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Artificial Cells, Blood Substitutes, and Biotechnology Volume 25, 1997 - Issue 1-2
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Original Article

Modified Hemoglobin Solution, with Desired Pharmacological Properties, Does not Activate Nuclear Transcription Factor NF-kappa B in Human Vascular Endothelial Cells

Jan Simoni Departments of Surgery, Texas Tech University Health Sciences Center, Lubbock, Texas, 79430, USACorrespondence[email protected]
,
Grace Simoni Departments of Surgery, Texas Tech University Health Sciences Center, Lubbock, Texas, 79430, USA
,
Charles D. Lox Obstetrics & Gynecology, Texas Tech University Health Sciences Center, Lubbock, Texas, 79430, USA
,
Samuel D. Prien Obstetrics & Gynecology, Texas Tech University Health Sciences Center, Lubbock, Texas, 79430, USA
&
G. Tom Shires Departments of Surgery, Texas Tech University Health Sciences Center, Lubbock, Texas, 79430, USA
Pages 193-210 | Published online: 11 Jul 2009

Citations (27)

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Read on this site (6)

Thomas Ming Swi Chang. (2022) The role of artificial cells in the fight against COVID-19: deliver vaccine, hemoperfusion removes toxic cytokines, nanobiotherapeutics lower free radicals and pCO2 and replenish blood supply. Artificial Cells, Nanomedicine, and Biotechnology 50:1, pages 240-251.
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Thomas Ming Swi Chang. (2015) Red blood cell replacement, or nanobiotherapeutics with enhanced red blood cell functions?. Artificial Cells, Nanomedicine, and Biotechnology 43:3, pages 145-147.
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Jan Simoni, Grace Simoni, John F. Moeller, James P. Tsikouris & Donald E. Wesson. (2007) Evaluation of Angiotensin Converting Enzyme (ACE)-Like Activity of Acellular Hemoglobin. Artificial Cells, Blood Substitutes, and Biotechnology 35:2, pages 191-210.
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Professors Mario Feola & Jan Simoni. (2000) Editorial Comments on: “Is There a Need for Blood Substitutes in the New Millennium and What should we Expect in the Way of Safety and Efficacy?”. Artificial Cells, Blood Substitutes, and Biotechnology 28:2, pages v-ix.
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Guro Valen, Wolfgang Erl, Per Eriksson, Dirk Wuttge, Gabrielle Paulsson & Göran K. Hansson. (1999) Hydrogen peroxide induces mRNA for tumour necrosis factor α in human endothelial cells. Free Radical Research 31:6, pages 503-512.
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Jan Simoni, Grace Simoni, Shelley Weinstock, Charles Lox & Mario Feola. (1998) An improved blood substitute. Emerging Therapeutic Targets 2:1, pages 85-91.
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Articles from other publishers (21)

