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Artificial Cells, Blood Substitutes, and Biotechnology Volume 26, 1998 - Issue 5-6
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Original Article

Validation of the Heat Treatment Step Used in the Production of Diaspirln Crosslinked Hemoglobin (DCLHb™) For Viral Inactivation

M. Azari Blood Substitutes Program, Baxter Healthcare Corporation, Round Lake, Illinois, 60073, USA
,
A. Ebeling Blood Substitutes Program, Baxter Healthcare Corporation, Round Lake, Illinois, 60073, USA
,
R Baker Blood Substitutes Program, Baxter Healthcare Corporation, Round Lake, Illinois, 60073, USA
,
K. Burhop Blood Substitutes Program, Baxter Healthcare Corporation, Round Lake, Illinois, 60073, USA
,
T. Camacho Blood Substitutes Program, Baxter Healthcare Corporation, Round Lake, Illinois, 60073, USA
,
T. Estep Blood Substitutes Program, Baxter Healthcare Corporation, Round Lake, Illinois, 60073, USA
,
S. Guzder Blood Substitutes Program, Baxter Healthcare Corporation, Round Lake, Illinois, 60073, USA
,
T. Marshall Blood Substitutes Program, Baxter Healthcare Corporation, Round Lake, Illinois, 60073, USA
,
K. Rohn Blood Substitutes Program, Baxter Healthcare Corporation, Round Lake, Illinois, 60073, USA
,
R Sarajari Blood Substitutes Program, Baxter Healthcare Corporation, Round Lake, Illinois, 60073, USA
,
J. A. Boose Process Validation Division, Microbiological Associates, Inc., Rockville, Maryland, 20850, USA
,
G. Gauvin Process Validation Division, Microbiological Associates, Inc., Rockville, Maryland, 20850, USA
,
R Homer Process Validation Division, Microbiological Associates, Inc., Rockville, Maryland, 20850, USA
,
B. Lu Process Validation Division, Microbiological Associates, Inc., Rockville, Maryland, 20850, USA
,
L. Pearson Process Validation Division, Microbiological Associates, Inc., Rockville, Maryland, 20850, USA
&
D. Vacante Process Validation Division, Microbiological Associates, Inc., Rockville, Maryland, 20850, USA
 show all
Pages 577-582 | Published online: 04 Aug 2009

Citations (7)

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Read on this site (3)

Tao Li, Rong Yu, Hong-Hui Zhang, Hong Wang, Wei-Guang Liang, Xiao-Ming Yang & Cheng-Min Yang. (2006) A Method for Purification and Viral Inactivation of Human Placenta Hemoglobin. Artificial Cells, Blood Substitutes, and Biotechnology 34:2, pages 175-188.
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H. Abe, K. Ikebuchi, J. Hirayama, M. Fujihara, S. Takeoka, H. Sakai, E. Tsuchida & H. Ikeda. (2001) VIRUS INACTIVATION IN HEMOGLOBIN SOLUTION BY HEAT TREATMENT. Artificial Cells, Blood Substitutes, and Biotechnology 29:5, pages 381-388.
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H Abe, H Sugawara, J Hirayama, H Ihara, T Kato, H Ikeda & K Ikebuchi. (2000) Removal of Parvovirus B19 from Hemoglobin Solution by Nanofiltration. Artificial Cells, Blood Substitutes, and Biotechnology 28:5, pages 375-383.
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Articles from other publishers (4)

Michael A. PitinoDeborah L. O’ConnorAllison J. McGeerSharon Unger. (2021) The impact of thermal pasteurization on viral load and detectable live viruses in human milk and other matrices: a rapid review. Applied Physiology, Nutrition, and Metabolism 46:1, pages 10-26.
Crossref
Jean G. Riess. (2001) Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some Physiology Blut ist ein ganz besondrer Saft . Chemical Reviews 101:9, pages 2797-2920.
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Robert M. Winslow. (2000) alphaalpha-Crosslinked Hemoglobin: Was Failure Predicted by Preclinical Testing?. Vox Sanguinis 79:1, pages 1-20.
Crossref
Mahmood Azari, Jeri Ann Boose, Kenneth E. Burhop, Theresa Camacho, James Catarello, Alan Darling, August A. Ebeling, Timothy N. Estep, Luisa Pearson, Sarosh Guzder, Janelle Herren, Kristen Ogle, Jennifer Paine, Kimberly Rohn, Ramin Sarajari, Chong-Son Sun & Liang Zhang. (2000) Evaluation and Validation of Virus Removal by Ultrafiltration During the Production of Diaspirin Crosslinked Haemoglobin (DCLHb). Biologicals 28:2, pages 81-94.
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