of Experimental Myocarditis in a Rodent Animal Model. International Journal of Biomedical Imaging 2023, pages 1-8.
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Irene Lim, Eric Yu Lin, Joseph Garcia, Shang Jia, Robert E. Sommerhalter, Subrata K. Ghosh, John A. Gladysz & Ellen M. Sletten. (2022) Shortwave Infrared Fluorofluorophores for Multicolor In Vivo Imaging** . Angewandte Chemie International Edition 62:6.
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Irene Lim, Eric Yu Lin, Joseph Garcia, Shang Jia, Robert E. Sommerhalter, Subrata K. Ghosh, John A. Gladysz & Ellen M. Sletten. (2022) Shortwave Infrared Fluorofluorophores for Multicolor In Vivo Imaging** . Angewandte Chemie 135:6.
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Phillip G. Durham & Paul A. Dayton. (2021) Applications of sub-micron low-boiling point phase change contrast agents for ultrasound imaging and therapy. Current Opinion in Colloid & Interface Science 56, pages 101498.
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Tarun Agarwal, Sara Kazemi, Marco Costantini, Francisca Perfeito, Clara R. Correia, Vítor Gaspar, Leila Montazeri, Carmelo De Maria, João F. Mano, Massoud Vosough, Pooyan Makvandi & Tapas Kumar Maiti. (2021) Oxygen releasing materials: Towards addressing the hypoxia-related issues in tissue engineering. Materials Science and Engineering: C 122, pages 111896.
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Fanourios Georgiades, Sarah A. Hosgood & Michael L. Nicholson. 2021. Organ Repair and Regeneration. Organ Repair and Regeneration 75 93 .
V. Prakash Reddy. 2020. Organofluorine Chemistry. Organofluorine Chemistry 279 327 .
Jeffrey W. Simkins, Philip S. Stewart, Sarah L. Codd & Joseph D. Seymour. (2019) Non‐invasive imaging of oxygen concentration in a complex in vitro biofilm infection model using 19 F MRI: Persistence of an oxygen sink despite prolonged antibiotic therapy . Magnetic Resonance in Medicine 82:6, pages 2248-2256.
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Nan Zhang, Ming-Yuan Wei & Qiang Ma. (2019) Nanomedicines: A Potential Treatment for Blood Disorder Diseases. Frontiers in Bioengineering and Biotechnology 7.
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Ivo P. Torres Filho. (2019) Mini-review: Perfluorocarbons, Oxygen Transport, and Microcirculation in Low Flow States: in Vivo and in Vitro Studies. Shock 52:1S, pages 19-27.
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Palmira Villa-Valverde, Ignacio Rodríguez, Daniel Padró, Marina Benito, Carlos Ernesto Garrido-Salmon & Jesús Ruiz-Cabello. (2019) A dual 1H/19F birdcage coil for small animals at 7 T MRI. Magnetic Resonance Materials in Physics, Biology and Medicine 32:1, pages 79-87.
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Sonia Waiczies, MinChi Ku & Thoralf Niendorf. 2016. Fluorine Magnetic Resonance Imaging. Fluorine Magnetic Resonance Imaging 243 282 .
Xuejiao Song, Liangzhu Feng, Chao Liang, Kai Yang & Zhuang Liu. (2016) Ultrasound Triggered Tumor Oxygenation with Oxygen-Shuttle Nanoperfluorocarbon to Overcome Hypoxia-Associated Resistance in Cancer Therapies. Nano Letters 16:10, pages 6145-6153.
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Christoph Jacoby, Sebastian Temme, Friederike Mayenfels, Nicole Benoit, Marie Pierre Krafft, Rolf Schubert, Jürgen Schrader & Ulrich Flögel. (2014) Probing different perfluorocarbons for in vivo inflammation imaging by 19 F MRI: image reconstruction, biological half-lives and sensitivity . NMR in Biomedicine 27:3, pages 261-271.
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Pedro Cabrales & Marcos Intaglietta. (2013) Blood Substitutes. ASAIO Journal 59:4, pages 337-354.
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Martijn Wolters, Seyede G. Mohades, Tilman M. Hackeng, Mark J. Post, Marianne E. Kooi & Walter H. Backes. (2013) Clinical Perspectives of Hybrid Proton-Fluorine Magnetic Resonance Imaging and Spectroscopy. Investigative Radiology 48:5, pages 341-350.
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Diana M. Vásquez, Daniel Ortiz, Oscar A. Alvarez, Juan C. Briceño & Pedro Cabrales. (2013) Hemorheological implications of perfluorocarbon based oxygen carrier interaction with colloid plasma expanders and blood. Biotechnology Progress 29:3, pages 796-807.
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Sebastian Temme, Florian Bönner, Jürgen Schrader & Ulrich Flögel. (2012) 19 F magnetic resonance imaging of endogenous macrophages in inflammation . Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 4:3, pages 329-343.
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Pedro Cabrales. 2010. Alternatives to Blood Transfusion in Transfusion Medicine. Alternatives to Blood Transfusion in Transfusion Medicine 380 388 .
Donald J. AbrahamStefano Bruno, Luca Ronda, Serena Faggiano, Stefano Bettati & Andrea Mozzarelli. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 609 660 .
Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Toru Maruyama, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toshiya Kai & Masaki Otagiri. (2009) Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier. Drug Metabolism and Disposition 37:7, pages 1456-1463.
