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Original Article

Changes in the Functional Properties of Bovine Hemoglobin Induced by Covalent Modification with Polyethylene Glycol

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Pages 185-202 | Published online: 11 Jul 2009

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Fantao Meng, Amy G. Tsai, Marcos Intaglietta & Seetharama A. Acharya. (2015) PEGylation of αα-Hb using succinimidyl propionic acid PEG 5K: Conjugation chemistry and PEG shell structure dictate respectively the oxygen affinity and resuscitation fluid like properties of PEG αα-Hbs. Artificial Cells, Nanomedicine, and Biotechnology 43:4, pages 270-281.
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Minghua Yu, Jianqun Han, Min Dai, Peilin Cui, Hongwei Li, Qian Liu & Ruijuan Xiu. (2008) Influence of PEG-conjugated Hemoglobin on Tumor Oxygenation and Response to Chemotherapy. Artificial Cells, Blood Substitutes, and Biotechnology 36:6, pages 551-561.
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Seetharama A. Acharya, Joel M. Friedman, Belur N. Manjula, Marcos Intaglietta, Amy G. Tsai, Robert M. Winslow, Ashok Malavalli, Kim Vandegriff & Paul K. Smith. (2005) Enhanced Molecular Volume of Conservatively Pegylated Hb: (SP-PEG5K)6-HbA is Non-Hypertensive. Artificial Cells, Blood Substitutes, and Biotechnology 33:3, pages 239-255.
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Articles from other publishers (7)

Ying Wang, Linli Wang, Weili Yu, Dawei Gao, Guoxing You, Penglong Li, Shan Zhang, Jun Zhang, Tao Hu, Lian Zhao & Hong Zhou. (2017) A PEGylated bovine hemoglobin as a potent hemoglobin-based oxygen carrier. Biotechnology Progress 33:1, pages 252-260.
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Fantao Meng, Belur N. Manjula, Amy G. Tsai, Pedro Cabrales, Marcos Intaglietta, Paul K. Smith, Muthuchidambaram Prabhakaran & Seetharama A. Acharya. (2009) Hexa-thiocarbamoyl Phenyl PEG5K Hb: Vasoactivity and Structure. The Protein Journal 28:5, pages 199-212.
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Minghua Yu, Min Dai, Qian Liu & Ruijuan Xiu. (2007) Oxygen carriers and cancer chemo- and radiotherapy sensitization: Bench to bedside and back. Cancer Treatment Reviews 33:8, pages 757-761.
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Belur N. Manjula, Amy G. Tsai, Marcos Intaglietta, Ching-Hsuan Tsai, Chien Ho, Paul K. Smith, Krishnaveni Perumalsamy, Nirmala Devi Kanika, Joel M. Friedman & Seetharama A. Acharya. (2005) Conjugation of Multiple Copies of Polyethylene Glycol to Hemoglobin Facilitated Through Thiolation: Influence on Hemoglobin Structure and Function. The Protein Journal 24:3, pages 133-146.
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F. Carlucci, F. Miraldi, A. Barretta, A.G.M. Marullo, E. Marinello & A. Tabucchi. (2002) Preservation of myocardial energy status by bovine hemoglobin solutions during ischemia. Biomedicine & Pharmacotherapy 56:5, pages 247-253.
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Jean G. Riess. (2001) Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some Physiology Blut ist ein ganz besondrer Saft . Chemical Reviews 101:9, pages 2797-2920.
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Dan L. Serna, Ledford L. Powell, Chadi Kahwaji, William C. Wallace, Justin West, Greg Cogert, Peter Smulowitz, Earl Steward, Ralph E. Purdy & Jeffrey C. Milliken. (2000) Cardiac Function after Eight Hour Storage by Using Polyethylene Glycol Hemoglobin Versus Crystalloid Perfusion. ASAIO Journal 46:5, pages 547-552.
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