Jan Simoni. 2022. Blood Substitutes and Oxygen Biotherapeutics. Blood Substitutes and Oxygen Biotherapeutics 227 234 .
Thomas Ming Swi Chang. 2022. Blood Substitutes and Oxygen Biotherapeutics. Blood Substitutes and Oxygen Biotherapeutics 99 115 .
Jan Simoni. (2017) Artificial Oxygen Carriers: Exactly How Close Are We to an Ultimate Product?. Artificial Organs 41:4, pages 316-318.
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Jan Simoni, Grace Simoni, John F. Moeller, Mario Feola & Donald E. Wesson. (2014) Artificial Oxygen Carrier With Pharmacologic Actions of Adenosine-5′-Triphosphate, Adenosine, and Reduced Glutathione Formulated to Treat an Array of Medical Conditions. Artificial Organs 38:8, pages 684-690.
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Christina Lisk, Doug Kominsky, Stefan Ehrentraut, Joe Bonaventura, Rachelle Nuss, Kathryn Hassell, Eva Nozik-Grayck & David C. Irwin. (2013) Hemoglobin-Induced Endothelial Cell Permeability Is Controlled, in Part, via a Myeloid Differentiation Primary Response Gene–88–Dependent Signaling Mechanism. American Journal of Respiratory Cell and Molecular Biology 49:4, pages 619-626.
Crossref
Jan Simoni, Grace Simoni & John F. Moeller. 2013. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics 315 337 .
Thomas Ming Swi Chang. 2013. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics 3 26 .
Paul W. BuehlerJin Hyen BaekChristina LiskIan ConnorTim SullivanDouglas Kominsky, Susan MajkaKurt R. StenmarkEva Nozik-GrayckJoe Bonaventura & David C. Irwin. (2012) Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism. American Journal of Physiology-Lung Cellular and Molecular Physiology 303:4, pages L312-L326.
Crossref
Jan Simoni, Grace Simoni, John F. Moeller, Mario Feola, John A. Griswold & Donald E. Wesson. (2012) Adenosine‐5′‐Triphosphate‐Adenosine‐Glutathione Cross‐Linked Hemoglobin as Erythropoiesis‐Stimulating Agent. Artificial Organs 36:2, pages 139-150.
Crossref
Jan Simoni, Javier Villanueva-Meyer, Grace Simoni, John F. Moeller & Donald E. Wesson. (2009) Control of Oxidative Reactions of Hemoglobin in the Design of Blood Substitutes: Role of the Ascorbate-Glutathione Antioxidant System. Artificial Organs 33:2, pages 115-126.
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Jan Simoni, Grace Simoni & John F. Moeller. (2009) Intrinsic Toxicity of Hemoglobin: How to Counteract It. Artificial Organs 33:2, pages 100-109.
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Dongxin Hu & Ronald Kluger. (2008) Efficient generation of dendritic arrays of cross-linked hemoglobin: symmetry and redundancy. Org. Biomol. Chem. 6:1, pages 151-156.
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Jan Simoni, Grace Simoni, John A. Griswold, John F. Moeller, James P. Tsikouris, Apurv Khanna, Chanwit Roongsritong & Donald E. Wesson. (2006) Role of Free Hemoglobin in 8-Iso Prostaglandin F2-Alpha Synthesis in Chronic Renal Failure and Its Impact on CD163-Hb Scavenger Receptor and on Coronary Artery Endothelium. ASAIO Journal 52:6, pages 652-661.
Crossref
Jun Mohara, Irene Aguilera, Bruce I. Goldman, Carol A. Fisher, John P. Gaughan, Joseph R. Libonati, Satoshi Furukawa & Arun K. Singhal. (2005) Effects of Nutrient and Hemoglobin Enriched Cell Free Perfusates Upon Ex Vivo Isolated Rat Heart Preparation. ASAIO Journal 51:3, pages 288-295.
Crossref
Jan Simoni. 2005. Artificial Oxygen Carrier. Artificial Oxygen Carrier 75 126 .
Ann L. Baldwin. (2004) Blood Substitutes and Redox Responses in the Microcirculation. Antioxidants & Redox Signaling 6:6, pages 1019-1030.
Crossref
M. Toussaint-Hacquard, Y. Devaux, D. Longrois, B. Faivre-Fiorina, S. Muller, J.F. Stoltz, C. Vigneron & P. Menu. (2003) Biological response of human aortic endothelial cells exposed to acellular hemoglobin solutions developed as potential blood substitutes. Life Sciences 72:10, pages 1143-1157.
Crossref
Jean G. Riess. (2001) Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some Physiology Blut ist ein ganz besondrer Saft . Chemical Reviews 101:9, pages 2797-2920.
Crossref
Linda S. Marton, Xiaoyu Wang, Andrew Kowalczuk, Zhen-Du Zhang, Emily Windmeyer & R. Loch Macdonald. (2000) Effects of hemoglobin on heme oxygenase gene expression and viability of cultured smooth muscle cells. American Journal of Physiology-Heart and Circulatory Physiology 279:5, pages H2405-H2413.
Crossref
Jan Simoni, Grace Simoni, Donald E. Wesson, John A. Griswold & Mario Feola. (2000) A Novel Hemoglobin-Adenosine-Glutathione Based Blood Substitute: Evaluation of Its Effects on Human Blood Ex Vivo. ASAIO Journal 46:6, pages 679-692.
Crossref
T.M.S. Chang. 1998. Biotechnolgy Annual Review. Biotechnolgy Annual Review 75 112 .

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