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PEDRO CABRALES, BEATRIZ Y. SALAZAR VÁZQUEZ, ADOLFO CHÁVEZ NEGRETE & MARCOS INTAGLIETTA. (2007) Perfluorocarbons as gas transporters for O 2 , NO, CO and volatile anesthetics . Transfusion Alternatives in Transfusion Medicine 9:4, pages 294-303.
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Anand Sundararajan & Lu-Kwang Ju. (2007) Use of cyanobacterial gas vesicles as oxygen carriers in cell culture. Cytotechnology 52:2, pages 139-149.
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Marcos IntagliettaPedro CabralesAmy G. Tsai. (2006) MICROVASCULAR PERSPECTIVE OF OXYGEN-CARRYING AND -NONCARRYING BLOOD SUBSTITUTES. Annual Review of Biomedical Engineering 8:1, pages 289-321.
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Danja Strumper-Groves. (2006) Perioperative blood transfusion and outcome. Current Opinion in Anaesthesiology 19:2, pages 198-206.
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Lawrence T. Goodnough. (2005) Rationale for Blood Conservation. Surgical Infections 6:s-1, pages s-3-s-8.
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Lawrence T. Goodnough. (2005) Rationale for Blood Conservation. Surgical Infections 6:s1, pages s3-s8.
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Yorck Olaf Schumacher & Michael Ashenden. (2004) Doping with Artificial Oxygen Carriers. Sports Medicine 34:3, pages 141-150.
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Kenneth C. Lowe. (2003) Engineering Blood: Synthetic Substitutes from Fluorinated Compounds. Tissue Engineering 9:3, pages 389-399.
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Lawrence T. Goodnough, Aryeh Shander & Richard Spence. (2003) Bloodless medicine: clinical care without allogeneic blood transfusion. Transfusion 43:5, pages 668-676.
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Lawrence T Goodnough, Aryeh Shander & Mark E Brecher. (2003) Transfusion medicine: looking to the future. The Lancet 361:9352, pages 161-169.
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Sherri Ozawa, Aryeh Shander & Teekam D. Ochani. (2001) A Practical Approach to Achieving Bloodless Surgery. AORN Journal 74:1, pages 32-47.
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Kenneth C Lowe. (2001) Fluorinated blood substitutes and oxygen carriers. Journal of Fluorine Chemistry 109:1, pages 59-65.
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Gus J. Vlahakes. 2001. Surgical Research. Surgical Research 1037 1046 .
Phillip T. Leese, Robert J. Noveck, Jolene S. Shorr, Catherine M. Woods, Kathryn E. Flaim & Peter E. Keipert. (2000) Randomized Safety Studies of Intravenous Perflubron Emulsion. I. Effects on Coagulation Function in Healthy Volunteers. Anesthesia & Analgesia 91:4, pages 804-811.
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Françoise Nielloud & Gilberte Marti-MestresKatrin Buszello & Bernd Müller. 2000. Pharmaceutical Emulsions and Suspensions. Pharmaceutical Emulsions and Suspensions 191 228 .
J. Treib, M. T. Grauer & A. Haass. 2000. Volume Therapy. Volume Therapy 78 122 .
K.C. Lowe. (1999) Perfluorinated blood substitutes and artificial oxygen carriers. Blood Reviews 13:3, pages 171-184.
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Diane Savarese, Heidi Waitkus, F. Marc Stewart & Mark Callery. (1999) Bloodless Medicine and Surgery. Journal of Intensive Care Medicine 14:1, pages 20-33.
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Diane Savarese, Heidi Waitkus, F. Marc Stewart & Mark Callery. (2016) Bloodless Medicine and Surgery. Journal of Intensive Care Medicine 14:1, pages 20-33.
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N.S. Faithfull & J.G. Weers. (2011) Perfluorocarbon Compounds. Vox Sanguinis 74:S2, pages 243-248.
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J.G. Riess & P.E. Keipert. 1998. Blood Substitutes, Present and Future Perspectives. Blood Substitutes, Present and Future Perspectives 91 102 .
N. Mertes, M. Booke & H. Van Aken. (1997) Strategies to reduce the need for peri-operative blood transfusion. European Journal of Anaesthesiology 14:Supplement 14, pages 24-34.
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H.W. Eijkhout & W.G. van Aken. 1997. 296 309 .
U. B. Brückner. 1997. Forschung in der Chirurgie. Forschung in der Chirurgie 286 296 .
Veronique M. Sadtler, Marie Pierre Krafft & Jean G. Riess. (2006) Herstellung stabiler, inverser Wasser‐in‐Fluorkohlenstoff‐Emulsionen. Angewandte Chemie 108:17, pages 2106-2108.
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Thao D. Le, Rebecca A. Arlauskas & Jeffry G. Weers. (1996) Characterization of the lipophilicity of fluorocarbon derivatives containing halogens or hydrocarbon blocks. Journal of Fluorine Chemistry 78:2, pages 155-163.
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Peter E. Keipert, N. Simon Faithfull, Duane J. Roth, JoAnn D. Bradley, Sanjay Batra, Philip Jochelson & Kathryn E. Flaim. 1996. Oxygen Transport to Tissue XVII. Oxygen Transport to Tissue XVII 603 609 .

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